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Hassan Azari(Hassan Azari ),Angela Poff(Angela Poff ),Dominic D’Agostino(Dominic D’Agostino ),Brent Reynolds(Brent Reynolds ) 대한해부학회 2024 Anatomy & Cell Biology Vol.57 No.1
Heavy reliance on glucose metabolism and a reduced capacity to use ketone bodies makes glioblastoma (GBM) a promising candidate for ketone-based therapies. Ketogenic diet (KD) is well-known for its promising effects in controlling tumor growth in GBM. Moreover, synthetic ketone ester (KE) has demonstrated to increase blood ketone levels and enhance animal survival in a metastatic VM-M3 murine tumor model. Here, we compared the efficacy of a KE-supplemented Atkins-type diet (ATD-KE) to a classic KD in controlling tumor progression and enhancing survival in a clinically relevant orthotopic patient-derived xenograft GBM model. Our findings demonstrate that ATD-KE preserves body weight (percent change from the baseline; 112±2.99 vs. 116.9±2.52 and 104.8±3.67), decreases blood glucose (80.55±0.86 vs. 118.6±9.51 and 52.35±3.89 mg/dl), and increases ketone bodies in blood (1.15±0.03 mM vs. 0.55±0.04 and 2.66±0.21 mM) and brain tumor tissue (3.35±0.30 mM vs. 2.04±0.3 and 4.25±0.25 mM) comparable to the KD (results presented for ATD-KE vs. standard diet [STD] and KD, respectively). Importantly, the ATD-KE treatment significantly enhanced survival compared to the STD and was indistinguishable from the KD (47 days in STD vs. 56 days in KD and ATD-KE), suggesting that a nutritionally balanced low carbohydrate ATD combined with KE may be as effective as the KD alone in reducing brain tumor progression. Overall, these data support the rationale for clinical testing of KE-supplemented low-carb diet as an adjunct treatment for brain tumor patients.
Hassan Ahmed Hassan Ahmed Ismail,강병훈,김재수,이재형,최인욱,차광호,육재민,이영하 대한기생충학ㆍ열대의학회 2017 The Korean Journal of Parasitology Vol.55 No.6
IL-12 and IL-23 are closely related in structure, and have been shown to play crucial roles in regulation of immune responses. However, little is known about the regulation of these cytokines in T cells. Here, we investigated the roles of PI3K and MAPK pathways in IL-12 and IL-23 production in human Jurkat T cells in response to Toxoplasma gondii and LPS. IL-12 and IL-23 production was significantly increased in T cells after stimulation with T. gondii or LPS. T. gondii and LPS increased the phosphorylation of AKT, ERK1/2, p38 MAPK, and JNK1/2 in T cells from 10 min post-stimulation, and peaked at 30-60 min. Inhibition of the PI3K pathway reduced IL-12 and IL-23 production in T. gondii-infected cells, but increased in LPS-stimulated cells. IL-12 and IL-23 production was significantly reduced by ERK1/2 and p38 MAPK inhibitors in T. gondii- and LPS-stimulated cells, but not in cells treated with a JNK1/2 inhibitor. Collectively, IL-12 and IL-23 production was positively regulated by PI3K and JNK1/2 in T. gondii-infected Jurkat cells, but negatively regulated in LPS-stimulated cells. And ERK1/2 and p38 MAPK positively regulated IL-12 and IL-23 production in Jurkat T cells. These data indicate that T. gondii and LPS induced IL-12 and IL-23 production in Jurkat T cells through the regulation of the PI3K and MAPK pathways; however, the mechanism underlying the stimulation of IL-12 and IL-23 production by T. gondii in Jurkat T cells is different from that of LPS.
Ismail Hassan Ahmed Hassan Ahmed,차승만,김연,홍성태 대한기생충학ㆍ열대의학회 2023 The Korean Journal of Parasitology Vol.61 No.2
In several schistosomiasis-endemic countries, the prevalence has remained high in some areas owing to reinfection despite repeated mass drug administration (MDA) interventions; these areas are referred to as persistent hot spots. Identifying hotspots is critical for interrupting transmission. This study aimed to determine an effective means of identifying persistent hot spots. First, we investigated the differences between Schistosoma haematobium and Schistosoma mansoni prevalence among school-aged children (SAC) estimated by a community-based survey, for which local key informants purposively selected communities, and a randomly sampled school-based survey. A total of 6,225 individuals residing in 60 villages in 8 districts of North Kordofan, Blue Nile, or Sennar States, Sudan participated in a community-based survey in March 2018. Additionally, the data of 3,959 students attending 71 schools in the same 8 districts were extracted from a nationwide school-based survey conducted in January 2017. The community-based survey identified 3 districts wherein the prevalence of S. haematobium or S. mansoni infection among SAC was significantly higher than that determined by the randomly sampled school survey (e.g., S. haematobium in the Sennar district: 10.8% vs. 1.1%, P<0.001). At the state level, the prevalence of schistosomiasis among SAC, as determined by the community-based survey, was consistently significantly higher than that determined by the school-based survey. Purposeful selection of villages or schools based on a history of MDA, latrine coverage, open defecation, and the prevalence of bloody urine improved the ability for identifying persistent hot spots.
Clinical Findings of Sydenham Chorea in Pediatric Patients: A Single-Center Retrospective Study
Hassan Mottaghi Mohaddam Shahri,Ehsan Hassan Nejad,Mehran Beiraghi Toosi,Abdolreza Malek,Asma Payandeh 대한소아신경학회 2023 대한소아신경학회지 Vol.31 No.3
Purpose: Sydenham chorea is known for its rapid, irregular, and aimless involuntary movements and is considered a benign and self-limiting condition among the major manifestations of rheumatic fever. The current study reviewed the demographic, clinical, and paraclinical findings of pediatric patients with Sydenham chorea. Methods: This cross-sectional study was conducted among 22 patients with Sydenham chorea who were admitted to the pediatric wards of Mashhad Imam Reza and Ghaem Hospitals between 2006 and 2016. Data from these patients’ medical records were extracted, organized using checklist forms, and analyzed. Results: Eight patients were male and 14 were female. The average age was 10.09±3.53 years. In 31.8% of patients, chorea was the only sign of rheumatic fever. Chorea was unilateral in 21.1% of patients. The most common clinical findings were, in descending order, jerky movements, facial grimacing, gait disorders, mental disorders, speech disorders, muscle weakness, and milkmaid’s grip. Cardiac auscultation was normal in 76.2% of patients, while a holosystolic murmur was heard in 23.8%. In laboratory exams, 50% of patients were erythrocyte sedimentation rate (ESR)-positive, 31.2% were C-reactive protein (CRP)-positive, and 53.3% were anti-streptolysin O (ASO)-positive. Echocardiography showed the prevalence of mitral regurgitation (63.6%), aortic regurgitation (45.5%), tricuspid regurgitation (22.7%), pulmonary regurgitation (4.5%), and pericardial effusion (4.5%). Conclusion: This study showed that Sydenham chorea can be the only sign of rheumatic fever. This disease typically occurs in children between the ages of 7 and 12. ESR, CRP, and ASO can be the most effective laboratory tests for diagnosis.
Wide range and stable ink-jet printed humidity sensor based on graphene and zinc oxide nanocomposite
Hassan, Gul,Bae, Jinho,Lee, Chong Hyun,Hassan, Arshad Springer-Verlag 2018 Journal of materials science Materials in electron Vol.29 No.7
<P>Nanocomposite materials are being used for different applications due to their hybrid and unique properties. In this paper, we propose a humidity sensor based on Graphene and zinc oxide nanocomposite thin film. The composite combines the advantages of both the individual materials and improves sensor performance. Addition of conductive graphene to the insulator ZnO results in fall of intrinsic impedance and also in improvement of sensitivity at low relative humidity levels. The sensor consists of silver inter-digital electrodes (IDEs) that are printed on a low cost transparent polyethyleneterephthalate (PET) substrate by DMP-3000 with dimension of 100 A mu m finger width, 50 A mu m spacing, and 500 nm thickness. To achieve a high sensitivity and wide sensing range, the active layer of composite thin film was deposited over the IDEs through spin coating to achieve a thickness of similar to 300 nm. The sensor can effective detect relative humidity in range of 0-85% RH with fast response and recovery times of 1 and 2 s respectively that are comparable to high end commercial sensors.</P>
Hassan, H.M.A.,Mohamed, M.A.,Youssef, Amani W.,Hassan, Eman R. Asian Australasian Association of Animal Productio 2010 Animal Bioscience Vol.23 No.10
A grower broiler experiment (from 14 to 35 days of age) was conducted to study the effect of using two commercial mixtures of organic acids (Galliacid$^{(R)}$ and Biacid$^{(R)}$) to substitute antibiotic growth promoter (Eneramycin$^{(R)}$) on performance, carcass characteristics and intestinal microflora. 400 (Ross 308) broiler chicks were used. A basal corn-soybean meal diet were formulated and served as a control treatment. The control diet was supplemented with either 0.06% Galliacid, 0.1% Biacid or 0.02% Eneramycin. Birds fed the Galliacid-supplemented diet had 16% (p<0.001) more gain than the control, while those fed the Biacid- or Enramycinsupplemented diets recorded 3 and 5.5% more gain, respectively. Organic acids mixtures and Enramycin supplementation significantly (p<0.001) improved feed conversion ratio. These results indicated that birds fed either organic acid mixtures or Enramycinsupplemented diets utilized feed more efficiently than those fed the control diet. Galliacid significantly (p<0.01) increased dressing percentage and bursa weight (% body weight). No significant differences were detected on liver, spleen and thymus (% body weight) among treatments. Galliacid or Biacid significantly (p<0.001) decreased intestinal Escherichia coli and Salmonella compared to the control and Enramycin-supplemented diets. Dietary Enramycin significantly (p<0.001) decreased Escherichia coli, but had no effect on Salmonella counts. In conclusion, organic acid mixtures are more efficient than antibiotic growth promoter (Enramycin) in improving broiler performance and decreasing intestinal Escherichia coli and Salmonella spp., and could be successfully used to substitute antibiotic growth promoters in broiler diets. However, not all of the organic acid mixtures gave the same effect either on performance or intestinal bacterial counts.
Chitosan effects on glass matrices evaluated by biomaterial. MAS-NMR and biological investigations
Hassane Oudadesse,Eric Wers,Xuang Vuong Bui,Claire Roiland,Imane Akhiyat,Amany Mostafa,Hassan Chaair,Hicham Benhayoune,Joel Fauré,Pascal Pellen-Mussi,Bruno Bureau 한국화학공학회 2013 Korean Journal of Chemical Engineering Vol.30 No.9
Bioactive glass 46S6 and biodegradable therapeutic polymer (Chitosan: CH) have been elaborated to form 46S6-CH composite by freeze-drying process. The kinetics of chemical reactivity and bioactivity at the surface were investigated by using physicochemical techniques, particularly solid-state MAS-NMR. Immortalized cell line used to construct multicellular spheroids was employed as three-dimensional (3D) cell cultures for in vitro studies. Obtained results showed a novel structure of the composite; the chemical treatment (ultrasound, magnetic stirring, freeze drying process and lyophilization) led the bioactive glass particles to be loaded in the chitosan-based materials. 29Si and 31P MAS-NMR results showed the emergence of two new species, QSi 3(OH) and QSi 4, which are characteristic of the vitreous network dissolution in simulated body fluid (SBF). MAS-NMR also confirmed the formation of amorphous calcium phosphate (ACP) at the surface of the initial 46S6-CH. Three-dimensional (3D) cell cultures highlighted the effect of chitosan, where the cell viability reached up to 78% in 46S6-CH composite and up to 67% in 46S6. The association of (CH) and bioactive glass (BG) matrix promotes a highly significant bioactivity, demonstrating surface bone formation and satisfactory behavior in biological environment.