Regular Exercise increased the Stress Protein 70 Content Following Hindlimb Suspension

Choi, Dai Hyuk,Choi, Hee Nam 한국운동과학회 2000 운동과학 Vol.9 No.2

규칙적인 운동은 후족거양에 따른 스트레스 단백질 70의 함량을 증가시킨다. 운동과학, 제9권 제2호, 265-275, 2000. 본 연구의 목적은 후족거양에 따른 무중력상태가 스트레스 단백질 70의 생성과 함량에 미치는 영향을 분석하고 규칙적인 운동이 무중력상태에서 변화하는 스트레스 단백질 70의 생성과 함량에 어떠한 영향을 미치는가를 규명하고자 하였다. 본 연구를 위하여 20마리의 Sprague-Dawley 쥐를 무선으로 표집하여 4개 집단으로 구분하였다. 1) 통제집단, 2) 후족거양 집단, 3) 후족거양후 일회성 운동집단, 4) 규칙적인 운동후 후족거양 집단. 실험계획은 9주간의 훈련 또는 통제기간후에 2주간의 후족거양을 실시하였다. 근섬유 분포는 생화학적 ATPase 염색방법으로 분석한 결과 집단간의 유의한 차이는 없었으나 후족거양 집단의 근섬유 형태 type I이 6% 정도 감소하였다. 그러나 규칙적인 운동후 후족거양을 한 집단은 통제집단과 같은 근섬유분포를 나타내었다. 후족거양에 따른 스트레스 단백질 70의 생성을 살펴보면 가자미근(soleus)은 후족거양 집단이 2.3배, 후족거양후 일회성 운동집단이 2.7배, 규칙적인 운동후 후족거양 집단이 2.1배 증가하였다. 그러나 후족광근(white vastus)에는 별 차이가 없었다. 스트레스 단백질 70의 함량은 규칙적인 운동후 후족거양 집단에서 1.56배가 증가하였으나 다른 후족거양 집단은 40∼60% 감소하였다. 이상의 결과를 분석하여 볼 때, 후족거양에 의한 무중력 상태는 일상시 규칙적인 운동을 통하여 스트레스 단백질 70의 함량(content)을 증가시키나 스트레스 단백질 70의 생성(synthesis)을 자극하는 환경요인으로 나타났다. Regular Exercise increased the Stress Protein 70 Content Following Hindlimb Suspension. Exercise Science, 9(2): 265-275, 2000. The purpose of this study wat to investigate the effects of microgravity on Stress Protein 70 synthesis and content and regular exercise can raised the SP 70 content which may lead to a protective mechanism against the hindlimb suspension induced SP 70 synthesis and content. Thirty day old female Sprague-Dawley rats were randomly assign to 1) control(n=5), 2) C-HS W/O(n=5), 3) C-HS(n=5), 4) T-HS(n=5). The experimental segments were eleven weeks long in duration and hindlimb suspension segment was administered the two weeks after the nine weeks training or control. There were no significant differences in soleus muscle fiber types among the groups and the results from histochemical ATPase staining showed type I fibers in two C-HS groups(C-HS W/O and C-HS) were 6% lower than control group and T-HS group had similar to control values. The effects hindlimb suspension on SP 70 synthesis was higher in the C-HS W/O, C-HS, T-HS groups with 2.3, 2.7, 2.1 fold increases in soleus muscle, respectively. However, there were similar values in white vastus muscle. The relative amounts of SP 70 content, compared to the control, were increased 1.56 told for the T-HS group. On the contrary, decreasing SP 70 content in soleus muscle were observed for the C-HS W/O and C-HS groups. Therefore, it is speculated that microgravity is a stressor that induce SP 70 synthesis even though exercise training raised SP 70 content.

A Comparative Study on the Physiological Profiles of Aerobic and Korean Traditional Dancers

Choi, Dai Hyuk,Choi, Hee Nam,Yang, Sun Hee 한국운동과학회 1998 운동과학 Vol.7 No.2

에어로빅과 한국전통무용수의 생리학적 변인 비교. 운동과학, 제7권 제2호, 233-240, 1998. 에어로빅과 한국전통무용에 참가하는 학생들이 증가하고 있는 가운데 이러한 유산소성 운동이 체력적 요인 및 심폐기능에 미치는 효과에 대한 관심이 증대되고 있다. 따라서 본연구의 목적은 에어로빅과 한국전통무용수들의 규칙적 운동에 따른 체지방, 기초체력, 등속성근력, 최대산소섭취량의 차이를 규명하고자 하였다. 현재 운동을 규칙적으로 하고 있는 44명의 대학생을 대상으로 참가 동의서를 받고 체지방, 유연성, 악력, 윗몸일으키기, 민첩성, 높이뛰기, 등속성근력 및 최대산소 섭취량을 측정하였고 일원변량 분석을 실시하였다. 이 논문에서의 주요결과로서는 에어로빅 선수들은 체력요인에서 뛰어났으며 한국전통무용 선수들은 상대적·절대적 등속성 근력이 높았다(P< .05). 또한 에어로빅 선수들은 한국전통 무용 선수들보다 체지방이 유의하게 낮았다(p< .05). 결론적으로 에어로빅과 한국전통 무용은 비슷한 유형의 유산소성 운동이지만 훈련의 형태나 과정에 따라서 운동의 효과가 다르게 나타났다.

Effects of Acute and Chronic Exercise on the Heat Shock Protein 70 Synthesis and Content

Choi, Dai Hyuk 한국운동과학회 1999 운동과학 Vol.8 No.3

일회성운동 및 지구력훈련이 HSP70 생성과 함량에 미치는 영향. 운동과학, 제8권 제3호, 519-528, 1999. 본 연구의 목적은 11주간의 트레드밀 트레이닝이 Heat Shock Protein 70의 생성과 함량에 미치는 영향을 규명하고자 하였다. 본 연구를 위하여 15 마리의 Sprague-Dawley 쥐를 3개 집단으로 구분하였다. 1) 통제집단, 2) 일회성 운동집단, 3) 트레드밀 훈련집단 실험당일 통제집단을 제외한 일회성 운동집단과 훈련집단은 지칠 때까지 트레드밀을 뛰었으며 soleus와 white vastus 근육을 채취하여 근섬유 분포와 Heat Shock Protein 70 단백질의 함량과 생성을 측정하였다. 본 연구결과 11주간의 트레드밀 훈련 집단은 통제집단과 비교하여 Soieus 근섬유의 type I 비율이 3%로 감소되었으나 type II의 근섬유 비율은 5%에서 8%로 향상되었다. Soleus 근섬유에서 Heat Shock Protein 70 단백질의 생성(synthesis)은 통제집단과 비교하여 볼 때 일회성 운동집단이 28%, 트레드밀 훈련집단이 13% 증가하였다. 이와는 반대로 Heat Shock Protein 70 단백질의 함량(content)은 일회성 운동집단이 16% 감소한 반면 트레드밀 훈련집단은 71% 증가하였다. White vastus 근성유의 Heat Shock Protein 70 단백질의 생성은 일회성 운동집단이 6%, 트레드밀 훈련집단은 7% 감소하였다. Heat Shock Protein 70 단백질의 함량은 일회성 운동집단이 23% 감소하였고 트레드밀 훈련집단은 30% 증가하였다. 이상의 결과를 분석하여 볼 때, 단기간의 일회성 운동은 Heat Shock Protein 70 단백질의 생성을 증가시키며 11주간의 트레드밀 훈련집단은 Heat Shock Protein 70의 함량이 비운동군에 비하여 증가함을 나타내어 지속적 훈련이 세포의 HSP 70의 함량을 증가시키는 것으로 사료된다. Effects of Exercise and Training on the Heat Shock Protein 70 Content and Synthesis. Exercise Science. 8(3): 519-528, 1999. The purpose of this study was to investigate the effects of acute and chronic exercise on Heat Shock Protein 70 synthesis and content. Thirty day old female Sprague-Dawley rats were randomly assign to 1) control(n=5), 2) acute exercise(n=5), 3) trained group(n=5). On the experimental day, rats were run to volitional fatigue and were sacrificed except for the control group. Tissue samples of soleus and vastus lateralis were analyzed for muscle fiber type and HSP 70 synthesis and content. Training group increased the type II fiber 5% to 8% whereas type I fiber decreased 3% in soleus. HSP 70 synthesis in soleus muscle was increased 28% for acute exercise as well as training group increased 13%. On the contrary, HSP 70 content were decreased 16% in acute exercise whereas training group increased 71%, HSP 70 synthesis in white vastus was decreased 6% and 7% in acute and training groups, respectively. However, HSP 70 content in training group was increased 30% compare to 23% decreased in acute group. This study suggested that acute exercise was the stimulator for inducing HSP 70 synthesis and exercise training increased the HSP 70 content in soleus and white vastus muscle.

중년 고혈압 남성의 심근허혈 예방을 위한 적정운동강도 설정

최대혁 ( Dai Hyuk Choi ) 한국운동생리학회(구-한국운동과학회) 2003 운동과학 Vol.12 No.1

규칙적 운동참여가 건강체력에 미치는 영향

최대혁(Choi Dai-Hyuk),최희남(Choi Hee-Nam),이철호(Lee Cheol-Ho) 한국체육과학회 2002 한국체육과학회지 Vol.11 No.2

The purpose of this study was to find out effects of regular exercise on aging variables which is health related fitness levels of 20 and 30. Physical characteristics(age, height, weight) and physical fitness and blood pressure, total cholesterol, blood glucose were investigated in samples of 400 male officials who is regular participated in exercise(E) or non exercise groups(C). The test data were compared with Korean standard which estimated by Korea Sports Science Institute and statistical analysed via Two-way ANOVA. The results were summarized as follows: 1) Coronary artery disease risk factors BMI, systolic and diastolic blood pressure, total cholesterol, blood glucose were normal in all groups. But there was a significantly lower of BMI in exercise group than non-exercise group of 20. In addition, total cholesterol were significantly lower in exercise group among groups. 2) Health related fitness VO₂max were significantly higher in exercise group than non-exercise group which was 7.3%, 9% higher at 20, 30 generation. 3) Skill related fitness Power was "good" in all groups. Agility was "poor" in non exercise but "fair" in exercise group. The statistics analysis indicated significantly difference between groups in agility(p<.05). These results indicate that regular exercise increases physical fitness and decrease risk factors of hypokinetis disease. More importantly, regular exercise can prevent a decreasing VO₂max following aging.

p-Type aliovalent Li(I) or Fe(III)-doped CuO hollow spheres self-organized by cationic complex ink printing: Structural and gas sensing characteristics

Choi, Yun-Hyuk,Kim, Dai-Hong,Hong, Seong-Hyeon Elsevier 2017 Sensors and actuators. B Chemical Vol.243 No.-

<P><B>Abstract</B></P> <P>The p-type CuO hollow sphere films doped with aliovalent Li(I) or Fe(III) have been prepared directly on the substrate through a self-organization process in the printed films using the formulated cationic complex inks. The Li(I) or Fe(III) ions are substitutionally incorporated into CuO lattice with the variation in lattice parameters and act as a shallow acceptor or donor leading to the increase or decrease of the hole density, respectively. Such an electronic modification shifts the optical band gap and binding energy of Cu. The increased hole density by Li(I) doping reduces the overall sensor resistance and the width of hole-accumulation layer (<I>λ<SUB>d</SUB> </I>) in CuO grains, resulting in the decrease in gas response toward the reducing ethanol gas to ca. 50% compared to that of undoped CuO. In contrast, the decreased hole density by Fe(III) doping increases the sensor resistance and <I>λ<SUB>d</SUB> </I>, leading to the enhancement in gas response to ca. 150%, based on the electronic sensitization mechanism. These results show clearly that the substitutional doping of aliovalent cation is effective for the manipulation of electronic structure and gas sensing properties of p-type CuO.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Li(I) or Fe(III)-doped CuO hollow sphere films are prepared via cationic complex ink. </LI> <LI> Substitutional doping of aliovalent cations modifies the electronic structure of CuO. </LI> <LI> The gas response of CuO toward ethanol was enhanced with aliovalent Fe(III) doping. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

p-Type CuBi₂O₄ thin films prepared by flux-mediated one-pot solution process with improved structural and photoelectrochemical characteristics

Choi, Yun-Hyuk,Yang, Ki Dong,Kim, Dai-Hong,Nam, Ki Tae,Hong, Seong-Hyeon Elsevier 2017 Materials letters Vol.188 No.-

<P><B>Abstract</B></P> <P>The flux-mediated one-pot solution process based on the metal-organic decomposition (MOD) has been developed for the preparation of p-type complex oxide semiconductor CuBi<SUB>2</SUB>O<SUB>4</SUB> thin films. The precursor solutions with the various concentrations (0.5, 2, 5, and 10mol% vs. CuBi<SUB>2</SUB>O<SUB>4</SUB>) of aliovalent Li(I) flux produced the continuous and dense CuBi<SUB>2</SUB>O<SUB>4</SUB> thin films with stoichiometric composition by facilitating the crystallization from the liquid precursor solution. These films showed the high hole density and charge transfer characteristics, which lead to the high photoelectrochemical activity for water reduction.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The flux-mediated one-pot solution process for CuBi<SUB>2</SUB>O<SUB>4</SUB> thin films is developed. </LI> <LI> The dense and continuous CuBi<SUB>2</SUB>O<SUB>4</SUB> film is obtained with the aliovalent Li(I) flux. </LI> <LI> CuBi<SUB>2</SUB>O<SUB>4</SUB> films exhibit high photoelectrochemical activity for water reduction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

생산직 근로자와 규칙적 운동참여 사무직 근로자의 관상동맥질환 위험요인 및 기초체력 기준치설정

최대혁,이철호 한국운동과학회 2002 운동과학 Vol.11 No.1

최대혁, 이철호. 생산직 근로자와 규칙적 운동참여 사무직근로자의 관상동맥질환 요인 및 기초체력 기준치 설정. 운동과학, 제11권 제1호, 105-117, 2002. 본 연구는 20·30대 연령층으로 육체적 노동을 하는 생산직 근로자들과 좌업생활을 하지만 규칙적인 운동을 하는 사무직 근로자의 관상동맥질환 위험인자와 기초체력기준치를 설정하고 규칙적인 운동이 관삼동맥질환 요인에 미치는 관계를 분석하여 근로자들의 체력향상을 위한 운동프로그램개발의 기초자료를 제공하는데 목적을 두었다. 본 연구의 목적을 달성하기 위해 K공단지역 남자 규칙적 운동참가 없는 생산직근로자(I) 20대 89명, 30대 124명과 규칙적으로 운동에 참여하는 사무직근로자(O) 20대 173명, 20대 99명으로 272명을 대상으로 신장, 체중, 스텝테스트, 악력, 앉아 윗몸 앞으로 굽히기, 윗몸 일으키기, 팔굽혀펴기, 사이드스텝, 제자리높이뛰기 등 기초체력 항목과 BMI, 혈압, 혈당, 총콜레스테롤 등 관상동맥질환 위험인자 항목 검사를 실시하였다. 연구결과를 종합해 볼 때 기초체력은 전반적으로 생산직근로자집단과 규칙적 운동 참여 사무직 공무원집단간 유의한 차이가 있었다. 좌업생활을 하지만 규칙적으로 운동을 하는 사무직근로자집단이 유연성을 제외한 항목에서 유의하게 높게 나타났다. 비교적 육체노동을 하는 생산직근로자들의 체력수준이 "보통" 이하 수준으로 나타난 것으로 보아 적극적인 체력관리는 이루어지지 않고 있는 것으로 사료된다. 생산직근로자집단온 윗몸일으키기와 유연성이 "나쁨"으로 공무원집단도 유연성이 "나쁨"으로 나타났는데 이는 요통의 원인인 유연성 결여와 근력의 불균형에 해당하므로 향상운동이 필요할 것으로 사료된다. 최대산소섭취량과 관상동맥질환 위협요인간의 상관관계는 20대 생산직과 사무직 모두 BMI, 수축기 혈압에서 유의한 관계가 나타났으며 연령을 제외한 편상관분석에서는 혈당, 이완기 혈압, BMl순으로 나타났다. 따라서 본 연구를 통하여 제시된 생산직 및 사무직 근로자의 관상동맥질환 위험인자와 기초체력 기준치 설정을 기초로 이를 예방하는 규칙적 운동이 실시되어야 하며, 차후의 연구는 생활습관과 신체활동을 통제한 종속적인 연구가 이루어져야 할 것으로 사료된다. Choi, D.H., Lee, C.H. Study on the Determination of Criteria for Coronary Artery Disease and Physical Fitness for Industrial Workers and Regular Exercise Participation Officials. Exercise Science, 11(1): 105-117, 2002.The purpose of this study was to determination of criteria for physical fitness as well as coronary artery disease risk factors and revealed the correlation coefficience between VO_2max and coronary artery disease risk factors in 20 to 39 years old industrial workers and regular exercise participation officials of Korean. The subjects of this study were consisted of both 213 male(20s: 89, 30s: 124) industrial workers and 272(20s: 173, 30s: 99) regular exercise participation male officials who checked medical examination and physical fitness test at K-Fitness Center. The results were summarized as follows; 1) Coronary artery disease risk factors- BMI, systolic and diastolic blood pressure, total cholesterol, blood glucose were normal in all groups. 2) Health related fitness- Caroliopulmonary endurance was "good" in O but "fair" in I. Muscle endurance was better than "fair" in O but less than "fair" in I. Muscle strength was "good" in 20's O and "fair" in other groups. Flexibility was "poor" in all groups. The statistics analysis was shown significantly difference between groups except flexibility(p<.05). 3) Skill related fitness- Power was "good" in all groups. Agility was "poor" in I but "fair" in O. skill related fitness. The statistics analysis indicated significantly difference between groups in agility(p<.05). Also, There were significant correlation coefficience between VO_2max and coronary artery risk factors which were BMI(-.183), systolic blood pressure(-.286), diastolic blood pressure and BMI(-.128), systolic blood pressure(.161) for 20's in industrial workers and officials and systolic blood pressure(-.294), diastolic blood pressure(-.276) for 30's in industrial workers, respectively. In addition, there were significant partial correlation coefficience when age was controlled between VO_2max and coronary artery factors which were BMI(.118), diastolic blood pressure(-.165) and BMI(-.114), blood glucose(.254) for industrial workers and officials. These results indicate that regular exercise increases physical fitness and decrease risk factors of coronary artery disease even if sedentary whit colors. Therefore, Industrials workers need to participate physical fitness program for health and prevention of absence from work.

Direct Printing Synthesis of Self-Organized Copper Oxide Hollow Spheres on a Substrate Using Copper(II) Complex Ink: Gas Sensing and Photoelectrochemical Properties

Choi, Yun-Hyuk,Kim, Dai-Hong,Han, Hyun Soo,Shin, Sun,Hong, Seong-Hyeon,Hong, Kug Sun American Chemical Society 2014 Langmuir Vol.30 No.3

<P>The direct printing synthesis of metal oxide hollow spheres in the form of film on a substrate is reported for the first time. This method offers facile, scalable, high-throughput production and device fabrication processes. The printing was carried out via a doctor-blade method using Cu(II) complex ink with controllable high viscosity based on formate–amine coupling. Following only thermal heating in air, well-defined polycrystalline copper oxide hollow spheres with a submicrometer diameter (≤1 μm) were formed spontaneously while being assembled in the form of a film with good adhesion on the substrate. This spontaneous hollowing mechanism was found to result from the Kirkendall effect during oxidation at elevated temperature. The CuO films with hollow spheres, prepared via direct printing synthesis at 500 °C, led to the creation of a superior p-type gas sensor and photocathode for photoelectrochemical water splitting with completely hollow cores, a rough/porous shell structure, a single phase, high crystallinity, and no organic/polymer residue. As a result, the CuO hollow-sphere films showed high gas responses and permissible response speeds to reducing gases and high photocurrent density compared to conventional CuO powder films and the values previously reported. These results exemplify the successful realization of a high-throughput printing fabrication method for the creation of superior nanostructured devices.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/langd5/2014/langd5.2014.30.issue-3/la404098s/production/images/medium/la-2013-04098s_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/la404098s'>ACS Electronic Supporting Info</A></P>

P236 : Study on the characteristics and clinical manifestations of 113 patients with pigmented purpuric dermatoses (PPD)

( Dai Hyun Kim ),( In Hyuk Kwon ),( Hee Sang Kye ),( Ga Na Oh ),( Hwa Jung Ryu ),( Soo Hong Seo ),( Hyo Hyun Ahn ),( Young Chul Kye ),( Jae Eun Choi ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2

Background: The entity of PPD remains an enigma and a therapeutic challenge. Objectives: The purpose of this study was to investigate the characteristics and clinical manifestations of PPD and to elucidate the relationship between the assumed causative factors and clinical manifestations of PPD and treatment responses. Methods: Retrograde analyses were made from 2002 to 2012. A total of 113 patients were selected. Results: Male to female ratio was 1.05:1. The mean age at diagnosis was 47.06±18.19 years. The most common involved location was confined to lower extremities in 79.65%. The patients whose lesions were distributed on both upper and lower extremities were 11.50%. Only 0.88% of the patients showed whole body involvement. The concomitant diseases were HTN(18.58%), DM(8.85%), angina(7.96%), venous stasis(7.96%). Associated medication histories were aspirin(13.27%), CCB(11.50%), ARB(10.62%), antiplatelet agents(8.85%), statin(7.96%). A total of 104 patients(92.04%) were treated with one or more treatment methods. 39 patients(34.51%) were prescribed with oral antihistamine and topical steroid. Oral pentoxifylline was additionally given to 34 patients(30.09%). Only small number of patients(3.54%) were received phototherapy. 7.96% of patients were applied topical steroid only. Conclusion: There was no difference in the clinical course according to the treatment. We could not find any statistically significant relevance between medication history, underlying disease and PPD.