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Pathophysiologic and Therapeutic Perspectives Based on Thrombus Histology in Stroke
Ji Hoe Heo,Hyo Suk Nam,Young Dae Kim,Jin Kyo Choi,Byung Moon Kim,Dong Joon Kim,Il Kwon 대한뇌졸중학회 2020 Journal of stroke Vol.22 No.1
Recent advances in endovascular thrombectomy have enabled the histopathologic analysis of fresh thrombi in patients with acute stroke. Histologic analysis has shown that the thrombus composition is very heterogeneous between patients. However, the distribution pattern of each thrombus component often differs between patients with cardiac thrombi and those with arterial thrombi, and the efficacy of endovascular thrombectomy is different according to the thrombus composition. Furthermore, the thrombus age is related to the efficacy of reperfusion therapy. Recent studies have shown that neutrophils and neutrophil extracellular traps contribute to thrombus formation and resistance to reperfusion therapy. Histologic features of thrombi in patients with stroke may provide some clues to stroke etiology, which is helpful for determining the strategy of stroke prevention. Research on thrombus may also be helpful for improving reperfusion therapy, including the development of new thrombolytic agents.
A Computerized In-Hospital Alert System for Thrombolysis in Acute Stroke
Heo, Ji Hoe,Kim, Young Dae,Nam, Hyo Suk,Hong, Keun-sik,Ahn, Seong Hwan,Cho, Hyun Ji,Choi, Hye-Yeon,Han, Sang Won,Cha, Myoung-Jin,Hong, Ji Man,Kim, Gyeong-Moon,Kim, Gyu Sik,Kim, Hye Jin,Kim, Seo Hyun,K Ovid Technologies Wolters Kluwer -American Heart A 2010 Stroke Vol.41 No.9
<P>Background and Purpose-An effective stroke code system that can expedite rapid thrombolytic treatment requires effective notification/communication and an organized team approach. We developed a stroke code program based on the computerized physician order entry (CPOE) system and investigated whether implementation of this CPOE-based program is useful for reducing the time from arrival at emergency departments (ED) to evaluation steps and the initiation of thrombolytic treatment in various hospital settings. Methods-The CPOE-based program was implemented by 10 hospitals. Time intervals from arrival at the ED to blood tests, computed tomography scanning, and thrombolytic treatment during the 1-year period before and the 1-year period after the program implementation were compared. Results-Time intervals from ED arrival to evaluation steps were significantly reduced after implementation of the CPOE-based program. Times from ED arrival to CT scan, complete blood counts, and prothrombin time testing were reduced by 7.7 minutes, 5.6 minutes, and 26.8 minutes, respectively (P<0.001). The time from ED arrival to intravenous thrombolysis was reduced from 71.7 +/- 33.6 minutes to 56.6 +/- 26.9 minutes (P<0.001). The number of patients who were treated with thrombolysis increased from 3.4% (199/5798 patients) before the CPOE-based program to 5.8% (312/5405 patients) afterward (P<0.001). The CPOE implementation also improved the inverse relationship between onset-to-door time and door-to-needle time. Conclusions-The CPOE-based stroke code could be successfully implemented to reduce in-hospital time delay in thrombolytic therapy in various hospital settings. CPOE may be used as an efficient tool to facilitate in-hospital notification/communication and an organized team approach. (Stroke. 2010; 41:1978-1983.)</P>
( Ji Yeon Kim ),( Se Hoon Lee ),( Jong Il Kim ),( Jong Yeon Shin ),( Kyung Chul Moon ),( Cheol Kwak ),( Hyeon Hoe Kim ),( Dae Seog Heo ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background:Papillary renal cell carcinoma type2 (PRCC2) has poor prognosis, treatment strategy is not established and the genetic alteration is poorly understood. We sequenced PRCC2 samples using custom-made kidney cancer panel to fi gure out genetic alterations of PRCC2. Methods: We have reviewed publications about the genetics of kidney cancer including all subtypes and selected 55 candidate genes. This cancer panel consisted of 1022 regions by Agilent SureSelect Target Enrichment. We sequenced 12 PRCC2 tumor samples along with 6 paired normal tissue samples. The patients` age were ranged from 26 to 82 year-old, and 3 patients were female (25%). Genomic DNA was isolated from dissected tumor tissue samples (6 fresh, frozen and 6 formalin-fi xed, paraffi n-embedded) and normal tissue samples. Sequencing was performed by Illumina platform and aligned to H. sapiens, hg19, GRCh37. Total probe number was 4103 and size was 283.494 kbp. Results: fifty-four of 55 target genes had 100% coverage, in spite of 92.7% coverage of one target gene. We found two novel FH mutations (one single nucleotide variant and one 5bp indel) and one novel NFE2L2 mutation. Two out of 12 samples (17%) were altered in NRF2 pathway (1 NFE2L2 and 1 KEAP) which was already well-known as driver in PRCC2. Novel PBRM1 mutation in two samples and SETD2 mutation in one sample were identifi ed. In addition, PTEN, TSC1, KDM5C and AKT1 mutation are observed in one case, respectively. No VHL mutation in PRCC2 was revealed. Conclusions: We analyzed somatic mutation of PRCC2 with custom-made kidney cancer panel. We found several candidate driver mutations of PRCC2. Our result reveals that the genetics of PRCC2 is heterogeneous, therefore, the approach using kidney cancer panel could be used to characterize individual PRCC2.
35세 이상 고령산모의 임신과 출산에 대한 임상적 연구
허혁 ( Heo Hyeog ),황지영 ( Hwang Ji Yeong ),김도균 ( Kim Do Gyun ),이형종 ( Lee Hyeong Jong ),심재철 ( Sim Jae Cheol ),양회생 ( Yang Hoe Saeng ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.3
Objective : We studied the effects of the age factor in pregnant women who are over the age of 35 on pregnancy, parturition and verified its usefulness in the future managements of the old aged pregnancy. Methods : Out of 2,526 mothers who delivered in Dongguk university hospital from April 2000 to June 2003, we selected 183 mothers who aged more than 35 years as a study group, and 150 mothers aged between 25 and 29 years as a control group. We then statistically evaluated and analyzed the two groups. Results : Study group consumed up to 7.24%. Placenta previa, male birth delivery abnormal presentation, low birth weight, iron deficiency anemia and preterm labor was noted more in the study group. Likewise, preterm delivery, pregnancy induced hypertension and cesarean section rates were significantly high in the study group. Conclusion : Pregnancy in old age is currently a rising trend. While they might have the tendency to show prenatal complications, neonatal complication and difficult decision making in delivery method, early detection and treatment of presumable complications by adequate antenatal care and appropriate selection of delivery method can reduce the section rates and obtain relatively successful pregnancy outcome.
SD rats의 성별에 따른 형개 열수추출물의 방사선 방호효과
이지은(Ji-Eun Lee),김장오(Jang-Oh Kim),이윤지(Yoon-Ji Lee),전찬희(Chan-hee Jeon),허성회(Sung-Hoe Heo),민병인(Byung-In Min) 한국방사선학회 2021 한국방사선학회 논문지 Vol.15 No.3
본 연구는 형개 열수추출물이 흰 쥐의 성별에 따라 미치는 방사선 방호효과를 평가하는 것이다. 형개는 활성산소를 제거하는 대표적인 물질인 polyphenol과 flavonoid를 함유하고 있다. 이에 따라 방사선 방호효과를 알아보기 위해 형개 열수추출물을 SD rat 수컷과 암컷에 2 주 동안 경구투여 한 후 혈액학적 분석, 소장 융모 길이 변화 분석, SOD 활성 평가를 실시하였다. 수컷 SD rat ST+IR군은 IR군에 비해 혈소판의 회복능력이 조금 더 증가한 것으로 나타났다. 암컷 또한 ST+IR군이 IR군에 비해 혈소판 회복능력이 더 높게 나타났다. 림프구 수치도 혈소판 수치와 마찬가지로 수컷과 암컷 SD rat ST+IR군이 IR군보다 회복능력이 더 높게 나타났다. 방사선 조사 후 수컷 SD rat과 암컷 SD rat의 소장 융모 길이가 IR군보다 ST+IR군이 덜 감소한 것으로 보아 모든 성별의 SD rat 소장 융모가 손상이 적은 것을 확인하였다. 이 결과를 통해 형개 열수추출물이 방사선 방호효과가 있음을 확인 할 수 있었다. This study evaluates the radiation protection effects of Schizonepeta tenuifolia water extract on white rat by gender. Schizonepeta tenuifolia contains polyphenol and flavonoid, which are typical substances that remove free radical. Thus, to determine the effectiveness of radiation protection, the Schizonepeta tenuifolia water extract was administered to Sparaqu-Dawely (SD) rat males and females for two weeks, followed by hematological analysis, analysis of changes in the length of the small intestine villi length, and SOD activity evaluation. The male rat in ST+IR group showed a slightly greater recovery of platelets than the IR group. The ST+IR group also showed a higher platelet recovery capability than the IR group. lymphocyte showed that male and female rat ST+IR groups have higher resilience than IR groups likewise platelet. After irradiation, the villi length of the male rat and female rat decreased less in ST+IR group than in the IR group, indicating that the villi length of all genders was less damaged. This result confirmed that the Schizonepeta tenuifolia water extract had a radiation protection effect.