IL-10 prevents aging-associated inflammation and insulin resistance in skeletal muscle

Dagdeviren, Sezin,Jung, Dae Young,Friedline, Randall H.,Noh, Hye Lim,Kim, Jong Hun,Patel, Payal R.,Tsitsilianos, Nicholas,Inashima, Kunikazu,Tran, Duy A.,Hu, Xiaodi,Loubato, Marilia M.,Craige, Siobhan The Federation of American Societies for Experimen 2017 The FASEB Journal Vol.31 No.2

<P>Altered energy balance and insulin resistance are important characteristics of aging. Skeletal muscle is a major site of glucose disposal, and the role of aging-associated inflammation in skeletal muscle insulin resistance remains unclear. To investigate, we examined glucose metabolism in 18-mo-old transgenic mice with muscle-specific overexpression of IL-10 (M-IL10) and in wild-type mice during hyperinsulinemic-euglycemic clamping. Despite similar fat mass and energy balance, M-IL10 mice were protected from aging-associated insulin resistance with significant increases in glucose infusion rates, whole-body glucose turnover, and skeletal muscle glucose uptake (similar to 60%; P < 0.05), as compared to age-matched WT mice. This protective effect was associated with decreased muscle inflammation, but no changes in adipose tissue inflammation in aging M-IL10 mice. These results demonstrate the importance of skeletal muscle inflammation in aging-mediated insulin resistance, and our findings further implicate a potential therapeutic role of anti-inflammatory cytokine in the treatment of aging-mediated insulin resistance.</P>

The Characteristics of Successful e-marketplaces

Craig Standing 한국경영정보학회 2001 한국경영정보학회 학술대회논문집 Vol.2001 No.-

교회교육 지도자들을 위한 전문지 / 현대 기독교교육사상 5 : 신앙발달과 종교교육

(Craig R . Dykstra),고용수 (역) 장로회신학대학교 기독교교육연구원 1985 교육교회 Vol.- No.114

Tackling Geoenvironmental Problems in the Unsaturated Zone: Principles and Practice

( Craig Benson ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2

Many geoenvironmental problems involve processes in the vadose zone, where flow and transport are complex, and rapid changes in conditions occur spatially and temporally. Historically this complexity made predictions highly uncertain, if not impossible. Advances over the last two decades have led to substantial improvements in characterization of hydraulic and transport properties in the vadose zone and predictions regarding flow and transport, permitting practical design and analysis with relative ease. New standard methods have made extremely tedious and complex measurements more practical and reliable, and new software packages have made predictions expedient. Modern methods used for vadose zone characterization are described, predictive models are presented, and examples are shared where unsaturated hydraulic properties and variably saturated flow modeling have been used to design and evaluate geoenvironmental problems in the vadose zone. The examples include comparisons with field data, demonstrating the strengths of current techniques as well areas in need of additional development.

Contact Lens During the COVID-19 Pandemic

Craig A Woods 대한시과학회 2020 대한시과학회지 학술대회 Vol.2020 No.11

China as the Leader of the Small and Weak: The "Ruoxiao" Nations and Guomindang Nationalism

Craig A. Smith 고려대학교 민족문화연구원 2017 Cross-Currents Vol.0 No.24

Frustrated with the “white imperialism” of the League of Nations and the “red imperialism” of the Third Communist International, a number of Chinese intellectuals began discussing possibilities for a third option during the interwar years. Turning away from liberalism and Marxism, they examined Sun Yat-sen’s Three Principles of the People and began working to promote his Principle of Nationalism as a concept that focused on the ruoxiao (weak and small nations) and could liberate people around the world that were suffering under imperialism. This discourse often centered on the possibility of creating a new form of “International,” the International of Nations, which would unite the oppressed nations of the world in opposition to the imperialist nations, rather than divide nations along class lines, as Chinese critics perceived the Comintern to do. This article examines Chinese intellectual discussions of a China-centered “International” by a variety of writers, including Dai Jitao and Hu Hanmin, from 1925 to 1937. The author shows that, although this discourse on a China-centered “International of Nations” influenced intellectuals’ perceptions of China’s position and responsibility in the world, it was consumed and invalidated by Japanese imperialism, as the Japanese Empire employed a similar discourse of pan-Asianism to justify militarism in the 1930s and 1940s.

Responsible Hermeneutics

Craig G. Bartholomew(크레이그 G. 바돌로뮤) 한국신학정보연구원 2016 Canon&Culture Vol.10 No.2

이 글은 이제 우리가 하나님께 응답할 수 있는 능력을 우리에게 주셨다는 성경해석학을 발전시킬 수 있는 때가 무르익었음을 논증하고자 한다. 그리고 이것을 ‘책임질 수 있는(response-able) 해석학’ 으로 부르고자 한다. 역사를 되돌아 볼 때, 역사비평학은 이와 같은 해석학에 손상을 입혔으므로, 이제 ‘책임질 수 있는 해석학’으로 신학적인 해석의 르네상스를 다시 열 수 있는 새로운 가능성을 생각하게 한다. 특히 이 글은 신학과 철학의 역할에 대하여 특히 초점을 가지고 Kevin Vanhoozer, N. T. Wright, Francis Watson, 그리고 Herman Dooyeweerd의 사상과 씨름하면서, ‘책임질 수 있는 해석학’을 제안한다. This article argues that the time is ripe for us to develop a biblical hermeneutic that takes our God-given capacity to respond to God seriously, what I call a response-able hermeneutic. In the context of the damaging effects of historical criticism on such a hermeneutic and the new possibilities opened up by the renaissance of theological interpretation, this article focuses in particular on the role of theology and philosophy in such a responsible hermeneutic through an engagement with the works of Kevin Vanhoozer, N. T. Wright, Francis Watson and Herman Dooyeweerd. It is argued that insights from rigorous Christian work in philosophy, theology and exegesis will be required for a responsible hermeneutic for today.

TFOS DEWS II Definition and Classification Report

Craig, Jennifer P.,Nichols, Kelly K.,Akpek, Esen K.,Caffery, Barbara,Dua, Harminder S.,Joo, Choun-Ki,Liu, Zuguo,Nelson, J. Daniel,Nichols, Jason J.,Tsubota, Kazuo,Stapleton, Fiona Elsevier 2017 The ocular surface Vol.15 No.3

<P><B>Abstract</B></P> <P>The goals of the TFOS DEWS II Definition and Classification Subcommittee were to create an evidence-based definition and a contemporary classification system for dry eye disease (DED). The new definition recognizes the multifactorial nature of dry eye as a disease where loss of homeostasis of the tear film is the central pathophysiological concept. Ocular symptoms, as a broader term that encompasses reports of discomfort or visual disturbance, feature in the definition and the key etiologies of tear film instability, hyperosmolarity, and ocular surface inflammation and damage were determined to be important for inclusion in the definition. In the light of new data, neurosensory abnormalities were also included in the definition for the first time. In the classification of DED, recent evidence supports a scheme based on the pathophysiology where aqueous deficient and evaporative dry eye exist as a continuum, such that elements of each are considered in diagnosis and management. Central to the scheme is a positive diagnosis of DED with signs and symptoms, and this is directed towards management to restore homeostasis. The scheme also allows consideration of various related manifestations, such as non-obvious disease involving ocular surface signs without related symptoms, including neurotrophic conditions where dysfunctional sensation exists, and cases where symptoms exist without demonstrable ocular surface signs, including neuropathic pain. This approach is not intended to override clinical assessment and judgment but should prove helpful in guiding clinical management and research.</P>

New Zealand

Craig Elliffe 한국국제조세협회 2016 조세학술논집 Vol.32 No.2

Practical Guidance for Knowledge Synthesis: Scoping Review Methods

Craig Lockwood,Kelli Borgessdos Santos,Robin Pap 한국간호과학회 2019 Asian Nursing Research Vol.13 No.5

Scoping reviews are a useful approach to synthesizing research evidence although the objectives and methods are different to that of systematic reviews, yet some confusion persists around how to plan and prepare so that a completed scoping review complies with best practice in methods and meets international standards for reporting criteria. This paper describes how to use available guidance to ensure a scoping review project meets global standards, has transparency of methods and promotes readability though the use of innovative approaches to data analysis and presentation. We address some of the common issues such as which projects are more suited to systematic reviews, how to avoid an inadequate search and/or poorly reported search strategy, poorly described methods and lack of transparency, and the issue of how to plan and present results that are clear, visually compelling and accessible to readers. Effective pre-planning, adhering to protocol and detailed consideration of how the results data will be communicated to the readership are critical. The aim of this article is to provide clarity about what is meant by conceptual clarity and how pre-planning enables review authors to produce scoping reviews which are of high quality, reliability and readily publishable.