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Jeong-Hye YOON,Ga Young KIM,Min-Jeong LEE,Hee-Jeong CHA,Deok-Kun OH,Jin-Byung PARK 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Lipoxygenase (LOX) is the key enzyme involved in the regio- and stereoselective synthesis of oxylipins. The oxylipins, a group of structurally diverse and biologically active oxygenated molecules, are essential signaling messengers involved in human physiological responses. Herein, we discovered bacterial LOX from Enhygromyxa salina (Es-LOX) with unique regiospecificity. C18-polyunsaturated fatty acids (PUFAs) were converted to 9S-form products, indicating that the regiospecificity of Es-LOX differs from that of other bacterial LOXs. The catalytic efficiency (kcat/KM) was the highest for Linoleic acid. The kcat/KM of linoleic acid was 1.51 s<SUP>-1</SUP> μM<SUP>-1</SUP>, which was 2.4-fold higher than the second favored substrate ɣ-linolenic acid. The Es-LOX was engineered to improve the solubility by fusion with maltose binding protein (MBP), which led to the synthesis of target products with high-conversion. For instance, 100 mM linoleic acid was transformed into 83 mM 9Shydroxy-(10E,12Z)-octadecadienoic acid by the recombinant Escherichia coli BL21(DE3) pb4-Es-LOX and tris(2-carboxyethyl)-phosphine (TCEP). In addition, we produced the secondary fatty alcohol [i.e., 8S-hydroxy-(9E,11Z)-heptadecadiene] from the hydroxy fatty acid [i.e., 9S-hydroxy-(10E,12Z)-octadecadienoic acid] by using a single whole-cell biocatalyst, coexpressing Es-LOX and photoactivated decarboxylase from Chlorella variabilis. This study will contribute to the development of biotransformation processes for the synthesis of diverse fatty acid derivatives.
Pillar Type Silicon-Oxide-Nitride-Oxide-Silicon Flash Memory Cells with Modulated Tunneling Oxide
Lee, Sang-Youl,Yang, Seung-Dong,Yun, Ho-Jin,Jeong, Kwang-Seok,Kim, Yu-Mi,Kim, Seong-Hyeon,Lee, Hi-Deok,Lee, Ga-Won,Oh, Jae-Sub The Korean Institute of Electrical and Electronic 2013 Transactions on Electrical and Electronic Material Vol.14 No.5
In this paper, we fabricated 3D pillar type silicon-oxide-nitride-oxide-silicon (SONOS) devices for high density flash applications. To solve the limitation between erase speed and data retention of the conventional SONOS devices, bandgap-engineered (BE) tunneling oxide of oxide-nitride-oxide configuration is integrated with the 3D structure. In addition, the tunneling oxide is modulated by another method of $N_2$ ion implantation ($N_2$ I/I). The measured data shows that the BE-SONOS device has better electrical characteristics, such as a lower threshold voltage ($V_{\tau}$) of 0.13 V, and a higher $g_{m.max}$ of 18.6 ${\mu}A/V$ and mobility of 27.02 $cm^2/Vs$ than the conventional and $N_2$ I/I SONOS devices. Memory characteristics show that the modulated tunneling oxide devices have fast erase speed. Among the devices, the BE-SONOS device has faster program/erase (P/E) speed, and more stable endurance characteristics, than conventional and $N_2$ I/I devices. From the flicker noise analysis, however, the BE-SONOS device seems to have more interface traps between the tunneling oxide and silicon substrate, which should be considered in designing the process conditions. Finally, 3D structures, such as the pillar type BE-SONOS device, are more suitable for next generation memory devices than other modulated tunneling oxide devices.
Functional Polymers for Drug Delivery Systems in Nanomedicines
Lee, Eun-Seong,Kim, Ji-Hoon,Yun, Jeong-Min,Lee, Kyung-Soo,Park, Ga-Young,Lee, Beom-Jin,Oh, Kyung-Taek The Korean Society of Pharmaceutical Sciences and 2010 Journal of Pharmaceutical Investigation Vol.40 No.special
Polymeric based nanomedicines have been developed for diagnosing, treating, and preventing diseases in human body. The nanosized drug delivery systems having various structures such as micelles, nanogels, drug-conjugates, and polyplex were investigated for a great goal in pharmaceutics: increasing therapeutic efficacy for diseases and decreasing drug toxicity for normal tissues. The functional polymers used for constituting these drug delivery systems should have several favorable properties such as stimuli-responsibility and biodegrdability for controlled drug release, and solublization capacity for programmed drug encapsulation. This review discusses recent developments and trends of functional polymers (e.g., pH-sensitive polymers, biodegradable polymers, and cationic polymers) used for nanosized drug carriers.
( Ga Eul Lee ),( Young Ju Jeong ),( Sung Nam Cho ),( Jeong Heon Lee ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: Our objective was to evaluate the effect of combined use of transient bilateral ovarian artery clamping, uterine artery ligation, and Bakri balloon tamponade during cesarean section in women with placenta previa. 방법: We performed a retrospective cohort study of all cesarean deliveries performed due to placenta previa from April 2013 until June 2016 at Chonbuk National University Hospital. Charts were reviewed to determine the amount of RBC transfusion, degree of blood loss and incidence of postpartum hysterectomy and uterine artery embolization (UAE) between conventional method and combined technique to control hemorrhage during cesarean section for placenta previa. Patients with unsortable technique were excluded. The outcome was analyzed using independent t-test. 결과: There was a total of 118 cesarean deliveries for placenta previa during the study period, with two groups of 100 patients using conventional hemostatic method and 17 patients using combined hemostatic technique. There were not different between two groups in the mean amount of PRC transfusion during operation (0.88 ± 2.12 unit vs. 0.24 ± 0.66 units, respectively, p=0.22) and the index of blood loss (0.22 ± 0.13 vs. 0.23 ± 0.14, respectively, p=0.78). The incidence of postpartum hysterectomies (0.05 ± 0.22 vs. 0 ± 0, respectively, p=0.03) and postpartum care (0.13 ± 0.46 vs. 0 ± 0, respectively, p=0.01) for continuous bleeding after cesarean section were significantly low in combined technique group. 결론: Our findings show that utilization of the combined technique (transient bilateral ovarian artery clamping, uterine artery ligation, and Bakri balloon tamponade) during cesarean section for placenta previa is associated with a decreased rate of postpartum hysterectomy and additional hemostatic procedure after cesarean section.