Introducing a New Quantitative Evaluation Method for Segregation of Normal Concrete

In?Deok Han,Dongyeop Han 한국콘크리트학회 2021 International Journal of Concrete Structures and M Vol.15 No.3

The aim of this research is to provide a quantitative method for evaluating concrete segregation. Because of various conditions of concrete materials, mix proportions, and delivery, concrete can be segregated. The acquisition inspection executed in construction field for supplied ready-mixed concrete is an important quality control process for concrete. Among the inspections conducted at the project site, segregation of concrete mixture should be evaluated before placing the concrete mixture, currently a qualitative inspection on concrete segregation was conducted. For a normal concrete mixture with slumping behavior, shear slump or collapse slump often occur as an indication of segregation. The suggested evaluation index of segregation for normal concrete (EISN) was induced from the shape of the concrete slumping: relation between the maximum distance of flow and the minimum distance of flow. To evaluate the feasibility of EISN, two different concrete mixture conditions were tested. The recommended EISN parameter of segregation is 1.09 using the three grades of concrete quality. This new quantitative method of evaluating segregation of the concrete mixture is expected to contribute to a more efficient quality control in concrete construction.

고속 반도체 소자에서 배선 간의 Crosstalk에 의한 Coupling Capacitance 변화 분석

지희환,한인식,박성형,김용구,이희덕,Ji Hee-Hwan,Han In-Sik,Park Sung-Hyung,Kim Yong-Goo,Lee Hi-Deok 대한전자공학회 2005 電子工學會論文誌-SD (Semiconductor and devices) Vol.42 No.5

In this paper, novel test patterns and on-chip data are presented to indicate that the variation of coupling capacitance, ${\Delta}Cc$ by crosstalk can be larger than static coupling capacitance, Cc. It is also shown that ${\Delta}Cc$ is strongly dependent on the phase of aggressive lines. for anti-phase crosstalk ${\Delta}Cc$ is always larger than Cc while for in-phase crosstalk ${\Delta}Cc$ is smaller than Cc. HSPICE simulation shows good agreement with the measurement data. 본 논문에서는 Crosstalk에 의한 coupling capacitance의 변화량, ${\Delta}Cc$이 기본값인 Cc보다 더 커질 수 있음을 제안한 테스트 회로를 이용하여 실험적으로 증명하였다. 또한 ${\Delta}Cc$가 Aggressive line의 위상에 매우 의존함을 보였으며 위상이 같은 경우보다 반대인 경우에 ${\Delta}Cc$가 크게 됨을 보였다. 실험 결과의 타당성을 검증을 위해 HSPICE 시뮬레이션을 수행하여 실험치와 잘 맞음을 나타내었다.

PC12 세포에서 Sertraline을 위시한 항우울제에 의한 칼슘길항 유사효과

박기창,공인덕,정해숙,한준규,박규상,이중우,백인호 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.3

본 실험에서는 PC12 세포를 신경세포 모델로 형광물질인 fura-2 및 bisoxonol을 이용하여 세포내 유리 칼슘이온 농도 및 막전압을 각각 측정하여 화학구조가 서로 다른 몇몇 항우울제가 막전압 의존성 칼슘통로의 활성화 및 ATP를 통한 수용체 의존성 칼슘통로의 활성화에 미치는 영향을 관찰하여 아래와 같은 결과를 얻었다. 1) 선택적 serotonin 재흡수 억제제의 하나인 sertraline은 60mM KCI 자극 및 100μM ATP 자극에 의한 [Ca²+]i의 증가를 억제하였으며 이때 IC50 값은 각각 2.5μM과 5.3μM이었다. 2) 막전압 의존성 칼슘통로 및 ATP에 의한 수용체 의존성 칼슘통로의 억제효과는 sertraline을 비롯한 선택적 serotonin 재흡수 억제제나 삼환계 항우울제인 경우 크나, 비전형 항우울제인 trazodone 이나 MAO 억제제인 moclobemide의 경우에는 효과가 미미했다. 3) Sertraline 자체는 농도 의존적으로 지속적인 막전압의 탈분극을 유발하였으며 이에 따라 안정시의 세포내 유리 칼슘이온 농도를 일부 증가시켰다. 4) Sertraline에 의한 칼슘이온 농도 증가효과는 일부 세포내 Ca²+ 저장소로부터 동원이 관여하나 주로 세포막을 통한 칼슘유입에 의해 일어난다. 5) 여러 항우울제 중 sertraline에 의한 탈분극 효과가 가장 컸으며 그 외의 선택적 serotonin 재섭취 억제제, 삼환계 항우울제들은 탈분극 효과가 있었으나 비전형 항우울제인 trazodone은 일부의 효과를 그리로 MAO 억제제인 moclobemide는 막전압에 전혀 영향을 주지 않았다. 6) ATP는 일시적인 탈분극을 유발하였는데 sertraline 전처지로 탈분극 효과가 억제되었으며 이때 IC50는 30μM이었다. 7) ATP에 의한 세포내 칼슘이온 농도의 증가는 nimodipine에 의해 일부만 억제되었으나 sertraline을 함께 투여한 경우에는 그 억제 효과가 훨씬 더 증가하였다. 이상의 실험결과로 미루어 보아 항우울제 중에서 sertraline을 비롯한 선택적 serotonin 재흡수 억제제나 삼환계 항우울제들은 신경세포를 지속적으로 탈분극 시키고 세포내 유리 칼슘농도를 증가시키는 한편 막전압 의존성 칼슘통로와 수용체 의존성 칼슘통로를 차단하여 그 효과가 나타나는 것으로 사료된다. It has been known that antidepressants have calcium antagonist-like action in neuronal tissues. However, their mechanisms are still obscure. For the study of neurochemical mechanism of antidepressants, the authors examined the effects of antidepressants(1-100μM) on the intracellular Ca²+ concentration ([Ca²+]i) and the membrane potential in PC12 cells using fluorescent dyes, fura-2/AM and bisoxonol, respectively. The results were as follows : 1) Sertraline, a selective serotonin reuptake inhibitor(SSRI), inhibited the increment of [Ca²+]i induced by high 60 mM KCl and 100μM ATP with an IC50 value of 2.5μM and 5.4μM, respectively. 2) SSRIs(sertraline, paroxetine and fluoxetine) and tricyclic antidepressants(imipramine and amitriptyline) had strong effects on the inhibition of both voltage-dependent Ca²+ channel and receptor-dependent Ca²+channel, whereas atypical antidepressant(trazodone) and MAO inhibitor(moclobemide) had little effects. 3) Sertraline itself depolarized the membrane potential in a sustained manner depending on its own concentration and it also increased the basal level of [Ca²+]i. 4) The increment of [Ca²+]i might be induced partly by the release from the intracellular calcium store, but mostly induced by the calcium transport through membrane. 5) Among those antidepressants tested, sertraline was the most potent one, Other SSRIs(paroxetine and fluoxetine) and tricyclic antidepressants(imipramine and amitriptyline) were moderately potent. Atypical antidepressant(trazodone) had little effects, and MAO inhibitor(moclobemide) had no effect on the depolarization. 6) External application of ATP induced temporary depolarization. This effect was blocked by prior treatment with sertraline with an IC50 value of 30μM. 7) The increment of [Ca²+]i through voltage-dependent Ca²+ channel was almost inhibited by a selective calcium channel blocker(nimodipine). However, the ATP-induced increment of [Ca²+]i was partially inhibited by nimodipine. These inhibitor effects were potentiated by the addition of sertraline. In the light of these results, it is likely that SSRIs and tricyclic antidepressants could show the blocking effects on both voltage-dependent and receptor-dependent calcium channel by depolarizing neuronal cell membrane potential in a sustained manner and by increasing intracellular free calcium level.

웹 문서 자동 분류를 위한 학습 방법에 관한 연구

韓光錄,尹德鎬,李仁政 湖西大學校工業技術硏究所 1999 工業技術硏究所論文集 Vol.18 No.-

In this paper, we implemented learning system and categorization system for categorizing internet documents. Learning system uses back propagation algorithm of neural network and, categorization system categorizes documents by using learning data from learning system. Web agent was used for retrieving documents from internet. We set 90 categories for learning and categorization. We evaluate the performance of learning and categorization system. Also, in this paper, we compare documents categorization performance to similarity measure of linear document vector.

Avifauna of Southern Coast of Ganghwado, Seokmodo and Gyodongdo

Yu, Jae-Pyoung,Kang, Jeong-Hoon,Kim, Wan-Byung,Kim, Seok-Yee,Jin, Seon-Deok,Paik, In-Hwan,Lee, Han-Soo,Paek, Woon-Kee national science museum of korea 2010 Journal of Korean nature Vol.3 No.1

In June and September of 2009, a total of 11,590 individuals (sum of maximum individuals by each species) of 68 species of 31 families and 12 orders were found in the southern coast of Ganghwado (island), Seokmodo (island) and Gyodongdo (island). Dominant species included, in decreasing order of, Larus crassirostris (29.18%, 3,382 individuals), Larus saundersi (10.52%, 1,219 individuals), Egretta garzetta (9.19%, 1,065 individuals), Egretta alba modesta (9.01%, 1,044 individuals) and Numenius madagascariensis (8.57%, 993 individuals). In June of 2009 (1st survey), the study recorded a total of 4,915 individuals of 50 species, and in September of 2009 (2nd survey), a total of 8,246 individuals of 45 species were recorded. The number of birds was relatively low in the 1st survey, but its species diversity (H') of 2.35 and species richness (Da) of 4.76 were higher than those of the 2nd survey, with the H' of 2.22 and Da of 4.87. Furthermore, depending on the region, Seokmodo (island) recorded the highest species diversity (37 species) in the 1st survey, with H' of 2.57 and Da of 5.59, and in the 2nd survey, Gyodongdo (island) recorded the highest species diversity of 36 species, at H' of 2.46 and Da of 4.79. In this study, Egretta eulophote and Platalea minor, natural mouments numbers 361 and 205-1, as well as 1st grade endangered species, along with 13 government protected species, were found.

Identification of candidate genomic region associated with seed longevity by re-sequencing in rice

In-Seon Jeong,Jun-Hyeon Cho,Chang-Deok Han,Hyun-Ju Lee,Hyeon-So Ji,Gang-Seob Lee,Ung-Han Yoon,Jang-Ho Hahn,Tae-Ho Kim 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07

It is well known that Dharial (Bangladesh origin and weedy rice line) has longer seed longevity than indica and japonica rice varieties. To study the genetic basis of seed longevity of Dharial, we developed 240 BC3F7 backcross recombinant inbred lines derived from the crosses between Dharial (a donor parent) and two korea rice accessions (recurrent parents) including Ilmi and Gopum, respectively. Among these lines, we selected two introgression lines with longer seed longevity and named them Ilmi-NIL and Gopum-NIL. Also, we developed an EMS-induced mutant line from Dharial which has shortened seed longevity, and named it Dharial-EMS. We performed re-sequencing of four rice accessions that are Dharial, Dharial-EMS, Ilmi-NIL, and Gopum-NIL. A total of 706×106 raw reads were generated which provided sequence data over 46x rice genome coverage per each accession. We did genome-wide variation analysis comparing produced re-sequencing data and the re-sequencing data of Ilmi from NABIC database with the Nipponbare reference sequence. By graphical analysis of SNP distribution in rice genome of the five accessions, we could select candidate chromosomal segments introgressed from Dharial in Ilmi-NIL and Gopum-NIL. The introgressed chromosomal segments were in seven regions in Ilmi-NIL and eight regions in Gopum-NIL, and four common introgressed regions between Ilmi-NIL and Gopum-NIL were identified. 2,758 SNPs between Dharial and Dharial-EMS were found in the introgressed regions. Also, we detected 450 genes including at least one SNP among these SNPs. This result will facilitate identification of genes and development of molecular markers for improvement of seed longevity.

TDI 노출 작업자에서 직업성천식 및 항체반응

김덕인 ( Deok In Kim ),김형렬 ( Hyoung Ryoul Kim ),박해심 ( Hae Sim Park ),박신구 ( Sin Gu Park ),임종한 ( Jong Han Leem ),노재훈 ( Jae Hoon Roh ),김정구 ( Jeong Goo Kim ),윤병갑 ( Byeong Kab Yoon ),김철우 ( Cheol Woo Kim ) 대한천식알레르기학회 2005 천식 및 알레르기 Vol.25 No.4

Background: Toluene diisocyanate (TDI) is known to be the most common cause of occupational asthma (OA) in Korea. Although TDI can elicit humoral immune responses including specific-IgE (sIgE) and specific-IgG (sIgG) responses, the exact role of these immune responses has not been clearly clarified yet. Objective: This study was carried out to estimate the prevalence of TDI-induced OA, and to evaluate the clinical significance of TDI-related humoral immune responses in currently TDI-exposed workers. Method: Questionnaire interview for respiratory symptoms was conducted to 170 workers with direct exposure to TDI (exposed group). After screening survey, workers with suspected occupational asthma were selected for methacholine and TDI bronchial provocation tests (BPTs). Serum sIgG and sIgE antibodies to TDI-HSA conjugate, and sIgG to cytokeratin (CK) 8, 18, and 19 were detected by enzyme-linked immunosorbent assay in 170 exposed workers, and compared with 61 unexposed workers in the same workplace (unexposed group) and 75 unexposed healthy controls(healthy control group). Result: Eleven (6.9%) among 170 workers complained symptoms of OA, and 7 of 11 symptomatic workers showed positive airway hyperresponsiveness to methacholine (4.1%). One worker with spray-painting job was confirmed as having TDI-induced asthma by showing positive responses to both methacholine and TDI BPTs. The prevalence of sIgG to TDI-HSA conjugate was significantly higher in TDI-exposed workers (10.1%) than in unexposed workers (0%) and healthy control (2.7%). However, no significant difference was noted between symptomatic (18.2%) and asymptomatic workers (9.5%) among the exposed group. The prevalences of sIgE to TDI-HSA conjugate and sIgG to CK 8, 18, 19 were not significantly different between the three groups. Conclusion: The prevalence of TDI-induced OA was noted to 0.58% in the current working environments. The clinical significance of TDI-induced humoral immune responses may be clarified by further prospective studies. (Korean J Asthma Allergy Clin Immunol 2005;25:276-283)

Hydroxyurea 처리시 적혈구계 전구세포에서의 감마글로빈 프로모터-269∼-240 부위의 역할

박주인,김태겸,김덕인,김인후,정진숙,한진영 대한임상병리학회 1998 대한임상병리학회지 Vol.18 No.1

잉어의 생체 내 대사체 변화에 미치는 플록세틴 영향규명 연구

정인영 ( In-young Chung ),박유미 ( Yu-mi Park ),김상민 ( Sang-min Kim ),김일규 ( Il-gyu Kim ),도영선 ( Young-sun Do ),김석만 ( Suhkmann Kim ),한상범 ( Sang Beom Han ),조현덕 ( Hyun-deok Cho ),석광설 ( Kwang-seol Seok ) 한국환경분석학회 2017 환경분석과 독성보건 Vol.20 No.1

The purpose of this study was to clarify the effect of fluoxetine, one of the most frequently prescribed antidepressant drugs, on Cyprinus carpio by comparing the variations in its metabolite concentrations after exposure to the drug, using NMR and LC/Orbitrap MS. Three experimental reactors were employed, and the total experimental period was 14 days. Cyprinus carpio were acclimatized for 3 months in the laboratory and then subjected to the study. One reactor was used as a 14-day control, and the others were exposed to fluoxetine at 10 ng/L and 10 μg/L for 7 days and depurate for 7 days. The variations in metabolite concentration after exposure were analyzed by NMR and LC/Orbitrap MS. Before exposure, the concentration trends of fluoxetine and its main metabolite, norfluoxetine were almost the same in blood and liver samples of Cyprinus carpio. However, after the depuration period, the concentrations of norfluoxetine in the liver and blood samples were higher than those of fluoxetine. The concentration of the remaining norfluoxetine in the liver sample was higher than that in the blood sample. This means that the liver mainly metabolized pharmaceuticals. The main change in the concentrations of metabolites of Cyprinus carpio was shown in amino acids such as leucine, isoleucine, glutamate, tyrosine, and valine; organic acids such as acetate and formate; creatine; and glucose. Although after the depuration period, the control, and 10 ng/L and 10 μg/L exposure groups had overlapping results, the exposure and control groups could be classified clearly after 14 days. These results are expected to contribute to identifying the effects of environmental pollutants by tracing metabolite changes and building a chemical metabolite database.

Inhabiting Condition and Preservation of Black-faced Spoonbill around Ganghwa County

Paik, In-Hwan,Chun, Byung-Sun,Kim, In-Gyu,Lee, Ki-Sup,Jin, Seon-Deok,Yu, Jae-Pyung,Lee, Han-Soo,Paek, Woon-Kee national science museum of korea 2010 Journal of Korean nature Vol.3 No.1

Regular monitoring on the Black-faced Spoonbill and survey on their breeding were performed in the vicinity of Ganghwa County from August 2002 till July 2003 in order to understand the inhabiting conditions of the endangered species of the bird (EN) defined by IUCN. Maximum 230 individuals of the Black-faced Spoonbill around the County were observed at the southern tidal flat of Ganghwa, which was the largest and 51 at Gyodongdo Island, 55 at Boreumdo Island while one at Seokmodo Island. No Black-faced Spoonbill was observed at Jumundo Island. For the inhabiting status of the bird as per the time of survey, 203 individuals were observed in August 2002, which was recorded as the largest of its kinds, on the other hand, only 5 individuals were found in March, which was the least. No Black-faced Spoonbill was observed from November till February of the following year. For the areas of survey, more individuals of the endangered bird were observed at the southern tidal flat of Ganghwa during the period of survey than other areas and it is because the bird took a rest at the southern tidal flat of Ganghwa and fed their foods. Breeding of the bird was verified at Yudo Island, Seokdo Island, Bido Island and Suribongdol Island and the breeding status as per each island is 100 individuals at Yudo Island, 10 at Seokdo Island, 8 at Bido Island and 5 at Suribongdol Island. On the other hand, the Black-faced Spoonbill found at the southern tidal flat of Ganghwa fed their foods at the nearby rice paddy during May and June. Heavy rainfall in 2007 and the pressure on developing the area surrounding Ganghwdo Island may force the endangered birds to breed at the artificial island of the Incheon Songdo International City or the main inhibiting place is in danger of vanishing. In order to protect the Black-faced Spoonbill, therefore, development and use of not only the tidal flat but also the rice paddy that is the wetland with fresh water and shallow tidal flat should be minimized. Also, converting to the eco-friendly development plan of the reclaimed land and collecting information to restore the inhabiting place of Black-faced Spoonbill is essential.