http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Na Eun Lee ),( Hong Seon Son ),( Sung Hoon Choi ),( Chang Hun Lee ),( Seung Young Seo ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ),( In Hee Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Tenofovir disoproxil fumarate (TDF) is considered as the preferred treatment option for chronic hepatitis B (CHB) patients with treatment failure or resistance to prior nucleos(t)ide analogues (NAs) treatment. We investigated the efficacy of long-term TDF-based therapy in CHB patients with previous NAs-experience. Methods: This study included total 251 patients who had previous history of NAs therapy and were treated with TDF mono (n=173) or TDF combined with other NA (n=78) from August 2012 to March 2017. Virologic response (VR) was defined as undetectable serum HBV DNA by PCR (<20 IU/mL). Results: Mean age of patients was 49.3 years, median duration of TDF therapy was 27.2 months, 75.7% were HBeAg-positive, and median HBV DNA was 3.7 log10IU/mL. The cumulative rates of VR were 188/244 (77.0%), 180/211 (85.3%), and 146/161 (90.7%) at 12, 24, and 36 months, respectively. Multivariate analysis showed that body mass index (OR 0.77, 95% CI 0.61-0.95, p=0.0189) and duration of TDF therapy (OR 1.09, 95% CI 1.02-1.18, p=0.0221) was significantly associated with VR. TDF monotherapy, HBeAg-positivity, platelet count, serum albumin was associated with VR in the univariate analysis, but not significant in the multivariate analysis. In relation to renal safety, patients showed renal impairment (7, 3.0%), mild hypophosphatemia (15, 7.2%), severe hypophosphatemia (1, 0.4%). Conclusions: Long-term TDF-based therapy demonstrated highly effective in viral suppression and relatively favorable renal safety in CHB patients with previous NA-experience. The body mass index and duration of TDF therapy was independent factors associated with VR.
( Hyun Ju Lee ),( Ja Sung Rho ),( Shao Ran Gui ),( Mi Kyung Kim ),( Yu Kyoung Lee ),( Yeon Sook Lee ),( Jeong Eun Kim ),( Eu Na Cho ),( Mong Cho ),( Tae Ho Hwang ) 대한간학회 2011 Clinical and Molecular Hepatology(대한간학회지) Vol.17 No.3
Background/Aims: JX-594 is an oncolytic virus derived from the Wyeth vaccinia strain that causes replication-dependent cytolysis and antitumor immunity. Starting with a cross-examination of clinical-trial samples from advanced hepatocellular carcinoma patients having high levels of aldosterone and virus amplification in JX-594 treatment, we investigated the association between virus amplification and aldosterone in human cancer cell lines. Methods: Cell proliferation was determined by a cell-counting-kit-based colorimetric assay, and vaccinia virus quantitation was performed by quantitative polymerase chain reaction (qPCR) and a viral plaque assay. Also, the intracellular pH was measured using a pH-sensitive dye. Results: Simultaneous treatment with JX-594 and aldosterone significantly increased viral replication in A2780, PC-3, and HepG2 cell lines, but not in U2OS cell lines. Furthermore, the aldosterone treatment time altered the JX-594 replication according to the cell line. The JX-594 replication peaked after 48 and 24 hours of treatment in PC-3 and HepG2 cells, respectively. qPCR showed that JX-594 entry across the plasma membrane was increased, however, the changes are not significant by the treatment. This was inhibited by treatment with spironolactone (an aldosterone-receptor inhibitor). JX-594 entry was significantly decreased by treatment with EIPA [5-(N-ethyl-N-isopropyl)amiloride; a Na+/H+-exchange inhibitor], but aldosterone significantly restored JX-594 entry even in the presence of EIPA. Intracellular alkalization was observed after aldosterone treatment but was acidified by EIPA treatment. Conclusions: Aldosterone stimulates JX-594 amplification via increased virus entry by affecting the H+ gradient. (Korean J Hepatol 2011;17:213-219)
( Hong Seon Son ),( Sung Hoon Choi ),( Na Eun Lee ),( Chang Hun Lee ),( Seung Young Seo ),( Seong Hun Kim ),( Sang Wook Kim ),( Seung Ok Lee ),( Soo Teik Lee ),( Dae Ghon Kim ),( In Hee Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: Tenofovir (TDF) entecavir (ETV) are considered as the preferred treatment options for treatment-naïve chronic hepatitis B (CHB) patients. We compared the virologic response and renal safety of long-term TDF versus ETV therapy in naïve CHB patients. Methods: This retrospective study included total 432 patients who were treated with TDF (n=205) or ETV (n=227) from August 2012 to March 2017. Virologic response (VR) was defined as undetectable serum HBV DNA by PCR (<20 IU/mL). Results: Mean age of patients, sex, baseline serum levels of AST, ALT, creatinine, and HBV DNA were not significantly different between TDF and ETV groups. The cumulative rates of VR between TDF and ETV groups were 71.6% vs. 61.8% (p=0.477), 88.1% vs. 79.6% (p=0.058), and 84.8% vs. 83.7% (p=0.966) at 1, 2, and 3 years, respectively. The cumulative rates of genotypic resistance between TDF and ETV groups were 0% vs. 0%, 0% vs. 1.5% (p=0.404), and 0% vs. 2.2% (p=0.447) at 1, 2, and 3 years, respectively. Incidences of renal impairment and hypophosphatemia during treatment up to 3 years were not significantly different between two groups. Multivariate analysis showed that HBeAg-positivity (OR 0.27, 95% CI 0.12-0.58, p=0.0012) and serum HBV DNA at 1 year 2000 IU/mL (OR 0.09, 95% CI 0.03-0.25, p<0.0001) were significantly associated with VR. Conclusions: Long-term TDF and ETV treatments appear to have similar virologic response and renal safety in naïve CHB patient. However, long-term ETV therapy might to be associated with genotypic resistance in 2.2% up to 3 years, while none of patients on TDF therapy did.
Prioritizing Disaster Management Measures for Effective Management of Earthquakes
Sung Soo Byun,Seong Cho,Jong Il Na,Jae Eun Lee 위기관리 이론과 실천 2018 Crisisonomy Vol.14 No.8
This study aims to identify priorities for sequential and intensive policy implementation by overcoming the resource constraints of local government and identifying important policy contents for efficient seismic management. The AHP analysis was applied to the classified policy contents in seismic management. The results of the analysis showed that, in the areas of seismic and volcanic disaster responses, earthquake prevention was the most important content, followed by earthquake-proof measures, research on seismic mitigation, and response to earthquakes. Considering the priorities identified by these AHP method, effective policy implementation for seismic disaster management requires the establishment and improvement of evacuation plans, the seismic reinforcement of the existing facilities, and the development of seismic prevention technologies and systems. Furthermore, seismic management should be directed toward prevention, enhancement of the existing disaster management response systems, and efficient distribution of resources. 이 연구는 지방정부의 자원의 한계를 극복하고 효율적 지진재난관리에 포함된 정책내용의 중요도를 도출하여 순차적이고 집중적인 정책집행을 위한 우선순위를 파악하는 것에 목적을 두고 있다. 연구목적을 달성하기 위하여, 지진·화산재해대책법에서 규정하고 있는 지진재난관리와 관련한 정책내용 영역을 계층화하여 AHP 분석을 실시하였다. 분석결과, 지진·화산재해대책법의 측정영역에서는 1순위 지진 재해 예방 ·대비, 2순위 내진대책, 3순위 지진재해경감 연구·기술개발, 4순위 지진재해 대응 순으로 나타났다. 그리고 복합가중치를 적용한 각 측정요소별 상대적 중요도는 1순위 주민대피계획, 2순위 기존 시설물 내진보강, 3순위 지진방재 기술 및 제도 연구개발, 4순위 연구 및 기술개발 계획 수립, 5순위 지진방재 교육 및 훈련, 6순위 지역 지진위험지도의 제작 및 활용 등 측정영역 1위부터 3순위의 영역에서 나타났다. 이러한 AHP 분석결과의 우선순위를 고려하여, 지진·화산재해대책법의 효과적 정책집행을 위해서는 주민대피계획 수립 및 개선, 기존 시설물의 내진보강, 지진방재 기술 및 제도 연구·개발 등에 초점을 맞추어야 할 것이다. 또한 지진재난관리의 방향은 예방과 대비, 내진 등에 중점을 두고 진행하며, 자원의 효율적 분배를 위해 붕괴·화재 등의 기존 재난관리 대응체계의 개선을 통한 활용이 필요하다.
Transtherapy for moderate to severe acne scar: a study of 2 cases
Sung, Soo-Hyun,Park, Jong-Hyun,Han, Chang-Hyun,Hong, Seung-Min,Park, Eun-Jung,Na, Ho-Ik,Park, Sung-Jin,Yu, Ji-Hee,Ha, Ji-Hun The Society of Korean Medicine 2015 대한한의학회지 Vol.36 No.4
Objectives: The purpose of this study is to present effect of transtherapy which is treatment of Korean Medicine to acne scar patients. Methods: We used transtherapy to moderate and severe acne scar patients and evaluated by a Photo evaluation with 10-point score and Qualitative Global Acne Scarring Grading System. Results: After transtherapy treatment, mean of Qualitative Global Acne Scarring Grading System of patients changed from $3.5{\pm}0.71$ to $1.5{\pm}0.71$. Acne scar showed an improvement at least 8 up to 9 and mean of their acne scar improvement scores was $8.33{\pm}0.52$ on photo evaluation with 10-point score. Conclusions: This paper shows that transtherapy in the treatment of moderate to severe acne scars is beneficial for promoting skin regeneration.
Risk factors and Clinical symptoms of Gastroesophageal reflux disease (초)
( Eun Sil Lee ),( Na Young Kim ),( Jong Chon Nah ),( Youn Mu Jung ),( Ji Eon Won ),( Min Sik Uhm ),( Kwang Ho Lee ),( Sang Hyub Lee ),( Young Soo Park ),( Jin Wook Kim ),( Sook Hyang Jeong ),( Dong Ho 대한내과학회 2008 대한내과학회지 Vol.75 No.1S
효율적인 의약품 평가를 위한 약물계량학 분석법 도입의 전략 방안
( Sang Min Lee ),( Boyoon Choi ),( Hwi Yeol Yun ),( Da Hae Jun ),( Myung Gou Kim ),( Ji Hye Ha ),( Young Hoon Kim ),( Eun Hee Ji ),( Won Ku Kang ),( Na Young Han ),( Wan Gyoon Shin ),( Jung Mi Oh ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
Over the past few decades, drug regulatory agencies in advanced countries have been emphasizing pharmacomctrics as a tool for an effective and efficient drug evaluation. Despite this international movement, the value of pharmacometrics is still poorly recognized by the Korean drug evaluation system. This study aimed to analyze the current state of utiliza-tion of pharmacometrics by foreign drug regulatory agencies and develop a road map to guide the implementation phar- macometrics into the Krean drug evaluation system. MEDLINE and foreign drug regulatory agency database were extensively searched to obtain scientific research articles, guidance, regulations and pharmacometric review reports on foreign pharmacometric drug evaluation system. A systematic roadmap comprised of 3 stages to implement pharmaco-metrics in Lorean drug evaluation system was formulated after analyzing the collected data in tune with the current evaluation system. Pharmacometrics is an urgently required tool to achieve an efficient drug evaluation and review in Korea. The road map developed by this study is expected to aid in setting up a policy to implement and utilize phar-macometrics in Korea.