황성군 일대의 육산 패류 분포에 관한 연구

최준길,조후묵,송병용 尙志大學校 1995 論文集 Vol.16 No.-

In order to explore the detailed distribution of land snails inhabitated in Heongseong, this study was conducted for 2 years (from March 20, 1992 to March 20, 1994) for four optional areas. Total appearances of species were 3 order, 1 Families, 17 Genera, 22 species and total individuals were 3,009. the dominant species were Chamalycaeus cyclophoroides and Diplommatina (Sinica) paxillus. The stati of land snails on size were that there were, in Minute species, Carychium pessinum with 1.5mm shell height and 0.8mm shell diameter, in macro species Acusta despecta sieboldiana, Koreanohadra Kurodana, Aegista (Plectotropis) diversa with 11-21mm sell height, 20-28mm shell diameter. The height and diameter variation of Aegista (Plectoropis) diversa were bigger than anyone else. Also, Numbers of spiral were four to 10, and body colors were mainly white or brown. In terms of inhabitation area, data were gathered more than 14 areas. Among them, species which were inhabitated in the fallen leaves were shown 31.8%, 9-15.9% in stone wall, garden and farming field. Especially Cionella lubrica being known endemic species of Ulung Island was confirmed in Hoengseong.

중소기업형 CIM시스템 구축을 위한 생산계획수립 및 실적파악 모듈

최후곤,신완선,장중순,서준성,여명구,안동근,김진봉 成均館大學校 科學技術硏究所 1996 論文集 Vol.47 No.2

This study Focuses on developing several modules involved in an integrated production information system for medium- or small-sized industries. The modules of order management, quality control, production scheduling, and shop management are executed for an example case industry. The potential values of this research includes that the major information modules to collect, analysis, and display production data and shop data for constructing the computer integrated manufacturing system(CIMS) are programmed with various features of medium- or small-sized industries

國際貿易環境變化에 따른 韓國輸出保險制度의 改善方案

박남규,최준호 건국대학교 사회정책연구소 1999 사회과학연구 Vol.11 No.-

With the launch of the WTO regime in 1995, many changes have taken place in the International Trade Environment. Among other things, means for direct export support of government have been curtailed or abolished. But, the relative importance of export insurance is becoming greater as the very efficient means for indirect export support under the IMF supported regime as well as the WTO regime. The Korea Export Insurance System, began for export support, is highly valued in that whenever any difficulty has occurred in export activity and export financing, it has made a great contribution to overcome it, But the Export Insurance System is still poorly used in Korea compared to advanced countries. Therefore, this study attempted to present the following improvement to attain the goal of the export insurance system that is said to contribute to the increase in export: First, in order to cope actively with changes in the International Trade Environment, it is necessary to improve the content of the existing system, to increase its utilization rate of the current 20.5% and to expand export insurance funds. Second, it is necessary to secure the active operation of export insurance, the reasonable operation of the premium rate, the diversification of the items intended for export insurance. Third, it is necessary to reinforce the publicity and marketing activity for export insurance, diversify the overseas credit research method. In conclusion, there is a need the activate export insurance through effective support so as to increase exports based on these improvements.

국산 감잎으로부터 추출한 폴리페놀화합물군이 지질대사에 미치는 영향

백경연,손준호,박무희,성태수,최청 경산대학교 생명자원개발연구소 2000 생명자원과 산업 Vol.4 No.-

한국산 감잎으로보터 polyphenol 화합물군을 분리 및 정제하여 5주간 고지방 식이를 한 후, 혈장 및 간장에서의 지질대사에 미치는 영향을 분석한 결과 혈장에서는 polyphenol 화합물군 Ⅱ에서 총지질, 총콜레스테롤이 유의성 있게 감소하였다. 또한 간장에서는 총지질, 중성지질이 대조군에 비해서 유의성 있는 결과가 나타났다. 5주 동안 고지방 식이를 한 후 분변을 채취하여 총지질, 총콜레스테롤 및 중성지질을 측정한 결과 감잎에서 추출한 polyphenol 화합물 군이 고지방식이 만을 섭취 시킨 대조군에 비해 다소 감소되는 경향을 보였다. 감잎 화합물군을 섭취시킨 후 총단백질과 알부민 함량을 측정한 결과 대조군과 실험군에서 유의성 있는 차이는 나타나지 않았다. This study was conducted to investigate the effects of the polyphenol fraction isolated from persimmon leaves on the reduction of fat accumulation in rats fed on hight fat diet for 5 weeks. It was to examine metabolism by analyzing biochemically the fat composition in serum was remarkably reduced in polyphenol fraction Ⅱ as compared with the control group. The liver was that the levels of total lipid and triglyceride was significantly lower than the control group. The contents of total lipid, total cholesterol and triglyceride in feces were tended to be slightly increase polyphenol fraction compounds compared to control group. In the total protein and albumin, all experimental groups were lower compared to control group, which were not significant.

Enhanced bioavailability of paclitaxel after oral coadministration with flavone in rats

( Jun Shik Choi ),( Hoo Kyun Choi ),( Sang Chul Shin ) 전남대학교 약품개발연구소 2004 약품개발연구지 Vol.13 No.-

Recruitment of Sprouty1 to Immune Synapse Regulates T Cell Receptor Signaling.

Lee, Jun Sung,Lee, Ji Eun,Oh, Yu Mi,Park, Jong Bae,Choi, Heonsik,Choi, Chung Yeon,Kim, In-Hoo,Lee, Seung Hoon,Choi, Kyungho Williams Wilkins 2009 JOURNAL OF IMMUNOLOGY Vol.183 No.11

<P>TCR stimulation not only initiates positive signals for T cell activation, but also induces negative signals that down-regulate T cells. We previously reported that Sprouty1, a negative regulator of Ras-MAPK pathway of receptor tyrosine kinases, was induced by TCR signal and inhibited TCR signaling in CD4(+) T cell clones. In this study, we addressed the mechanism underlying Sprouty1 inhibition of T cells. When overexpressed in Jurkat T cells, Sprouty1 inhibited TCR signal-induced IL-2 transcription, and also AP-1, NFAT, and NF-kappaB activation, which suggests that Sprouty1 acts at proximal TCR signalosome. Accordingly, we found that Sprouty1 translocated to immune synapse upon TCR engagement in both Jurkat cells and activated primary T cells and interacted with various signaling molecules in the TCR signalosome, such as linker for activation of T cells (LAT), phospholipase C-gamma1 (PLC-gamma1), c-Cbl/Cbl-b, and HPK1. Sprouty1 inhibited LAT phosphorylation, leading to decreased MAPK activation and IL-2 production. Deletion of C-terminal 54 amino acids in Sprouty1 abolished its inhibitory effect and this deletion mutant was unable to translocate to immune synapse and interact with LAT. Overall, our data suggest that Sprouty1 induced by TCR signal negatively regulates further TCR signaling by interacting with proximal signaling molecules in immune synapse, providing a novel regulatory mechanism of T cells.</P>

궤도유지보수를 위한 차량진동가속도 모니터링 시스템 구축

이후석(Hoo-Seok Lee),최일윤(Il-Yoon Choi),이준석(Jun S. Lee),전준창(Jun Chang Jeon),최승엽(Seung-Yeob Choi) 한국철도학회 2017 한국철도학회 학술발표대회논문집 Vol.2017 No.05

해군 지휘통제실의 실내 공기 중 라돈 농도에 관한 연구

최원준 ( Won-jun Choi ),김성민 ( Sung-min Kim ),이상봉 ( Sang-bong Lee ),신영후 ( Young-hoo Shin ) 국군의무사령부 2012 대한군진의학학술지 Vol.43 No.1

Objective: The purpose of this study was conducted to investigate indoor air radon level in Naval Cmmand and Control rooms, and through this, to produce a reduction strategy of airbone radon. Method: Alpha track detectors were used to measure air radon level. Measurement for 1st period was from Jun 21, 2011 to Sep 23, 2011 and 2nd period was from Sep 24, 2011 to Dec 27, 2011. Two Naval Command and Control rooms and one non-command building were involved. Results: Mean indoor air radon levels of 1st period were 0.90 pCi/L for Busan, 13.5 pCi/L for Jinhae, 1.16 pCi/L for MMC.. Mean indoor air radon levels of 2nd period were 1.36 pCi/L for Busan, 1.39 pCi/L for Jinhae, 1.17 pCi/L for MMC. There was no area which indoor air radon level exceeds 4 pCi/L. Conclusion: It seems that current administration for indoor air radon is not poor. Persistent concern will be needed.

Porcine LMNA Is a Positional Candidate Gene Associated with Growth and Fat Deposition

Choi, Bong-Hwan,Lee, Jung-Sim,Lee, Seung-Hwan,Kim, Seung-Chang,Kim, Sang-Wook,Kim, Kwan-Suk,Lee, Jun-Heon,Seong, Hwan-Hoo,Kim, Tae-Hun Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.12

Crosses between Korean and Landrace pigs have revealed a large quantitative trait loci (QTL) region for fat deposition in a region (89 cM) of porcine chromosome 4 (SSC4). To more finely map this QTL region and identify candidate genes for this trait, comparative mapping of pig and human chromosomes was performed in the present study. A region in the human genome that corresponds to the porcine QTL region was identified in HSA1q21. Furthermore, the LMNA gene, which is tightly associated with fat augmentation in humans, was localized to this region. Radiation hybrid (RH) mapping using a Sus scrofa RH panel localized LMNA to a region of 90.3 cM in the porcine genome, distinct from microsatellite marker S0214 (87.3 cM). Two-point analysis showed that LMNA was linked to S0214, SW1996, and S0073 on SSC4 with logarithm (base 10) of odds scores of 20.98, 17.78, and 16.73, respectively. To clone the porcine LMNA gene and to delineate the genomic structure and sequences, including the 3'untranslated region (UTR), rapid amplification of cDNA ends was performed. The coding sequence of porcine LMNA consisted of 1,719 bp, flanked by a 5'UTR and a 3'UTR. Two synonymous single nucleotide polymorphisms (SNPs) were identified in exons 3 and 7. Association tests showed that the SNP located in exon 3 (A193A) was significantly associated with weight at 30 wks (p<0.01) and crude fat content (p<0.05). This association suggests that SNPs located in LMNA could be used for marker-assisted selection in pigs.

Solid Dispersion as a Strategy to Improve Drug Bioavailability

Jun-Hyung Park(박준형),Myung-Kwan Chun(전명관),Hoon Cho(조훈),Hoo-Kyun Choi(최후균) 한국생물공학회 2011 KSBB Journal Vol.26 No.4

Solid dispersion is one of well-established pharmaceutical techniques to improve the dissolution and consequent bioavailability of poorly water soluble drugs. It is defined as a dispersion of drug in an inert carrier matrix. Solid dispersions can be classified into three generations according to the carrier used in the system. First and second generations consist of crystalline and amorphous substances, respectively. Third generation carriers are surfactant, mixture of polymer and surfactants, and mixture of polymers. Solid dispersions can be generallyprepared by melting method and solvent method. While melting method requires high temperature to melt carrier and dissolve drug, solvent method utilizes solvent to dissolve the components. The improvement in dissolution through solid dispersions is attributed to reduction in drug particle size, improvement in wettability, and/or formation of amorphous state. The primary characteristics of solid dispersions, the presenceof drug in amorphous state, could be determined by differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), and fourier-transformed infrared spectroscopy (FTIR). In spite of the significant improvement in dissolution by solid dispersion technique, some drawbacks have limited the commercial application of solid dispersions. Thus, further studies should be conducted in a direction to improve the congeniality to commercialization.