What do Options have to do With It?: Inclusion of Options Market Indicators in Bid-ask Spread Decomposition

Henry Y. K. Yip,David Michayluk,Laurie Prather,Li-Anne E. Woo 한국증권학회 2009 Asia-Pacific Journal of Financial Studies Vol.38 No.3

This paper develops a cross-market model to extend Huang and Stoll (1997) by utiliz-ing information from trade flows in the options market. Empirical tests reveal a significant increase in the estimated adverse information component, which stays consistent irrespective of the degree of option leverage. Further, intraday variation in stock bid-ask spread components is affected by the stock trade size and the extent of imbalance in information-based option trades. Including the options market information in decomposition of the stock bid-ask spread enhances the quality of its estimation.

TEM Investigation of Nitrided Inconel 690 Prepared by Low Temperature Plasma Assisted Processes

Xiaona Li,Chuang Dong,Henry Michelh,Huan He,Shengzhi Hao,Thierry Czerwiec 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.1

Low-temperature plasma assisted nitriding (PAN) treatment was used to produce a highly nitrogen-enriched N layer on the nickel-based superalloy Inconel 690. Such a layer showed greatly improved wear and corrosion performance. In this paper, we investigate the microstructure of the N layers thoroughly by using transmission-electron microscopy and XRD. As a comparison, nitriding layers were also prepared by the reactive magnetron sputtering technique. It was found that the nitrogen-enriched ¯lm deposited at 400 ±C by RMS consists of mainly CrN-type nitride and fcc ° phase and a small amount of °N phase, while the PAN treatments at 400 ±C on bulk samples produce only N single-phase layer with gradually changing lattice parameters from the outermost surface to the underlying substrate in the range of 0.393 to 0.355 nm.

Rescue of epithelial HCO₃⁻ secretion in murine intestine by apical membrane expression of the cystic fibrosis transmembrane conductance regulator mutant F508del

Xiao, Fang,Li, Junhua,Singh, Anurag Kumar,Riederer, Brigitte,Wang, Jiang,Sultan, Ayesha,Park, Henry,Lee, Min Goo,Lamprecht, Georg,Scholte, Bob J.,De Jonge, Hugo R.,Seidler, Ursula Blackwell Publishing Ltd 2012 The Journal of physiology Vol.590 No.21

<P><B>Key points</B></P><P><P>Cystic fibrosis (CF) is a lethal disease characterized by low rates of epithelial Cl<SUP>−</SUP> and HCO<SUB>3</SUB><SUP>−</SUP> secretion and obstruction of the airways and gastrointestinal and reproductive organs by sticky mucus. HCO<SUB>3</SUB><SUP>−</SUP> secretion has recently been demonstrated to be necessary for mucus hydration.</P><P>The most frequent CF mutation is F508del. This mutant protein is usually degraded in the proteasome. New therapeutic strategies have been developed which deliver F508del to the plasma membrane.</P><P>Utilizing transgenic F508del mutant and cystic fibrosis transmembrane conductance regulator (CFTR) knockout mice, apical membrane expression of F508del protein was found to be associated with enhanced stimulation of intestinal HCO<SUB>3</SUB><SUP>−</SUP> secretion.</P><P>The predominant molecular mechanism for enhanced F508del HCO<SUB>3</SUB><SUP>−</SUP> stimulation appeared to be the activation of a Cl<SUP>−</SUP> recycling pathway, with Cl<SUP>−</SUP> exit via membrane‐resident F508del protein and Cl<SUP>−</SUP> entry in exchange for HCO<SUB>3</SUB><SUP>−</SUP> by apical Cl<SUP>−</SUP>/HCO<SUB>3</SUB><SUP>−</SUP> exchange. In contrast, the predominant molecular mechanism for cAMP‐activated HCO<SUB>3</SUB><SUP>−</SUP> secretion in WT intestine appears to be HCO<SUB>3</SUB><SUP>−</SUP> exit via CFTR itself.</P></P><P><B>Abstract </B> This study investigated whether expression of the common cystic fibrosis transmembrane conductance regulator (CFTR) mutant F508del in the apical membrane of enterocytes confers increased bicarbonate secretory capacity on the intestinal epithelium of F508del mutant mice compared to that of CFTR knockout (KO) mice. CFTR KO mice, F508del mutant mice (F508del) and wild‐type (WT) littermates were bred on the FVB/N background. F508del isolated brush border membrane (BBM) contained approximately 5–10% fully glycosylated band C protein compared to WT BBM. Similarly, the forskolin (FSK)‐induced, CFTR‐dependent short‐circuit current (Δ<I>I</I><SUB>sc</SUB>) of F508del mucosa was approximately 5–10% of WT, whereas the HCO<SUB>3</SUB><SUP>−</SUP> secretory response (<IMG src='/wiley-blackwell_img/equation/TJP_5291_mu1.gif' alt ='inline image'/>) was almost half that of WT in both duodenum and mid‐colon studied <I>in vitro</I> and <I>in vivo.</I> While WT intestine retained full FSK‐induced <IMG src='/wiley-blackwell_img/equation/TJP_5291_mu2.gif' alt ='inline image'/> in the absence of luminal Cl<SUP>−</SUP>, the markedly higher <IMG src='/wiley-blackwell_img/equation/TJP_5291_mu3.gif' alt ='inline image'/> than Δ<I>I</I><SUB>sc</SUB> in F508del intestine was dependent on the presence of luminal Cl<SUP>−</SUP>, and was blocked by CFTR inhibitors. The Ste20‐related proline–alanine‐rich kinases (SPAK/OSR1), which are downstream of the with‐no‐lysine (K) protein kinases (WNK), were rapidly phosphorylated by FSK in WT and F508del, but significantly more slowly in CFTR KO intestine. In conclusion, the data demonstrate that low levels of F508del membrane expression in the intestine of F508del mice significantly increased FSK‐induced HCO<SUB>3</SUB><SUP>−</SUP> secretion mediated by Cl<SUP>−</SUP>/HCO<SUB>3</SUB><SUP>−</SUP> exchange. However, in WT mucosa FSK elicited strong SPAK/OSR1 phosphorylation and Cl<SUP>−</SUP>‐independent HCO<SUB>3</SUB><SUP>−</SUP> efflux. This suggests that therapeutic strategies which deliver F508del to the apical membrane have the potential to significantly enhance epithelial HCO<SUB>3</SUB><SUP>−</SUP> secretion.</P>

CCM.G-K2 key comparison

Francis, Olivier,Baumann, Henri,Ullrich, Christian,Castelein, Stefaan,Van Camp, Michel,Andrade de Sousa, Mauro,Lima Melhorato, Rodrigo,Li, Chunjian,Xu, Jinyi,Su, Duowu,Wu, Shuqing,Hu, Hua,Wu, Kang,Li, BUREAU INTERNATIONAL DES POIDS ET MESURES 2015 METROLOGIA -BERLIN- Vol.52 No.1

Ixabepilone Plus Capecitabine for Metastatic Breast Cancer Progressing After Anthracycline and Taxane Treatment

Thomas, Eva S.,Gomez, Henry L.,Li, Rubi K.,Chung, Hyun-Cheol,Fein, Luis E.,Chan, Valorie F.,Jassem, Jacek,Pivot, Xavier B.,Klimovsky, Judith V.,de Mendoza, Fernando Hurtado,Xu, Binghe,Campone, Mario,L Grune & Stratton 2007 Journal of clinical oncology Vol.25 No.33

<B>Purpose</B><P>Effective treatment options for patients with metastatic breast cancer resistant to anthracyclines and taxanes are limited. Ixabepilone has single-agent activity in these patients and has demonstrated synergy with capecitabine in this setting. This study was designed to compare ixabepilone plus capecitabine versus capecitabine alone in anthracycline-pretreated or -resistant and taxane-resistant locally advanced or metastatic breast cancer.</P><B>Patients and Methods</B><P>Seven hundred fifty-two patients were randomly assigned to ixabepilone 40 mg/m<SUP>2</SUP>intravenously on day 1 of a 21-day cycle plus capecitabine 2,000 mg/m<SUP>2</SUP>orally on days 1 through 14 of a 21-day cycle, or capecitabine alone 2,500 mg/m<SUP>2</SUP>on the same schedule, in this international phase III study. The primary end point was progression-free survival evaluated by blinded independent review.</P><B>Results</B><P>Ixabepilone plus capecitabine prolonged progression-free survival relative to capecitabine (median, 5.8 v 4.2 months), with a 25% reduction in the estimated risk of disease progression (hazard ratio, 0.75; 95% CI, 0.64 to 0.88; P = .0003). Objective response rate was also increased (35% v 14%; P < .0001). Grade 3/4 treatment-related sensory neuropathy (21% v 0%), fatigue (9% v 3%), and neutropenia (68% v 11%) were more frequent with combination therapy, as was the rate of death as a result of toxicity (3% v 1%, with patients with liver dysfunction [≥ grade 2 liver function tests] at greater risk). Capecitabine-related toxicities were similar for both treatment groups.</P><B>Conclusion</B><P>Ixabepilone plus capecitabine demonstrates superior efficacy to capecitabine alone in patients with metastatic breast cancer pretreated or resistant to anthracyclines and resistant to taxanes.</P>

Quantum Packet for the Next Generation Network/ISDN3

Ray Y. W. Lam,Henry C. B,Hui Chen,Tharam S. Dillon,Victor O. K. Li,Victor C. M. Leung 한국통신학회 2008 Journal of communications and networks Vol.10 No.3

This paper proposes a novel method for transporting various types of user traffic effectively over the next generation network called integrated services digital network 3 (ISDN3) (or quantum network) using quantum packets. Basically, a quantum packet comprises one or more 53-byte quanta as generated by a “quantumization” process. While connection-oriented traffic is supported by fixed-size quantum packets each with one quantum to emulate circuit switching, connectionless traffic (e.g., IP packets and active packets) is carried by variable-size quantum packets with multiple quanta to support store-and-forward switching/routing. Our aimis to provide frame-like or datagram-like services while enabling cellbased multiplexing. The quantum packet method also establishes a flexible and extensible framework that caters for future packetization needs whilemaintaining backward compatibility with ATM. In this paper, we discuss the design of the quantum packet method, including its format, the “quantumization” process, and support for different types of user traffic. We also present an analytical model to evaluate the consumption of network resources (or network costs) when quantum packets are employed to transfer losssensitive data using three different approaches: cut-through, storeand- forward and ideal. Close form mathematical expressions are obtained for some situations. In particular, in terms of network cost, we discover two interesting equivalence phenomena for the cut-through and store-and-forward approaches under certain conditions and assumptions. Furthermore, analytical and simulation results are presented to study the system behavior. Our analysis provides valuable insights into the design of the ISDN3/quantum network.

Efficient Single‐Layer Polymer Light‐Emitting Diodes

Kabra, Dinesh,Lu, Li Ping,Song, Myoung Hoon,Snaith, Henry J.,Friend, Richard H. WILEY‐VCH Verlag 2010 Advanced Materials Vol.22 No.29

<P><B>Single‐layer polymer light‐emitting diodes</B> are fabricated using poly (9,9′‐dioctylfluorene)‐<I>co</I>‐ benzothiadiazole (F8BT) as the emissive layer in contact with metal oxide injection layers ITO/ZnO/Cs<SUB>2</SUB>CO<SUB>3</SUB>/F8BT/MoO<SUB>3</SUB>/Au. Luminous efficiencies of up to 23 cd A<SUP>−1</SUP> are achieved for polymer layer thicknesses near 1 <I>μ</I>m. </P>

Drinking Water with Red Beetroot Food Color Antagonizes Esophageal Carcinogenesis in N-Nitrosomethylbenzylamine-Treated Rats

John F. Lechner,Li-Shu Wang,Claudio M. Rocha,Bethany Larue,Cassandra Henry,Colleen M. McIntyre,Kenneth M. Riedl,Steven J. Schwartz,Gary D. Stoner 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3

This study was undertaken to determine if the oral consumption of red beetroot food color would result in an inhibition of N-nitrosomethylbenzylamine (NMBA)-induced tumors in the rat esophagus. Rats were treated with NMBA and given either regular water ad libitum or water containing 78μg/mL commercial red beetroot dye, E162. The number of NMBA-induced esophageal papillomas was reduced by 45% (P<.001) in animals that received the food color compared to controls. The treatment also resulted in reduced rates of cell proliferation in both precancerous esophageal lesions and in papillomas of NMBA-treated rats, as measured by immunohistochemical staining of Ki-67 in esophageal tissue specimens. The effects of beetroot food color on angiogenesis (microvessel density by CD34 immunostaining), inflammation (by CD45 immunostaining), and apoptosis (by terminal deoxynucleotidyl transferase dUTP nick end-labeling staining) in esophageal tissue specimens were also determined. Compared to rats treated with NMBA only, the levels of angiogenesis and inflammation in the beetroot color-consuming animals were reduced, and the apoptotic rate was increased. Thus, the mechanism(s) of chemoprevention by the active constituents of red beetroot color include reducing cell proliferation, angiogenesis, and inflammation and stimulating apoptosis. Importantly, consumption of the dye in the drinking water for a period of 35 weeks did not appear to induce any overt toxicity. Based on the fact that red beetroot color contains betanins, which have strong antioxidant activity, it is postulated that these effects are mediated through inhibition of oxygen radical-induced signal transduction. However, the sum of constituents of E162 has not been determined, and other components with other mechanisms may also be involved in antagonizing cancer development.

Nitrophenyl Functionalization of Carbon Nanotubes and Its Effect on Properties of MWCNT/LCP Composites

Nanda Gopal Sahoo,Henry Kuo Feng Cheng,Hongqian Bao,Siew Hwa Chan,Lin Li,Jianhong Zhao 한국고분자학회 2011 Macromolecular Research Vol.19 No.7

Multiwalled carbon nanotubes (MWCNTs) were functionalized on their sidewalls with p-nitrophenyl (C_6H_4NO_2) to make MWCNTs compatible with liquid crystalline polymer (LCP) through a specific interaction with LCP. This study examined the rheological, morphological, mechanical, dynamic mechanical, and thermal properties of LCP in detail with a variation of the nitrophenyl-functionalized MWCNTs in the LCP matrix. A higher complex viscosity, storage, and loss modulus were observed in the nitrophenyl-functionalized MWCNTs/LCP composites than the composites with the same loading of raw MWCNTs. The nitrophenyl groups attached to the MWCNTs improved their dispersion and interfacial adhesion with the LCP matrix, which was confirmed by field emission scanning electron microscopy (FESEM). As a result, the incorporation of the nitrophenyl-functionalized MWCNTs effectively enhanced the mechanical and thermal stability of the LCP.

Cycle-Consistent Generative Adversarial Network: Effect on Radiation Dose Reduction and Image Quality Improvement in Ultralow-Dose CT for Evaluation of Pulmonary Tuberculosis

Yan Chenggong,Lin Jie,Li Haixia,Xu Jun,Zhang Tianjing,Chen Hao,Woodruff Henry C.,Wu Guangyao,Zhang Siqi,Xu Yikai,Lambin Philippe 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.6

Objective: To investigate the image quality of ultralow-dose CT (ULDCT) of the chest reconstructed using a cycle-consistent generative adversarial network (CycleGAN)-based deep learning method in the evaluation of pulmonary tuberculosis. Materials and Methods: Between June 2019 and November 2019, 103 patients (mean age, 40.8 ± 13.6 years; 61 men and 42 women) with pulmonary tuberculosis were prospectively enrolled to undergo standard-dose CT (120 kVp with automated exposure control), followed immediately by ULDCT (80 kVp and 10 mAs). The images of the two successive scans were used to train the CycleGAN framework for image-to-image translation. The denoising efficacy of the CycleGAN algorithm was compared with that of hybrid and model-based iterative reconstruction. Repeated-measures analysis of variance and Wilcoxon signedrank test were performed to compare the objective measurements and the subjective image quality scores, respectively. Results: With the optimized CycleGAN denoising model, using the ULDCT images as input, the peak signal-to-noise ratio and structural similarity index improved by 2.0 dB and 0.21, respectively. The CycleGAN-generated denoised ULDCT images typically provided satisfactory image quality for optimal visibility of anatomic structures and pathological findings, with a lower level of image noise (mean ± standard deviation [SD], 19.5 ± 3.0 Hounsfield unit [HU]) than that of the hybrid (66.3 ± 10.5 HU, p < 0.001) and a similar noise level to model-based iterative reconstruction (19.6 ± 2.6 HU, p > 0.908). The CycleGAN-generated images showed the highest contrast-to-noise ratios for the pulmonary lesions, followed by the model-based and hybrid iterative reconstruction. The mean effective radiation dose of ULDCT was 0.12 mSv with a mean 93.9% reduction compared to standard-dose CT. Conclusion: The optimized CycleGAN technique may allow the synthesis of diagnostically acceptable images from ULDCT of the chest for the evaluation of pulmonary tuberculosis.