Cytosolic Hsp60 orchestrates the survival and inflammatory responses of vascular smooth muscle cells in injured aortic vessels

Choi, Boae,Choi, Mina,Park, Charny,Lee, Eun Kyung,Kang, Dong Hoon,Lee, Doo Jae,Yeom, Jae Yoon,Jung, Yeonjoo,Kim, Jaesang,Lee, Sanghyuk,Kang, Sang Won Oxford University Press 2015 Cardiovascular research Vol.106 No.3

<P><B>Aims</B></P><P>Pro-inflammatory response of vascular smooth muscle cells (VSMCs) is triggered by endothelial damage and a causative step for thrombosis and neointimal thickening in the injured arterial vessels. Therefore, we investigate a role of cytosolic Hsp60 as a novel pro-inflammatory mediator in VSMCs.</P><P><B>Methods and results</B></P><P>Hsp60 was detected in the cytosol of VSMCs. The selective depletion of cytosolic Hsp60 in VSMCs reduced the IκB kinase activation, repressed the induction of nuclear factor (NF)-κB-dependent survival genes (MnSOD and Bfl-1/A1), and enhanced apoptotic death in response to TNF-α. Moreover, a quantitative RNA sequencing revealed that the expression of 75 genes among the 774 TNF-α-inducible genes was significantly reduced by the depletion of cytosolic Hsp60. In particular, the expression of pro-inflammatory cytokines/chemokines, such as CCL2, CCL20, and IL-6, was regulated by the cytosolic Hsp60 in VSMCs. Finally, the depletion of cytosolic Hsp60 markedly inhibited the neointimal thickening in the balloon-injured arterial vessels by inducing apoptotic cell death and inhibiting chemokine production.</P><P><B>Conclusions</B></P><P>This study provides the first evidence that cytosolic Hsp60 could be a therapeutic target for preventing VSMC hyperplasia and inflammatory response in the injured vessels.</P>

Association Between Hearing Level and Mental Health and Quality of Life in Adults Aged >40 Years

Choi Yeonjoo,Go Junyong,Chung Jong Woo 대한청각학회 2024 Journal of Audiology & Otology Vol.28 No.1

Background and Objectives: In this study, we investigated the effects of hearing loss on mental health and quality of life (QoL) using survey data in adults aged >40 years.Subjects and Methods: We obtained data from 10,921 individuals who responded to the fifth Korean National Health and Nutrition Examination Survey. Primary outcomes were measured using questionnaires that recorded stress perception, depressive mood, and suicidal ideation to evaluate mental health and motor ability, self-management, activities of daily living, pain or discomfort, and anxiety or depression to evaluate QoL.Results: On multivariate analysis, suicidal ideation was more prevalent among older adults with hearing loss than in older adults without hearing loss. Motor ability was lower in individuals with hearing loss of >20 dB than in older adults with normal hearing. Categorization of the EuroQol-5 Dimension (EQ-5D) health state into upper and lower groups showed that the EQ-5D values were lower in the moderate-tosevere hearing loss group than in the mild hearing loss group.Conclusions: Among adults aged >40 years, those with hearing loss experienced more suicidal ideation, had lower motor ability, and lower overall QoL compared with these variables in older adults with normal hearing. Additionally, QoL scores were low in individuals with poor hearing.

Cardiopulmonary Resuscitation in cancer patients -Is it really necessary and unavoida ble?

( Yeonjoo Choi ),( Jin Won Kim ),( Beo-deul Kang ),( Ji-won Kim ),( Se-hyun Kim ),( Jeong-ok Lee ),( Yu Jung Kim ),( Keun-wook Lee ),( Jee Hyun Kim ),( Soo-mee Bang ),( Jong Seok Lee ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1

Introduction: In-hospital cardiopulmonary-resuscitation (CPR) is one of the disastrous situations. There are concerns whether patients in a palliative phase of cancer are the candidate for CPR or not. The avoidance of unnecessary CPR is important issues in palliative care of cancer. Methods: We reviewed medical records of division of hematology and medical Oncology, department of Internal Medicine in Seoul National University Bundang Hospital and analyzed characteristics of CRP situations from March 2003 toJune 2015. Total a 137 patients with cancer happened cardio-pulmonary- arrest and were given CPR including cardiac massage, intubation, DC cardioversion and intensive care unit treatment. We used modified pre-arrest morbidity (mPAM) score to evaluate medical conditions which result in arrest. Results: The mean age was 67 years (range, 39 99). Eighty eight patients (64.2%) were men and 50 patients (36.4%) were women. The primary malignancies were acute leukemia in 13 patients (9.4%), lung cancer in 40 patients (29.1%), lymphoma in 20 patients (14.6%), gastric cancer in 23 patients (16.7%), and other tumor type in 42 patients (30.2%). The causes of arrest were asphyxia from pulmonary aspiration in 15 patients (10.9%), cancer-related bleeding in 21 patients (15.3%), infection related chemotherapy in 23 patients (16.7%), infection not-related chemotherapy in 13 patients (9.4%), cancer progression in 33 patients (24.0%) and other causes in 34 patients (24.8%). The mean of mPAM score was 1.35. The 52 patients (37.9%) were given unnecessary CPR. Of unnecessary CPR, their relatives wanted resuscitation in 4 (2.9%). 85 patients (62.0%) received necessary CPR because they were on chemotherapy cycle or had chemotherapy plans. However, first return of spontaneous circulation (ROSC) rate was 43.7%, but re-arrest happened to most of them. So in-hospital survival rate was 8.7%. Discussions: The prognosis in patients who received CPR in palliative care of cancer was poor. Therefore, we should make an effort to avoid arrest events.

전정편두통 환자에서 비디오 두부충동검사로 확인되는 반고리관의 이상 소견과 증상 호전과의 관계

Ji Won Choi,Won Sub Lim,Sung Seok Ryu,Yeonjoo Choi,Sang Hun Lee,Seung Cheol Ha,Hong Ju Park 대한평형의학회 2022 Research in Vestibular Science Vol.21 No.2

Objectives: Video head impulse test (vHIT) can evaluate function of the vestibulo- ocular reflex for high frequency range of head rotation. We aimed to characterize the abnormal patterns of canal dysfunction by vHIT in vestibular migraine (VM) and evaluate the relationship between the presence of canal dysfunction and symptomatic improvement. Methods: Eighty-seven patients with VM were included. Abnormality of vHIT at the initial examination was determined by the vHIT gain and the degrees of the corrective saccades at each canal and each side. The relationship between the abnormal patterns and the symptomatic improvement (no need for preventive medication) after modification of life styles and preventive medications for 1, 3, and 6 months was evaluated. Results: Abnormal vHIT of the lateral canal was 13.8% when determined by the gain criteria and 31.0% when based on both gain and corrective saccade, regard-less of the side. Abnormal vHIT of the superior and posterior canals were 18.4% and 27.6%, regardless of the side. Abnormal vHIT at any canal and side was ob-served in 47%. Patients showed symptomatic improvement in 29.9%, 71.3%, and 88.5% after modification of life styles and preventive medications for 1, 3, and 6 months. Abnormal vHIT results of canals were significantly related to the poor response to preventive mediations. Conclusions: Prolonged preventive medication was required for symptomatic im-provement in VM patients when vHIT results of any canals were abnormal, sug-gesting that peripheral vestibular abnormality is closely related to the pathophy-siology of vestibular migraine.

WHAT TRIGGERS CUSTOMER EMOTION IN THE LUXURY RETAIL SETTING: CUSTOMER EMOTION BEFORE VS. AFTER ENTERING A LUXURY SHOP AND ITS CUSTOMER EFFECT

Sooyun Kim,Geebum Park,Yeonjoo Lee,Sunmee Choi 글로벌지식마케팅경영학회 2015 Global Fashion Management Conference Vol.2015 No.06

Customer emotion evoked during shopping is closely linked to customers’ central attitude toward the brand. Few studies, however, have examined what type of customer emotion is triggered at what stage of shopping by what factors, particularly in the luxury fashion retail context. This study intends to fill this gap in the research. To differentiate between customer emotions displayed before and after entering a luxury shop, we first identified what emotions are displayed at each stage and what factors triggered such emotions. We then examined the impact of customer emotions at each stage on customer responses, such as evaluations of service quality and brand attitude. Further, we attempted to identify patterns in the change in the type of customer emotions between before and after entering a luxury shop (i.e., from positive to negative or from negative to positive) and examined their effect on brand attitude. We collected 298 valid responses through a self-administered survey among luxury shop visitors in a major duty free complex in Seoul, Korea. The results show that customers display diverse emotions prior to entering a luxury shop. When customers were divided into four emotion groups (positive emotions only, mixed emotions, negative emotions only, no emotion), the positive emotion only group was the largest. As for specific emotions, happiness, contentment, and feeling comfortable were the three most experienced emotions. Negative emotions such as fear or shame were rarely experienced. Brand familiarity affected the type of emotion customers felt. While customers with high brand familiarity tended to feel privileged and comfortable, those with low brand familiarity tended to feel fear and shame. The emotions customers felt also differed by the shopping motive. When the motive was browsing only, customers tended to feel shame. When purchasing was a part of the motive, they tended to feel comfortable. Customer emotions displayed after entering a luxury shop were also diverse. The positive emotion only group was the largest, but it was not as large in the case of emotions felt prior to entering the shop. The effect of the retail service quality (RSQ) dimensions on in-store emotions varied depending on the specific emotion. The RSQ dimensions of "reliability" and "physical aspect" influenced the greatest number of in-store customer emotions. The moderating effect of brand familiarity was significant. The number of emotions affected significantly by RSQ dimensions was higher with the group with low familiarity. The moderating effect of the shopping motive was also significant. The RSQ dimensions that influenced emotion differed by the shopping motive. In terms of the effect of in-store emotions on brand attitude, it differed by the specific emotion. A significant effect was only present in three positive emotions (happiness, pride, privileged) and one negative emotion (anger). This implies that not all in-store emotions are equally influential on customer attitude. As for the effect of emotion change pattern on brand attitude, due to a large difference in the sample size of the emotion change pattern group (positive to positive (PP), positive to negative (NP), negative to positive (NP), negative to negative (NN)), we could not conduct a meaningful statistical analysis but could only observe some directions and tendencies. The brand attitude of the NP group tended to be higher than that of the PP group. This study contributes academically by extending the research on customer emotion, particularly in the luxury fashion retail context, in three ways. Firstly, we differentiated customer emotion before and after entering a shop. Secondly, we identified the triggers for specific emotions. Thirdly, we attempted to identify and examine the patterns of changes in customer emotion between before and after entering a shop and the impact of this pattern on customer responses. Managerially, this study contributes in two ways. Firstly, we demonstrated the importance of managing customer emotion at various stages of shopping at a specific emotional level. Secondly, we showed what factors should be managed for a particular customer emotion. Our research could be further extended in several ways. Customer experience research has shown that other customers present in the service setting can influence customer emotion; hence, in a luxury retail store, the degree of customers’ sense of compatibility with other customers may affect customer emotion and therefore should be explored. Another factor for future consideration is gender. Extant research in a luxury setting shows that the characteristics of luxury consumption tend to vary by gender. Considering that males’ luxury consumption is increasing, the difference in customer emotions based on gender might be worth investigating.

Characteristics and Treatment Trends for Emphysematous Pyelonephritis in Korea: A 10-Year Multicenter Retrospective Study

최승권(Seung-Kwon Choi),유구한,Jeong Woo Lee,Seung Il Jung,Eu Chang Hwang,Joongwon Choi,김웅빈,Jung-Sik Huh,최진봉,Yeonjoo Kim,Jae Min Chung,Ju-Hyun Shin,정재흥,정홍,배상락,김태형 대한요로생식기감염학회 2021 Urogenital Tract Infection Vol.16 No.2

Purpose: This study examined the characteristics, current treatment trends, and outcomes of patients with emphysematous pyelonephritis (EPN) in Korea. Materials and Methods: Two hundred and seventeen patients diagnosed with EPN were evaluated using abdominal computed tomography in 2011-2021 at 15 institutes in Korea. The patients’ demographic and clinical characteristics, treatment modalities, and treatment outcomes were analyzed. The total study period was divided arbitrarily into groups A (2011-2014), B (2015-2017), and C (2018-2021) to analyze the trends in the EPN treatment. Results: The mean age of the patients was 65.1 years; there were more female patients (74.2%) than male patients. The overall mortality rate was 10.6%. Ninety-five (43.8%), 98 (45.2%), and 24 (11.0%) patients were treated with medical, minimally invasive, and surgical management, respectively; the corresponding mortality rates were 13.7%, 6.1%, and 16.7%. There was no significant change in the proportion of patients treated with medical management over time (group A=46.5%, group B=47.0%, and group C=38.8%). The proportion of patients treated with minimally invasive management gradually increased over time (group A=35.2%; group B=43.9%; group C=55.0%), while those who underwent surgical management decreased gradually over time (group A=18.3%, group B=9.1%, and group C=6.3%). No differences in mortality rates were observed between the groups. Conclusions: EPN with medical and minimally invasive management had a relatively high treatment success rate, which increased gradually, while surgical management decreased gradually over time in Korea. The mortality rate was relatively lower than that reported in studies published before the 2010s.

배가스 내 미세먼지 제거를 위한 정전분무 습식 전기집진 기술에 대한 연구

조연주(Yeonjoo Cho),김소연(Soyeon Kim),임현정(Hyunjeong Lim),김찬중(Chan Joong Kim),최상미(Sangmi Choi),김민성(Minsung Kim) 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.11

With increased dust pollution, enforcement on air pollution regulation is expected thus bringing forth the need for a better particulate removal process. This paper capitulates on electrostatic spraying for its use in particulate matter removal. The range of appropriate voltage and solution concentration together is often referred to as the `Stability Island`. In this study, the influence of geometric and chemical factors on the stability island is analyzed. Effect of each variable in a 8 step vertical nozzle design will be illustrated. The suitable range of nozzle geometry and solution concentration pair will be investigated.

A superconducting joint for GdBa2Cu3O7−δ-coated conductors

Park, Yeonjoo,Lee, Myungwhon,Ann, Heesung,Choi, Yoon Hyuck,Lee, Haigun Springer Science and Business Media LLC 2014 NPG Asia Materials Vol.6 No.5

2015 개정 교육과정의 통합과학 및 통합사회 교과서에 제시된 과학기술관련 사회쟁점 비교분석

최지연(Choi, Jiyun),고연주(Ko, Yeonjoo),이현주(Lee, Hyunju) 학습자중심교과교육학회 2019 학습자중심교과교육연구 Vol.19 No.16

본 연구는 2015 개정 교육과정 통합과학과 통합사회 교과서에 제시된 과학기술관련 사회쟁점(SSI)을 비교분석하는 것을 목적으로 한다. 통합과학 교과서 5종과 통합사회 교과서 5종을 분석대상으로 하였으며, 교과서에 등장한 SSI 소재를 추출한 후 각 소재를 내용, 제시 관점, 교수학습방법의 세 차원에서 분석해보았다. 연구 결과는 다음과 같다. 첫째, 교과서에 제시된 SSI 소재는 내용차원에 따라 11가지 영역으로 범주화되었으며, 생명 다양성 보존, 환경오염, 에너지 등의 주제가 빈번하게 제시되 었다. 또한 통합과학과 통합사회 교과서 모두 SSI 소재를 제시함에 있어 개인적, 세계적 수준의 맥락보다는 사회적 맥락에 해당하는 내용을 주로 소개하고 있었다. 둘째, SSI 소재에 드러난 주요 제시관점을 분석한 결과, 통합과학은 환경적, 과학적 관 점을 주로 제시한 반면, 통합사회는 환경적, 사회적, 정책적 관점이 다수를 차지하였다. 셋째, SSI 소재와 관련된 교수학습방법을 분석한 결과, 통합과학과 통합사회 모두 토의토론, 발표, 글쓰기 등의 교실기반 활동이 주를 이루었으며, 학생들의 실천과 참여를 유도하는 교수학습활동은 다소 적은 것으로 드러났다. 본 연구의 결과는 교사들이 효과적인 SSI 수업을 계획하고 진행하는 데 시사점을 제공할 것으로 기대된다. This study aimed to analyze the socioscientific issues (SSI) presented in the 2015 revised integrated science and social studies textbooks, and to compare SSI in terms of contents, perspectives, and instructional activities. Five integrated science textbooks and five integrated social studies textbooks were examined, and SSI topics were extracted from the textbooks and categorized based on the criteria. The results were as follows. First, SSI topics were categorized into 11 content areas, and among them, biodiversity conservation, environmental pollution, and environment-friendly energy development were frequently presented in both science and social studies textbooks. Additionally, integrated science and social studies textbooks introduced SSI largely from societal contexts rather than individual and global contexts. Second, integrated science textbooks mostly emphasized environmental and scientific perspectives, whereas integrated social studies textbooks focused on environmental, social, and political perspectives. Third, both textbooks somewhat limited to provide classroom-based activities such as discussion, presentation, and writing; only few activities lead the students take responsible actions. This study will contribute to the effective use of SSI in classes.

자유학기제 영어 수업에 대한 중학생 및 교사의 인식 분석

최은아 ( Choi Eun-a ),정연주 ( Jung Yeonjoo ) 한국외국어대학교 외국어교육연구소 2021 외국어교육연구 Vol.35 No.2

본 연구는 자유학기제 영어 수업에 대한 중학생 및 교사의 인식을 파악하는 데 목적이 있다. 이를 위해 중학교 1, 2학년을 대상으로 설문조사를 실시하고, 중학교 영어교사 8명을 대상으로 면담을 실시하였다. 자료 수집은 2019년 12월부터 2020년 2월까지 이뤄졌으며 설문조사 응답은 신뢰도 검증과 기술통계 분석을 통해 결과를 도출하였고, 면담은 반구조적 방식으로 진행한 후 녹음된 자료를 전사하여 주제별로 분석하였다. 연구결과 자유학기 영어 수업에 대해 중학생과 교사는 대체적으로 긍정적인 인식을 갖고 있었다. 특히 수업의 참여도가 높아져 적극적이고 활발한 수업 분위기가 형성된 점이 학생과 교사 모두에게 긍정적인 요소로 꼽혔다. 그러나 학생들은 적성 및 소질 발견, 진로 탐색, 자기주도 학습 측면에서 자유학기 영어 수업이 효과적이지 못한 것으로 인식하였다. 학생들이 현장체험활동과 같은 유형의 수업을 가장 선호하였으므로 교실 밖의 실제 환경에서 영어에 노출될 기회를 더욱 제공하면 좋을 것이다. 한편 교사들은 평가에 대한 어려움을 호소하였고 협동학습의 효과와 자유학기 연계에 대해 회의적이었다. 따라서 좀 더 현실성 있는 교수법에 대한 충분한 연수 제공이 요구되며 평가방식의 개선을 통해 교사의 업무 부담을 줄이고 평가결과의 활용도를 높여 학습효과 단절에 대한 우려를 감소시킬 필요가 있겠다. This study analyzed the perceptions of middle school students and teachers towards the English curriculum during a Free Semester Program. For the research, 541 Korean middle school students participated in the survey, and eight English teachers were interviewed. The results are as follows: First, students perceived that the free-semester English classes are student-centered, providing ample opportunities for cooperation. However, most students failed to engage in self-directed learning. Second, teachers perceived that the advantages of the Free Semester Program were a resulting decrease in the burden of the examination and greater teacher autonomy in devising the contents of classes. However, problems with the program included inducing lower-level students’ participation and organizing classes with suitable difficulty. Moreover, it was burdensome to record a vast amount of formative assessments for each student. Third, teachers emphasized learning the core concepts of the first-year course in order for the free and general semesters to be well connected. They also emphasized the importance of strengthening standard academic levels and giving students a chance to adjust to the examination.