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Don-Kyu Kim(김돈규),Young-Joon Cho(조영준) 한국생명과학회 2009 생명과학회지 Vol.19 No.5
화학적 변형 방식에 의한 트로포마이오신과 액틴의 상호작용을 규명하기 위하여 액틴결합에 중요한 역할을 하는 C-말단부위의 아미노산 잔기 276 또는 277을 단일 시스테인 잔기로 치환한 돌연변이 트로포마이오신을 제조하여 대장균에서 대량 발현시킨 후 액틴 결합력을 측정하였다. 잔기277을 시스테인 잔기로 치환시킨 TM24(QC) 및 TM29(HC)는 액틴 결합 성질을 잃어버렸을 뿐만 아니라 트로포닌 존재 하에서도 액틴결합력이 증가하지 않았다. 이 결과는 잔기 277이 트로포마이신 기능에 중요한 역할을 한다는 것을 제시한다. 반면 잔기 276을 시스테인 잔기로 치환한 TM22(CT) 및 TM23(CA)는 액틴과 비교적 잘 결합하였을 뿐만 아니라 트로포닌 존재 하에서 액틴결합력이 증가하였다. 따라서 TM23(CA)는 시스테인 잔기를 도입하여도 트로포마이오신의 기능을 유지하였으며 향후 화학적 변형 연구를 위한 도구로 중요하게 사용될 수 있을 것이다. It has been previously reported that the carboxyl terminal residues 276 and 277 of α-tropomyosin are important for actin affinity. In order to investigate actin affinities of these two residues of skeletal (HA) and smooth (QT) muscle α-tropomyosins, a series of mutant tropomyosins were constructed in which residues at either 276 or 277 were individually replaced with a cysteine residue for chemical modification. These mutants were overexpressed in E. coli as unacetylated and Ala-Ser (AS) dipeptide fusion forms. While actin affinities of unacetylated tropomyosins were considerably low, those of AS/TMs were remarkably higher than those of corresponding unacetylated tropomyosins. However, actin affinities of AS/TM24 (QC) and AS/TM29 (HC) were dramatically lower than those of other AS/TMs and were close to those of unacetylated tropomyosins. In addition, actin affinities of unacetylated TM24 (QC) and TM29 (HC) failed to be restored in the presence of troponin, unlike unacetylated TM10 (HA) and TM23 (CA). These results indicated that the presence of a cysteine residue at 277 caused a drastic decrease in actin affinity, and also that the residue 277 is important for actin affinity of α-tropomyosin. Since TM23 (CA) showed high actin affinity, it may serve as a valuable tool for chemical modification studies for investigating the interaction of the carboxyl terminal residues of α-tropomyosin with actin and/or troponin.
십자인대 재건술 후 슬관절 신전근의 근기능 향상을 위한 대퇴사두근 운동의 유용성
장경모,서동익,서경묵,김돈규,Jang, Kyung-Mo,Seo, Dong-Ick,Seo, Kyung-Mook,Kim, Don-Kyu 대한물리치료과학회 2009 대한물리치료과학회지 Vol.16 No.3
Background: The purpose of this study was to investigate the usefulness of quadriceps exercise for improvement of knee extensor muscular function after cruciate ligament reconstruction. Methods: Participate in 18 of patients with cruciate ligament reconstruction, ACL & PCL reconstruction was 9 of patients, respectively. All subjects instructed that quadriceps exercise repeated daily, composed to QSE(quadriceps femoris setting exercise) and SLR(straight leg raises). Knee extensor muscular function was measured before and after quadriceps exercise. Initial test was measured before cruciate ligament reconstruction, and retest was measured 6month after cruciate ligament reconstruction. Results: Knee extensor muscular function significantly increased in both ACL and PCL reconstruction(P<0.05). Conclusion: The results of this study indicated that quadriceps exercise useful for improve knee extensor muscular function in patients with cruciate ligament reconstruction.
박헌종 ( Heon Jong Park ),서경묵 ( Kyung Mook Seo ),강시현 ( Si Hyun Kang ),성상윤 ( Sang Yoon Sung ),김돈규 ( Don Kyu Kim ) 대한스포츠의학회 2008 대한스포츠의학회지 Vol.26 No.1
We conducted a survey of 184 female caddies working in the Seoul area concerning their general characteristics in a season and painful body sites. Their work-related stress factors were classified into 8 categories. 91 persons had leg pain which was related to age, carrier and the physical working environment as a job stress factor. 76 persons had shoulder pain which was related to the body mass index, job burden and past injuries. 50 persons had back pain which was related to job burden, the physical working environment, work demand, work self-regulation and culture. 42 persons had neck pains which was related to past injuries and number of years on the job. 10 persons had arm pain which was related to the average time spent in housework(p<0.05). Our study demonstrated that musculo skeletal pain experienced by caddies is correlated with various work-related stress factors. Therefore, improvement in those factors, safety education, and precautionary measures should be taken for prevention.
반복작업으로 유발된 수근관내의 굴곡근 건초염과 수근관 증후군 : 증례 보고 Case Report
김돈규,서경묵,신주연,강시현,송인섭 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.1
A 46 year-old woman who had worked repetitive manual job for 3 years visited our hospital because of aggravated right hand sensory symptom and newly developed limitation of 3, 4, 5th finger extension. In physical examination, moderate swelling of volar aspect of wrist and limitation of finger extension was noticed as well as positive tinnel sign. We confirmed carpal tunnel syndrome after electrodiagnostic studies and associated flexor tenosynovitis of 4th flexor tendon in the carpal tunnel through MRI (magnetic resonance imaging) study. She was successfully treated with conservative program including wrist splint and steroid injection. We also tracked the result of treatment using MRI and electrodiagnositic studies. Analyzing her work procedure, we concluded that repetitive and forceful exertional nature of job impose a high burden on hand and wrist region and it caused her carpal tunnel syndrome.
아마추어 골퍼에서의 골프 관련 통증의 발생 빈도 및 분포
서경묵,김돈규 대한스포츠의학회 2003 대한스포츠의학회지 Vol.21 No.1
The purpose of this study is to investigate prevalence of golf-related pain and understand the regional distribution of golf-related pain and associated factors. We sended e-mail questionnaire to one thousand thirty four amateur golfers among members of a internet golf site in the period from August, 2001 to December, 2001. There were 602 respondent of whom 63.5% reported recent pain associated with golf activity. Based on regional pain distribution, upper extremity including shoulder, elbow, wrist and hand was the most common area of pain complaints, followed by spine, lower extremity, fib and chest in order. Based on anatomical distribution, back was the most common pain site. Overuse factor like number of round per week was associated with golf-related pain. Golf itself imposes relatively more burden on upper extremity and spine. Among risk factors, overuse was associated with development of golf-related pain.
전사억제인자 Small Hetrodimer Partner-Interacting Leucine Zipper(SMILE)의 당대사와 지질대사 조절
박우람,최병윤,사다시밤 난티니,김돈규 전남대학교 농업과학기술연구소 2022 농업생명과학연구동향 Vol.60 No.-
Small heterodimer partner-interacting leucine zipper (SMILE) is a member of the cAMP response element-binding protein / activator transcription factor (CREB/ATF) family of basic leucine zipper (bZIP) transcription factors. Structurally, it exists in small and long isoforms resulting from alternative usage of the initiation codon. Though structurally similar to bZIP proteins, SMILE cannot bind to DNA but can homodimerize like them. SMILE acts as a corepressor for nuclear receptors related transcriptional activity and other transc- ription factors. SMILE plays a crucial role in metabolic signaling pathways by inhibiting DNA binding, competing with coactivators, and directly repressing transcription. This review focuses on the role of SMILE in hepatic glucose and lipid metabolism. Regulation of SMILE improves pathological conditions such as hepatitis, diabetes and fatty liver disease. Therefore, understanding the role of SMILE in metabolism and signaling pathways paves the way to consider SMILE as a potential target in treating liver metabolic diseases.