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Enhanced Systemic siRNA Delivery Using Reducible Bile Acid-modified PEI for Cancer Therapy
Chae eun PARK,Su yeon LIM,Da hwun KIM,Siyan LYU,Byung deok KIM,Oui bo WHANG,Ji hoon JEONG 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Small interfering RNA (siRNA) contributes to RNA interference(RNAi) by inhibiting target gene expression in a sequence-specific manner. siRNA delivery system have become increasingly popular for cancer therapy. In this study, we used a low molecular weight polyethylenimine (PEI, 1.8 kDa) conjugated with deoxycholic acid (DA). A DA-PEI conjugate was further modified with 4-fluorothiophenol (4-FTP) (4-FTP-DA-PEI) to enhance systemic siRNA delivery. The thiophenol group would be involved with disulfide bonds between the polymer chains and siRNA modified with free thiols (thiol-siRNA) to form and π-π interactions between the pendent aromatic groups and coprostane ring of the bile acid. The stabilized TP-DA-PEI conjugate with thiol-siRNA achieved developed intracellular uptake, serum stability, and transfection efficiency. Furthermore, it shows high accumulation of TP-DA-PEI/thiol-siRNA polyplexes and significant tumor growth inhibition effect in tumor-bearing mice after systemic administration.
( Da Hyun Kim ),( Hye Ree Jang ),( En Bee Cho ),( Jeong Eun Jeong ),( Jung Mi Byun ),( Dae Hoon Jeong ),( Kyung Bok Lee ),( Moon Su Sung ),( Ki Tae Kim ),( Young Nam Kim ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: The colonization rate for GBS infection in pregnant women have been reported to vary from 4.8% up to 11.5% in Korea. These discrepancies might result from different sampling procedure and media among studied centers. Recently, the Centers for Disease Control and Prevention (2010) recommended a universal prenatal screening strategy to identify GBS carrier and intrapartum antimicrobial prophylaxis (IAP) with positive cultures. We aimed to analyze the prevalence of maternal GBS colonization and vertical transmission under a universal prenatal screening using selective culture media. 방법:We included 830 pregnant women who visited and delivered at Busan Paik Hospital between January 2015 and June 2016. The specimens for GBS culture were obtained from both the lower vagina and perianal area in women who were admitted for threatened preterm delivery or who visited at our clinic for antenatal care at 35-37 weeks of gestation. These swabs were then inoculated into Todd-Hewitt broth and CHROMagar StrepB agar. IAP were given to women with rectovaginal GBS-positive cultures under CDC guideline. 결과: Among the 830 cultured pregnant women, 94 (11.3%) were positive for GBS colonization. 22 (23.4%) were positive culture from lower vagina, 33 (35.1%) from perianal area and 39 (41.5%) from both. Maternal characteristics including age, delivery mode and time were not different between positive and negative GBS groups. GBS positive rate was also not differ between preterm and full-term delivery groups. Among 115 neonates who were born from GBS colonized women, 37 (32.2%) neonates had neonatal sepsis, however, GBS was not causative organism and there was no early onset GBS sepsis. 결론: With the universal prenatal screening using selective culture media, the GBS colonization rate of 11.3% was higher than that performed by previous studies in Korea. Therefore, it is necessary to screen for GBS colonization using selective culture media, and IAP for positive culture women or high risk women is obligatory.
Lee Jeong Hoon,Ha Eun Ju,Lee Da Hyun,Han Miran,Park Jung Hyun,Kim Ji-hoon 대한영상의학회 2022 Korean Journal of Radiology Vol.23 No.7
Objective: Preoperative differential diagnosis of follicular-patterned lesions is challenging. This multicenter cohort study investigated the clinicoradiological characteristics relevant to the differential diagnosis of such lesions. Materials and Methods: From June to September 2015, 4787 thyroid nodules (≥ 1.0 cm) with a final diagnosis of benign follicular nodule (BN, n = 4461), follicular adenoma (FA, n = 136), follicular carcinoma (FC, n = 62), or follicular variant of papillary thyroid carcinoma (FVPTC, n = 128) collected from 26 institutions were analyzed. The clinicoradiological characteristics of the lesions were compared among the different histological types using multivariable logistic regression analyses. The relative importance of the characteristics that distinguished histological types was determined using a random forest algorithm. Results: Compared to BN (as the control group), the distinguishing features of follicular-patterned neoplasms (FA, FC, and FVPTC) were patient’s age (odds ratio [OR], 0.969 per 1-year increase), lesion diameter (OR, 1.054 per 1-mm increase), presence of solid composition (OR, 2.255), presence of hypoechogenicity (OR, 2.181), and presence of halo (OR, 1.761) (all p < 0.05). Compared to FA (as the control), FC differed with respect to lesion diameter (OR, 1.040 per 1-mm increase) and rim calcifications (OR, 17.054), while FVPTC differed with respect to patient age (OR, 0.966 per 1-year increase), lesion diameter (OR, 0.975 per 1-mm increase), macrocalcifications (OR, 3.647), and non-smooth margins (OR, 2.538) (all p < 0.05). The five important features for the differential diagnosis of follicular-patterned neoplasms (FA, FC, and FVPTC) from BN are maximal lesion diameter, composition, echogenicity, orientation, and patient’s age. The most important features distinguishing FC and FVPTC from FA are rim calcifications and macrocalcifications, respectively. Conclusion: Although follicular-patterned lesions have overlapping clinical and radiological features, the distinguishing features identified in our large clinical cohort may provide valuable information for preoperative distinction between them and decision-making regarding their management.