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      • KCI등재

        급성 중독 환자에 대한 역학적 고찰 : 서울과 지방의 비교

        김성중,김인병,최성욱,김경수,이영수,Choi, Jong Moo 대한응급의학회 1995 大韓應急醫學會誌 Vol.6 No.2

        Study objective: To compare patients with acute poisoning between urban and rural areas Design: Retrospective chart review of 217 patients with acute poisoning Setting: Two University Hospital EDs Methods: patients were divided into two groups according to hospital. The group A was 109 patients who came to ED of Asan Medical Center and the group B was patients who came to ED of Ajou University Hospital from June 1994 to February 1995. We analysed the age and sex distributions, poisoning substances. causes of poisoning and the past history of psychiatric problems in patients of the two groups. Results: Total number of patients with acute poisoning were 109 in the group A and 108 in the group B. Female was more prevalent than male in the group A and male was more than female in the group B. There was a significant difference in sex distribution between two groups. The mean age of the group A was 27.7 years which was significantly different from the mean age of the group B, 33.7 years. The age incidences in both group were highest in 2nd decade. The accidental poisoning cases were 37% in the group A and 31% in the group B. The rates of committed suicide were 7% in the group A and 22% in the group B. The most common agent of poisoning was therapeutic drug in the group A and agricultural or industrial chemical in the group B. The overall mortality was 5% in the group A and 15% in the group B. Conclusion: There were significant differences in age and sex distributions. poisoning substances, causes of poisoning and the past history of psychiatric problems between two groups.

      • KCI등재

        분진의 개수농도 및 질량농도에 입각한 서울시 지하철 역사내 오염원의 기여도 결정

        최형욱,황인조,김신도,김동술 한국대기환경학회 2004 한국대기환경학회지 Vol.20 No.1

        The subway play an important part in serious traffic problems. However, because subway system is a closed environment, many serious air pollution problems occurred in subway stations and injured passenger's health. Therefore, it is a necessary to identify sources and to estimate pollutant sources in order to protect passenger's health and to keep clean subway environment. The purpose of this study was to analyze a air quality in the subway stations and to apply a new receptor methodology for quantitatively estimate of PM 10 sources. In this study, the size distributions of particulate matters has been measured by using Aerosizer LD (U.S.A., API, Inc.). It's realtime measurement capability of time-of-flight technique offers a significant advantage of user convenience and air pollution management. Also, the mass concentrations of PM 10 has been measured by using mini-vol portable sampler (U.S.A., Airmetrics Co.). The sampling performed in Seoul subway stations during the period of February 2000 and April 2000. The number distribution data used in this study consisted of 26 raw data sets in the Jongno-sam-ga station. Correlation Analysis can be used in subway stations for source separation and identification. Then, number contribution from each source is determined by the particle number balance (PNB). The mass concentration data used in this study consisted of 31 raw data in the 8 different stations. The mass contributions of PM 10 sources in the concourse by using PMF/CMB model.

      • SCIESCOPUSKCI등재

        Treadmill exercise prevents diabetes-induced increases in lipid peroxidation and decreases in Cu,Zn-superoxide dismutase levels in the hippocampus of Zucker diabetic fatty rats

        Jong Whi Kim,Junghyun Chae,Sung Min Nam,Yo Na Kim,Dae Young Yoo,Jung Hoon Choi,Hyo Young Jung,Wook Song,In Koo Hwang,J 대한수의학회 2015 JOURNAL OF VETERINARY SCIENCE Vol.16 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        In the present study, we investigated the effects of treadmill exercise on lipid peroxidation and Cu,Zn-superoxide dismutase (SOD1) levels in the hippocampus of Zucker diabetic fatty (ZDF) rats and lean control rats (ZLC) during the onset of diabetes. At 7 weeks of age, ZLC and ZDF rats were either placed on a stationary treadmill or made to run for 1 h/day for 5 consecutive days at 16∼22 m/min for 5 weeks. At 12 weeks of age, the ZDF rats had significantly higher blood glucose levels and body weight than the ZLC rats. In addition, malondialdehyde (MDA) levels in the hippocampus of the ZDF rats were significantly higher than those of the ZLC rats whereas SOD1 levels in the hippocampus of the ZDF rats were moderately decreased. Notably, treadmill exercise prevented the increase of blood glucose levels in ZDF rats. In addition, treadmill exercise significantly ameliorated changes in MDA and SOD1 levels in the hippocampus although SOD activity was not altered. These findings suggest that diabetes increases lipid peroxidation and decreases SOD1 levels, and treadmill exercise can mitigate diabetes-induced oxidative damage in the hippocampus.

      • KCI등재

        DTF를 이용한 순산소연소 조건에서 탈황반응과 CaSO₄ 분해 특성

        최욱(Wook Choi),조항대(Hang Dae Jo),최원길(Won Kil Choi),박영성(Yeong Sung Park),길상인(Sang In Keel),이형근(Hyung Keun Lee) 大韓環境工學會 2011 대한환경공학회지 Vol.33 No.6

        순산소연소 조건하의 로내 탈황공정에서 황화반응 생성물인 CaSO₄의 재분해가 탈황반응에 미치는 영향이 크다. 본 연구에서는 DTF (Drop Tube Furnace)를 이용하여 반응온도, CO₂, O₂, SO₂ 농도 등을 포함한 다양한 실험 변수들이 CaSO₄ 탈황반응에 미치는 영향을 파악하기 위하여 분해반응의 전환율을 측정하고 반응속도를 계산하였다. 반응온도가 상승함에 따라 CaSO₄ 분해반응의 전환율과 반응속도가 증가하였고 O₂가 존재하는 조건에서 CO₂ 농도의 영향은 크지 않았다. 동일한 조건에서 CaSO₄ 분해속도는 O₂ 농도가 감소함에 따라 증가하였으나 SO₂ 농도가 증가함에 따라 감소되었다. In general, the decomposition of CaSO₄ formed by sulfation reaction in the in-furnace desulfurization process using limestone has strong effect on the desulfurization reaction under the oxy-fuel combustion condition. In this study, the conversion rates were measured and reaction rates were calculated in order to investigate the effects of the experimental variables such as temperature and the concentrations of CO₂, O₂, SO₂, on the CaSO₄ decomposition reaction using DTF (Drop Tube Furnace) in the desulfurization reaction. The conversion rate and the reaction rate of CaSO₄ decomposition reaction were increased with reaction temperature. CO₂ concentration has little effect on CaSO₄ decomposition reaction in the presence of O₂. Under the same experimental conditions, the decomposition rate of CaSO₄ was enhanced with the decreasing the O₂ concentration, but vice versa with the increasing of SO₂ concentration.

      • KCI등재후보
      • 서울시 지하철 역사내 라돈의 농도분포

        황인조,한근혁,최형욱,김동술,김신도 경희대학교 환경연구소 2001 環境硏究 論文集 Vol.10 No.-

        The various existing situations like overpopulation, urbanization, industrialization, and heavy traffic volume in the Seoul metropolitan area have led to the air pollution problem, traffic problem, and increase in opportunities of residing underground place. So, recently in Korea, the residents using underground working place have been of great concerns on indoor air pollutants such as HCHO, radon, particulate matter, carbon monoxide. However, the studies on indoor air pollution have been not extensively conducted in Korea. Indoor radon is an odorless, colorless, tasteless, invisible, inert, and naturally occurring radioactive gas. And it has been known as one of the notorious carcinogens. The purpose of this study was to survey the concentration variations of radon in the subway stations located Seoul metropolitan area. Total of 216 subway stations were surveyed by the continuous radon monitors from Mar. 2001 to Jun. 2001. The study showed that average radon levels of concourses in each line were 1.51, 1.45, 1.51, 1.23, 1.28, 1.37, 1.12, 1.28 pCi/L and those of platforms in each line were 2.09, 1.43, 1.37, 1.67, 1.44, 1.54, 1.40, 1.22 pCi/L, respectively. The study results showed that the average radon concentrations were 1.19 pCi/L in outdoor, 1.34 pCi/L in concourse, and 1.52 pCi/L in platform, respectively.

      • 톡소포자충 감염마우스의 Cytokine 및 Heat shock protein 생산 분석

        노형준,최인욱,신대환,이영하 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

        T. gondii frequently causes severe congenital defects and life-threatening disease in immunocompromised individuals. Cytokines. nitric oxide (NO) and heat shock proteins (HSP) are important to control the parasite multiplication and host resistance. However. there were only fen reports about HSP70 in toxoplasmosis. Moreover. we do not know the cytokines and HSP70 production in case of NO inhibition. Therefore. this study was performed to analyze the production of NO. HSP70 and cytokines after adminstration of aminoguanidine (AMG. suppressor of NO production) in mice infected with T. gondii. BALB/c and C57BL/6 mice were injected with either 5 brain cysts of Me49 strain of T. gondii or 50㎍ of AMG for 2 weeks every day. and then mice were sacrificed at day 4. 7. 14 and 28. HSP70 production in the brain and spleen of both mice strains mere decreased after treatment with AMG. however Toxoplasma-infected ones were significantly increased. HSP70 production of Infection/AMG-treated group of C57BL/7mice was significantly decreased in comparison to Infection group. Whereas Infection/AMG-treated group of BALB/c mice showed similar HSP70 production compared to Infection group. After T. gondii infection. the IFN-γ and TNF-α mRNA expression in the brain and spleen was significantly increased in BALB/c or C57BL/6 mice. IFN-γ mRNA expression in the brain and spleen of Infection/AMG-treated BALB/c mice were not significant differences compared to those of infected ones. however there were significant differences in the spleen of C57BL/6 mice. TNF-α mRNA expression in the spleen of Infection/AMG-treated BALB/c or C57BL/6 mice were significantly decreased in comparison to those of infected ones. Taken together. HSP70. IFN-γ and TNF-α production were significantly increased in Toxoplasma-infected BALB/c and C57L/6 mice. After treatment with NO inhibitor in infected C57BL/6 mice, the production of HSP70 and IFN-γ were significantly decreased. whereas BALB/c mice were not significant differences of HSP70 and IFN-γ production between Infection and Infection/AMG-treated group.

      • KCI등재

        DTF를 이용한 순산소연소 조건에서 탈황반응과 $CaSO_4$ 분해 특성

        최욱,조항대,최원길,박영성,길상인,이형근,Choi, Wook,Jo, Hang-Dae,Choi, Won-Kil,Park, Yeong-Sung,Keel, Sang-In,Lee, Hyung-Keun 대한환경공학회 2011 대한환경공학회지 Vol.33 No.6

        순산소연소 조건하의 로내 탈황공정에서 황화반응 생성물인 $CaSO_4$의 재분해가 탈황반응에 미치는 영향이 크다. 본 연구에서는 DTF (Drop Tube Furnace)를 이용하여 반응온도, $CO_2$, $O_2$, $SO_2$, 농도 등을 포함한 다양한 실험 변수들이 $CaSO_4$ 탈황반응에 미치는 영향을 파악하기 위하여 분해반응의 전환율을 측정하고 반응속도를 계산하였다. 반응온도가 상승함에 따라 $CaSO_4$ 분해반응의 전환율과 반응속도가 증가하였고 $O_2$가 존재하는 조건에서 $CO_2$ 농도의 영향은 크지 않았다. 동일한 조건에서 $CaSO_4$ 분해속도는 $O_2$ 농도가 감소함에 따라 증가하였으나 $SO_2$ 농도가 증가함에 따라 감소되었다. In general, the decomposition of $CaSO_4$ formed by sulfation reaction in the in-furnace desulfurization process using limestone has strong effect on the desulfurization reaction under the oxy-fuel combustion condition. In this study, the conversion rates were measured and reaction rates were calculated in order to investigate the effects of the experimental variables such as temperature and the concentrations of $CO_2$, $O_2$, $SO_2$, on the $CaSO_4$ decomposition reaction using DTF (Drop Tube Furnace) in the desulfurization reaction. The conversion rate and the reaction rate of $CaSO_4$ decomposition reaction were increased with reaction temperature. $CO_2$ concentration has little effect on $CaSO_4$ decomposition reaction in the presence of $O_2$. Under the same experimental conditions, the decomposition rate of $CaSO_4$ was enhanced with the decreasing the $O_2$ concentration, but vice versa with the increasing of $SO_2$ concentration.

      • Poster Session : PS 1015 ; GI Motility : Pegylated-Photosensitizer Enhances the Effi cacy of Photodynamic Therapy Through Escaping of ATPBinding Cassette Subfamily G Member 2 in Pancreatic Cancer Cells

        ( Jae Myung Park ),( In Wook Kim ),( Ju Hee Kim ),( Tayyaba Hasan ),( Myung Gyu Choi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: Porphyrin-based photosensitizers are most commonly used in photodynamic therapy (PDT). However, these drugs are exported extracellularly by a cell-membrane transporter, the ATP-binding cassette subfamily G member 2 (ABCG2), decreasing the PDT-induced cytotoxicity in cancer treatment. In this study, we showed that intracellular level of a porphyrin was increased by its Pegylated form, which enhance the PDT-induced cytotoxicity. Methods: Pancreatic cancer cells, AsPC-1 and MIA PaCa-2, were selected. We also used ABCG2-overexpressed MIA Paca-2 cells. We pretreated them with chlorine e6 (Che6) or its pegylated-Che6, then irradiated with a diode laser emitting at 670 nm wave length with total radiation dose of 6 J/cm2. We measured the intracellular level of Che6 and peglated-Che6 with fl uorescence meter, FACS and confocal microscope. Cell viability and survival was analyzed by MTT assay and clonogenic survival assay, respectively. Singlet oxygen level was quantified with photomultiplier-tube based singlet oxygen detection system. In-vivo PDT effects were investigated with AsPC-1 cell-bearing BALC/nude mice of the Che6 and pegylated-Che6. Results: The intracellular level of Che6 was higher in MIA PaCa-2 than AsPC-1 and MIA PaCa-2/ABCG2 cells. However, intracellular level of Che6 was increased by its pegylated form in AsPC-1 and MIA PaCa2/ABCG2 cells. Cell viability after PDT was signifi cantly decreased in MIA PaCa-2 compared to AsPC-1 and MIA PaCa-2/ABCG2. However, PDT using pegylated-Che6 caused the similar cytotoxicity among the three cancer cell lines. The production level of singlet oxygen was higher in pegylated-Che6 than Che6-treated cells. The tumor volume after PDT using pegylated-Che6 was signifi cant smaller than that of Che6 in AsPC-1-xenograft mouse model. Conclusions: Pegylated-photosensitizer escaped ABCG2 function, which suggests potential improvement of ABCG2-related resistant to porphyrin-based PDT in cancer treatment in pancreatic cancers.

      • KCI등재

        옥천대에 대한 고자기 연구 : 태백지역에서의 대자율 비등방성과 지구조적 응력장

        김성욱,최은경,정연규,김인수,Kim, Sung-Wook,Choi, Eun-Kyeong,Jung, Yeon-Kyu,Kim, In-Soo 대한자원환경지질학회 1997 자원환경지질 Vol.30 No.6

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 9시까지 원문보기가 가능합니다.

        A study of anisotropy of magnetic susceptibility (AMS) was conducted on the Ordovician-Eocene strata in the Taebaek area. The study area is a northeastern part of the Okchon belt, sometimes called as Paegunsan Synclinal Area. A total of 600 independently oriented samples were collected from 60 sites covering the whole area. With a few exception of late Cretaceous-Eocene volcanic rocks, all the sampled strata are nonmetamorphosed sedimentary rocks, mainly sandstones. Among the 60 sites, 5 sites showed flow lineation lying on the bedding plane, 11 sites showed load foliation parallel to the bedding plane, and 21 sites showed tectonic foliation unrelated to the bedding plane. The tectonic foliations are defined by $k_1-k_2$ ($k_{max}-k_{int}$) anisotropy plane, and are considered as a result of tectonic forces acted perpendicularly to the foliation plane in the geologic past. Regardless of sample-site locations, tectonic force directions defined by $k_3$ ($k_{min}$) axis perpendicular to the tectonic foliation are consistent among the strata of the same geologic age. In the course of geologic time, however, the tectonic force directions showed a clockwise rotation: approximately E-W in the Ordovician sites, NW-SE in the Permian sites, N-S in the Triassic sites, and lastly NE-SW in the late Cretaceous-Eocene sites. The pre-Permian directions showed better clustering in the in-situ (geographic) coordinates, while the younger directions become better clustered after the bedding-tilt correction. It is interpreted that the major tectonic structures of the Taebaek area were controlled by the above-mentioned tectonic forces: The Paegunsan Syncline and the Hambaeksan Fault must have been generated by the NW-SE force of late Permian-early Triassic time. It was then reactivated in the reverse (dextral) sense by the N-S force of Triassic time. The Osipchon Fault in the eastern part of the study area was either generated or reactivated by the NE-SW force of late Cretaceous-Eocene time. The Permo-Triassic NW-SE force should be an expression of the Songnim Disturbance in the Korean peninsula, which is in turn related with the SCB/NCB collision in China.

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