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Yoon, Hana,Lee, Alex Taekyung,Choi, Eun-Ae,Seo, Kwanyong,Bagkar, Nitin,Cho, Jaehun,Jo, Younghun,Chang, K. J.,Kim, Bongsoo American Chemical Society 2010 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.132 No.49
<P>Single-crystalline free-standing hexagonal Fe<SUB>1.3</SUB>Ge nanowires (NWs) are synthesized for the first time using a chemical vapor transport process without using any catalyst. Interestingly, Fe<SUB>1.3</SUB>Ge NWs are found to be ferromagnetic at room temperature, while bulk Fe<SUB>1.3</SUB>Ge has the lower critical temperature of 200 K. We perform first-principles density functional calculations and suggest that the observed strong ferromagnetism is attributed to the reduced distances between Fe atoms, increased number of Fe−Fe bonds, and the enhanced Fe magnetic moments. Both experimental and theoretical studies show that the magnetic moments are enhanced in the NWs, as compared to bulk Fe<SUB>1.3</SUB>Ge. We also modulate the composition ratio of as-grown iron germanide NWs by adjusting experimental conditions. It is shown that uniaxial strain on the hexagonal plane also enhances the ferromagnetic stability.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2010/jacsat.2010.132.issue-49/ja104189p/production/images/medium/ja-2010-04189p_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja104189p'>ACS Electronic Supporting Info</A></P>
Yoon, Hana,Seo, Kwanyong,Bagkar, Nitin,In, Juneho,Park, Jeunghee,Kim, Jaemyung,Kim, Bongsoo WILEY‐VCH Verlag 2009 Advanced Materials Vol.21 No.48
<P><B>Vertically aligned single‐crystalline Co<SUB>5</SUB>Ge<SUB>7</SUB> nanowire (NW) and nanobelt arrays</B> are grown on a very thin graphite layer as well as a curved graphite layer with a good epitaxial lattice match. Co<SUB>5</SUB>Ge<SUB>7</SUB> NW arrays, thus grown, show very efficient field emission properties comparable to those of carbon nanotubes and may be used for flexible field emission displays in the future. </P>
단기간 귀리 추출물 섭취의 혈당 및 콜레스테롤 저하 효과 평가
김하나(Hana Kim),이인수(Insoo Lee),신경숙(Kyungsook Shin),윤순규(Soonkyu Yoon),이부형(Buhyung Lee),윤승규(Seungkyu Yoon),최진우(Jinwoo Choi),서인범(In Bum Suh) 한국콘텐츠학회 2015 한국콘텐츠학회논문지 Vol.15 No.3
최근 혈당조절에 도움이 되는 다양한 천연추출물에 대한 연구가 진행되고 있다. 귀리는 다양한 생리효능이 있는 것으로 알려져 있는데 특히 β 클루칸은 체내 혈중 콜레스테롤 수치를 낮추어 심혈관 질환을 예방하고 비만과 관련된 성인병 예방에 효과를 보이는 것으로 보고되고 있다. 이에 본 연구는 상품화된 귀리 추출물로 이루어진 다운앤컨트롤(비엠제약)을 이용하여 6주간 무작위, 이중맹검, 실험군-대조군 임상 연구를 통해 혈당 및 혈중 콜레스테롤에 대한 효과를 평가한 결과, 통계학적으로 유의한 차이를 보이지는 않았지만 당화알부민은 각각 시험군에서 50.33% 감소, 대조군에서 37.91% 감소 및 중성지방은 시험군에서 7.51% 감소, 대조군에서 3.98% 증가로 상대적으로 차이를 보여 시험약의 혈당저하 효과 및 중성지방의 감소효과를 일부에서 관찰할 수 있었다. Recently, studies about various natural extracts to help control blood glucose has been in progress. Avena sativa is well known to have various physilogical effects. Especially, β-glucan has effect about lowering blood glucose level and prevent cardiovascular dz and adult dz related to obesity. In this study we evaluated the effect of Down and control (BM pharmaceutical) which is consist of commercialized Avena sativa fextracts on blood glucose and cholesterol, 6weeks, randomized, double-blind, placebo-controlled trials. The results show not significantly different in all blood index test group from control group, but in glycated albumin decreased 50.33% for test group, decreased 37.91% for control group, in triglyceride decreased 7.51% for test group, increased 3.98 for control group and we can observed Avena sativa has blood glucose and triglyceride lowering effect in some.
Park, Hana,Yoon, Jin Young,Park, Kyeong Hye,Kim, Do Young,Ahn, Sang Hoon,Han, Kwang-Hyub,Chon, Chae Yoon,Park, Jun Yong WJG Press 2012 WORLD JOURNAL OF GASTROENTEROLOGY Vol.18 No.16
<P>To evaluate long-term clinical course of Budd-Chiari syndrome (BCS) and predictive factors associated with the development of hepatocellular carcinoma (HCC) and survival.</P>
Hyun Suk Yoon,Yong Tae Kim,Bong Suk Shim,Hana Yoon 대한요로생식기감염학회 2018 Urogenital Tract Infection Vol.13 No.3
Purpose: The effects of Lactobacillus fermentation extract (LFE) on cystitis induced by Escherichia coli lipopolysaccharide (LPS) in the mouse bladder were investigated by pathological analyses and measurement of the levels of tumor necrosis factor-alpha (TNF-) and interleukin-18 (IL-18).Materials and Methods: LFE was administered orally (5 g/L) to mice for 10 days after which the study group (n=12) received transurethral injection of 5 g/L LPS. The bladder tissue was then harvested after 24 hours and subjected to hematoxylin and eosin staining. A semi-quantitative score was used to evaluate inflammation (bladder inflammation index, BII). TNF- immunohistochemical staining and multiplex cytokine assays were also performed. TNF- and IL-18 levels were determined. The results were compared with those of the control group (n=12).Results: The BII in the control and study groups was 2.7±0.5 and 1.1±0.7, respectively, with the control group scores differing significantly from the study group scores (p<0.001). TNF- immunohistochemical staining results were similar. The TNF- levels determined by the multiplex cytokine assay were 2.82±1.35 pg/mg and 1.55±0.56 pg/mg for the control and study groups, respectively, and the difference between these groups was statistically significant (p=0.007).Conclusions: Oral administration of LFE appears to have a preventive effect against the inflammatory responses and TNF- expression induced by transurethral instillation of LPS in the mouse bladder. Further studies are required to determine the clinical application of this finding.
Hana Cho,Jae-Rin Lee,Jong-Yoon Lee,김현지,Myong-Joon Hahn,Jong-Sun Kang 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Chloride intracellular channel 1 (CLIC1) is a promising therapeutic target in cancer due to its intrinsic characteristics; it is overexpressed in specific tumor types and its localization changes from cytosolic to surface membrane depending on activities and cell cycle progression. Ca2+ and reactive oxygen species (ROS) are critical signaling molecules that modulate diverse cellular functions, including cell death. In this study, we investigated the function of CLIC1 in Ca2+ and ROS signaling in A549 human lung cancer cells. Depletion of CLIC1 via shRNAs in A549 cells increased DNA double-strand breaks both under control conditions and under treatment with the putative anticancer agent chelerythrine, accompanied by a concomitant increase in the p-JNK level. CLIC1 knockdown greatly increased basal ROS levels, an effect prevented by BAPTA-AM, an intracellular calcium chelator. Intracellular Ca2+ measurements clearly showed that CLIC1 knockdown significantly increased chelerythrine-induced Ca2+ signaling as well as the basal Ca2+ level in A549 cells compared to these levels in control cells. Suppression of extracellular Ca2+ restored the basal Ca2+ level in CLIC1-knockdown A549 cells relative to that in control cells, implying that CLIC1 regulates [Ca2+]i through Ca2+ entry across the plasma membrane. Consistent with this finding, the L-type Ca2+ channel (LTCC) blocker nifedipine reduced the basal Ca2+ level in CLIC1 knockdown cells to that in control cells. Taken together, our results demonstrate that CLIC1 knockdown induces an increase in the intracellular Ca2+ level via LTCC, which then triggers excessive ROS production and consequent JNK activation. Thus, CLIC1 is a key regulator of Ca2+ signaling in the control of cancer cell survival.