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스태빌라이저와 짐볼을 이용한 배 안정화 운동이 호흡근 활성도에 미치는 영향 비교
이수민 ( Su-min Lee ),김명철 ( Myung-chul Kim ),안청좌 ( Chung-joa Ahn ),문소라 ( So-ra Moon ) 대한물리의학회 2018 대한물리의학회지 Vol.13 No.3
PURPOSE: The purpose of this study was to identify the effect of abdominal stabilization exercise with Stabilizer and Gymball. METHODS: The participants were divided randomly into 2 groups each of 20 participants in the gymball exercise group and 20 participants in the exercise group. The changes of respiratory muscle activity between the two groups were measured three times a week for 4 weeks. The activity of rectus abdominis and internal oblique was measured using surface EMG to measure respiratory muscle activity. The training was repeated five sets, and one set was repeated 6 times with one 10 second exercise and 5 second rest. RESULTS: The results of the study showed that there was a significant difference in the amount of respiratory accessory muscle activation, inspiratory pressure, respiratory minute volume at the experimental group with stabilizer and control group with gymball exercise. Between-group difference was statistically significant only for rectus abdominis muscle activation. CONCLUSION: Both the stabilizer and the gymball exercises were effective in improving the respiratory rate but there was no difference between the two groups. Also, when comparing activity of muscle in both group, both groups were effective in improving and more effective than improvement of muscular activity of stabilizer in muscle of stabilizer.
Hong Seong Su,Choi Chun Whan,Lee Ji Eun,Jung Yeon Woo,Lee Jung A,Jeong Wonsik,Choi Yun-Hyeok,Cha Hanna,Ahn Eun-Kyung,Oh Joa Sub 한국응용생명화학회 2021 Applied Biological Chemistry (Appl Biol Chem) Vol.64 No.1
Amomum tsao-ko (Zingiberaceae), an important traditional medicinal herb, possesses many biological activities, including anti-inflammatory effects. Though the anti-obesity properties of the crude ethanol extract of A. tsao-ko fruits have been reported, the anti-adipogenic properties of its phytochemical constituents have not been reported. Therefore, in the present study, we isolated the active constituents of A. tsao-ko and investigated their anti-adipogenic effects. The bioassay-guided isolation of the phytochemicals from the ethanol extract of A. tsao-ko fruits identified four bioactive compounds, comprising one fatty acid (1), one sesquiterpene alcohol (2), and two phenolic compounds (3 and 4). Their structures were elucidated by a combination of 1D and/or 2D nuclear magnetic resonance and mass spectrometry. The anti-adipogenic activities of the four compounds evaluated by Oil Red O staining in 3T3-L1 cells revealed that the treatment with the isolated compounds 1 and 3 reduced the lipid accumulation in 3T3-L1 adipocytes more strongly than the compounds 2 and 4, in a dose-dependent manner.
Excavasides A and B, two new flavonoid glycosides from <i>Clausena excavata</i> Burm. f. (Rutaceae)
Seo, Changon,Ahn, Eun-Kyung,Kang, Jae-Shin,Lee, Jae-Ho,Oh, Joa Sub,Hong, Seong Su Elsevier 2017 PHYTOCHEMISTRY LETTERS Vol.20 No.-
<P><B>Abstract</B></P> <P>Two new flavonoid glycosides, excavaside A (<B>1</B>) and B (<B>2</B>), together with 14 known compounds, myricetin 3-<I>O</I>-β-<SMALL>D</SMALL>-rutinoside (<B>3</B>), myricetin 3,3′-di-α-<SMALL>L</SMALL>-rhamnopyranoside (<B>4</B>), myricetin 3′-α-<SMALL>L</SMALL>-rhamnopyranoside (<B>5</B>), myricitrin (<B>6</B>), myricetin (<B>7</B>), quercitrin (<B>8</B>), clauslactone B (<B>9</B>), clauslactone A (<B>10</B>), murrayacoumarin C (<B>11</B>), clauslactone E (<B>12</B>), triphasiol (<B>13</B>), clauslactone P (<B>14</B>), seseline (<B>15</B>), and 5-geranyloxy-7-hydroxycoumarin (<B>16</B>) have been isolated from the ethanol extract of the leaves and twigs of <I>Clausena excavata</I>. Among them, compounds <B>3</B>–<B>5</B> and <B>13</B> were isolated and identified from this plant for the first time. The structures of the new compounds were established by spectroscopic data interpretation, particularly HRESIMS, 1D and 2D NMR data including HSQC and HMBC. Also, those of the known compounds were identified by spectral comparison with those of the reported values.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Sixteen compounds, including two new flavonoid glycosides were isolated from the leaves and twigs of <I>Clausena excavata</I>. </LI> <LI> Four compounds were reported from <I>Clausena excavata</I> for the first time. </LI> <LI> Structure elucidation was based on spectroscopic techniques (1D-, 2D-NMR, and HRMS experiments). </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
초과로 부터 Amotsaokonal A-C, Benzaldehyde, Cycloterpenal의 성분분리
WonSik Jeong,Seong Su Hong,Changon Seo,Jin Gwan Kwon,Eun Kyung Ahn,Ju Hyeong Park,Hana Cho,Joa Sub Oh 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.10
Background : Amomum tsao-ko (Zingiberaceae) is widely distributed among several countries in Asia. It’s dried fruit is widely used in Korea for medical plant, China and Japan for the treatment of dyspepsia, eliminates, vomiting, abdominal pain, phlegm, warms the spleen, and malaria. In this study, we describe the structural determination of the new compounds and the inhibitory activities of isolated compounds against LPS-induced NO production in RAW264.7 cells. Methods and Results : The fruits of A. tsao-ko were extracted with 80% EtOH two times at room temperature. The EtOH extract was suspended in distilled water and partitioned with solvent to give CH2Cl2, EtOAc and n-BuOH. The CH2Cl2 was suspended in n-hexane and partitioned with solvent to give 50%, 70% and 90% MeOH. The purification of each fraction by column chromatography separation and HPLC analysis. Consequently, one new benzaldehyde (1) and two new cycloterpenals (2 and 3) along with five known compounds (4 –8) have been isolated from the fruits of A. tsao-ko. The structure and relative stereochemistry were determined from HRMS, 1D and extensive 2D NMR techniques as well as by comparison of their data with the published values. Conclusion : These compounds were identified as Amotsaokonal A (1), Amotsaokonal B (2), Amotsaokonal C (3), methyl linolenate (4), trans-nerolidol (5), (2E)-dodecenyl acetate (6), (2E)-dodecenyl acetate (7), and pyrrole-2-carboxylic acid (8). All isolates were tested for their inhibitory activities on LPS-induced nitric oxide production in RAW264.7 cells.
Won Sik Jeong,Seong Su Hong,Changon Seo,Jin Gwan Kwon,Eun Kyung Ahn,Ju Hyeong Park,Hana Cho,Joa Sub Oh 한국약용작물학회 2016 한국약용작물학술대회 발표집 Vol.2016 No.10
Background : The objective of this study was to Amomum tsao-ko Crevost et Lemarié, (Zingiberaceae) is widely distributed among several countries in South Asia and Southeast Asia. It is a well known spice in Asia, produces a nice refreshing effect in the mouth. Additionally, it's dried fruit is used in Traditional Chinese Medicine (TCM) for cardiac diseases, edema, eye trouble, skin, itch and impotence. The objective of this study was evaluated the inhibitory activity on adipogenesis in 3T3-L1 cells from A. tsao-ko. Methods and Results : The fruits of A. tsao-ko were extracted with 80% EtOH two times at room temperature. The EtOH extract was suspended in distilled water and partitioned with solvent to give CH2Cl2, EtOAc and n-BuOH. The CH2Cl2 was suspended in n-hexane and partitioned with solvent to give 50%, 70% and 90% MeOH. The purification of each fraction by column chromatography separation and HPLC analysis. Consequently, several constituents were isolated five known compounds. The identification and structural elucidation of compounds were established by using NMR (1D and 2D) and mass spectrometry. Conclusion : These compounds were identified as fluorenone (1), phenanthrene (2), anthracene (3), methyl linolenate (4), 1,2-benzenediol (5). All isolates were tested for their inhibitory activities on adipogenesis in 3T3-L1 cells.
Atypical Manifestation of Primary Hepatocellular Carcinoma and Hepatic Malignancy Mimicking Lesions
Jiyoung Yoon,So Hyun Park,Su Joa Ahn,Young Sup Shim 대한영상의학회 2022 대한영상의학회지 Vol.83 No.4
Hepatocellular carcinoma (HCC) can be diagnosed noninvasively on multiphasic CT and MRI based on its distinctive imaging findings. These features include arterial phase hyperenhancement and washout on portal or delayed phase images. However, radiologists face significant diagnostic challenges because some HCCs exhibit atypical imaging characteristics. In addition to many HCC-mimicking lesions, such as arterioportal shunts, combined HCC-cholangiocarcinoma, intrahepatic cholangiocarcinoma, and hemangioma present a challenge for radiologists in actual clinical practice. The ability to distinguish HCCs from mimickers on initial imaging examinations is crucial for appropriate management and treatment decisions. Therefore, this pictorial review presents the imaging findings of atypical HCCs and HCCs mimicking malignant and benign lesions and discusses important clues that may help narrow down the differential diagnosis.