방광경부 현수술후 봉합사에 의해 발생된 재발성 방광결석

유구한,안규일,장성구 경희대학교 2006 慶熙醫學 Vol.22 No.1

Stress urinary incontinence is a common problem which can be corrected surgically. Burch colposuspension is one of successful operation performed for stress urinary incontinence. We report a patient who presented urgency, tenesmus, frequency, dysuria after Burch colposuspension. Any patients with unexplained lower urinary tract symptoms following Burch colposuspension must be evaluated radiologically and urologically to find iatrogenic bladder stone.

Association of IL10, IL10RA, and IL10RB Polymorphisms with Benign Prostate Hyperplasia in Korean Population

유구한,김수강,정주호,장성구 대한의학회 2011 Journal of Korean medical science Vol.26 No.5

Cytokines such as interleukin 10 (IL10) may play an important role in the process of inflammation. The aim of this study was to analyze the association between IL10, IL10RA and IL10RB single nucleotide polymorphisms (SNPs), and benign prostate hyperplasia (BPH)in Korean population. All patients with BPH were divided into two groups according to international porostate symptom score (IPSS), prostate specific antigen (PSA) level, Q_max,and prostate volume. We selected two IL10 SNPs (rs1518111 and rs1554286), three IL10RA SNPs (rs2256111, rs4252243, and rs2228054), and two IL10RB SNPs (rs999788 and rs2834167). Genotypes of seven SNPs were determined through direct sequencing. The G/G genotype of IL10RB polymorphism (rs2834167) was associated with a high PSA level compared with the A/G + A/A genotypes (P = 0.009). Of IL10 SNP, the A/A genotype of rs1518111 and T/T genotype of rs1554286 were associated with small prostate volume,respectively (P = 0.011, P = 0.014). Moreover, the T/T genotype of IL10RB polymorphism (rs999788) was associated with high prostatic volume compared with the T/C + C/C genotypes (P = 0.033). The linkage disequilibrium (LD) blocks were formed in IL10 and IL10RA. However, haplotypes in the LD block were not associated with BPH. It is concluded that there is a strong association between the IL10 and IL10RB SNPs, and BPH in Korean population.

Renal Function Outcomes in Patients Undergoing Open or Laparoscopic Radical Nephrectomy

유구한,이형래,장성구,전승현 대한비뇨의학회 2009 Investigative and Clinical Urology Vol.50 No.6

Purpose: We compared renal function outcomes in patients undergoing open or laparoscopic radical nephrectomy. Materials and Methods: Seventy-one patients undergoing open or laparoscopic radical nephrectomy for kidney disease with a normal contralateral kidney were identified between January 2004 and December 2007. Renal function was calculated by using the Cockcroft-Gault formula. Serial renal functions were checked from the day before surgery to 1 year after surgery. Exclusion criteria were preexisting renal insufficiency, urinary stone disease, and pancreatic and liver disorders. Results: Forty-one and 30 patients were treated with open radical nephrectomy or laparoscopic radical nephrectomy, respectively. The operative time and urine output of patients who underwent open and laparoscopic radical nephrectomy were 211.7±5.8 and 330.8±15.6 and 196.4±19.6 and 130.7±12.1, respectively (p=0.001, p=0.013). The glomerular filtration rates of patients who underwent open or laparoscopic radical nephrectomy were insignificant from baseline to postoperative day 360 (p>0.05). Conclusions: No significant differences in renal function were detected in the groups of patients who underwent open or laparoscopic radical nephrectomy from baseline to long-term follow-up. Purpose: We compared renal function outcomes in patients undergoing open or laparoscopic radical nephrectomy. Materials and Methods: Seventy-one patients undergoing open or laparoscopic radical nephrectomy for kidney disease with a normal contralateral kidney were identified between January 2004 and December 2007. Renal function was calculated by using the Cockcroft-Gault formula. Serial renal functions were checked from the day before surgery to 1 year after surgery. Exclusion criteria were preexisting renal insufficiency, urinary stone disease, and pancreatic and liver disorders. Results: Forty-one and 30 patients were treated with open radical nephrectomy or laparoscopic radical nephrectomy, respectively. The operative time and urine output of patients who underwent open and laparoscopic radical nephrectomy were 211.7±5.8 and 330.8±15.6 and 196.4±19.6 and 130.7±12.1, respectively (p=0.001, p=0.013). The glomerular filtration rates of patients who underwent open or laparoscopic radical nephrectomy were insignificant from baseline to postoperative day 360 (p>0.05). Conclusions: No significant differences in renal function were detected in the groups of patients who underwent open or laparoscopic radical nephrectomy from baseline to long-term follow-up.

Experimental Animal Models of Neurogenic Bladder Dysfunction

유구한,이선주 대한배뇨장애요실금학회 2010 International Neurourology Journal Vol.14 No.1

Neurogenic bladder is related to various types of neurogenic disease and injury, including cerebrovascular accident, brain tumor, spinal cord injury, and Parkinson’s disease. The results of urodynamic study show different types of detrusor and sphincter function. According to these urodynamic results, the physician decides on a treatment plan, such as anticholinergics or alpha- blockers. In the development of a new medication, it is necessary to test the medication’s efficacy and toxicity by using a laboratory animal. The proper laboratory animal should have several characteristics. These are biological similarity to humans, a short generation period, and an environment that is easy to control. We describe the development of laboratory animals for the study of neurogenic bladder by decerebration, stroke, and spinal cord injury.

투석 환자에서 복강경 근치적 신적출술 및 신요관적출술

유구한,전승현,김태환,이형래 대한비뇨의학회 2007 Investigative and Clinical Urology Vol.48 No.8

전립선암 진단을 위한 경직장초음파검사에서 저반향병소와 혈류증가의 의의

유구한,전승현,임주원,장성구 대한비뇨의학회 2007 Investigative and Clinical Urology Vol.48 No.2

방광경부 현수술후 봉합사에 의해 발생된 재발성 방광결석

유구한,안규일,장성구 경희대학교 경희의료원 2006 慶熙醫學 Vol.22 No.1

Treatment of Infected Urachal Cysts

유구한,이성주,장성구 연세대학교의과대학 2006 Yonsei medical journal Vol.47 No.3

약물요법/전립선비대의 약물요법

유구한,이선주 대한의사협회 2008 대한의사협회지 Vol.51 No.7

Benign prostate hyperplasia (BPH) is the most common cause of lower urinary tract symptoms (LUTS) in men older than the middle age, and is a pathologic process that contributes to lower urinary tract symptoms in aging men. Despite the significantly different proportion of men with moderate to severe symptoms, a clear trend toward an increase in symptom scores with advancing age is noticeable. Complications of LUTS and BPH, such as urinary tract infections, bladder decompensation, bladder stones, hematuria, urinary incontinence, upper urinary tract deterioration with renal insufficiency, and others are in general rare in properly supervised patients. Medical therapies investigated for BPH include α- adrenergic blockers, 5α- reductase inhibitors, combination, aromatase inhibitors, and numerous plant extracts. Medical therapy is now the usual first- line management of uncomplicated BPH with either an α- adrenergic blocker or (if the prostate is large) a 5α- reductase inhibitor. Combination therapy with both an α- adrenergic blocker and a 5α- reductase inhibitor has been demonstrated to be the most effective means of preventing disease progression.

유치원 물리적 환경 변인이 유아의 사회·정서 능력에 미치는 영향

유구종 ( Ku Jong Yoo ),심우경 ( Woo Kyung Sim ) 한국유아교육학회 2014 유아교육연구 Vol.34 No.1

본 연구의 목적은 유치원의 물리적 환경 변인 측정에 있어 맥락적이고 의미 있는 도구를 제공하기 위한 유치원 물리적 환경 구성 평정척도를 개발하고, 물리적 환경구성이 유아의 사회·정서 능력에 어떠한 영향력을 미치는지 확인하여 의미 있는 실증적 결과를 제시하는데 있다. 그 결과 첫째, 유치원 물리적 환경 척도 개발을 위해 구성된 131개의 예비문항을 대상으로 2차에 걸친 내용타당도 검증, 탐색적 요인분석을 실시하여 최종 7개 요인, 총 78개의 문항이 구성되었다. 또한 이들 각 요인점수와 전체 점수는 모두 유의미한 상관이 있는 것으로 나타났으며, 제 2주기 유치원 평가 매뉴얼 점수간의 상관은 유의한 정적 상관이 있었고, 전체 신뢰도는 .972로 매우 높은 신뢰도 값을 나타냈다. 이는 본 척도가 유치원 물리적 환경을 평가 할 수 있는 도구로서 안정성이 높다고 판단되는 결과이다. 둘째, 물리적 환경 구성이 유아의 사회적 능력과 정서능력에 미치는 영향을 알아보기 위해 구성요소 7개를 예측변인으로 사회적 능력과 정서능력 각각을 종속변인으로 한 중다회귀분석을 실시 한 결과, 유아의 사회적 능력과 정서 능력 모두에 있어서 안전성, 편의성, 심미성 요소 등이 유의미한 예측요소로 분석되었다. The purposes of this study are developing a rating-scale to evaluate the physical environment of kindergartens, that would provide contextual and useful information on how the environment affect social and emotional development of children. The first phase of this study produced 7 factors consisting of 78 items by executing content validity analysis and exploratory factor analysis. The 78 items of the scale showed high reliability value(r=.972). In the second phase, the researchers executed multiple regression analysis on social and emotional development of children with 7 factors as estimators. As a result of the analysis, security, aesthetics, and convenience were confirmed as significant estimators for both social and emotional development of children.