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- 저자 : Dong Heub Lee (검색결과 69 건)
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加味香砂六君子湯이 생쥐 小腸에서 放射線照射 後 保護效果와 Apoptosis에 미치는 影響
이태업,김진성,윤상협,류봉하,박동원,류기원 대한한방종양학회 2000 대한한방종양학회지 Vol.6 No.1
The present study was performed in order to evaluate the effects of the gamihyangsayukgunjatang on radioprotection and apoptoss in small intestines of mice after whole bdy irradiation. Two hundred forty mice were divided into 40 groups according to the radiation dose and the gamihyangsayukgunjatang treatment. The extracts of the herbal medicines were orally administered to each group differently before and/or after irradiation. The gamihyangsayukgunjatang treated groups were divided into 3 groups. Sample Ⅰ was the group treated with the gamihyangsayukgunjatang for 3 days before the radiation, sample Ⅱ was the group treated with the gamihyangsayukgunjatang for 3 days after the radiation. Sample Ⅲ was the group treated with the gamihyangsayukgunjatang for both 3 days before and after the radiation. To analyze the crypt survival, the micradony survival assay was used according to the Withers and Elind's method. To analyze the apptosis, the TUNEL assay was done. The reslts obtained are a follows : 1. From the microcolony survival assay, the gamihyangsayukgunjatang treated groups showed theradioprotective effect with a statistical ignificance(p<0.05), as compared to the control group. Comparing the radioprotective effect among the 3 groups, sample Ⅲ was statistically more significant than sample Ⅰand Ⅱ (p<O.O5). Sample Ⅰ showed no effect. In accordance with the research mentioned above, it is suggested that the radioprotective effect of the gamihyangsayukgunjatang is more useful for the treatment of the radiation injury rather that the prevention. 2. The results of the TUNEL assay showed that the apoptotic index in the gamihyangsayukgunjatang treaed group was slightly decreased with no effectiveness, as compared to the control group. According to the above results, it could be suggested that the gammyangsayukgummang has a prominent protective effect in mice intestines against the radiation damage. However, the radioprotective effect does not seem to be related to inhibition of the apoptosis.
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Development and Current Situation of the Constitutional Adjudication in Korea
( Dong Heub Lee ) 서울대학교 법학연구소 2012 서울대학교 法學 Vol.53 No.2
After having gone through the inactive and sometimes merely ornamental forms of constitutional adjudication systems such as the Constitutional Committee or the American type judicial review system in the past, the Republic of Korea finally established the Constitutional Court in 1988. And, different from its predecessors, the Constitutional Court has been known for its active and successful performance in adjudicating constitutional matters, as the last resort of upholding the Constitution and protecting fundamental rights of the citizens. However, there are also some obstacles that should be hurdled by the Court, such as the issues related to its competence and jurisdiction, including lack of jurisdiction over the election disputes, lack of competence of constitutional review of statutory legislation in abstracto and no power to adjudicate the constitutional complaint against ordinary court`s judgments, and the issues related to the process of nomination and appointment and term of Justices. In order to solve these problems, the Constitutional Court must examine in depth these issues and make necessary improvements. This paper reviews 1) the institutional foundations of constitutional review in Korea, including current constitutional adjudication model and historical and legal reasons for its adoption and relations between the Constitutional Court and ordinary courts; 2) status and composition of the Constitutional Court of Korea, including qualifications, terms of Justices, possibility of their reappointment, procedure for nomination and appointment of Justices and guarantee of their independence; 3) jurisdictions of the Constitutional Court such as constitutional review of statutory provisions, adjudication on constitutional complaint, adjudication on competence disputes between state agencies, between state agency and a local government or between local governments, adjudication on the dissolution of political party and adjudication on the impeachment of high public officials; and 4) binding effect of the Court`s decisions on the Legislature, the ordinary courts and on the Executive. Also, in its last part, this paper introduces several important cases in practice concerning civil liberties, social rights in pursuit of social justice, other fundamental rights and principle of equality for protecting women or particularly vulnerable minorities.
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Dong Heub Lee 한국산림과학회 1992 한국산림과학회지 Vol.81 No.1
Four organoiodone fungicides[4-chlorophenyl-3-iodopropargyl(IF-1000), 3-iodo-2--propynyl butyl carbonate(IPBC), 3-bromo-2. 3-diiodo-2-propenylethyl carbonate (EBIP), and 2, 3, 3-triiodoallyl alcohol (TIAA)] were proved to possibly be used as an alternative to tri-n-butyltin oxide (TnBTO) and conventioal wood preservatives, based on the Japanese standardized methods for their fungicidal and termiticidal efficacy. Fungal decomposition and physico-chemical degradation of these fungicides were also examined in the laboratory. The important results obtained are summarized as follows. In PART I , fundamental fungicidal and termiticidal efficacy and their synergistic effects with organophosphate termiticide(chlorpyrifos), synergist and stabilizer were described. The order of their fungicidal effect in single use was TIAA(0.5%) $gt; IPBC(0.75%) $gt;IF-1000(1.0%)≥EBIP($gt;1.0%) . Fungicidal efficacy of TnBTO was equal to 1F-1000. Mixing of all fungicides with chlorpyrifos and surface active agent gave a synergistic fungicidal effect against Coriolus versicolor. However, the effect was not always found in other test fungi. Only IPBC gave a desirable synergistic effect against. all fungi tested by mixing with surface active agent, IF -1000 and TnBTO caused an undesirable antagonistic effect against Tyromycer palustris when mixed with chlorpyrifos. EBIP showed a synergistic and/or additive effect against T. palustris and Serpula lacrymans, only when they were mixed with commercial synergistic and stabilizing agents. In PART II, fungal decomposition of organoiodine fungicides in shake culture was discussed . Lowering of pH during incubation and the decomposition rate of fungicides were closely related to each other. Most of organoiodine chemicals were degraded at various extents by fungal metabolic activities. The degrading ability of C. versicolor was found in intracellular and extracellular components. However, those of T. palustris gave a poor degradation of the fungicides tested. Detoxifying activity of this fungus occurred exclusively in-cell wall components. S. lacrymans was positioned between the two fungi, in its degrading activity of test fungicides. In PART III, the physicochemical degradation of organoiodine ungicides was described. Chemical bond energies of carbon-iodine and carbon-bromine in these compounds were comparatively lower than those of the other chemical bonds. Thus, these chemicals could be decomposed by exogenous energies, such as ultraviolet energy, causing the decline of fungicidal efficacy. The iodopropargyl-containing IF-1000 and IPBC were converted to propargyl compounds by iodine releasing through carbon-iodone bond cleavage. TIAA, in the similar manner, was convened to 1-propanol. However, these chemicals were not degraded by thermochemical exogenous energy. Although some of the four organoiodone fungicides tested have some defects such as degradation by fungi and photoirradiation, they showed the over-all good fungicidal efficacies. Their relatively lower resistance to C. versicolor might be overcome by mixing with chlorpyrifos which is specifically toxic to this fungus. Photodegradation of the chemicals might not be considered as fault in their actual application to timber treatments, because the degradation has been proved to be limited on the surface of the treated woods.
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이동흡 ( Dong Heub Lee ),이종신 ( Jong Shin Lee ) 한국목재공학회 2014 목재공학 Vol.42 No.1
To development of the low toxic preservatives, we prepared 29 kinds of chemicals using dinotefuran of low toxic insecticide, IPBC and propiconazol of fungicide, and clove oil has fungicidal activity, but is harmless to humans. It was conducted to investigate the inhibitory effectiveness of mycelial growth and anti-mold effectiveness to treated PDA medium and wood specimen with prepared chemicals. It was not showed anti-mold effectiveness that solvent and emulsifier form preservatives. Therefor, we thought that only four component, dinotefuran, IPBC, propiconazol and clove oil, has anti-mold effectiveness. In the PDA medium test, the preservative which has much IPBC showed high anti- mold effectiveness. By the wood specimen test, it was known that many prepared preservatives which showed good inhibitory effectiveness of mycelial growth in the PDA medium test, have not anti-mold effectiveness. Of all prepared preservatives in this study, only three preservatives containing dinotefuran and IPBC, or adding clove oil appeared the excellent anti-mold effectiveness.
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