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- 저자 : 박해심 ( Hae Sim Park ) (검색결과 187 건)
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Toluene diisocyanate ( TDI ) 에 의한 직업성천식에서 TDI - 인혈청 암부민 접합체에 대한 특이 IgG 및 IgE 항체의 임상적 의의
박해심(Hae Sim Park),김희연(Hee Yeon Kim),서정희(Jung Hee Suh),남동호(Dong Ho Nahm),손지웅(Jee Woong Sohn),김유영(You Young Kim) 대한천식알레르기학회 1999 천식 및 알레르기 Vol.19 No.4
Background and objective : TDI is known to be the most prevalent cause of occupational asthma ( OA ) in Korea. However, the pathogenesis of TDI - induced occupational asthma still re- mains to be further clarified. So, we evaluated clinical significance of serum specific IgG and IgE antibodies to TDI - HSA conjugate in TDI - induced occupational asthma. Subjects and methods : Serum specific IgG and IgE antibodies to TDI - HSA conjugate were measured by enzyme linked immunosorbent assay. Serum was collected from 50 TDI- induced OA patients ( classified as group I ), and was compared with that from 13 asthmatic subjects with negative TDI - bronchoprovocation test ( BPT, group II ), allergic asthmatics ( group III ), and unexposed healthy controls ( group IV ). Results : The prevalence of specific IgG was significantly higher in group I than in group II (p = 0.01) or group III (p〈 0.01). No significant difference was noted between group II and group III (p > 0.05). However, the prevalence of specific IgE was not different between group I and group II (p > 0.05 ) or group II and group III( p > 0.05 ). There was no significant difference in prevalence of specific IgG according to the asthmatic response during TDI bronchoprovocation test ( p > 0.05 ). No statistical significance was noted between specific IgG and IgE antibodies in group I subjects ( p > 0.05 ). Conclusion : These findings demonstrate that presence of specific IgG to TDI - HSA conjugate is closely related to TDI - BPT results and it may contribute to the development of TDI - induced asthma.
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면역효소법에 의한 한국산 쑥 화분에 대한 특이 IgE 측정 및 Radioallergosorbent Test ( RAST ) 와의 상관성에 관한 연구
박해심(Hae Sim Park),홍천수(Chein Soo Hong),이수곤(Soo Kon Lee),오승헌(Seung Hun Oh) 대한내과학회 1988 대한내과학회지 Vol.34 No.2
N/A We developed a micro-KLISA assay by use of Korean sagebrush allergen to measure sagebrush-specific IgE. The assay was carried out in polyethylene flat microtitre plates by incubating the allergen, 10% new-born calf serum, test sera and finally horseradish peroxidase conjugated monoclonal anti-IgE. Preincubated with 1 mg/ml of the allergen we prepared, W5-RAST was inhibited by 80.9% and the inhibition curve showed dose-responsive pattern with serial dilution of crude lyophilized sagebrush extracts. The cut-off point for this assay for specific IgE was established by that mean and S.D values from 30 different negative control sera were 0,012 and 0,014 in absorbance value, respectively (Mean+ 2S.D. =0.041). The positive probability of ELISA and RAST assay was 76% and 74%, respectively in 52 patients with positive skin prick test with korean sagebrush extract. The influence from high levels of total IgE was negligible, ranged from 0.063 (5000 u/ml of IgE) to 0.082 (1000 u/ml of IgE). The coefficient variation for the intrassay and interassay reproducibility ranged from 2.83 to 24.14% and 9.64 to 27.03%, respectively. The absorbance value obtained in this assay correlated with the bound radioactivity (%) in RA5T assay (r= 0.553, p<0.05), This showed a higher degree of correlation (r=0.41) with the wheal size on skin prick test than that. This ELISA assay is well suited for mass screening and can be a useful method for measuring specific IgE. It compares favorable in sensitivity and specificity with RAST assay.
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배과수원 주위 거주민에서 발생된 범박이웅애에 의한 천식 1 례
박해심(Hae Sim Park),지영구(Young Koo Jee),황의창(Eui Chang Hwang),박재석(Jae Suk Park),이계영(Kye Young Lee),김건열(Keun Youl Kim) 대한천식알레르기학회 1999 천식 및 알레르기 Vol.19 No.4
There have been a few reports of occupational asthma caused by Tetranychus urticae in fruit farmers or greenhouse workers. We report a case of bronchial asthma induced by Tetranychus urticae from a pear orchard in Cheonan city. An 18-year-old female student living around a pear orchard suffered from intermittent cough, rhinorrhea, and dyspnea for the 3 years. Her PC20 -methacholine was 0.15mg/ml, and skin prick test done with 55 inhalant allergens showed nega- tive responses except Tetranychus urticae extract which was prepared with highly parasitized pear leaves. Bronchial provocation test with Tetranychus urticae extract showed a dual asthma- tic response. These findings indicate that Tetranychus urticae, which include parasites in fruit trees, herba,ceous plants, and greenhouse cultures, can cause IgE-mediated bronchoconstriction in Korea.
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기관지천식 환자에서 아스피린과 음식첨가물에 대한 과민성의 빈도
박해심(Hae Sim Park),조요한(Yo Han Cho),김선신(Sun Sin Kim),김희연(Hee Yeon Kim),남동호(Dong Ho Nahm),서창희(Chang Hee Suh),한명호(Myung Ho Hahn) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.4
Objective and method: In order to identify the aggravating agents for intrinsic asthma, we performed ASA- and food additive-challenge tests on 182 subjects diagnosed as having intrinsic asthma. The following tests were performed: Lysine-aspirin bronchoprovocation test to confirm aspirin-sensitivity, sodium bi-sulfite (40-200mg) oral provocation test for sulfite sensitivity, tartrazine oral provocation test (50mg) for tartrazine sensitivity, and sodium benzoate (400mg) oral provocation test for sodium benzoate sensitivity. Positive reaction was defined as decrease in FEV, by more than 20% from the baseline value after the provocation. Result: Seventy-five (41.2%) of 182 subjects showed positive responses to more than one agent among the aspirin and three food additives challenged. The prevalence of aspirin-sensitivity was the highest (22.5%), followed by sulfite-sensitivity (8.8%), and then concurrent sensi- tivity to both aspirin and sulfite (6.0% ), to both aspirin and tartrazine (1.6% ), to aspirin, sulfite and tartrazine (1.1%) and to aspirin, sulfite and sodium benzoate (0.5%). Rhino-sinusitis was noted in 62.5% of aspirin-sensitive asthmatic subjects, 60% of sulfite-sensitive ones, and 80% of tartrazine-sensitive ones. Urticaria was noted in 21.4% of aspirin-sensitive asthmatic subjects, 16.6% of sulfite-sensitive ones and 6.3% of tartrazine-sensitive ones. Thirty-seven to 83% of positive responders had no adverse reaction history. Conclusion: These findings suggest that ASA and food additive challenge tests should be considered as a screening test to evaluate any aggravating factors in subjects with intrinsic asthma, even though they may not have experienced any adverse reactions.
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