http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
消癌去痰益氣湯의 cyclophosphamide 부작용 형성 억제효과
홍종희,류기원,류봉하,윤상협,김진성 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2002 東西醫學硏究所 論文集 Vol.2002 No.-
Object : It is well known that modern chemotherapy against cancer has side effcts to a living body, especially hemopoietic and immunologial disfunctions. However, there are no effctive ways to reduce them.Recently, traditonal Korean herb medicine has been repoted to have some biological modifying responses. Therefore, we hypothesized that additional application of herb medicine during chemotherapy is more effective to reduce its side effects. While we were studying the effects, we have observed the inhibitory effect of Soamgudamikgitang on formation of side effects derived from Cyclophosphamide, it has been used in clinical practice at Kyung Hee Medicd Center.Methods : We injected 200㎎/㎏ of Cyclophosphamide, one time, to an experimental group, consisting of ten mice. We divided them into eight groups: normal, CPX, SAKT 2㎎, SAKT 10㎎, SAKT 50㎎, SAKI 2㎎+CPX, SAKT 10㎎+CPX, SAKT 50㎎+CPX. We injeted Soamgudamikgitang seven days, five days, three days, and one day before we injected CPX. One day, three days, and five days after CPX injection, we injected Soamgudamikgitang again and then killed all the mice.The parameters determined in this experiment were daily body weight liver and spleen weight, RBC, WBC, and platelet for hemopoietic dysfunction and AST, ALT for hepatotoxicity, BUN, creatine for renal toxcity, Iymphocyte proliferation activity and lymphocyte subsets for immunological toxvity.Results : We have found that Soamgdamikgitang has inhibitory effects on the formation of Cyclophosphamide 's side effects. Significant differences between the group, which contained Cyclophosphamide, and the other group, which contains Cyclophosphamide and 2, 10, 50㎎ of Soamgudamikgitang respectively were observed. Platelets(2㎎ of Soamgudamikgitang, p<O.05 ;10㎎, p<0.Ol ;50㎎, p<0.001), liver weight(SOw p.001), spieen weight(10mg, p<0.05), AST(all groups, p<0.01), ALT(2㎎, p<001 ;10㎎, p<O.05 ;50㎎, p<0.01), BUN(2㎎, p<0.01 ;50㎎, p<0.05). Althought immunological in both lymphocyte proliferation and its subsets were not observed, which shows that Soamgudamikgilang has a strong effect on T cell activities Conclusions : From the above results, we can expect that the combined therapy of Soamgudamikgitang and Cyclophosphamide is more effective for treating cancer Patients.
( Jae-hong Min ),( Seong-man Kim ),( Ji-won Park ),( Nam Hoon Kwon ),( Soo Hyeon Goo ),( Ngatinem ),( Sri Ningsih ),( Jin-hyub Paik ),( Sangho Choi ),( Sei-ryang Oh ),( Sang-bae Han ),( Kyung-seop Ahn 한국미생물 · 생명공학회 2021 Journal of microbiology and biotechnology Vol.31 No.11
Lagerstroemia ovalifolia Teijsm. & Binn. (LO) (crape myrtle) has reportedly been used as traditional herbal medicine (THM) in Java, Indonesia. Our previous study revealed that the LO leaf extract (LOLE) exerted anti-inflammatory effects on lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. Based on this finding, the current study aimed to evaluate the protective effects of LOLE in a mouse model of LPS-induced acute lung injury (ALI). The results showed that treatment with LPS enhanced the inflammatory cell influx into the lungs and increased the number of macrophages and the secretion of the inflammatory cytokines in the bronchoalveolar lavage fluid (BALF) of mice. However, these effects were notably abrogated with LOLE pretreatment. Furthermore, the increase of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and monocyte chemoattractant protein-1 (MCP-1) expression in the lung tissues of mice with ALI was also reversed by LOLE. In addition, LOLE significantly suppressed the LPS-induced activation of the MAPK/NF-κB signaling pathway and led to heme oxygenase-1 (HO-1) induction in the lungs. Additionally, in vitro experiments showed that LOLE enhanced the expression of HO-1 in RAW264.7 macrophages. The aforementioned findings collectively indicate that LOLE exerts an ameliorative effect on inflammatory response in the airway of ALI mice.
한성협 ( Sung Hyub Han ),송희진 ( Hee Jin Song ),홍원규 ( Won Kyu Hong ),이현숙 ( Hyun Sook Lee ),신정현 ( Jeong Hyun Shin ),최광성 ( Kwang Seong Choi ) 대한피부과학회 2008 대한피부과학회지 Vol.46 No.8
Metastatic cancer of the umbilicus is very rare and is called Sister Mary Joseph`s nodule. Metastasis to the umbilicus usually presents as diffuse spreading of primary cancer or recurrence after treatment of primary cancer, carries very poor prognosis, and is generally inoperable. However, umbilical metastasis presents rarely as a first sign of primary cancer and can lead to its diagnosis. The diagnosis is usually made with the histologic examination and the most common primary cancer is an adenocarcinoma of the stomach. We report a case of umbilical metastasis as a first sign of gastric cancer which leads to its diagnosis. This report emphasizes the need for careful evaluation of any umbilical lesion. (Korean J Dermatol 2008;46(8):1103~1107)
Rhabdomyomatous Mesenchymal Hamartoma of the Vagina
HAN, SUNG HYUB,SONG, HEE JIN,HONG, WON KYU,LEE, HYEON SOOK,CHOI, GWANG SEONG,SHIN, JEONG HYUN Blackwell Publishing Ltd 2009 Pediatric dermatology Vol.26 No.6
<P>Abstract: </P><P>Rhabomyomatous mesenchymal hamartoma (RMH) is a rare hamartomatous lesion in the dermis and subcutaneous tissue. We report a case of solitary RMH occurring on the vagina of a newborn infant.</P>
( Hyun Woong Lee ),( Seokchan Hong ),( Dong Yeop Chang ),( Soo Seong You ),( Jun Yong Park ),( Sang Hoon Ahn ),( Dongeun Yong ),( Kwang Hyub Han ),( Hyung Joon Kim ),( Ook Joon Yoo ),( Eui Cheol Shin 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: The antigen-specificity and phenotypes of Antibody- secreting cells (ASCs) have not been studied during a primary acute viral infection. We investigated the nature of ASCs here by direct ex vivo assays in patients with acute hepatitis A (AHA) which is caused by the primary infection of hepatitis A virus (HAV). Methods: The study included 39 patients diagnosed with AHA infection who were hospitalized at Chung-Ang University Hospital or at Severance Hospital. All patients were seropositive for anti-HAV IgM, and all had clinical features of acute hepatitis. Peripheral blood samples at the acute stage were collected on the day of admission from all of the 39 patients. Follow- up sampling was performed at the subacute stage (5-14 days) or at the convalescent stage (35-150 days). Serum levels of the total IgM, IgG and the subisotype of IgG were measured by a CBA assay. ELISpot filter plates were coated overnight with anti-human Ig to detect the total IgM or IgG-secreting ASCs. Results: A robust plasmablast response was detected in peripheral blood during the acute stage and was dominated by IgM secretion. It was demonstrated that a substantial portion of the response was non-virus-specific in the study of the plasmablasts and the secreted IgM. We detected HAV-specific plasmablasts by staining with fluorochrome-tagged VP1 protein and compared them with non-HAV-specific plasmablasts. Non-HAV-specific plasmablasts have the phenotype of Ki- 67low/CD138high/CD31high/CD38high as compared with HAV-specific plasmablasts, demonstrating that non-HAV-specific plasmablasts have a bone marrow (BM) plasma cell-like phenotype while HAV-specific plasmablasts have a typical phenotype of circulating plasmablasts. Conclusions: These data suggest that non-HAV-specific plasmablasts are mobilized ASCs from the BM niches of plasma cells, whereas HAV-specific plasmablasts are newly generated ASCs. In this study, we demonstrated that pre-existing BM plasma cells are released to circulation during AHA and contribute to the non-virus-specific ASC response and IgM secretion.