少陰人 補中益氣湯의 效能에 關한 實驗的 硏究

尹相協,朴東遠,?基遠 慶熙大學校韓醫科大學韓醫學硏究所 1987 慶熙韓醫大論文集 Vol.10 No.-

흰쥐 水溝穴 電鍼刺戟이 血壓, 脈搏 및 局所腦血流湯量에 미치는 影響

尹相協 경희대학교 1992 慶熙醫學 Vol.8 No.4

흰쥐의 虛血性 中風證 모델에 관한 硏究 : 중뇌동맥 원 및 근위부폐색에 대한 양측 경동맥 1시간 결찰의 효과 Effect of 1 hour occlusion of CCA on the distal or procimal MCA occlusioned site

윤상협 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1997 東西醫學硏究所 論文集 Vol.1997 No.-

With the purpose of producing easily the basal ganglia infarction into Chen's, scerebral ischemic model which is almost cortical infarct made by the ligation of distal part of MCA and 1 hr obliteration of both common carotid arteries in rat, the MCA obstruction was extended between rhinal fissure and olfactory tract with electrocauterization in place of 10-0 silk suture ligation of distal part of MCA. Both original Chen's model and modified Chen's have shown the cortical infarction in dorsolateral & lateral frontoparietal cortex, but not any infarction in basal ganglia. However, the modified Chen's model have shown the effect of average 12% increase in cortical infarct than that of original Chen's model. This experimental results suggest the modified Chen's model can not reduce the blood flow of the lateral lenticulostriatal artery enough to make the basal ganglia infarction and that blood circulation of basal gagglia under its condition is probably being kept partly through the posterior cerebral artery via vertebral artery. Therefore, The follow-up observation on ischemic time lapse would be needed.

腦卒中後 腦萎縮에 대한 調經論的 接近

윤상협,이종수 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Objective : The aim of this study was to investigate the neuroprotection effect of estrogen on brain atrophy following cerebral infarction. Method : All animals in this study were classified into 4 groups; ovariectomy group (OVXgroup), cerebral infarction group (INF group), combination ovariectomy and cerebral infarction group ( OVX + INF group), and naturally intact group for control data (NOR group ). Cerebral infarction was made by Chen's method with some modification. Ovariectomy was performed by Wayforth's method. Experimental data for each group was collected at 15days, 1 month, 3 months, and 6 months after starting observation. Serum 17β-estradiol(E2) was determined by radioimmunoassay. Brain volume was measured and calculated with image analysis. Each brain was sliced at intervals of 2mm in chamber after 30 min of freezing in refregerater. Cerebral volume was obtained by sum of volume of each slice level, which was mean area × 2mm. Results : Cerebral ischemia was fou8nd to decrease the serum concentration of 17β-estradiol and to inhibit the physiologically conpensatary function of the ovariectomized rats. Also we found that deprivation of estrogen have resulted in more severe cerebral atrophy followed by cerebral infarction. Conclusion : It is suggested that estrogen has a neuroprotection effect on cerebral atrophy following cerebral infarction.(J Korean Oriental Med 2000;21(4):9-15)

만성(慢性)기침 환아(患兒)의 원인질환(原因疾患)에 관(關)한 임상적(臨床的) 고찰(考察)

윤상협,최인화,Yoon Sang-Hyub,Choi In-Hwa 대한한방소아과학회 1998 대한한방소아과학회지 Vol.12 No.1

Chronic cough is one of the most common respiratory symptoms, especially in children. And it can be the sale presenting manifestation of bronchial asthma. Although most coughs are self limiting, chronic cough often proves to be a frustrating problem. It is commonly defined as a persistent or recurrent cough exceeding 3weeks duration. The post nasal syndrome has been determined to be the most common cause of chronic cough, followed by asthma, chronic bronchitis, gastroesophageal reflux and bronchiectasis. This study was performed at both City-Oriental Medicine Hospital and Pundang Cha Oriental Medicine Hospital from January,1,1998 to November 31,1998, and 114 children with chronic cough persisting for longer than 3 weeks were evaluated. We investigated the clinical findings and evaluated the etiology in children with chronic cough syndrome including: type of cough (with or with out sputum and daily onset) and associated signs & symptoms. The results were as follows: The most common cause of chronic cough was asthma with sinusitis (27.2%); The second and third were post nasal drip syndrome(22.8%) and bronchial hypereactivitic cough(14.9%). The other causes included asthma, paranasal sinusitis, bronchitis and rhinitis. Therefore, in the diagnostic and therapeutic approach to this symptom, it should be considered that the cause of this type of cough is either bronchus and pulmonary disease or that associated with another problem, especially sinusitis, gastroesophageal reflux and allergic disease. Also, in infants and toddlers, congenital abnormaly should be considered.

女性 中風에 있어서 衝脈의 役活에 대한 豫備的 實驗硏究

尹相協 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 1998 東西醫學硏究所 論文集 Vol.1998 No.-

The aim of this study was to assess ischemic effect on sex hormonal alteration(17βestradiol, LH, FSH) in ovarectomized rats. Rats were divided into 3 groups; normal group(n=10), ovariectomized group without cerebral ischemia(OV group, n=10), and ovariectomized group with cerebral ischemia (OVCI group, n=10). Sex hormons in both ovariectomized groups were determined on 15th day(n=5) and 30th (n=5) after ovariectomy. For normal data and its comparison, the same numbers of rat in normal group were killed on the same day. Cerbral ischemia w as induced by electrocauterization of rhinal fissure portion of left middle cerebral artery and 1 hour ligation of both common carotid artery. After l hour ligation, right common carotid artery was reperfusioned and left artery was occluded permantly. after finishing ischemia, rats were returned to their cages. It have been found that concentration of 17β-estradiol, LH,and FSH were more lower in the cerebral ischemia treated ovariectomized group than in the non treated ovariectomized (p<0.05) This study shows that cerebral ischemic injury can inhibit the compensatory function of adrenal gland on estrogen production and that also impair the hypothalmus and hypophysis functions in the ovariectomized rats.

비허(脾虛)(기허(氣虛).양허(陽虛))증(證)에 관(關)한 문헌적(文獻的) 고찰(考察)

윤상협,류봉하,박동원,장인규,류기원,Yun, Sang-Hyeop,Ryu, Bong-Ha,Park, Dong-Won,Jang, In-Gyu,Ryu, Gi-Won 대한한방내과학회 1989 大韓韓方內科學會誌 Vol.10 No.1

In an attempt to investigate the current of clinical researches on spleen yang or vital energy deficiency syndrome, the results were as follows. 1. It is possible to occure spleen deficiency syndrome which come from genetic factor. 2. The absorption disturbance in spleen deficiency syndrome can be likely caused by gastrointestinal mucosa injury, disorder of vagus nerve funtion and impairment of excretion of exocrine gland in pancreas. 3. Owing to the failure of tansporting and converting funtion of spleen, minerals, hematogenic substance and nutritional substance are scanty and then imbalanced metabolism state which heat production is decreasing is appeared. 4. By the failure of vital energy and blood growth, decreasement of $O_2$ transportation ability of RBC, disoder of blood coagulation, immune system disturbance which humoral immunity is enhanced and cellular immunity is decreased, are noted. 5. While there is not still an attemt to study the spleen deficiency sydrome in muscle disease or disease of four extremities, but it is likely suggested that spleen-stomach supplyment thereapy is very excellent effect on muscle disease and disease of four extremities.

腦卒中患者에 倂發된 肺炎에 대한 東西醫學 協力治療의 臨床的 硏究 : 抗生劑 使用實態와 死亡率을 中心으로

尹相協,柳在煥,景銀培,羅嶺雪,閔炳一,金裕國,金鍾烈,柳基遠 경희대학교 1992 慶熙醫學 Vol.8 No.4

Intraluminal Suture Technique에 의한 실험적 뇌허혈-재관류가 혈압, 국소뇌혈류량, 뇌경색 및 뇌부종 형성에 미치는 영향

윤상협,류재환 경희대학교 1994 慶熙醫學 Vol.10 No.2

기능성 소화불량증 환자에 대한 반하사심탕 엑기스제의 임상효과

윤상협,류봉하,류기원,김진성 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective : We evaluated the therapeutic effect of Banwhasasimtang dry extract powder on gastrointestinal symptoms and its side effects in patients with functional dyspepsia. Methods : Patients with functional dyspepsia, defined as discomfort in the epigastrium. A total 45 patients participated participated in this study. Dyspeptic symptoms ratio was obtained by patients, total point of symptom score / total 21 points x 100(%). On each of symptom after 4 weeks administration of Banwhasashim-tang was made by variation of symptom score: If symptoms score of posttreatment is lower than that of pretreatment, It is improved ; Otherwise aggravated, and if there is no change between them, unchangeable. When a full health condition of normal control is assumed 100%, relative health condition of dyspeptic patient could be calculated from 'full health condition- dyspeptic symptoms ratio. Therefore a whole satisfaction rate on symptom improvement was presented with variation of a relative health condition to dyspepsia between pretreatment and post. Results : Banwhasashimtang significantly unproved symptoms in patients. The significance was shown in both all seven items(p< 0.01, respectively) and 19.2% (p<0.01) of increase of a whole symptom improvement. There is no remarkable side-effect in all laboratory test, excepting 1 case abdominal pain another one case of recurred pain of chronic prostatitis. Conclusion : Banwhasashimtang extract provides symptomatic relief in functional dyspepsia and is no remarkable side-effect drug.