http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Dinesh Babu,박수영,김영휘,양홍철,김정애,Dinesh Thapa,이종숙,김아라 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.1
An aqueous extract of Cornus kousa Burg. leaves (ACK) that contained high amount of polyphenols showed significant antioxidant activity against diphenylpicrylhydrazyl (DPPH) radicals and TNF-α-generated reactive oxygen species. ACK at concentrations of 10 and 50 μg/mL significantly inhibited TNF- α-induced adhesion of U937 pre-monocytic cells to HT-29 colon epithelial cells in a concentrationdependent manner. The reduced adhesion by ACK correlated with the suppressed expressions of monocyte chemoattractant protein (MCP)-1 and interleukin (IL)-8, the major inflammatory bowel disease (IBD)-associated chemokines. Moreover, ACK significantly suppressed TNF-α-induced translocation of redox-sensitive nuclear factor (NF)-κB as well as degradation of cytosolic I-κBα. The effective concentrations of ACK were much lower than that of 5-aminosalicylic acid (3.06 mg/mL), which is an active metabolite of sulfasalazine, a well-known drug used in the treatment of IBD. The results indicate that ACK may provide a potential benefit for the prevention and treatment of inflammatory diseases such as IBD.
Babu, Dinesh,Lee, Jong-Suk,Park, Su-Young,Thapa, Dinesh,Choi, Mi-Kyoung,Kim, Ah-Ra,Park, Young-Joon,Kim, Jung-Ae 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.6
Oxidative stress and the activation of nuclear factor (NF)-${\kappa}B$ play crucial roles in the pathogenesis of inflammatory bowel disease (IBD). In the present study, we examined the effects of the ethanol extract of Platycarya strobilacea Sieb. stem (EPS) on TNF-$\alpha$-induced monocyte adhesion to HT29 human colon epithelial cells, an initial step of colon inflammation. EPS contained high amount of polyphenols ($0.241{\pm}0.017\;mg$ of catechin equivalent/g of extract) and showed substantial DPPH radical scavenging activity. In addition, EPS significantly suppressed TNF-$\alpha$-induced reactive oxygen species (ROS) increase. Moreover, TNF-$\alpha$-induced monocyte adhesion to HT29 colon epithelial cells was significantly suppressed by EPS in a concentrationdependent manner. The reduced adhesion by EPS was correlated with suppressed expression of MCP-1 and IL-8, the major chemokines in IBD. EPS also prevented the TNF-$\alpha$-induced nuclear translocation of NF-${\kappa}B$, one of the redox-sensitive transcription factors, in a concentration-dependent manner. Taken together, our results suggest that the anti-oxidant components of EPS prevent TNF-$\alpha$-induced NF-${\kappa}B$ activation, chemokine induction, and monocyte adhesion at the site of intestinal inflammation.
Dinesh Varshney,Neha Dodiya 한국물리학회 2013 Current Applied Physics Vol.13 No.7
The electrical resistivity behaviour of alkali metal (Na, K, Rb) substitutions at La site in LaxAyMnwO3(A = Na, K, Rb) manganites is studied caused by electronephonon, electroneelectron and electron emagnon scattering. Substitutions affect average mass and ionic radii of A-site and hence resulting lattice and optical phonon softening. Estimated resistivity compared with reported metallic resistivity,accordingly rdiff. = [rexp - {r0 + reeph (=rac + rop)}], infers electroneelectron and electronemagnon dependence over most of the temperature range. Electronephonon contribution indicates that alkali metal K doping provoked larger lattice distortion, while electroneelectron interaction is more dominating process for Na and Rb doped compound favouring motion of excess charge carrier. Semiconducting nature is discussed with variable range hopping and small polaron conduction model. The change in activation energies and the density of states at the Fermi-level is consistently explained by cationic disorder and Mn valence.
Deadline Constrained Adaptive Multilevel Scheduling System in Cloud Environment
( Dinesh Komarasamy ),( Vijayalakshmi Muthuswamy ) 한국인터넷정보학회 2015 KSII Transactions on Internet and Information Syst Vol.9 No.4
In cloud, everything can be provided as a service wherein a large number of users submit their jobs and wait for their services. Thus, scheduling plays major role for providing the resources efficiently to the submitted jobs. The brainwave of the proposed work is to improve user satisfaction, to balance the load efficiently and to bolster the resource utilization. Hence, this paper proposes an Adaptive Multilevel Scheduling System (AMSS) which will process the jobs in a multileveled fashion. The first level contains Preprocessing Jobs with Multi-Criteria (PJMC) which will preprocess the jobs to elevate the user satisfaction and to mitigate the jobs violation. In the second level, a Deadline Based Dynamic Priority Scheduler (DBDPS) is proposed which will dynamically prioritize the jobs for evading starvation. At the third level, Contest Mapping Jobs with Virtual Machine (CMJVM) is proposed that will map the job to suitable Virtual Machine (VM). In the last level, VM Scheduler is introduced in the two-tier VM architecture that will efficiently schedule the jobs and increase the resource utilization. These contributions will mitigate job violations, avoid starvation, increase throughput and maximize resource utilization. Experimental results show that the performance of AMSS is better than other algorithms.