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Hirotaka Hasegawa,Masahiro Shin,Jun Kawagishi,Hidefumi Jokura,Toshinori Hasegawa,Takenori Kato,Mariko Kawashima,Yuki Shinya,Hiroyuki Kenai,Takuya Kawabe,Manabu Sato,Toru Serizawa,Osamu Nagano,Kyoko Ao 대한뇌졸중학회 2022 Journal of stroke Vol.24 No.2
Background and Purpose To assess the long-term outcomes of intracranial dural arteriovenous fistula (DAVF) treated with stereotactic radiosurgery (SRS) alone or embolization and SRS (Emb- SRS) and to develop a grading system for predicting DAVF obliteration. Methods This multi-institutional retrospective study included 200 patients with DAVF treated with SRS or Emb-SRS. We investigated the long-term obliteration rate and obliteration-associated factors. We developed a new grading system to estimate the obliteration rate. Additionally, we compared the outcomes of SRS and Emb-SRS by using propensity score matching. Results The 3- and 4-year obliteration rates were 66.3% and 78.8%, respectively. The post-SRS hemorrhage rate was 2%. In the matched cohort, the SRS and Emb-SRS groups did not differ in the rates of obliteration (P=0.54) or post-SRS hemorrhage (P=0.50). In multivariable analysis, DAVF location and cortical venous reflux (CVR) were independently associated with obliteration. The new grading system assigned 2, 1, and 0 points to DAVFs in the anterior skull base or middle fossa, DAVFs with CVR or DAVFs in the superior sagittal sinus or tentorium, and DAVFs without these factors, respectively. Using the total points, patients were stratified into the highest (0 points), intermediate (1 point), or lowest (≥2 points) obliteration rate groups that exhibited 4-year obliteration rates of 94.4%, 71.3%, and 60.4%, respectively (P<0.01). Conclusions SRS-based therapy achieved DAVF obliteration in more than three-quarters of the patients at 4 years of age. Our grading system can stratify the obliteration rate and may guide physicians in treatment selection.
Flow Field Change before Onset of Flow Separation
Hasegawa, Hiroaki,Sugawara, Takeru Korean Society for Fluid machinery 2009 International journal of fluid machinery and syste Vol.2 No.3
Jets issuing through small holes in a wall into a freestream has proven effective in the control of flow separation. This technique is known as the vortex generator jet (VGJs) method. If a precursor signal of separation is found, the separation control system using VGJs can be operated just before the onset of separation and the flow field with no separation is always attained. In this study, we measured the flow field and the wall static pressure in a two-dimensional diffuser to find a precursor signal of flow separation. The streamwise velocity measurements were carried out in the separated shear layer and spectral analysis was applied to the velocity fluctuations at some angles with respect to the diffuser. The pattern of peaks in the spectral analysis changes as the divergence angle increases over the angle of which the whole separation occurs. This change in the spectral pattern is related to the enhancement of the growth of shear layer vortices and appears just before the onset of separation. Therefore, the growth of shear layer vortices can be regarded as a precursor signal to flow separation.
Hasegawa, Koichi,Katagiri, Kiyofumi,Matsuda, Astunori,Tatsumisago, Masahiro,Minami, Tsutomu The Korean Ceramic Society 2000 The Korean journal of ceramics Vol.6 No.1
Thick inorganic-organic hybrid films were prepared on ITO-coated glass substrates by the electrophoretic sol-gel deposition of polyphenylsilsesquioxane particles. The morphology of the deposited films changed from the aggregate of the spherical particles to monolith by heat treatment at temperatures higher than $200^{\circ}C$. Transparency of the films was significantly improved accompanied by the morphological change of the particles. The degree of the morphological change was governed by two factors; maximum heat treatment temperature and heating rate. Transparent thick films of ca. 3$\mu\textrm{m}$ in thickness were obtained only by heat treatment at $400^{\circ}C$ for 2h with rapid heating from room temperature to $400^{\circ}C$. These films obtained were strongly adhered to the ITO-coated glass substrates and has a very smooth surface.
The opposition effect of the asteroid 4 Vesta
Hasegawa, Sunao,Miyasaka, Seidai,Tokimasa, Noritaka,Sogame, Akito,Ibrahimov, Mansur A.,Yoshida, Fumi,Ozaki, Shinobu,Abe, Masanao,Ishiguro, Masateru,Kuroda, Daisuke Oxford University Press 2014 Publications of the Astronomical Society of Japan Vol.66 No.5
Hasegawa, Takuya,Kim, Sun Woog,Ueda, Tadaharu,Ishigaki, Tadashi,Uematsu, Kazuyoshi,Takaba, Hiromitsu,Toda, Kenji,Sato, Mineo The Royal Society of Chemistry 2017 Journal of Materials Chemistry C Vol.5 No.36
<▼1><P>A novel red emitting, Ce<SUP>3+</SUP>-activated Sr3Sc4O9 phosphor were discovered, and its luminescent properties were investigated.</P></▼1><▼2><P>Most conventional white light emitting diodes (white-LEDs) that are widely used as a new lighting system in next generation lights with Y3Al5O12:Ce<SUP>3+</SUP> (YAG:Ce<SUP>3+</SUP>)-based phosphors have a low colour rendering index (CRI) because the YAG:Ce<SUP>3+</SUP> phosphor shows a weak emission intensity in the red spectral region. Therefore, discovering a red-emitting phosphor with a high-efficiency is quite important to enhance the CRI of white-LEDs. In this study, we successfully discovered a novel, red-emitting Ce<SUP>3+</SUP>-activated Sr3Sc4O9 phosphor that can be excited by blue-light irradiation at 425 nm. A crystal structure of the host material was first determined by Rietveld refinement, which indicated that it should be isostructural with Ba3Ln4O9 (Ln = Sc, Y and Dy-Lu). As the Ce<SUP>3+</SUP> content increased, the X-ray diffraction patterns shifted to a lower angle, which suggested that the Ce<SUP>3+</SUP> ion could substitute Sc in the Sr3Sc4O9 host. Under UV and blue-light excitation, the Ce<SUP>3+</SUP>-activated Sr3Sc4O9 phosphor exhibited a broad emission band with a maximum peak at 620 nm, and its full width half maximum (FWHM) was 180 nm (4530 cm<SUP>−1</SUP>). The highest emission intensity was obtained for Sr3(Sc0.997Ce0.003)4O9, and the internal quantum efficiency of this phosphor under excitation at 425 nm was 53%. To the best of our knowledge, the emission band of the Ce<SUP>3+</SUP>-activated Sr3Sc4O9 phosphor is the longest wavelength for a reported Ce<SUP>3+</SUP>-activated oxide phosphor.</P></▼2>
Hasegawa, Ai,Kurita, Asami,Hayashi, Shinji,Fukumoto, Takeshi,Sasamoto, Hamako 한국식물생명공학회 2013 Plant biotechnology reports Vol.7 No.2
The effects of sea salts, NaCl, KCl, $MgCl_2$, $MgSO_4$, and $CaCl_2$, on the growth of protoplast cultures of two mangrove species, Sonneratia alba and Avicennia alba, were investigated using 96-well culture plates. Plants of these two species naturally grow at the seaward side of a mangrove forest. Cotyledon protoplasts of S. alba showed halophilic nature to NaCl, KCl, and $MgCl_2$ at low concentrations (10-50 mM) when cultured in Murashige and Skoog's (MS) medium containing 0.6 M mannitol. $CaCl_2$ at a concentration higher than 25 mM was inhibitory to cell growth. On the other hand, in protoplast culture of A. alba suspension cells, which were induced from cotyledon tissues, in the modified amino acid (mAA) medium containing 1.2 M sorbitol, tolerance to NaCl, $MgCl_2$ and $MgSO_4$ were observed at a wide range of concentrations up to 400 mM. $CaCl_2$ was always inhibitory for cell divisions in A. alba, but stimulatory for spherical enlargement of cells. However, no difference in cell enlargement was observed among other salts. Similarity and difference in reactivity to salts between protoplasts and suspension cells from our previous studies were discussed in relation to the site of salt tolerance or halophilic adaptation within mangrove cells. For protoplast cultures, the site(s) for response of S. alba and A. alba are located in the cytoplasm and/or the cell membrane.
Blood vessel remodeling in the cerebral cortex induced by binge alcohol intake in mice
Hasegawa Hiroshi,Tanaka Toshiya,Kondo Mari,Teramoto Koji,Nakayama Kei,Hwang Gi-Wook 한국독성학회 2023 Toxicological Research Vol.39 No.1
Ethanol is toxic to the brain and causes various neurological disorders. Although ethanol can directly exert toxicity on neurons, it also acts on other cell types in the central nervous system. Blood vessel endothelial cells interact with, and are affected by blood ethanol. However, the effects of ethanol on the vascular structures of the brain have not been well documented. In this study, we examined the effects of binge levels of ethanol on brain vasculature. Immunostaining analysis indicated structural alterations of blood vessels in the cerebral cortex, which became more tortuous than those in the control mice after ethanol administration. The interaction between the blood vessels and astrocytes decreased, especially in the upper layers of the cerebral cortex. Messenger RNA expression analysis revealed a unique downregulation of Vegfa mRNA encoding vascular endothelial growth factor (VEGF)-A among VEGF, angiopoietin, endothelin family angiogenic and blood vessel remodeling factors. The expression of three proteoglycan core proteins, glypican-5, neurocan, and serglycin, was also altered after ethanol administration. Thus, binge levels of ethanol affect the expression of VEGF-A and blood vessel-supporting proteoglycans, resulting in changes in the vascular structure of the cerebral cortex.
Hasegawa, Tomoko,Fujimori, Shinichiro,Shin, Yonghee,Takahashi, Kiyoshi,Masui, Toshihiko,Tanaka, Akemi American Chemical Society 2014 Environmental science & technology Vol.48 No.1
<P>We assessed the impacts of climate change and agricultural autonomous adaptation measures (changes in crop variety and planting dates) on food consumption and risk of hunger considering uncertainties in socioeconomic and climate conditions by using a new scenario framework. We combined a global computable general equilibrium model and a crop model (M-GAEZ), and estimated the impacts through 2050 based on future assumptions of socioeconomic and climate conditions. We used three Shared Socioeconomic Pathways as future population and gross domestic products, four Representative Concentration Pathways as a greenhouse gas emissions constraint, and eight General Circulation Models to estimate climate conditions. We found that (i) the adaptation measures are expected to significantly lower the risk of hunger resulting from climate change under various socioeconomic and climate conditions. (ii) population and economic development had a greater impact than climate conditions for risk of hunger at least throughout 2050, but climate change was projected to have notable impacts, even in the strong emission mitigation scenarios. (iii) The impact on hunger risk varied across regions because levels of calorie intake, climate change impacts and land scarcity varied by region.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/esthag/2014/esthag.2014.48.issue-1/es4034149/production/images/medium/es-2013-034149_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/es4034149'>ACS Electronic Supporting Info</A></P>