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- 저자 : Chou, Namsun (검색결과 739 건)
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Cho, U.,Mete, O.,Kim, M. H.,Bae, J. S.,Jung, C. K. Nature Publishing Group 2017 Modern pathology Vol.30 No.6
<P>Thyroid tumors formerly classified as non-invasive encapsulated follicular variant of papillary thyroid carcinoma were recently renamed 'non-invasive follicular thyroid neoplasm with papillary-like nuclear features'. The current study investigated the frequency of lymph node metastasis and mutational profile of encapsulated follicular variant in the setting of a clinical practice where central neck dissection was the standard of practice. We defined the impact of rigid diagnostic criteria by regrouping such tumors based on the complete absence of papillae or presence of <= 1% papillae. Of a total of 6,269 papillary thyroid carcinomas, 152 tumors fulfilled the criteria for encapsulated follicular variant. The results were stratified according to two different diagnostic cutoff criteria with respect to the extent of papillae. When the cutoff of 1% papillae was used, the rates of lymph node metastasis and BRAF(V600E) mutation were 3% and 10% in non-invasive tumors and 9% and 4% in invasive tumors, respectively. Despite the lack of invasive growth, one patient with BRAF(V600E) mutant-tumor displaying predominant follicular growth and subtle papillae developed a bone metastasis. When absence of papillary structure was applied as rigid diagnostic criteria, no BRAF(V600E) mutation was found in all tumors. However, central lymph node micrometastasis still occurred in 3% of non-invasive tumors. Non-V600E BRAF and RAS mutations were detected in 4% and 47% of non-invasive tumors, respectively. Our findings suggest that non-invasive follicular thyroid neoplasm with papillary-like nuclear features should not be regarded as a benign thyroid neoplasm as it can present with lymph node micrometastasis and should not be diagnosed in the presence of even a single papillary structure. Our findings underscore the original American Thyroid Association recommendation that defined non-invasive encapsulated follicular variants as low risk thyroid cancers. Clinical surveillance similar to low risk differentiated thyroid cancers and capture of this diagnostic category by Cancer Registries should be considered.</P>
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Po-Han Chou(Po-Han Chou),Alexander T. Sack(Alexander T. Sack ),Kuan-Pin Su(Kuan-Pin Su) 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4
Repetitive transcranial magnetic stimulation (rTMS) has been widely used as a therapy for refractory obsessive-compulsive disorder (OCD). However, it remains unclear which exact target and stimulation sequence of rTMS is most effective for OCD. Here, we report the case of an 18-year-old female with treatment-refractory OCD whose symptoms markedly improved after combined rTMS and intermittent theta-burst stimulation over the bilateral dorsolateral prefrontal cortex and supplementary motor area. Our report indicates that combining treatment sequences that stimulate different brain regions sequentially is feasible and may clinically benefit patients suffering from OCD.
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Chou, Wen-Chung 이화여자대학교 음악대학 1991 音樂藝術論壇 Vol.- No.1
현대주의가 혁신의 새로운 세계로 부터 태어나고, 현대음악이 높은 궤도에 도달했을 때 그 진로는 오랜 전통으로 부터 이끌어진 것이다. 서양 문명의 마지막 거점으로 부터 동양의 음악적 아이디어(idea)가 아직도 새로운 것일 때부터, 동양 뿐만 아니라 서양의 음악적 아이디어가 다시 새롭게 조사되는 속에서, 문화적 교차로 인한 풍요로움의 중심지를 인도되는 과정을 Claude Debussy의 Syrinx(1913), Edgard Varese의 Density 21.5(1936), Luciano Berio의 Sequenza(1958), 그리고 Chou Wen-Chung의 Cursive(1963), 이상 4현대 풀룻 독주 작품을 통하여 설명하고 있다.
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Chung-Che Chou,Gee‑Jin Yu,Kung‑Juin Wang,Wei‑Tze Chang,Chiun‑Lin Wu,Charlene Chin‑Jie Zhao,Chun‑Yao Yang,Ming‑Ti Chou 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.9
This paper presents a study to investigate the feasibility of using robotic welding technologies to weld the continuity plate and the column flange plate during manufacturing steel built-up box columns in buildings. Specimens designed to emulate the key components in the steel beam-to-column moment connections for Special moment frame were fabricated and welded using a proposed automated procedure that performs multi-layer, multi-pass welding for thick steel plates. Effects of controlling parameters on robotic welding results that includes the manner of bead stacking, wire feed speed, travel speed, working angle, arc voltage, the path of the welding pass, and the methods to start and finish welding passes were investigated. The quality of the welded products was assessed by visual inspection and ultrasonic testing (UT). Further mechanical tests including tensile tests, bending tests, and cyclic loading tests were carried out on selected welded products that passed the UT examination. The test results indicated that the robotic welds showed no visible damage or cracks, met requirements specified in the AWS specification, and exhibited satisfactory strength and ductility.
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Chu-Chung Chou,Jai-Sing Yang,Hsu-Feng Lu,Siu-Wan Ip,Chyi Lo,Chih-Chung Wu,Jing-Pin Lin,Nou-Ying Tang,Jing-Gung Chung,Ming-Jen Chou,Ying-Hock Teng,Dar-Ren Chen 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.8
Dietary polyphenols have been correlated with a reduced risk of developing cancer. Quercetin (a natural polyphenolic compound) induced apoptosis in many human cancer cell lines, including breast cancer MCF-7 cells. However, the involvement of possible signaling pathways and the roles of quercetin in apoptosis are still undefined. The purpose of this study was to investigate the effects of quercetin on the induction of the apoptotic pathway in human breast cancer MCF-7 cells. When MCF-7 cells were treated with quercetin for 24 and 48 h and at various doses (10-175 μM), cell viability decreased significantly in time- and dose-dependent manners. Exposure of MCF-7 cells to 10-175 μM quercetin resulted in an approximate 90.25% decrease in viable cells. To explicate the mechanism underlying the antiproliferative effect of quercetin, cell cycle distribution and apoptosis in MCF-7 cells was investigated after exposure to 150 μM quercetin for 6-48 h. Quercetin caused a remarkable increase in the number of S phase (14.56%to 61.35%) and sub-G1 phase cells (0.1% to 8.32%) in a dose- and time-dependent manner. Quercetin caused S phase arrest by decreasing the protein expression of CDK2, cyclins A and B while increasing the p53 and p57 proteins. Following incubation with quercetin for 48 h, MCF-7 cells showed apoptotic cell death by the decreased levels of Bcl-2 protein and ΔΨ m and increased activations of caspase-6, -8 and -9. Moreover, quercetin increased the AIF protein released from mitochondria to nuclei and the GADD153 protein translocation from endoplasmic reticulum to the nuclei. These data suggested that quercetin may induce apoptosis by direct activation of the caspase cascade through the mitochondrial pathway in MCF-7 cells.
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David Jiyao Chou,Kelly Yinching Lam,Jianping Chen,Ping Yao,Tina Tingxia Dong,Aizhen Xiong,Guixin Chou,Zhengtao Wang,Karl Wah-Keung Tsim 셀메드 세포교정의약학회 2014 셀메드 (CellMed) Vol.4 No.4
Linderae Radix, the dry roots of Lindera aggregata (Sims) Kosterm, has long been used as traditional Chinese medicine for treatment of inflammatory diseases. The total alkaloids are believed to be the active components responsible for anti-inflammation of Linderae Radix. Here, the total alkaloids of Linderae Radix were extracted and isolated, including 12 isoquinoline alkaloids and 1 furan sesquiterpene. Within the alkaloids, norisoboldine, boldine, linderaline, isoboldine, reticuline, N-methyllaurotetanine, norjuziphine were found to be the major ingredients. In lipopolysaccharide-treated macrophage RAW 264.7 cells, application of Linderae Radix extract, or total alkaloids, suppressed the transcription of pro-inflammatory cytokines, interleukin-1β and interleukin-6. Out of the 12 alkaloids, norisoboldine, boldine, and isoboldine were tested in lipopolysaccharide-treated macrophages, and norisoboldine was the strongest alkaloid in suppressing the cytokine expressions. The current studies suggested that the identification of alkaloids from Linderae Radix could provide a plausible explanation for herbal therapeutic functions.
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Shen-En Chou,Cheng-Hsi Yeh,Shun-Yu Chi,Fong-Fu Chou,Yi-Ju Wu,Yen-Hsiang Chang,Yi-Chia Chan 대한외과학회 2024 Annals of Surgical Treatment and Research(ASRT) Vol.107 No.3
Purpose: Preoperative localization plays an important role in secondary hyperparathyroidism (SHPT) surgery. The advantages of neck ultrasound (US) include high availability and low cost. However, the reported sensitivity of US is 54%– 76%, and the reason for missed parathyroid glands (PGs) on US has been rarely addressed. Methods: Fifty-four patients who were diagnosed with renal SHPT from September 2020 to March 2022 were included in this retrospective study. Preoperative localization included surgeon-oriented US and technetium 99m-sestamibi single- photon emission CT (SPECT)/CT. Results: A total of 212 PGs were pathologically confirmed, resulting in a success rate of 96.2% (52 of 54). Using echo, 193 PGs (91.0%) were accurately localized, while 19 glands (9.0%) were not identified, including those in ectopic positions (n = 12, at thymus or intrathyroid or others), of small size (<1 cm, n = 6), or overlapping with an ipsilateral PG (n = 1). US accurately detected 4 PGs in 36 (66.7%) patients, while SPECT/CT localized 4 glands in 19 patients (35.2%). Although the number of US-detectable PGs was not associated with success rate, it showed a significant negative correlation with surgical time (rs = –0.459, P = 0.002). Conclusion: US detected 4 glands in 66% of SHPT patients with a sensitivity of 90% for localization. Ectopic position and small size were the most common reasons for the failure to detect PG on US. Complete preoperative echo localization might shorten operating time.
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