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Jo, Eunji,Park, Seong Ji,Choi, Yu Sun,Jeon, Woo-Kwang,Kim, Byung-Chul Neoplasia Press 2015 Neoplasia Vol.17 No.7
<P>Kaempferol, a natural dietary flavonoid, is well known to possess chemopreventive and therapeutic anticancer efficacy; however, its antimetastatic effects have not been mechanistically studied so far in any cancer model. This study was aimed to investigate the inhibitory effect and accompanying mechanisms of kaempferol on epithelial-to-mesenchymal transition (EMT) and cell migration induced by transforming growth factor-β1 (TGF-β1). In human A549 non–small lung cancer cells, kaempferol strongly blocked the enhancement of cell migration by TGF-β1–induced EMT through recovering the loss of E-cadherin and suppressing the induction of mesenchymal markers as well as the upregulation of TGF-β1–mediated matrix metalloproteinase-2 activity. Interestingly, kaempferol reversed TGF-β1–mediated Snail induction and E-cadherin repression by weakening Smad3 binding to the Snail promoter without affecting its C-terminus phosphorylation, complex formation with Smad4, and nuclear translocation under TGF-β1 stimulation. Mechanism study revealed that the phosphorylation of Smad3 linker region induced by TGF-β1 was required for the induction of EMT and cell migration, and selective downregulation of the phosphorylation of Smad3 at Thr179 residue (not Ser204, Ser208, and Ser213) in the linker region was responsible for the inhibition by kaempferol of TGF-β1–induced EMT and cell migration. Furthermore, Akt1 was required for TGF-β1–mediated induction of EMT and cell migration and directly phosphorylated Smad3 at Thr179, and kaempferol completely abolished TGF-β1–induced Akt1 phosphorylation. In summary, kaempferol blocks TGF-β1–induced EMT and migration of lung cancer cells by inhibiting Akt1-mediated phosphorylation of Smad3 at Thr179 residue, providing the first evidence of a molecular mechanism for the anticancer effect of kaempferol.</P>
차분 확률의 분포 분석을 위한 데이터 수집 방법 연구 : 블록암호 SPECK에 적용
조은지 ( Eunji Jo ),김성겸 ( Seonggyeom Kim ),홍득조 ( Deukjo Hong ),성재철 ( Jaechul Sung ),홍석희 ( Seokhie Hong ) 한국정보처리학회 2019 한국정보처리학회 학술대회논문집 Vol.26 No.2
본 논문은 차분 확률의 분포 분석에 대한 실험적 검증을 위한 효율적인 데이터 수집 방법에 관하여 연구한다. 효율적인 데이터 수집을 위해 병렬 프로그래밍 기술을 이용하고, SPECK64/128에 적용하여 결과를 얻는다. 첫 번째로 효율적인 데이터 수집 방법을 제시한다. 두 번째로 차분 확률의 분포를 분석하기 위해 평균과 분산에 대하여 실험적으로 검증한다. 마지막으로 SPECK의 경우에는 키의 영향이 상쇄되어 라운드 간의 독립성이 만족하지 않음을 Biryukov 등에 의해 알려졌다. 하지만 이를 실험적으로 보이지 않았으므로 라운드 간의 독립성을 차분 확률의 분포와 통계량 통해 검정한다.
중학생 인성 강화를 위한 미디어 활용 무용교육프로그램 개발 및 적용
조은지 ( Eunji Jo ),문영 ( Young Moon ) 대한무용학회 2017 대한무용학회논문집 Vol.75 No.4
This study developed and implemented an 8-session program which integrates dance and media by utilizing dance-making and interdisciplinary factors based on Sung Mi Park & Sung Hee Huhs` (2012) Personality Assessment Scale for Adolescents and Young Moon`s integrated dance education model based on holistic paradigm (2014). For this purpose, study conducted questionnaire surveys before and after the implementation of the dance education program on 4 classes of freshman (51 female students, 15 male students) in a middle school located in Seoul and compared and analyzed the scores of the questionnaires to verify its efficiency.
Eunji Lim,Bong-Jo Kim,Cheol-Soon Lee,Boseok Cha,So-Jin Lee,Ji-Yeong Seo,Jae-Won Choi,Young-Ji Lee,Nuree Kang,Seung Chan Kim,Dongyun Lee 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.10
Objective The suicide rate in Korea was the highest among countries in the Organisation for Economic Co-operation and Development in 2019. In a previous study, higher intake of vegetables and fruits was associated with a lower risk of suicidal ideation, and carotene-rich fruits and vegetables lowered the risk of depression. This study aimed to examine the direct relationship between carotene intake and suicidal ideation, adjusting for the effect on depression. Methods This study used data from the Korea National Health and Nutrition Examination Survey (KNHANES) conducted in 2012, 2013, and 2015. Carotene intake was assessed through a food intake frequency survey with a 24-hour recall. Suicidal ideation and depression were assessed using the mental health section of the KNHANES. We applied logistic regression to assess the relationship between carotene intake and suicidal ideation, adjusting for potential confounders. Results A total of 5,480 females aged 19-64 years were included in this study. Carotene intake was significantly lower in the suicidal ideation group (3,034.5±1,756.4 μg/day) than in the nonsuicidal ideation group (3,225.4±1,795.1 μg/day) (p=0.015). We found a significant inverse association between carotene intake and the risk of suicidal ideation after adjusting for potential confounders (odds ratio=0.934, 95% confidence interval=0.873-0.999). Conclusion These results suggest that carotene intake may be inversely associated with the risk of suicidal ideation. Our findings may inform the development of new nutritional interventions to prevent increases in the risk of suicide worldwide.
A novel role for bone-derived cells in ankylosing spondylitis: Focus on IL-23
Jo, Sungsin,Koo, Bon San,Lee, Bitnara,Kwon, Eunji,Lee, Young Lim,Chung, Heekyoung,Sung, Il-Hoon,Park, Ye-Soo,Kim, Tae-Hwan Elsevier 2017 Biochemical and biophysical research communication Vol. No.
<P><B>Abstract</B></P> <P>The main aim of this study are to explore the role of bone-derived cells (BdCs) in ankylosing spondylitis (AS) and determine the underlying molecular mechanisms of IL-23 production. Primary BdCs were isolated from diced bone of facet joints obtained during surgery from seven AS patients and seven disease control (Ct) patients. Osteoblastic activity of BdCs was assessed by measuring their alkaline phosphatase activity and by alizarin red staining. Osteoblast and endoplasmic reticulum (ER) stress-related genes were assessed by quantitative PCR, immunoblotting, immunofluorescence, and immunohistochemistry. In addition, expression of IL-23 in response to BIX (selective BIP inducer X)-induced ER stress was evaluated by qPCR and ELISA. Protein interaction and binding to IL-23 promoter were confirmed by Immunoprecipitation and Chromatin immunoprecipitation, respectively. Transcript levels of genes involved in osteoblast function, as well as of the ER stress marker were higher in the AS group than the Ct group, and elevated RUNX2, BiP and IL-23 expression were observed in the BdCs, serum, and bone biopsies from the AS group. BIX-induced ER stress stimulated osteoblastic activity and IL-23 secretion by upregulating RUNX2 expression. Furthermore, in AS BdCs, RUNX2 interacted with C/EBPβ to bind to IL-23 promoter and RUNX2 knockdown suppressed IL-23 secretion. These finding may provide a molecular mechanism involved in sustained ER stress in AS BdCs stimulates the activation of RUNX2 and C/EBPβ genes, leading to IL-23 production.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Bones and its-derived cells from patients with AS showed an increase in ER stress. </LI> <LI> IL-23 cytokine was significantly higher in AS patients than in healthy controls. </LI> <LI> Inducing ER stress in AS exhibited an increase of bone-related genes. </LI> <LI> Inducing ER stress in AS was accompanied with augmentation of IL-23 cytokine. </LI> <LI> ER stress-induced RUNX2 is involved in IL-23 secretion and bone-related genes. </LI> </UL> </P>
Jo, Seonyoung,Kim, Jongho,Noh, Jaeguk,Kim, Daigeun,Jang, Geunseok,Lee, Naeun,Lee, Eunji,Lee, Taek Seung American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.24
<P>A novel chemical warfare agent sensor based on conjugated polymer dots (CPdots) immobilized on the surface of poly(vinyl alcohol) (PVA)–silica nanofibers was prepared with a dots-on-fibers (DoF) hybrid nanostructure via simple electrospinning and subsequent immobilization processes. We synthesized a polyquinoxaline (PQ)-based CP as a highly emissive sensing probe and employed PVA–silica as a host polymer for the elctrospun fibers. It was demonstrated that the CPdots and amine-functionalized electrospun PVA–silica nanofibers interacted via an electrostatic interaction, which was stable under prolonged mechanical force. Because the CPdots were located on the surface of the nanofibers, the highly emissive properties of the CPdots could be maintained and even enhanced, leading to a sensitive turn-off detection protocol for chemical warfare agents. The prepared fluorescent DoF hybrid was quenched in the presence of a chemical warfare agent simulant, due to the electron transfer between the quinoxaline group in the polymer and the organophosphorous simulant. The detection time was almost instantaneous, and a very low limit of detection was observed (∼1.25 × 10<SUP>–6</SUP> M) with selectivity over other organophosphorous compounds. The DoF hybrid nanomaterial can be developed as a rapid, practical, portable, and stable chemical warfare agent-detecting system and, moreover, can find further applications in other sensing systems simply by changing the probe dots immobilized on the surface of nanofibers.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-24/am507206x/production/images/medium/am-2014-07206x_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am507206x'>ACS Electronic Supporting Info</A></P>
Jo, Hyunji,Park, Beomyoung,Oh, Mihwa,Gwak, Eunji,Lee, Heeyoung,Lee, Soomin,Yoon, Yohan Korean Society for Food Science of Animal Resource 2014 한국축산식품학회지 Vol.34 No.6
This study developed probabilistic models to determine the initiation time of growth of Pseudomonas spp. in combinations with $NaNO_2$ and NaCl concentrations during storage at different temperatures. The combination of 8 NaCl concentrations (0, 0.25, 0.5, 0.75, 1, 1.25, 1.5, and 1.75%) and 9 $NaNO_2$ concentrations (0, 15, 30, 45, 60, 75, 90, 105, and 120 ppm) were prepared in a nutrient broth. The medium was placed in the wells of 96-well microtiter plates, followed by inoculation of a five-strain mixture of Pseudomonas in each well. All microtiter plates were incubated at 4, 7, 10, 12, and $15^{\circ}C$ for 528, 504, 504, 360 and 144 h, respectively. Growth (growth initiation; GI) or no growth was then determined by turbidity every 24 h. These growth response data were analyzed by a logistic regression to produce growth/no growth interface of Pseudomonas spp. and to calculate GI time. NaCl and $NaNO_2$ were significantly effective (p<0.05) on inhibiting Pseudomonas spp. growth when stored at $4-12^{\circ}C$. The developed model showed that at lower NaCl concentration, higher $NaNO_2$ level was required to inhibit Pseudomonas growth at $4-12^{\circ}C$. However, at $15^{\circ}C$, there was no significant effect of NaCl and $NaNO_2$. The model overestimated GI times by $58.2{\pm}17.5$ to $79.4{\pm}11%$. These results indicate that the probabilistic models developed in this study should be useful in calculating the GI times of Pseudomonas spp. in combination with NaCl and $NaNO_2$ concentrations, considering the over-prediction percentage.