Population Model of Main Belt Asteroids by Debiasing Method

Hahn Yi,Yong-Ik Byun,Hong-Kyu Moon 한국천문학회 2009 天文學會報 Vol.34 No.1

Population Model of Main Belt Asteroids by Debiasing Method

Yi, Hahn,Byun, Yong-Ik,Moon, Hong-Kyu 한국우주과학회 2009 한국우주과학회보 Vol.18 No.1

Intraventricular Vancomycin Therapy for Intractable Bacillus cereus Ventriculitis

Hahn, Jong Woo,Ju, Hee young,Park, Meerim,Yi, Eun Sang,Park, Byung-Kiu,Shin, Sang-Hoon,Lee, Sang-Hyun,Park, Hyeon Jin,Kang, Ji-Man The Korean Society of Pediatric Infectious Disease 2019 Pediatric Infection and Vaccine Vol.26 No.2

Bacillus cereus causes serious central nervous system infections, especially in immunocompromised patients. Successful treatment requires adequate antimicrobial concentrations in the cerebrospinal fluid; however, in some cases, achieving this with systemic treatment alone is difficult. We treated intractable B. cereus ventriculitis with intraventricular vancomycin, with no major adverse events.

Sequence Analysis and Expression of ORF5 in Korean Isolate of Porcine Reproductive and Respiratory Syndrome Virus

Yi, Sun-Shin,Sun, Ji-Sun,Kim, Hyun-Soo,Kang, Shien-Young,Hahn, Tae-Wook The Korean Society for Microbiology 2011 Journal of Bacteriology and Virology Vol.41 No.3

Porcine reproductive and respiratory syndrome virus (PRRSV) is the causative agent of reproductive failure and respiratory disorders in pigs. The viral genome consists of eight overlapping open reading frames (ORFs). ORF5 encodes one of the major glycoproteins and is known as an immunologically important structural protein associated with virus neutralization. The ORF5 gene of the Korean PRRSV isolate, CNV-1, was amplified by reverse transcription-polymerase chain reaction (RT-PCR), cloned and sequenced. The nucleotide and amino acid sequences of CNV-1 ORF5 shared 91% and 83% identity, respectively, with the American isolate (VR2332 strain) and 57% and 49% identity with the European isolate. For the expression and easy purification of ORF5, the cDNA containing the complete ORF5 sequence fused in-frame with sequence encoding glutathione S-transferase (GST) was cloned into a baculovirus transfer vector and transfected into Sf9 cells. The GST-ORF5 fusion protein produced in Sf9 cells was detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and Western blotting. Sequencing results confirmed that the recombinant baculovirus from Sf9 cells contains the complete ORF5 gene. Further studies in this direction will address whether ORF5 can be a good candidate for a subunit vaccine against PRRSV in Korea.

Fast isotropic volumetric magnetic resonance imaging of the ankle: Acceleration of the three-dimensional fast spin echo sequence using compressed sensing combined with parallel imaging

Yi, Jisook,Lee, Young Han,Hahn, Seok,Albakheet, Salman S.,Song, Ho-Taek,Suh, Jin-Suck Elsevier 2019 European journal of radiology Vol.112 No.-

<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>To investigate the feasibility of three-dimensional fast spin echo (3D-FSE) imaging with compressed sensing (CS) and parallel imaging (PI) compared to 3D-FSE imaging with only PI in evaluating ankle joint pathologies.</P> <P><B>Materials and methods</B></P> <P>Twenty consecutive patients underwent ankle magnetic resonance imaging (MRI), including acquisition of image sets of 2D-FSE sequences, and 3D-FSE sequences without and with CS, between June 2016 and November 2017. Three MR image sets were independently rated by two radiologists for the presence/absence of ankle pathology. Quantitative image similarity and subjective image quality were evaluated using 3D-FSE images without CS and those with CS-PI. Inter-sequence agreement between 3D-FSE sequences without CS and with CS-PI in both readers was evaluated.</P> <P><B>Results</B></P> <P>Interobserver agreements were nearly perfect for sprain of the anterior talofibular ligament (ATFL, <I>κ=</I>0.77), osteochondral lesion of the talus (OLT, <I>κ=</I>0.76-0.88), osteochondral lesion of the distal tibia (OLTi, <I>κ=</I>0.74) and os subfibulare (OSF, <I>κ=</I>0.62-0.64). The structural similarity index (mean, 0.996; range, 0.990-0.997) between the 3D-FSE sequences without CS and with CS-PI was acceptable. There was no significant difference in subjective image quality between the two imaging sequences (ATFL, <I>p</I> = 0.317; bone marrow, <I>p</I> = 0.083; cartilage, <I>p</I> = 1.000, tendon, <I>p</I> = 1.000). Intersequence agreement between the 3D-FSE sequences with and without CS was nearly perfect (ATFL and OLTi, <I>κ=</I>1.00; OLT, <I>κ=</I>0.87-0.96; OSF, <I>κ=</I>0.62-0.64) in both readers.</P> <P><B>Conclusions</B></P> <P>Isotropic 3D-FSE ankle MRI with CS provides acceptable diagnostic performance with reduced scan time. Compressed sensing-related artifacts could be minimized with CS reconstruction enhancement, allowing for better image quality for evaluating ankle joint pathologies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Utilization of MRI for the ankle can be maximized by using the multiplanar imaging. </LI> <LI> Isovoxel 3D-fast spin echo sequence of ankle MRI has the capabilities of acquiring thin-sliced sections without any loss of spatial resolution. </LI> <LI> The CS technique is a method to accelerate MR acquisition by acquiring undersampling κ-space data. </LI> <LI> Compressed sensing accelerated isotropic 3D-FSE ankle MRI provides acceptable diagnostic performance with reduced scan time. </LI> </UL> </P>

제 3형 급성 견봉-쇄골 관절 분리 환자의 수술적 치료 결과

한성호,양보규,이승림,정선욱,이동호,김민석 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목적 : 본 연구를 통하여 Rockwood 제 3형 급성 견봉-쇄골 관절 분리 환자에서 Phemister 술식과 modified Phemister 술식의 치료 결과를 비교하고자 한다. 대상 및 방법 : 1992년 2월부터 2001년 8월까지 제 3형 급성 견봉-쇄골 관절 분리로 수술적 치료를 받고 1년 이상 추시 가능하였던 45명, 45예의 환자를 대상으로 하였다. 평균 연령은 28.1세였으며, 남자가 42명, 여자가 3명이었다. 진단은 이학적 검사와 단순 방사선 부하 촬영법을 이용하였으며, 수상일로부터 수술적 치료까지의 평균 기간은 7.8일이었다. 술장 소견상 오구-쇄골인대 봉합술이 어려운 15예에서는 Phemister 술식을 시행하였고 (Ⅰ군), 인대 봉합이 가능한 30예에서는 modified Phemister 술식을 시행하였다(Ⅱ군). 수술 후 추시 기간은 평균 16.2개월이었고, 결과 판정은 최종 추시 때의 임상 소견과 이학적 검사 및 방사선 촬영을 통해 UCLA shoulder scoring system과 acromio-clavicular separation scoring system을 이용하였다. 결과 : 술후 합병증은 Ⅱ군에만 표재성 감염이 2예, K-강선 이주가 1예에서 발생하였다. 최종 추시상 전예에서 동통, 관절 운동 범위의 제한은 없었고 , Ⅱ군에서만 방사선 촬영상 2예에서 아탈구가 관찰되었다. UCLA shoulder scoring system은 Ⅱ군에서 우수 93.3%, 양호 6.7%였고, acromio-clavicular shoulder scoring system은 Ⅱ군에서 우수 90%, 양호 10%였다. 결론 : 활동적인 연령에서 발생한 제 3형 급성 견봉-쇄골 관절 손상의 환자에서 Phemister 술식만으로도 좋은 결과를 보일 수 있을 것으로 사료된다. Purpose : The purpose of this study is to compare the Phemister technique with the modified Phemister technique for the patients with Rockwood type 3, acromio-clavicular separation. Materials and Methods : The 45 cases of 45 patients received surgical treatment for Rockwood type 3, acute acromio-clavicular separation in our hospital from Feb. 1992 to Aug. 2001 later with the follow-up study were selected as subjects. The average ages were 28.1 years old, male and female were 42, 3 persons, respectively. Physical examination and plain radiography were used for their diagnosis and the intervals between injury and surgical treatment were 7.8 days. In intraoperative finding, we performed Phemister technique in 15 cases according not to be able to repair coraco-clavicular ligament (groupⅠ), modified Phemister technique in 30 cases according to be able to repair that (groupⅡ). The average follow up period was 16.2 months, and the UCLA shoulder scoring system and the acromio-clavicular separation scoring system were used to obtain clinical results. Results : Only in Group Ⅱ, the complication after surgery were associated with superficial infection in two cases and K-wire migration in one case. At last follow up, there were no pain and limitation of range of motion in all cases, and two cases in Group Ⅱ were found to be subluxation in radiography. Clinical results revealed excellent was 93.3%, good was 6.7% in UCLA shoulder scoring system in both groups, and excellent was 90%, good was 10% for group Ⅱ in acromio-clavicular separation scoring system. Conclusion : The results are considered to be food with only Phemister technique in type 3, acute injury occurred in working ages.

Prevalence of Hepatic Parasites in Korean Wild Rats (Rattus norvegicus) and Their Association With Pulmonary Arteriolar Medial Hypertrophy

Yi, J.-Y.,Kim, Y.-H.,Kim, H.-C.,Hahn, T.-W.,Jeong, H.,Choi, C.-U.,Woo, G.-H.,Kim, Y.-B.,Han, J.-H.,Yoon, B.-I. VETERINARY PATHOLOGY 2010 Veterinary pathology Vol.47 No.2

카르보폴 - 젤라틴의 상분리법을 이용한 Acyclovir 마이크로캅셀 현탁액의 제조 및 생물학적 평가

한양희,조진호,이정우,최영옥 한국약제학회 1993 Journal of Pharmaceutical Investigation Vol.23 No.3

Microencapsulation of acyclovir, an effective antiviral agent which acts as a specific inhibitor of herpes DNA polymerase, by carbopol-gelatin complex coacervation has been carried out to develop an oral controlled release preparation, which could improve the absorption characteristics in GI tract. After dissolving carbopol and gelatin separately in distilled water at 40℃, gelatin solution was mixed with carbopol solution while stirring at the same temperature. The pH of the mixture was lowered gradually by dropwise addition of 10% HCl with continuous stirring, and then, at pH 3.5, positively charged gelatin molecules were attracted to negatively charged carbopol. These coacervation processes were observed by optical microscopy during preparation. Plasma concentrations of acyclovir in rats after an oral administration of microcapsule suspension were assayed by HPLC, and pharmacokinetic parameters were calculated based on the model-independent analyses. Two standard formulations, oral solution and intravenous bolus injection, were used as references to compare the bioavailability. It has been revealed that C_(max), t_(max), and MRT of microcapsule suspension were greater than those of oral solution, which results in about two-fold increases in bioavailability. Therefore, in conclusion, the carbopol-gelatin microcapsule of acyclovir might be evaluated as an effective oral controlled release preparation which could increase the bioavailability of acyclovir.

Pneumonia due to Schizophyllum commune in a Patient with Acute Myeloid Leukemia: Case Report and Literature Review

Kim Hahn,Yi Yunmi,Cho Sung-Yeon,Lee Dong-Gun,Chun Hye-Sun,Park Chulmin,Kim Yoo-Jin,Park Yeon-Joon 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.1

Schizophyllum commune is a mold in phylum Basidiomycota and is an uncommon human pathogen. Sinusitis and allergic bronchopulmonary mycosis are the two major diseases caused by S. commune. Although there have been several reports of invasive fungal diseases, most of them were invasive sinusitis. We present a case of invasive fungal pneumonia due to S. commune, developed in a patient with acute myeloid leukemia presenting neutropenic fever. The diagnosis was made by characteristic macroscopic and microscopic findings of fungal isolate and was confirmed via sequencing of internal transcribed spacer region. The patient was improved after 8 weeks of antifungal therapy based on the susceptibility result. We propose that S. commune should be considered as an emerging pathogen of invasive fungal pneumonia when a patient is under immunocompromised state. We also reviewed global literatures focused on the invasive fungal diseases caused by S. commune.

洪大容의 測管儀 연구

韓永浩(Hahn Young-ho),李載孝(Lee Jai-hyo),李文揆(Yi Moon-kyu),徐文浩(Seo Moon-hwo),南文鉉(Nam Moon-hyon) 역사학회 1999 역사학보 Vol.164 No.-