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Male Attitudes towards Infertility: Results from a Global Questionnaire
De Jonge Christopher J.,Gellatly Steven A.,Vazquez-Levin Mónica H.,Barratt Christopher L.R.,Rautakallio-Hokkanen Satu 대한남성과학회 2023 The World Journal of Men's Health Vol.41 No.1
Purpose: In general, men are less likely to seek health care than women. Infertility is a global disease that afflicts approxi-mately 15% of reproductive age couples and the male contributes to 40% of the diagnosable cause. Remarkably, no large or multi-national population data exist regarding men’s perceptions about their infertility. The purpose of this study was to advance our knowledge about the infertile male’s social experience regarding: (1) how they feel about their infertility, (2) what motivated them to seek health care, (3) how likely are they to talk with others about their infertility, (4) their awareness of male infertility support groups, and (5) what their primary source for information is regarding male infertility? Based on the results from this study, these simple questions now have clearer definition. Materials and Methods: An Institutional Review Board-approved, male-directed, anonymous questionnaire translated into 20 languages was made globally available through the Fertility Europe website (https://fertilityeurope.eu). Males (n=1,171) age 20–49 years were invited to complete the online survey after informed consent. Results: Most respondents were European (86%). Of European men, <15.8% were self-motivated to seek medical help. Fur-ther, their physician was not the primary source of information regarding their infertility. While most men (59%) viewed their infertility positively, a large majority were not very likely (73%) to talk about it. Most respondents indicated a lack of aware-ness or absence of male infertility support groups. Conclusions: These are the first multi-national population data revealing men’s feelings about their infertility, what motivates them to seek help and their awareness of resources for peer support and information. These findings also serve to highlight significant gaps that exist in the provision of male reproductive health care and in supportive resources for men suffering from infertility. We offer recommendations on how to address the problem(s).
Pollyana Marques de Moura(Pollyana Marques de Moura),James Seaward(Seaward James),Alex Kane(Alex Kane),Yong Jong Park(Yong Jong Park) 대한구순구개열학회 2023 대한구순구개열학회지 Vol.26 No.1
Objective: The aim of this study was to assess the pre-operative and post-operative aesthetic outcome of patients following primary lip repair to investigate the association of the severity of the cleft deformity after NAM therapy and final surgical outcome. Materials and Methods: To assess the correlation between severity of the cleft and the primary surgery outcome, four pediatric craniofacial surgeons from the affiliated teaching hospital were asked to independently rate 156 randomized sets of photographs from 39 case of non-syndromic patients with complete unilateral cleft lip and palate who received NAM treatment.by mean of visual analogue scale. The photographs were acquired in four different time points: (T1) Pre NAM therapy, (T2) Post NAM therapy, (T3) Immediate post-operative, (T4) Late post-operative. Results: The mean of VAS score for lip and nose improved significantly after NAM therapy. There was significant correlation between NAM treatment (T2) outcome and immediate post-operative outcome (T3) for nose. There was no significant correlation between NAM treatment outcome (T2) and immediate postoperative outcome (T3) or late postoperative outcome for lip. Conclusion: Cleft deformity improved significantly after NAM therapy and this improvement led to better nasal esthetics immediate post operatively.
De Jong, Wim H.,Hoffmann, Sebastian,Lee, Michelle,Kandá,rová,, Helena,Pellevoisin, Christian,Haishima, Yuji,Rollins, Beau,Zdawczyk, Austin,Willoughby, Jamin,Bachelor, Michael,Schatz, Timot Elsevier 2018 Toxicology in vitro Vol.50 No.-
<P><B>Highlights</B></P> <P> <UL> <LI> Alternative in vitro testing of medical device extracts for irritation is possible. </LI> <LI> Reconstructed human epidermis (RhE) model detects presence of irritant in extracts. </LI> <LI> High predictivity RhE model for presence of strong irritants in material extracts. </LI> <LI> Predictivity in saline or sesame oil extract depends on hydrophilicity of irritant. </LI> <LI> Four positive polymer test materials containing a known irritant were evaluated. </LI> </UL> </P>
De Peng Yuan,Xiao Feng Xu,Hong Woo-Jong,Si Ting Wang,Xin Tong Jia,Yang Liu,Shuang Li,Zhi Min Li,Qian Sun,Qiong Mei,Shuai Li,정기홍,Song Hong Wei,Yuan Hu Xuan 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.5
Sheath blight disease (ShB) severely afects rice production; however, the details of defense against ShB remain unclear. To understand the rice defense mechanism against ShB, an RNA sequencing analysis was performed using Rhizoctonia solani inoculated rice leaves after 48 h of inoculation. Among them, 3417 genes were upregulated and 2532 were downregulated when compared with the control group (>twofold or<1/2). In addition, the diferentially expressed genes were classifed via Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and MapMan analyses. Fifty-nine GO terms and seven KEGG pathways were signifcantly enriched. A MapMan analysis demonstrated that the phytohormone and metabolic pathways were signifcantly altered. Interestingly, the expression levels of 359 transcription factors, including WRKY, MYB, and NAC family members, as well as 239 transporter genes, including ABC, MFS, and SWEET, were signifcantly changed in response to R. solani AG1-IA inoculation. Additionally, OsWRKY53 and OsAKT1 negatively regulate the defense response in rice against R. solani via gain of function study for OsWRKY53 and loss of function study for OsAKT1, respectively. Furthermore, several diferentially expressed genes contain R. solani-responsive cis acting regulatory elements in their promoter regions. Taken together, our analyses provide valuable information for the additional study of the defense mechanisms against ShB, and the candidate genes identifed in this study will be useful resource for future breeding to enhance resistance against ShB.