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Chung-hum Kim,Soon-Kwon Nam Korean Nuclear Society 1982 Nuclear Engineering and Technology Vol.14 No.1
The nuclear LS-energy matrix elements have been calculated with the harmonic oscillator shell model wave functions for the configurations ( $l_{i}$ $l_{i+1}$| $l_{i}$ $l_{i+1}$) where 1$_1$= $l_{s}$ , $l_2$=lp, $l_3$=ld, 2s, $l_4$=1f, 2p, $l_{5}$ =1g, 2d, 3s. The resulting matrix elements are expressed in terms of both Talmi integrals $I_1$ and Slater integrals $F^{k}$ . In addition to this various sum rules are derived and applied to check the results of the calculations.ons. 조화 단진동자 파동함수를 써서 원자핵의 LS에너지 행열요소를 계산하였다. 범위는 1$_1$= $l_{s}$ , $l_2$=lp, $l_3$=ld, 2s, $l_4$=1f, 2p, $l_{5}$ =1g, 2d, 3s라 ( $l_{i}$ $l_{i+1}$| $l_{i}$ $l_{i+1}$)의 배치에 대한 것이었다. 계산결과는 Talmi적분 $I_1$과 Slater 적분 $F^{k}$ 를 써서 표시하였다. 또 여러가지 합법칙을 유도하고 이를 써서 계산의 결과를 검산하였다.하였다.
Spectrum of rhodopsin mutations in Korean patients with retinitis pigmentosa
Kim, Kwang Joong,Kim, Cinoo,Bok, Jeong,Kim, Kyung-Seon,Lee, Eun-Ju,Park, Sung Pyo,Chung, Hum,Han, Bok-Ghee,Kim, Hyung-Lae,Kimm, Kuchan,Yu, Hyeong Gon,Lee, Jong-Young Molecular Vision 2011 Molecular vision Vol.17 No.-
<P><B>Purpose</B></P><P>To determine the spectrum and frequency of rhodopsin gene (<I>RHO</I>) mutations in Korean patients with retinitis pigmentosa (RP) and to characterize genotype–phenotype correlations in patients with mutations.</P><P><B>Methods</B></P><P>The <I>RHO</I> mutations were screened by direct sequencing, and mutation prevalence was measured in patients and controls. The impact of missense mutations to RP was predicted by segregation analysis, peptide sequence alignment, and in silico analysis. The severity of disease in patients with the missense mutations was compared by visual acuity, electroretinography, optical coherence tomography, and kinetic visual field testing.</P><P><B>Results</B></P><P>Five heterozygous mutations were identified in six of 302 probands with RP, including a novel mutation (c.893C>A, p.A298D) and four known mutations (c.50C>T, p.T17M; c.533A>G, p.Y178C; c.888G>T, p.K296N; and c.1040C>T, p.P347L). The allele frequency of missense mutations was measured in 114 ethnically matched controls. p.A298D, newly identified in a sporadic patient, had never been found in controls and was predicted to be pathogenic. Among the patients with the missense mutations, we observed the most severe phenotype in patients with p.P347L, less severe phenotypes in patients with p.Y178C or p.A298D, and a relatively moderate phenotype in a patient with p.T17M.</P><P><B>Conclusions</B></P><P>The results reveal the spectrum of <I>RHO</I> mutations in Korean RP patients and clinical features that vary according to mutations. Our findings will be useful for understanding these genetic spectra and the genotype–phenotype correlations and will therefore help with predicting disease prognosis and facilitating the development of gene therapy.</P>
간암을 동반한 윌슨병(Wilson`s disease)1 예
김철,김은주,김대중,김홍수,이문호,김선주,박상흠,정일권,남기룡 대한소화기학회 1999 대한소화기학회지 Vol.33 No.3
Wilson's disease is an autosomal inherited disorder of copper metabolism; impaired copper excretion into the bile leads to copper accumulation in liver, brain and other organ. Hepatocellular carcinoma (HCC) has rarely been reported as a sequele of Wilson' s disease. It has been shown experimentally that copper has an inhibitory effect on the factors responsible for HCC development in rats, and the low prevalance of HCC in case with Wilson' s disease may result from hepatic copper deposition which has been postulated to have a protective effect against hepatic oncogenesis. The clinica features of these cases are characterized by relatively advanced age at diagnosis, the presence of cirrhosis and a male predominance. It is suggested that hepatic copper content in the patient with Wilson' s disease who was treated with penicillamine and subsequently developed HCC may be decreased toward a nonprotective range in response to penicillamine therapy. We report the one case of patient with Wilson' s disease combined with HCC.
Park, Chan Hum,Kim, Dae Hyun,Park, Min Hi,Kim, Mi Kyung,Kim, Nam Deuk,Kim, Cheol Min,Tanaka, Takashi,Yokozawa, Takako,Chung, Hae Young,Moon, Hyung Ryong Institute for Advanced Research in Asian Science a 2014 The American journal of Chinese medicine Vol.42 No.4
<P>This study examined whether Kangen-karyu and its crude drug, Salviae Miltiorrhizae Radix, have a reno-protective effect on the age-related oxidative stress and inflammatory response through the phosphoinositide 3-kinase (PI3K)/Akt or mitogen-activated protein kinase (MAPK) pathways in aged rats. Kangen-karyu or Salviae Miltiorrhizae Radix (20 mg/kg body weight/day) was administered orally to old groups of rats for 16 days, and their effects were compared with the vehicle-treated old and young rats. The administration of Kangen-karyu caused a slight decrease in the serum glucose level and a significant decrease in the serum insulin level in the old rats. The increased levels of serum renal functional parameter (urea-nitrogen) and oxidative parameter were significantly reduced by both Kangen-karyu and Salviae Miltiorrhizae Radix. The old rats exhibited a dysregulation of the protein expression related to insulin resistance, oxidative stress, and inflammation in the kidneys, but Kangen-karyu administration significantly reduced the expression of the inflammatory proteins through the PI3K/Akt pathway. On the other hand, the Salviae Miltiorrhizae Radix-treated old rats showed a decrease in the inflammatory cytokines through the MAPK pathway. These results provide important evidence that Kangen-karyu and Salviae Miltiorrhizae Radix have a pleiotropic effect on the PI3K/Akt and MAPK pathways, showing renoprotective effects against the development of inflammation in old rats. This study provides scientific evidence that Kangen-karyu and Salviae Miltiorrhizae Radix improve the inflammatory responses via the PI3K/Akt or MAPK pathways in the kidney of old rats.</P>
Se Joon Woo,Hum Chung,서종모,Jung Hyun Park,Su Jin Kim,Jae-Sung Lee,Yu-Kyeong Kim,Jing Ai Zhou,Eui Tae Kim,Sung June Kim 대한의용생체공학회 2012 Biomedical Engineering Letters (BMEL) Vol.2 No.2
Purpose Using 18F- fluorodeoxyglucose positron emission tomography (FDG PET), we aimed to assess the cortical areas activated by light and electrical stimuli in rabbits and to determine the nature of the electrically evoked visual perception by comparing the 2 activated cortical images. Methods Three adult white rabbits were used, and 5 18F -FDG PET scans were performed on 5 different days for each rabbit: a resting image, 2 light stimulation images, and 2electrical retinal stimulation images by suprachoroidal electrodes of the right and left eyes. A small-animal PET scanner (resolution: 1.18 to 1.45 mm) was used for image acquisition. Activated cortical areas were determined by voxel-wise statistical analysis of the difference between the stimulation and resting PET images, and three-dimensional brain imaging of functional activation was constructed. Results After visual and electrical stimulation of the rabbit retina, increased metabolism was found in 2 distinct cerebral cortical areas: (1) the ipsilateral frontal cortex (frontal eye field) and (2) the contralateral occipito-parietal cortex (visual cortex). Cortical areas activated after electrical retinal stimulation were nearly identical to the visually activated cortical areas. Conclusions Electrical stimulation of the rabbit retina using suprachoroidal electrodes induced a similar cortical activation response as that induced by light stimulation. Brain PET images obtained from stimulation of the retina with light and electric current increase our understanding of cortical perceptions by both stimuli and can be a useful methodology for retinal prosthesis research.
NOH, KYUNG KYUN,CHUNG, KI WUNG,SUNG, BOKYUNG,KIM, MIN JO,PARK, CHAN HUM,YOON, CHANGSHIN,CHOI, JAE SUE,KIM, MI KYUNG,KIM, CHEOL MIN,KIM, NAM DEUK,CHUNG, HAE YOUNG Spandidos Publications 2015 MOLECULAR MEDICINE REPORTS Vol.12 No.3
<P>In the Orient, loquat (Eriobotrya japonica) extract (LE) is widely used in teas, food and folk medicines. The leaves of the loquat tree have been used for generations to treat chronic bronchitis, coughs, phlegm production, high fever and gastroenteric disorders. One of the major active components of loquat leaves is ursolic acid, which was recently investigated in the context of preventing muscle atrophy. The present study investigated the therapeutic potential of LE on dexamethasone?induced muscle atrophy in rats. Daily intraperitoneal injections of dexamethasone caused muscle atrophy and evidence of muscle atrophy prevention by LE was demonstrated using various assays. In particular, dexamethasone?induced grip strength loss was alleviated by LE and the increase in serum creatine kinase activity, a surrogate marker of muscle damage, caused by dexamethasone injection was reduced by LE. Western blot analysis and immunoprecipitation demonstrated that dexamethasone markedly increased the protein expression levels of muscle ring finger 1 (MuRF1), which causes the ubiquitination and degradation of myosin heavy chain (MyHC), and decreased the protein expression levels of MyHC as well as increased the ubiquitinated MyHC to MyHC ratio. However, LE reduced the dexamethasone?induced protein expression levels of MuRF1 and ubiquitinated MyHC. Additional experiments revealed that LE supplementation inhibited the nuclear translocation of FoxO1 induced by dexamethasone. These findings suggested that LE prevented dexamethasone?induced muscle atrophy by regulating the FoxO1 transcription factor and subsequently the expression of MuRF1.</P>