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RISS 인기검색어
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- 저자 : 김충기(Chung Kee Kim) (검색결과 6 건)
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위 질환 환자들에서 분리된 Helicobacter pylori 의 공포화 독소 ( Vacuolating Toxin ) 생성
김충기(Chung Kee Kim),정승수(Sung Soo Jeong),이겸철(Gyum Cheol Lee),서대홍(Dae Hong Suh),송갑영(Gap Young Song),최경현(Kyung Hun Choi),장명웅(Myung Woong Chang) 대한내과학회 1998 대한내과학회지 Vol.54 No.5
N/A Objectives: This study was carried out to survey the prevalence of Helicobacter pylori infection and the incidence of vacuolating toxin producing H pylori. A further aim of this study was to evaluate the quantitative assay for cell vacuolation on the basis of the rapid uptake of neutral red dye by vaculoes of the cells. Methods: We studied the gastric biopsy specimens of patients with 154 cases of gastritis, 74 cases of gastric ulcer, and 167 cases of gastric cancer and in 44 cases of healthy persons, One of the biopsy specimen was placed into a CLOtest plate for rapid urease test and the other one of the biopsy spcimen was inoculated on Brain Heart Infusion blood agar for culture. The culture supernatant of isolated H. pylari was serially diluted with BHI broth. After 24 hour incubation of cultured RK-13 cells treated with the culture supernatgnt of H. pylori, cytoplasmic vacuolation of the cells were observed microscopically. Results: The positivity of urease test and the rate of isolation of K pylori from urease positive gastric biopsy materials were 34.1% and 93.3% in healthy person, 55.8% and 70.9% in gastritis, 60.8% and 71.1% in gastric ulcer, and 56.3% and 96.8% in gastric cancer. The isolation rate of H. pylari from patients between 20 and 39 years old was 16.8%, far patients between 40 and 59 years old it was 51.9%, and for patients above 60 years old it was 31.2%. The isolation rate of the vacuolating toxin producing H pylori from gastric biopsy specimens was 66.7% in a healthy person, 76.6% in gastritis, 79.4% in gastric ulcer, and 80% in gastric cancer. Conclusions: The isolation rate of H. pylori from the patients with gastric diseases is higher than the rate of H. pylori from healthy persons, but the isolation rate of the vacuolating toxin producing H. pylori is not different between the patients with gastric diseases and healthy persons. The titers of vacuolating toxin produced by some H, pylori isolated from the patients with gastric diseases are higher than those from healthy persons.
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내독소에 의한 다발성 기관기능장애의 발생에 있어서 Pentoxifylline 의 치료효과에 관한 연구
이겸철(Gyum Cjheol Lee),정승수(Sung Soo Jeong),김충기(Chung Kee Kim),서대홍(Dae Hong Su),임홍섭(Hong Sed Lim),김치대(Chi Dae Kim),홍기환(Ki Whan Hong) 대한내과학회 1998 대한내과학회지 Vol.54 No.5
N/A Objectives : Septic shock is characterized by the circulatory failure including vasodilation, hyporeactivity to vasoconstrictor agents and organ ischemia in association with multiple organ failure and increased platelet aggregation and blood coagulation. In the present study, we investigated the preventive effects of N-nitro- L-arginine methyl ester (I -NAME, 30mg/kg, i.p.), a non-selective nitric oxide synthase (NOS) inhibitor, S -methylisothiourea sulfate (SMT, 5mg/kg, i.p.) and pentoxifylline (PTX, 10mg/kg, i.p.) on the multiple organ dysfunction in a rat model of circulatory shock induced by bacterial endotoxin (E. coli lipopolysaccharide: LPS) and discussed the mechanism underlying the development of multiple organ failure. Methods . The effect of each other Nw-nitro-L- arginine methyl ester(L- NAME, 30 mg/kg, i.p.), a non- selective nitric oxide synthase(NOS) inhibitor, S-methylisothiourea sulfate(SMT, 5mg/kg, i.p.) and pentoxifylline (PTX, 10mg/kg, i.p.) were comparatively evaluated following inducing circulatory shock by means of infusion of bacterial endotoxin to thc rat model. Results : 1) The systemic mean arterial blood pressure deamsed by 48.7mmHg and vascular hyporeactivity to oradrenaline injection(l㎍/kg, i.v.) upon intravenous administration of LPS. 2) Endotoxemia for 6hours resulted in little change in the numbers of white blood cells and neutrophils but a significant reduction in the numbers of platelets. The variables were not affected by the inhibitors. 3) Endotoxemia for 6hours caused a significant increase in serum nitric oxide level (P<0.01) which was inhibited by SMT, but not by L-NAME and PTX. 4) Upon injection of LPS, serum creatinine(0,65± 0.08mg/dl) and urea(28.7±5.9mg/dl) were significantly elevated to 0.92±0.12 (P<0.05) and 54.3±2.1mg/dl (P< 0.01). These elevated levels were significantly attenuated by PTX but not by L-NAME and SMT. 5) Endotoxemia for 6 hours resulted in a significant increases in serum ALT(988.8±28.2 1U/L, P<0.01) and AST levels(l470.5±396.5 IU/I., P<0.01) from basal levels of ALT(67.8+ 11.7IU/I.) and AST(170.3±14.8IU/L). These increased activities were significantly attenuated by PTX, but not by L-NAME and SMT. The level of LDH(1279.8 ±156.2IU/L) was significantly increased by I.PS treatment to 2932.0519.9IU/L (P<0.05), which was inhibited by PTX. 6) Upon LPS treatnt, the myeloperoxidase activity in the lung homogenate was significantly increased by I.PS treatment (P<0.05), whereas that in the liver showed less change. The increased activity was reduced by PTX (P<0.05), but not by L-NAME and SMT. 7) The level of serum malondialdehyde, an index of lipid peroxidation by oxygen free radicals, was little influenced by LPS. Conelusion : Based on these results, it is summarized that PTX characteristically inhibited the development of multiple ogran dysfunction in a murine model of endotoxemia. Thus, it is concluded that the formation of TNF and increased activity of neutrophils may importantly contribute to the development of LPS-induced endotoxemia.
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가성낭을 동반한 만성 췌장염 환자에서 발생한 비장경색 및 비장파열 1 예
조용구(Yong Gu Cho),임영찬(Young Chan Lim),한병호(Beoung Ho Han),김충기(Chung Kee Kim),임홍섭(Hong Seub Lim),심영웅(Young Woong Sim),송갑영(Gap Young Song) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6
Splenic infarction is not common disease which is caused by occlusion of the main splenic artery or any of its branches. It is mainly caused by emboli that arise from cardiovascular disease, but sometimes by regional thrombosis associated with leukemia, myeloproliferative disorder, sickle cell anemia, pancreatitis, portal hypertension, splenic torsion, septicemia and drugs, etc. Splenic infarction accompained by chronic pancreatitis is most likely due to splenic vein thrombosis, surrounding tissue fibrosis accompanied with splenic vessel occlusion, and intrasplenic penetration of pancreatic pseudocyst. Recently, we experienced a case of splenic infarction and rupture in a 46-year-old male who had been diagnosed as chronic pancreatitis with pseudocyst. (Korean J Gastroenterol 2001;38:457-460)
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서대홍,임홍섭,김충기,이겸철,조용구,정승수,심영웅,송갑영 대한감염학회 1998 감염 Vol.30 No.2
우상복부 동통, 발열과 오한 그리고 의식 둔화를 주소로 내원한 당뇨 환자에서 Klebsiella pneumoniae에 의한 가스형성 간농양을 균배양 검사를 통하여 진단하고 항생제 투여와 경피적 농양 배액술을 통해 증상의 호전을 보인 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Gas-forming pyogenic liver abscess is an uncommon, life-threatening, necrotizing infection that is usually found in poorly-controlled diabetic patients. Herein, we report a case of gas-forming liver abscess caused by Klebsiella pneumoniae, as proven by aspirated pus culture, in a 70-year old woman with diabetes mellitus. The patient was successfully managed with broadspectrum antibiotics and transhepatic percutaneous drainage and was discharged after 3 weeks of hospitalization. In conclusion, strict control of diabetes mellitus is the most important factor in the prevention of gas-forming pyogenic liver abscess.
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