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강신몽,이원태,고영창,최상규,김윤희,이홍석,서재관,윤중진,이혜경,최득린,김종열,윤창육,변명식,이장홍 大韓法醫學會 1991 대한법의학회지 Vol.15 No.2
Individual identification is an important part in medicolegal field especially in mass disaster. At July, 27, 1989, KAL KE-803 was crashed on landing at Tripoli International Airport, Liba. The plane was caught in fire and sixty eight Koreans were sacrified. The majority of victims were severely charred and injured. The authors examed all dead bodies and successfully identified all the cases through visual, anthropological, odontological, radiological and pathological methods including fingerprint and blood typing.
Improvement in the Image Quality and the Capacity of the Reversible Data Hiding
Hong Lin JIN,Masaaki FUJIYOSHI,Hitoshi KIYA 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
This paper proposes a reversible data hiding method in the spatial domain. A reversible data hiding method not only extracts hidden data from a stego image that conveys data but also restores the original image. The proposed method modulates pixel values adaptively and reversibly before an embedding process to improve the image quality of a stego image and simultaneously to increase the capacity. Simulation results show the effectiveness of the proposed method.
Lin, Guo-Lin,Sohn, Mi-Ryeong,Cho, Rae-Kwnag,Hong, Jin-Hwan 한국근적외분광분석학회 2000 Near infrared analysis Vol.1 No.2
The objectives of this study are to discriminate the geographical origin and cultivation years of ginseng based on the near-infrared(NIR) reflectance spectroscopic analysis. Korea and China ginseng samples were prepared for discrimination of geographical origin. 4, 5 and 6 years-old ginseng samples from Korea were prepared for discrimination of cultivation years. Used spectrometer were InfraAlyzer 500, InfraAlyzer 400 and Fiber optic. Sample type of ginseng was 3, whole ginseng radix, slide section and powder type. The accuracy was affected by sample types and instruments. The accuracy for discrimination geographical origin was 97% in calibration model using IA 500 and ginseng powder. For discrimination of cultivation years, the model with slide selection using IA500 were relative accurate. The accuracy was 96.7% for 4-year, 91.3% for 5-year and 89.3% for 6-year old ginseng. The study shows that NIR spectroscopic analysis can be used to discriminate the geographical origin and cultivation years of ginseng with acceptable accuracy.
EFFECTIVE SYNTHESIS AND APPLICATION OF ZAO NANOPARTICLES WITH GOOD DISPERSION
LIN-LIN ZHANG,HONG-ZHEN XIE,MIN ZHANG,JIN-KU LIU,XIAO-HONG YANG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2012 NANO Vol.7 No.3
The well dispersed ZAO nanoparticle with 25?30 nm in diameter was prepared by an ultrasonictemplate method. The morphologies, structures, and photoelectricity of the ZAO nanoparticles were analyzed by TEM, XRD, UV-Vis, etc. The thermochemistry behaviors of the precursor were studied by TG-DSC. The composite ¯lm with semipermeable structure made from ZAO nanoparticles and collodion can be explored ¯rstly. The photocatalytic properties of the ZAO nanoparticles and composite ¯lm were investigated. The composite ¯lm can be applied in the sewage treatment ¯eld.
Application of Near Spectroscopy for Nondestructive Evaluation of Ginsenoside Content
Lin, Guo-Lin,Cho, Rae-Kwang,Hong, Jin-Hwan 한국근적외분광분석학회 2000 Near infrared analysis Vol.1 No.2
The effective component Ginsenoside in Ginseng has been widely used to cure some hypochondriasis and be as supplementary medicines. There are many chemical analysis methods to measure the contents of Ginsenoside in Ginseng; however, all these methods have some shortcomings such as long time, environmental pollution and damaging the samples. In this paper, it is possible to use near infrared spectroscopy to measure the content of Ginsenoside in Ginseng without destruction. As the results, Rg1, Rb1, Re and T-Saponin of Ginsenoside can be measured with the accuracy of R(0.81) SEP (1.704 mg/g), R(0.74) SEP (1.211 mg/g), R (0.78) SEP (1.049 mg/g) and R(0.84), SEP(4.537 mg/g).
A GFP-labeled Human Colon Cancer Metastasis Model Featuring Surgical Orthotopic Implantation
Chen, Hong-Jin,Yang, Bo-Lin,Chen, Yu-Gen,Lin, Qiu,Zhang, Shu-Peng,Gu, Yun-Fei Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9
Colorectal cancer has become a major disease threatening human health. To establish animal models that exhibit the characteristics of human colorectal cancer will not only help to study the mechanisms underlying the genesis and development effectively, but also provide ideal carriers for the screening of medicines and examining their therapeutic effects. In this study, we established a stable, colon cancer nude mouse model highly expressing green fluorescent protein (GFP) for spontaneous metastasis after surgical orthotopic implantation (SOI). GFP-labeled colon cancer models for metastasis after SOI were successfully established in all of 15 nude mice and there were no surgery-related complications or deaths. In week 3, primary tumors expressing GFP were observed in all model animals under fluoroscopy and two metastatic tumors were monitored by fluorescent imaging at the same time. The tumor volumes progressively increased with time. Seven out of 15 tumor transplanted mice died and the major causes of death were intestinal obstruction and cachexia resulting from malignant tumor growth. Eight model animals survived at the end of the experiment, 6 of which had metastases (6 cases to mesenteric lymph nodes, 4 hepatic, 2 pancreatic and 1 mediastinal lymph node). Our results indicate that our GFP-labeled colon cancer orthotopic transplantation model is useful with a high success rate; the transplanted tumors exhibit similar biological properties to human colorectal cancer, and can be used for real-time, in vivo, non-invasive and dynamic observation and analysis of the growth and metastasis of tumor cells.
Lin, Paul-Chang,Xu, Jin-Hai,Lu, Hong-Liang,Zhang, David Wei,Li, Pei The Institute of Electronics and Information Engin 2017 Journal of semiconductor technology and science Vol.17 No.3
Through silicon via (TSV) technology is extensively used in 3D IC integrations. The special structure of the TSV is realized by CMP (Chemically Mechanical Polishing) process with a high Cu removal rate and, low dishing, yielding fine topography without defects. In this study, we investigated the electrochemical behavior of copper slurries with various inhibitors in the Cu CMP process for advanced TSV applications. One of the slurries was carried out for the most promising process with a high removal rate (${\sim}18000{\AA}/Min$ @ 3 psi) and low dishing (${\sim}800{\AA}$), providing good microstructure. The effects of pH value and $H_2O_2$ concentration on the slurry corrosion potential and Cu static etching rate (SER) were also examined. The slurry formula with a pH of 6 and 2% $H_2O_2$, hadthe lowest SER (${\sim}75{\AA}/Min$) and was the best for TSV CMP. A novel Cu TSV CMP process was developed with two CMPs and an additional annealing step after some of the bulk Cu had been removed, effectively improving the condition of the TSV Cu surface and preventing the formation of crack defects by variations in wafer stress during TSV process integration.
Ginsenosides Rg5 and Rk1, the skin-whitening agents in black ginseng
Jin, Yan,Kim, Ji Hye,Hong, Hee-Do,Kwon, Jeonghun,Lee, Eun Jung,Jang, Mi,Lee, Sung-Young,Han, Ah-Ram,Nam, Tae Gyu,Hong, Seok Kyu,Huh, Tae-Lin,Kang, Nam Joo,Lim, Tae-Gyu Elsevier 2018 Journal of Functional Foods Vol.45 No.-
<P><B>Abstract</B></P> <P>Ginseng (<I>Panax ginseng</I> Meyer) is widely used to treat various chronic disorders. Black ginseng is obtained by repeated steaming and drying of raw ginseng, which turn it black and convert the ginsenoside compounds present into more potent bioactive ingredients. The effects of a black ginseng extract on melanin production and skin whitening were evaluated in vitro as well as <I>in vivo</I> using human skin and zebrafish embryos. Tyrosinase activity decreased when steamed and dried ginseng was used. A pronounced skin-whitening effect was observed in our clinical study, and inhibition of melanin activity and tyrosinase levels was confirmed in zebrafish embryos. Two ginsenosides specific to black ginseng activate the MEK-ERK signaling pathway and are the main factors responsible for skin whitening. The skin-whitening effects of black ginseng are associated with the formation of two ginsenosides, indicating that black ginseng can be used as a novel skin-whitening agent in cosmetic products.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Inhibitory effect of black ginseng extract on melanin production on B16F10 and zebrafish model. </LI> <LI> Skin whitening activity of black ginseng extract on human skin. </LI> <LI> Ginsenoside Rg5 and Rk1, bioactive compounds in black ginseng extract for skin whitening activity. </LI> <LI> Activation MEK-ERK signaling pathway, a underlying mechanism for skin whitening activity of black ginseng extract. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Effect of Conversion to CTLA4Ig on Tacrolimus-Induced Diabetic Rats
Jin, Long,Lim, Sun Woo,Jin, Jian,Luo, Kang,Ko, Eun Jeong,Chung, Byung Ha,Lin, Hong Li,Yang, Chul Woo Wolters Kluwer Health, Inc. All rights reserved. 2018 Transplantation Vol.102 No.4
<P>Conclusions CTLA4Ig was not diabetogenic, and conversion to CTLA4Ig reduced TAC-induced pancreatic islet injury.</P>
Lin, Jia,Chen, Hong,Gao, Yang,Cai, Yao,Jin, Jianbo,Etman, Ahmed S.,Kang, Joohoon,Lei, Teng,Lin, Zhenni,Folgueras, Maria C.,Quan, Li Na,Kong, Qiao,Sherburne, Matthew,Asta, Mark,Sun, Junliang,Toney, Mic National Academy of Sciences 2019 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.116 No.47
<P><B>Significance</B></P><P>Metal halide perovskites attract great interest for a wide range of applications due to their remarkable optoelectronic properties. The development of environmentally friendly halide perovskite materials with various crystal structures and compositions offers unprecedented opportunities to achieve desired properties and applications. In this work, we demonstrated an In-based, charge-ordered all-inorganic halide double perovskite with the composition of Cs<SUB>2</SUB>In(I)In(III)Cl<SUB>6</SUB> synthesized by solid-state reaction. High-pressure optical properties were studied, and a pressure-driven, fully reversible semiconductor–metal phase transition was discovered. This In-based charge-ordered structure may inspire new understanding of halide perovskite as well as provide a platform for future discovery of exotic electronic phenomena such as high-<I>T</I><SUB>C</SUB> superconductivity in halide perovskite compounds.</P><P>Phase transitions in halide perovskites triggered by external stimuli generate significantly different material properties, providing a great opportunity for broad applications. Here, we demonstrate an In-based, charge-ordered (In<SUP>+</SUP>/In<SUP>3+</SUP>) inorganic halide perovskite with the composition of Cs<SUB>2</SUB>In(I)In(III)Cl<SUB>6</SUB> in which a pressure-driven semiconductor-to-metal phase transition exists. The single crystals, synthesized via a solid-state reaction method, crystallize in a distorted perovskite structure with space group <I>I</I>4/<I>m</I> with <I>a</I> = 17.2604(12) Å, <I>c</I> = 11.0113(16) Å if both the strong reflections and superstructures are considered. The supercell was further confirmed by rotation electron diffraction measurement. The pressure-induced semiconductor-to-metal phase transition was demonstrated by high-pressure Raman and absorbance spectroscopies and was consistent with theoretical modeling. This type of charge-ordered inorganic halide perovskite with a pressure-induced semiconductor-to-metal phase transition may inspire a range of potential applications.</P>