Interaction between Brain-Derived Neurotrophic Factor Val66Met Polymorphism and Recent Negative Stressor in Harm Avoidance

Kim, Seog Ju,Cho, Seong-Jin,Jang, Ha Min,Shin, Jonghan,Park, Pil-Whan,Lee, Yu Jin,Cho, In Hee,Choi, Jung-Eun,Lee, Heon-Jeong S. Karger AG 2009 Neuropsychobiology Vol.61 No.1

<P>There have been controversial results regarding the association between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and anxiety-related traits such as harm avoidance (HA). We aimed to investigate the interaction between <I>BDNF</I> Val66Met polymorphism and negative life stressors in HA. <I>BDNF</I> Val66Met polymorphism was genotyped in 391 community-dwelling Koreans (152 males, 239 females; 43.2 ± 14.1 years old). The Temperament and Character Inventory (TCI) and the Center for Epidemiological Studies for Depression Scale (CES-D) were self applied. The Structured Clinical Interview for DSM-IV axis I disorders and face-to-face interviews investigating negative life stressors within the last 6 months were also performed. There was no significant difference in TCI score, major depressive disorder prevalence and CES-D score among the 3 genotypes (94 Met/Met, 188 Val/Met and 109 Val/Val subjects). There was no significant difference in TCI scores between subjects with stressors and those without stressors, while more common major depressive episodes (p = 0.03) and higher CES-D scores (p < 0.001) were found in subjects with stressors. However, there was a significant interaction between the <I>BDNF</I> genotype and negative life stressors in HA (p = 0.02). Only subjects with the Val/Val genotype showed higher HA with recent negative stressors. Our finding suggests that <I>BDNF</I> Val66Met polymorphism might influence HA by interacting with recent negative stress experience.</P><P>Copyright © 2009 S. Karger AG, Basel</P>

우리 나라 보건관리대행서비스 평가 연구

하은희,조수헌,김선민,주영수,한상환,하미나,권호장,홍윤철,김창엽 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.1

Group occupational health service programme started in 1990 is one of the measures to cope with limited human and financial resources in occupational health. The programme has expanded rapidly to include 52 institutions, private as well as public, all over the country. In spite of its potential impact on health of employees and practice of occupational health in small and medium sized industries, comprehensive evaluation in terms of quality has not been tried. This study has aims to develop the criteria to assess the quality of newly developed group occupational health service programme, and to investigate the quality of institutions, and finally to develop policies for the quality improvement. 1) Criteria development : By defining occupational health services, in particular for small and medium sized industries, as one of the primary health care, followings are included as core elements of qualitative occupational health programme; accessibility, continuity, comprehensiveness, technical quality, intersectoral collaboration, emphasis on preventive services, community participation, and adequacy. Again each element is divided into five major components of national health system infrastructure developed by the World Health Organization; development of health resources, organized arrangement of resources, delivery of health care, economic support, and management. In turn, each component is categorized into three aspects of quality assessment, structure, process and outcome. Expert panel selected several criteria for each category to evaluate the programme. Criteria were modified according to each group of interviewees, to produce two sets of questionnaire, one for chief operating officer and another for nurses in the institutions, and the chief operating officer and workers in the workplace. 2) Subject : Of all 52 institutions, 25 voluntarily participated in the survey. At individual institution, chief operating officer and practicing nurses were interviewed in depth. After intensive education for interviewees, every interviewees, every interview was performed with standardized guideline and questionnaire. The quality of the 'Group occupational health service programme' was found to be lower than expected. Especially in continuity, comprehensiveness, technical quality, community participation and adequacy, lower quality in structural aspect was commonly identified throughout all the institutions,. Quality in terms of accessibility and continuity highly varied among institutions., To improve quality of the programme, more comprehensive and systematic programme such as accreditation has to be introduced. In addition, human resources, governmental fund and information systems for individual workers are to be developed. As a long range plan, integration of occupational health services into the national health systems and pooling of financial resources and planned allocation should be considered.

보건관리자 직무평가도구의 개발

하은희,박혜숙,김영주 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

Objectives : The purpose of this study is to deliver effective worksite health management by specifying job of occupational physician, occupational nurse, occupational hygienist and making job reference manual and health performance audit. Therefore, We can contribute to disease prevention and health promotion of workers by enhancing quality of worksite health management. Method : The methodology of making performance audit is comprised of developing audit questions and weighting the questions. Measures are made by scoring the values. The question-naires were grouped by the categories and sections. This occupational audit was distributed to the health personnel of 350 workplaces by mail. The self-administered results were returned and analyzed, Results : We plot the field of occupational health service by basic policy, preventive health service, health care, administration, and other services. We gave the weight A on the primary job, B on the supplementary job, and C on the minor job. This weight was made through the delphi procedures where 30 specialists joined. Basic policy got score of 16.1% preventive health service got 36.5%, health care 20.4%, administration 10.9%, and other services 10.1%. Further weightings on the questionnaire sections were made through the survey on specialists and final weighting on each questionnaire was made by making formula considering weights of each stage. The audit was composed of 96 questions which has dichotomos scales and full score was 1,000. Person-nels from 80 workplaces (23%) replied the audit and the scores of physicians, nurses, and hygienists were 608.6, 587.1 and 535.4, respectively, all a little higher than 500. Discussion : The health performance audit can be used by the sorksite health personnels providing health service. However, this work would not be complete without further comprehe-sion and application in the real settings. 목적: 본 연구에서는 사업장 보건과리를 활성화하기 위하여 사업장에서 수행되고 있는 산업보건관리직무를 객관적으로 평가할 수 잇는 사업장 보건관리직무 평가항목과 평가척도를 개발하고자 하였다. 방법: 평가항목은 산업보건서비스의 내용별로 대항목, 소항목, 세부항목으로 구분하였다. 평가도구의 타당성을 검증하고 실제 사업장에서의 직무활동을 평가하여 평가의 기준을 현실에 맞게 설정하고자 위의 과정을 거쳐 만들어진 평가도구를 350개 사업장의 보건관리자에게 설문조사를 통해 적용하였다. 연구대상자는 산업간호사와 산업위생관리기사의 경우 한국산업안전공단 안전교육원에서 실시하는 보수교육자 이수자명단을 이용하였으며 설문실시기간은 1996년 7월 24일부터 8월 24일가지로 하여 우편설문의 형식을 취하였다. 결과: 1차 설문조사결과 산업보건의사, 산업간호사, 산업위생관리기사의 평균점수를 보면 기본방침 14.5%, 예방보건 서비스 39.0%, 치료서비스 18.0%, 관리 및 행정서비스 17.2%, 기타서비스 10.3%로 예방보건서비스가 가장 높은 점수를 보였다. 이 결과를 다시 1차 설문에 응하여준 응답자에게 통보하고 2차 Delphi를 시행한 결과 기본방침 16.1%, 예방보건서비스 36.5%, 치료서비스 20.4%, 관리 및 행정서비스 16.9%, 기타서비스 10.1%로 예방보건 서비스의 점수는 다소 낮아지고 기본방침과 치료서비스의 점수가 올라가는 결과를 보여주었다. 산업보건학계, 대행기관, 사업장 실무 인력인 산업보건의사 10인, 산업간호사 10인, 산업위생관리기사 10인을 대상으로 한 설문조사를 통해 대항목 각각을 100%로 하였을 때의 소항목의 점수(백분율)를 구하였다. 기본방침 중에서는 기본방침의 설정이 가장 높은 점수를 보였으며 예방보건서비스중에서는 건강상담 및 보건교육이 가장 높은 점수를 보였다. 치료서비스 중에서는 환자치료가 관리 및 행정 서비스에서는 기록 및 보고가 높은 점수를 보였다. 우편설문을 보낸 350개 사업장중 85개 사업장, 110명의 보건관리자에서 직무평가설문에 응답하였으며 응답사업장 보건관리자들의 직종별 인원수는 의사 41명, 간호사 78명, 산업위생관리기사 24명, 환경관리기사 65명, 기타 2명으로 산업위생관리기사 대신 환경관리기사를 채용한 사업장이 많았다. 응답사업장의 업종은 대부분이 제조업이었으나 매우 다양하였고 규모별로는 300인 미만이 38.5%, 300~999인 사업장이 32.5%, 1000인 이상이 28.8%었다. 결론: 본 평가도구가 개발목적에 부합되기 위해서는 사업장에 실제로 적용하여 사업장에서 실제 사용해 보고 이 결과를 바탕으로 사업장 규모별, 업종별로 내용을 분석하여 직무를 평가함으로써 문제를 파악하고 특히 보건관리 인력을 얼마만큼 투입할 것인가를 결정할 때에 반영되어야 할 것이다. 그리고 보건관리자의 직무 즉, 사업장내 산업보건서비스를 올바로 수행하기 위한 보건관리자의 교육훈련제도지에 대한 정책이 마련되어야 할 것이다.

송화분을 이용한 간기능 증진제 개발 연구

하은주,이해경,한준표 대구효성가톨릭대학교 1993 연구논문집 Vol.47 No.1

To investigate the effect of the pine pollen on serum and liver of rat pretreated with carbon tetrachloride. Rats were first administrated CCl₄and then treated orally with the water-washed pine pollen as indicated in the book of "Imperial courtcookery" The results are summarized as follows ; GPT activity of rat administrated the pine pollen was lower than that of rat treated with CCl₄to induce a chronic liver injury and was similar to that of nontreatment group. Totla cholesterol in serum of pine pollen administrated rat decreased significantly compared with that of the CCl₄-treated group. There was a noticeable improvement in the activity of the live protein synthesis of pine polllen-administrated rat, compared with that of CCl₄-treated group. Body weight of non-treated group are increased but that of CCl₄-treated and pine pollen-treated group were retarded according to time.

Klebsiella phage 前處置菌에 對한 Proteus phage의 吸着狀況

河銀鑄 全南大醫大 1973 전남의대학술지 Vol.10 No.1

위암수술 환자에서의 cp 개발과 cp적용에 따른 질 향상 활동에 관한 연구

임은주,황순휘,박도중,하광일,배현주,김형호 한국의료QA학회 2006 한국의료질향상학회지 Vol.13 No.2

Background : In an era of increasing medical costs, safe reduction in postoperative stay has become a major focus to optimize utilization of healthcare resources. The authors aimed to evaluate the clinical significance of the critical pathway(CP) for gastrectomy patients by implementing standardized postoperative management and electronic medical records. Method : From August 2006 to April 2007, critical pathways were introduced to inpatients and outpatients with gastric cancer. 60 consecutive patients undergoing distal gastrectomy were randomly divided into two groups; 30 CP group(A) and 30 non-CP group(B). Simultaneously, we also retrospectively reviewed the records of 438 patients(C:control group) who were able to be enrolled in CP program. We compared group(A) with (B), (C) in terms of hospital stay, complication rate, use of antibiotics and hospital costs. Patient satisfaction was surveyed by questionnaires. Result : There was no significant demographic difference between group(A) and (B). Of 30 patients in group(A), 5 drop-outs and 14 variances occurred. The mean postoperative hospital stays(Laparoscopy-assisted distal gastrectomy: LADG/Open distal gastrectomy: ODG) were 7.6/10.5 days for the group(A), 8.9/12.7 days for the group(B) and 12.6/14.5 days for the group(C) (p=0.02 in LADG). The total hospital cost of group(A) had a tendency to be less than that of group(B) and the amount of hospital cost per day in group(A) was significantly higher than that in group(B). The usage rates of the first generation antibiotics were 73.33%, 63.33%, and 59.2% in group(A), (B), and (C), respectively. Patients’ satisfaction had a tendency to be higher in the CP group than non-CP group. Conclusion : The mean hospital stay in LADG patients was shortened meaningfully and hospital cost per day was enlarged after introduction of clinical pathway. It is necessary to apply a number of patients to the critical pathway and to make an effort to reduce the variation and drop-out rates.

유아를 위한 손끝놀이프로그램의 적용사례

하정연,김은주 부산대학교 영유아보육연구소 2000 영유아보육연구 Vol.6 No.-

This program developed, implemented, and evaluated a "fingertip" handicraft program for early-childhood facilities. The program was conducted in one class of three-year-olds and two classes of five-year-olds of P child care center, from March to December, 2000. The program was implemented as two stages : a "preparation" stage (for 3~4 year-olds) and a "practice-and-deepening" stage (for 4~5 year-olds). The "fingertip activities" in the reparation stage of the program consisted of the following : transferring of small objects, clipping ㆍ folding ㆍ pasting ; using "clothing frames" ; and the basic stages of sewing. The activities in the practice-and-deepening stage consisted of the following : making cat's cradles, knitting, and doing embroidery. The program was evaluated positively by the children, teachers, and parents involved. The children developed the use of their fingertip muscles, power of concentration, and patience, as well as their capacity to recognize practical and artistic values, a sense of achievement, and the meaning of labor. By seeing positive changes in the children, the teachers realized that handicraft activities were beneficial. The parents of the children learned that "fingertip activities" were worthwhile at both school and at home, and they perceived a need for transferring traditional culture to younger generations through inter-generational interactions.

Shigella flexneri phage의 加熱非?化에 미치는 Calcium chloride 및 Sodium citrate의 影響

河銀鑄 全南大醫大 1973 전남의대학술지 Vol.10 No.1

Calcium chloride 및 Sodium citrate가 Shigella flexneri phage-宿主菌系에 미치는 影響

河銀鑄 全南大醫大 1973 전남의대학술지 Vol.10 No.1

부천집단의 타액내 Salivary acidic protein(Pa)의 다형현상에 대한 연구

이하규,이경은,이주희,이희천 가톨릭대학교 자연과학연구소 2003 자연과학논문집 Vol.24 No.-

한국인 집단의 타액 내 Salivary acidic protein의 다형현상과 유전자 빈도를 조사하기 위해 부천지역 초등학생 135명을 대상으로 해서 Alkaline slab polyacrylamide gel 전기영동을 실시해본 결과 Pa(+)와 Pb(-) 두 종류의 표현형질이 나타났으며, Pa(+)표현형은 44명 (32.59%), Pa(-)표현형은 91명(67.41%)로 나타나 이들의 유전자 빈도를 산출해 보니 Pa+=0.179, Pa-=0.821가 되었다. The polymorphism of phenotypes and allele frequencies of salivary acidic protein were studied on some unrelated individual of Bucheon elementary school students of Kerea. Two phenotypes were observed : Pa(+) and Pa(-). The gene frequencies were as follows ; Pa+=0.179, Pa-=0.821