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- 저자 : Fuli Wang (검색결과 9 건)
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Fuli Li,Yufeng Cao,Tingwu Liu,Guilong Yan,Liang Chen,Lilian Ji,Lun Wang,Bin Chen,Aftab Yaseen,Ashfaq A. Khan,Guo-Lin Zhang,Yunyao Jiang,Jianxun Liu,Gongcheng Wang,Ming-Kui Wang,Weicheng Hu 고려인삼학회 2019 Journal of Ginseng Research Vol.43 No.4
Background: The leaves and roots of Panax ginseng are rich in ginsenosides. However, the chemical compositionsof the leaves and roots of P. ginseng differ, resulting in different medicinal functions. In recent years,the aerial parts of members of the Panax genus have received great attention fromnatural product chemistsas producers of bioactive ginsenosides. The aim of this study was the isolation and structural elucidation ofnovel, minor ginsenosides in the leaves of P. ginseng and evaluation of their antiinflammatory activity in vitro. Methods: Various chromatographic techniques were applied to obtain pure individual compounds, andtheir structures were determined by nuclear magnetic resonance and high-resolution mass spectrometry,as well as chemical methods. The antiinflammatory effect of the new compounds was evaluated onlipopolysaccharide-stimulated RAW 264.7 cells. Results and conclusions: Two novel, minor triterpenoid saponins, ginsenoside LS1 (1) and 5,6-didehydroginsenoside Rg3 (2), were isolated from the leaves of P. ginseng. The isolated compounds 1and 2 were assayed for their inhibitory effect on nitric oxide production in LPS-stimulated RAW 264.7cells, and Compound 2 showed a significant inhibitory effect with IC50 of 37.38 mM compared with that ofNG-monomethyl-L-arginine (IC50 ¼ 90.76 mM). Moreover, Compound 2 significantly decreased secretionof cytokines such as prostaglandin E2 and tumor necrosis factor-a. In addition, Compound 2 significantlysuppressed protein expression of inducible nitric oxide synthase and cyclooxygenase-2. These resultssuggested that Compound 2 could be used as a valuable candidate for medicinal use or functional food,and the mechanism is warranted for further exploration.
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Fourth-Order Accurate Alternating Group Schemes for the Diffusion Problem
Fuli Qu,Wenqia Wang 보안공학연구지원센터 2015 International Journal of u- and e- Service, Scienc Vol.8 No.9
Based on the alternating group strategies, a new high accurate Alternating Group 8-point scheme (AG-8p) for the diffusion problem is presented. The scheme is proved to be unconditionally stable. In numerical experiments, we compare the AG-8p scheme with the AGE and the ASC-N schemes. Finally, numerical results show that the AG-8p scheme has high accuracy.
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Wang Feng,Min Hong Sung,Shan Haojie,Yin Fuli,Jiang Chaolai,Zong Yang,Ma Xin,Lin Yiwei,Zhou Zubin,Yu Xiaowei 대한면역학회 2022 Immune Network Vol.22 No.3
IL-34 can promote osteoclast differentiation and activation, which may contribute to steroid-induced osteonecrosis of the femoral head (ONFH). Animal model was constructed in both BALB/c and IL-34 deficient mice to detect the relative expression of inflammation cytokines. Micro-CT was utilized to reveal the internal structure. In vitro differentiated osteoclast was induced by culturing bone marrow-derived macrophages with IL-34 conditioned medium or M-CSF. The relative expression of pro-inflammation cytokines, osteoclast marker genes, and relevant pathways molecules was detected with quantitative real-time RT-PCR, ELISA, and Western blot. Up-regulated IL-34 expression could be detected in the serum of ONFH patients and femoral heads of ONFH mice. IL-34 deficient mice showed the resistance to ONFH induction with the up-regulated trabecular number, trabecular thickness, bone value fraction, and down-regulated trabecular separation. On the other hand, inflammatory cytokines, such as TNF-α, IFN-γ, IL-6, IL-12, IL-2, and IL-17A, showed diminished expression in IL-34 deficient ONFH induced mice. IL-34 alone or works in coordination with M-CSF to promote osteoclastogenesis and activate ERK, STAT3, and non-canonical NF-κB pathways. These data demonstrate that IL-34 can promote the differentiation of osteoclast through ERK, STAT3, and non-canonical NF-κB pathways to aggravate steroid-induced ONFH, and IL-34 can be considered as a treatment target.
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Yan Liu,Fuli Wang,Yulu Xiong,Zhenyu Liu,Ruicheng Ma,Fei Chu 제어·로봇·시스템학회 2024 International Journal of Control, Automation, and Vol.22 No.3
To improve the accuracy of feature representation and abnormal condition identification, a new abnormal condition identification method, named integrating multiple binary neural networks based on condition-relevantinformation (CRI-MBNN), is presented for the electro-fused magnesia smelting process in this study. Firstly, thefeatures related to each specific abnormal condition, which is named condition-relevant information (CRI), are analyzed and extracted from the multi-source heterogeneous information with the help of limited and consensus domainknowledge. Then, the CRI is fused at the feature-level to provide a comprehensive representation of each abnormalcondition. Furthermore, for each abnormal condition, a binary neural network (BNN) is established based on thefused feature. They are further integrated according to the frequency of each condition in the actual productionprocess to form the final abnormal condition identification network, i.e., CRI-MBNN. Finally, the effectiveness andfeasibility of the proposed CRI-MBNN are verified by the electro-fused magnesia smelting process.
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Jinhao Xu,Fuli Zhang,Binjie Xin,Yuansheng Zheng,Chun Wang,Shixin Jin 한국섬유공학회 2020 Fibers and polymers Vol.21 No.7
In this study, a novel polyvinylbutyral (PVB) bonded polypropylene (PP) composite fibrous mat was fabricated viamelt-electrospinning. In order to enhance the structure stability and mechanical properties of pristine PP fibrous mat system,preparation and characterization of the composite fibrous material by mixing different percentages of PVB and PP wasdesigned. The PVB can form bonding point between the PP fibers, which can ease the slip phenomenon between strainedfibers. The structure, morphology, tensile and tearing stress were measured systematically. The resultants exhibited that thetensile stress and tearing strength of composite fibrous mats were increased from 30.13 to 43.73 kPa and from 0.07 to 0.5 N,respectively. Meanwhile, the straight jet length and whipping range of each electrospun jets were analyzed via the imagescaptured by a high-speed photography system during the spinning process. The experimental resultants depicted thatcomposite system can lead to longer straight jet length and smaller whipping range.
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Huang Jiazhen,Wei Wei,Kang Fuli,Tan Shuang,Li Yibing,Lu Xiaohang,Wang Ning 한국유전학회 2023 Genes & Genomics Vol.45 No.12
Background Cervical cancer, as one of the most common cancers in women, remains a major health threat worldwide. Annexin A3 (ANXA3), a component of the annexin family, is upregulated in numerous cancers, with no explicit role in cervical cancer. Objective This study aims to investigate the function of ANXA3 in cervical cancer. Methods Differential expression genes between the cervical cancer tissues of patients and the controls were analyzed in The Cancer Genome Atlas (TCGA) and Gene Expression Profiling Interactive Analysis (GEPIA) database. Using transfection approaches to either upregulate or downregulate ANXA3, its role in cell proliferation and chemosensitivity of human cervical cancer cell lines (HeLa and C33A) was evaluated. Furthermore, the binding activity between YAP1 and ANXA3 was also explored. Results Genomics analysis indicated that differential genes were mostly associated with cell cycle progression and DNA replication. ANXA3 was highly expressed in the cervical cancer tissues and closely linked to malignancy degree. Knockdown of ANXA3 in cervical cancer cells inhibited cell cycle progression. A similar result was observed in the reduction of cyclin D, CDK4, cyclin E, and CDK2 in cervical cancer cells with ANXA3 silencing. Cervical cancer cells obtained high sensitivity to cisplatin (DDP) when ANXA3 was downregulated. Conversely, these capabilities were the opposite in cervical cancer cells overexpressing ANXA3. Furthermore, the expression levels of ANXA3 and YAP1 were positively correlated. YAP1 upregulation was positively connected with malignant behaviors, which were reversed by ANXA3 downregulation. Conclusion In light of our findings, targeting ANXA3 expressed in cervical cancer might contribute to more potential therapeutic strategies.
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Effect of digestion product of royal jelly protein on SGC-7901 gastric cancer cell
Fu Li,Wang Tianshi,Song Jianxin 한국응용곤충학회 2024 Journal of Asia-Pacific Entomology Vol.27 No.1
Royal jelly used for larvae and queens has many health-promoting properties such as spatial memory improvement, antibacterial activity and antioxidant capacity. However, the anticancer ability of the royal jelly is not unknown. In this study, effect of the royal jelly protein on SGC-7901 gastric cancer cell was investigated, and the key factors including the cell morphological, the colony formation, the proliferation, the cycle, and the expression of p53 and poly (ADP-ribose) polymerase-1 (PARP-1) proteins were analyzed. Result showed royal jelly protein was excellent in inhibiting the growth of SGC-7901gastric cancer cell. After treating with the digestion product of royal jelly protein (0.05 mg/mL~0.20 mg/mL), the morphological of gastric cancer cell significantly shrink, and both of density and quantity (1000~491) of gastric cancer cell significantly (p < 0.05) decreased. The proliferation of gastric cancer was strongest inhibited by 62.84 % of 0.20 mg/mL royal jelly protein. The expression of p53 and PARP-1 protein of gastric cancer cell was respectively enhanced (0.29~0.46) and reduced (0.51~0.42). Moreover, the higher content of royal jelly protein (0.05 mg/mL~ 0.2 mg/mL), the stronger inhibit ability of 45 SGC-7901 gastric cancer cell. In conclusion, royal jelly protein can be used as a potential food in adjunctive therapy for gastric cancer.
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Effect of digestion product of royal jelly protein on SGC-7901 gastric cancer cell
Fu Li,Wang Tianshi,Song Jianxin 한국응용곤충학회 2024 Journal of Asia-Pacific Entomology Vol.27 No.1
Royal jelly used for larvae and queens has many health-promoting properties such as spatial memory improvement, antibacterial activity and antioxidant capacity. However, the anticancer ability of the royal jelly is not unknown. In this study, effect of the royal jelly protein on SGC-7901 gastric cancer cell was investigated, and the key factors including the cell morphological, the colony formation, the proliferation, the cycle, and the expression of p53 and poly (ADP-ribose) polymerase-1 (PARP-1) proteins were analyzed. Result showed royal jelly protein was excellent in inhibiting the growth of SGC-7901gastric cancer cell. After treating with the digestion product of royal jelly protein (0.05 mg/mL~0.20 mg/mL), the morphological of gastric cancer cell significantly shrink, and both of density and quantity (1000~491) of gastric cancer cell significantly (p < 0.05) decreased. The proliferation of gastric cancer was strongest inhibited by 62.84 % of 0.20 mg/mL royal jelly protein. The expression of p53 and PARP-1 protein of gastric cancer cell was respectively enhanced (0.29~0.46) and reduced (0.51~0.42). Moreover, the higher content of royal jelly protein (0.05 mg/mL~ 0.2 mg/mL), the stronger inhibit ability of 45 SGC-7901 gastric cancer cell. In conclusion, royal jelly protein can be used as a potential food in adjunctive therapy for gastric cancer.
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