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Spillover Effect of FSS Audit Reviews on Quality of Accounting at Peer Firms
Kim,Jeehong,Cho,Eunjung,Kim,Sooin 한국회계정보학회 2018 한국회계정보학회 학술대회발표집 Vol.2018 No.1
This study examines whether a negative outcome for an industry-leading firm (i.e., a sanction) in the Financial Supervisory Service audit review affects the accounting quality of other firms in the same industry. We estimate accounting quality proxied by discretionary accruals, and run the OLS regression to test the prediction that the changes in peer firm discretionary accrual subsequent to regulatory audit review by the FSS will decrease. Test results shows peer firms reduce discretionary accruals in the next period, and this relationship amplifies according to the intensity of enforced disciplinary action and the materiality of errors in financial statement. This finding contributes to the literature by providing the first evidence of the spillover effect from regulatory review, and has important implications for regulators, investors, and scholars. First, this study shows that financial reporting regulations can affect the overall quality of an industry by increasing not only the sanctioned firm s accounting quality, but also that of its peers. Second, this study can be a fruitful venue for future research that investigates the effect of other regulations on the accounting quality of peer firms.
Kim, Hyun‐,Ouk,Kim, Eunjung,An, Yonghee,Choi, Jihye,Jang, Eunji,Choi, Eun Bi,Kukreja, Aastha,Kim, Myeong‐,Hoon,Kang, Byunghoon,Kim, Dong‐,Joo,Suh, Jin‐,Suck,Huh, Yong‐,Mi WILEY‐VCH Verlag 2013 Macromolecular bioscience Vol.13 No.6
<P><B>Abstract</B></P><P>Combined cancer treatment via co‐delivery of siRNAs and an anticancer drug can be a promising strategy due to the synergistic effect of simultaneously minimizing gene/drug administration. In this study, Bcl‐xL siRNA and doxorubicin (DOX) are encapsulated into designed methoxy‐poly(ethylene glycol)‐<I>block</I>‐poly(<SMALL>D</SMALL>,<SMALL>L</SMALL>‐lactic acid) (mPEG‐<I>b</I>‐PLA) block copolymer polymersomes (PSomes). A study of the cytotoxicity of Bcl‐xL siRNA and DOX co‐encapsulated PSomes (CPSomes) shows more inhibited proliferation of MKN‐45 and MKN‐28 human gastric cancer cell lines than only gene‐ and drug‐loaded ones. Consequently, these results demonstrate that co‐delivery of genes and drugs using PSomes results in a synergistic efficacy and indicates the potential of PSomes as efficient nanocarriers for combined cancer therapy. </P>
Kim, Min Woo,Lee, Bo-Rahm,You, SungYong,Kim, Eun-Jung,Kim, Ji-Nu,Song, Eunjung,Yang, Yung-Hun,Hwang, Daehee,Kim, Byung-Gee Springer-Verlag 2018 Applied microbiology and biotechnology Vol.102 No.7
<P>Most secondary metabolism in Actinobacteria is controlled by multi-layered, gene-regulatory networks. These regulatory mechanisms are not easily identified due to their complexity. As a result, when a strong transcriptional regulator (TR) governs activation of biosynthetic pathways of target antibiotics such as actinorhodin (ACT), additional enhancement of the biosynthesis is difficult in combination with other TRs. To find out any 'synergistic transcriptional regulators (sTRs)' that show an additive effect on the major, often strong, transcriptional regulator (mTR), here, we performed a clustering analysis using the transcriptome datasets of an mTR deletion mutant and wild-type strain. In the case of ACT biosynthesis in Streptomyces coelicolor, PhoU (SCO4228) and RsfA (SCO4677) were selected through the clustering analysis, using AfsS (SCO4425) as a model mTR, and experimentally validated their roles as sTRs. Furthermore, through analysis of synergistic effects, we were able to suggest a novel regulation mechanism and formulate a strategy to maximize the synergistic effect. In the case of the double TR mutant strain (Delta rsfA pIBR25::afsS), it was confirmed that the increase of cell mass was the major cause of the synergistic effect. Therefore, the strategy to increase the cell mass of double mutant was further attempted by optimizing the expression of efflux pump, which resulted in 2-fold increase in the cell mass and 24-fold increase in the production of ACT. This result is the highest ACT yield from S. coelicolor ever reported.</P>
Kim, Eunjung,Kim, Changhwan,Yang, Bokyung,Kim, Mihee,Kang, Jingu,Lee, Jiun The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.4
Eosinophilic pleural effusion (EPE) is defined as a pleural effusion that contains at least 10% eosinophils. EPE occurs due to a variety of causes such as blood or air in the pleural space, infection, malignancy, or an autoimmune disease. Undifferentiated connective tissue disease (UCTD) associated with eosinophilic pleural effusion is a rare condition generally characterized by the presence of the signs and symptoms but not fulfilling the existing classification criteria. We report a case involving a 67-year-old man with UCTD and EPE, who has been successfully treated with a single intrapleural corticosteroid injection.
Kim, Eunjung,Yang, Jaemoon,Park, Joseph,Kim, Soonhag,Kim, Nam Hee,Yook, Jong In,Suh, Jin-Suck,Haam, Seungjoo,Huh, Yong-Min American Chemical Society 2012 ACS NANO Vol.6 No.10
<P>We report smart nanoprobe, hyaluronic acid (HA)-based nanocontainers containing miR-34a beacons (bHNCs), for the intracellular recognition of miR-34a levels in metastatic breast cancer cells, which is distinct from the imaging of biomarkers such of cell membrane receptors such as HER2. In this study, we demonstrate that a nanoscale vesicle that couples a targeting endocytic route, CD44, and a molecular imaging probe enables the efficient detection of specific miRNAs. Furthermore, bHNCs showed no cytotoxicity and high stability due to the anchored HA molecules on the surface of nanocontainers, and enables the targeted delivery of beacons <I>via</I> CD44 receptor-mediated endocytosis. <I>In vitro</I> and <I>in vivo</I> optical imaging using bHNCs also allow the measurement of miR-34a expression levels due to the selective recognition of the beacons released from the internalized bHNCs. We believe that the technique described herein can be further developed as a cancer diagnostic as well as a miRNA-based therapy of metastatic cancer.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2012/ancac3.2012.6.issue-10/nn300289u/production/images/medium/nn-2012-00289u_0010.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn300289u'>ACS Electronic Supporting Info</A></P>
( Eunjung Kim ),( Chang Hwan Kim ),( Bo Kyung Yang ),( Mi Hee Kim ),( Jin Gu Kang ),( Ji Un Lee ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.4
Eosinophilic pleural effusion (EPE) is defined as a pleural effusion that contains at least 10% eosinophils. EPE occurs due to a variety of causes such as blood or air in the pleural space, infection, malignancy, or an autoimmune disease. Undifferentiated connective tissue disease (UCTD) associated with eosinophilic pleural effusion is a rare condition generally characterized by the presence of the signs and symptoms but not fulfilling the existing classification criteria. We report a case involving a 67-year-old man with UCTD and EPE, who has been successfully treated with a single intrapleural corticosteroid injection.
Antineuroinflammatory constituents from the root extract of <i>Paris verticillata</i>
Kim, Ki Hyun,Lee, Kyu Ha,Kim, Ho Kyung,Moon, Eunjung,Kim, Sung-Hoon,Kim, Sun Yeou,Kim, Kyung Ran,Lee, Kang Ro Canadian Science Publishing 2011 Canadian journal of chemistry Vol.89 No.4
<P> Two new cyclopropanoic fatty acid glycosides, named parisveroside A (1) and parisveroside B (2), were isolated from a MeOH extract of the roots of Paris verticillata (Liliaceae) together with three other known compounds, salicin (3), 3-(β-d-glucopyranosyloxymethyl)-2-(4-hydroxy-3-methoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-(2R,3S)-dihydrobenzofuran (4), and allantoin (5). Their structures were elucidated on the basis of spectroscopic data, including 1D and 2D NMR, HR-FAB-MS, and chemical evidence. To investigate the antineuroinflammatory effects of the isolated compounds (1-5), nitric oxide (NO) production was evaluated in the lipopolysaccharide-activated microglia cell line, BV-2. Compounds 2 and 4 significantly inhibited NO production with IC50 values of 74.8 and 60.5 µmol/L, respectively. </P>
Lee, Eunjung,Jung, Dae Young,Kim, Jong Hun,Patel, Payal R.,Hu, Xiaodi,Lee, Yongjin,Azuma, Yoshihiro,Wang, Hsun-Fan,Tsitsilianos, Nicholas,Shafiq, Umber,Kwon, Jung Yeon,Lee, Hyong Joo,Lee, Ki Won,Kim, The Federation of American Societies for Experimen 2015 The FASEB Journal Vol.29 No.8
<P>Insulin resistance is a major characteristic of obesity and type 2 diabetes, but the underlying mechanism is unclear. Recent studies have shown a metabolic role of capsaicin that may be mediated <I>via</I> the transient receptor potential vanilloid type-1 (TRPV1) channel. In this study, TRPV1 knockout (KO) and wild-type (WT) mice (as controls) were fed a high-fat diet (HFD), and metabolic studies were performed to measure insulin and leptin action. The TRPV1 KO mice became more obese than the WT mice after HFD, partly attributed to altered energy balance and leptin resistance in the KO mice. The hyperinsulinemic-euglycemic clamp experiment showed that the TRPV1 KO mice were more insulin resistant after HFD because of the ∼40% reduction in glucose metabolism in the white and brown adipose tissue, compared with that in the WT mice. Leptin treatment failed to suppress food intake, and leptin-mediated hypothalamic signal transducer and activator of transcription (STAT)-3 activity was blunted in the TRPV1 KO mice. We also found that the TRPV1 KO mice were more obese and insulin resistant than the WT mice at 9 mo of age. Taken together, these results indicate that lacking TRPV1 exacerbates the obesity and insulin resistance associated with an HFD and aging, and our findings further suggest that TRPV1 has a major role in regulating glucose metabolism and hypothalamic leptin’s effects in obesity.—Lee, E., Jung, D. Y., Kim, J. H., Patel, P. R., Hu, X., Lee, Y., Azuma, Y., Wang, H.-F., Tsitsilianos, N., Shafiq, U., Kwon, J. Y., Lee, H. J., Lee, K. W., Kim, J. K. Transient receptor potential vanilloid type-1 channel regulates diet-induced obesity, insulin resistance, and leptin resistance.</P>
스마트폰 기반 형광 smartscope의 입자계수 및 회전하는 나선형 채널의 입자정렬 성능 평가
박은정(Eunjung Park),김수빈(Subin Kim),조명옥(Myoung-Ock Cho),김경훈(Kyunghoon Kim),모히우띤(Mohiuddin Khan Shourav),김선욱(Sunwook Kim),이정훈(Jeonghoon Lee),김중경(Jung Kyung Kim) 한국산업정보학회 2015 한국산업정보학회논문지 Vol.20 No.3
스마트폰의 영상정보처리에 기반한 현장 진단기기 개발을 목표로 입자계수용 형광 smartscope와 DC 모터로 제어되는 입자정렬 시스템을 제작하였다. 크기가 작고 저렴한 비용으로 비전문가도 쉽게 다룰 수 있는 smartscope는 LED, 볼렌즈, 형광필터가 설치된 어댑터가 스마트폰 카메라 앞에 장착되어 전용 애플리케이션으로 형광입자와 형광염색된 백혈구를 계수할 수 있었다. 모터는 안드로이드 스마트폰의 블루투스 무선통신 기능을 통해 제어되었다. 나선형 미세유동채널이 축을 중심으로 회전하는 동안 백혈구와 크기가 유사한 입자가 정렬되는 현상을 관찰하였다. 모터로 회전 방향과 속도가 조절되는 입자 정렬 시스템은 많은 시간이 소요되는 수작업을 최소화하고 시료 전처리 과정을 자동화할 수 있으므로, smartscope와 통합될 경우 스마트폰을 이용한 현장진단기기에 활용될 수 있을 것이다. With the aim of developing a smartphone-based point-of-care device that is small, inexpensive, and easy to handle by non-expert, we designed a fluorescence smartscope for counting particles and a DC motor-controlled particle positioning system. Our smartscope can count the number of fluorescent particles and fluorescently-stained white blood cells through a phone camera with an adaptor containing a LED, a ball lens and optical filters and an application running on a smartphone. The motor was controlled wirelessly via Bluetooth with an Android smartphone. We found that axial spinning of a helical microfluidic channel allows arrangement of particles having size similar to the white blood cells. The motor-controlled particle positioning system can minimize time-consuming manual processes and automate sample preparation process and thus, if integrated with the smartscope, it can be used for a point-of-care testing device based on a smartphone.