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Park, Jun-Bean,Hwang, In-Chang,Lee, Whal,Han, Jung-Kyu,Kim, Chi-Hoon,Lee, Seung-Pyo,Yang, Han-Mo,Park, Eun-Ah,Kim, Hyung-Kwan,Chiam, Paul T.L.,Kim, Yong-Jin,Koo, Bon-Kwon,Sohn, Dae-Won,Ahn, Hyuk,Kang, Elsevier 2018 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.259 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Limited data exist regarding the impact of aortic valve calcification (AVC) eccentricity on the risk of paravalvular regurgitation (PVR) and response to balloon post-dilation (BPD) after transcatheter aortic valve replacement (TAVR). We investigated the prognostic value of AVC eccentricity in predicting the risk of PVR and response to BPD in patients undergoing TAVR.</P> <P><B>Methods</B></P> <P>We analyzed 85 patients with severe aortic stenosis who underwent self-expandable TAVR (43 women; 77.2±7.1years). AVC was quantified as the total amount of calcification (total AVC load) and as the eccentricity of calcium (EoC) using calcium volume scoring with contrast computed tomography angiography (CTA). The EoC was defined as the maximum absolute difference in calcium volume scores between 2 adjacent sectors (bi-partition method) or between sectors based on leaflets (leaflet-based method).</P> <P><B>Results</B></P> <P>Total AVC load and bi-partition EoC, but not leaflet-based EoC, were significant predictors for the occurrence of ≥moderate PVR, and bi-partition EoC had a better predictive value than total AVC load (area under the curve [AUC]=0.863 versus 0.760, <I>p</I> for difference=0.006). In multivariate analysis, bi-partition EoC was an independent predictor for the risk of ≥moderate PVR regardless of perimeter oversizing index. The greater bi-partition EoC was the only significant parameter to predict poor response to BPD (AUC=0.775, <I>p</I> =0.004).</P> <P><B>Conclusion</B></P> <P>Pre-procedural assessment of AVC eccentricity using CTA as “bi-partition EoC” provides useful predictive information on the risk of significant PVR and response to BPD in patients undergoing TAVR with self-expandable valves.</P> <P><B>Highlights</B></P> <P> <UL> <LI> AV calcification has been suggested to be associated with PVR after TAVR. </LI> <LI> We developed a bi-partition method to assess eccentricity of AV calcification (EoC). </LI> <LI> Bi-partition EoC predicted the risk of PVR and response to balloon post-dilation. </LI> <LI> Bi-partition EoC had better predictive power than the conventional leaflet-based method. </LI> <LI> Measurement of the bi-partition EoC may be helpful in a patient undergoing TAVR. </LI> </UL> </P>
이현빈(Hyun bean Yi),박성주(Sung ju Park),민병우(Pyoung woo Min),박창원(Chang won Park) 대한두경부종양학회 2000 대한두경부 종양학회지 Vol.16 No.2
본 논문은 통신 시스템에서 오류 검출을 위해 널려 사용되고 있는 Cyclic Redundancy Check (CRC) 회로의 병렬 구현을 위한 새로운 회로 축소 알고리즘 및 설계 기술을 소개한다. 논리 수준을 최소화하여 CRC 속도를 증진시키기 위해서 입력데이터와 CRC 내부 신호를 두 개 단위로 그룹화 하는 새로운 알고리즘을 개방하였다 성능 평가를 위해 16 비트와 32 비트 CRC 를 PLD (Programmable Logic Device) 및 표준 셀 라이브러리를 이용하여 합성하였으며, 기존에 제시되었던 방법보다 성능이 향상되었음을 보여준다. This paper presents an optimization algorithm and technique for designing parallel Cyclic Redundancy Check (CRC) circuit, which is most widely adopted for error detection A new heuristic algorithm is developed to find as many shared terms as possible, thus eventually to minimize the number and level of the exclusive-or logic blocks in parallel CRC circuits. 16-bit and 32-bit CRC generators are designed with different types of Programmable Logic Devices, and it has been found that our new algorithm and architecture significantly reduce the delay.
Chan Soon Park,Tae-Min Rhee,Hyun Jung Lee,Yeonyee E. Yoon,Jun-Bean Park,Seung-Pyo Lee,Yong-Jin Kim,Goo-Yeong Cho,In-Chang Hwang,Hyung-Kwan Kim 대한심장학회 2023 Korean Circulation Journal Vol.53 No.9
Background and Objectives: The prognostic or safety implication of renin-angiotensin-aldosterone system inhibitors (RASi) in hypertrophic cardiomyopathy (HCM) are not well established, mainly due to concerns regarding left ventricular outflow tract (LVOT) obstruction aggravation. We investigated the implications of RASi in a sizable number of HCM patients. Methods: We enrolled 2,104 consecutive patients diagnosed with HCM in 2 tertiary university hospitals and followed up for five years. RASi use was defined as the administration of RASi after diagnostic confirmation of HCM. The primary and secondary outcomes were all-cause mortality and hospitalization for heart failure (HHF). Results: RASi were prescribed to 762 patients (36.2%). During a median follow-up of 48.1 months, 112 patients (5.3%) died, and 94 patients (4.5%) experienced HHF. Patients using RASi had less favorable baseline characteristics than those not using RASi, such as older age, more frequent history of comorbidities, and lower ejection fraction. Nonetheless, there was no difference in clinical outcomes between patients with and without RASi use (log-rank p=0.368 for all-cause mortality and log-rank p=0.443 for HHF). In multivariable analysis, patients taking RASi showed a comparable risk of all-cause mortality (hazard ratio [HR], 0.70, 95% confidence interval [CI], 0.43–1.14, p=0.150) and HHF (HR, 1.03, 95% CI, 0.63–1.70, p=0.900). In the subgroup analysis, there was no significant interaction of RASi use between subgroups stratified by LVOT obstruction, left ventricular (LV) ejection fraction, or maximal LV wall thickness. Conclusions: RASi use was not associated with worse clinical outcomes. It might be safely administered in patients with HCM if clinically indicated.
Hwang, In-Chang,Park, Hyo Eun,Kim, Hack-Lyoung,Kim, Hyue Mee,Park, Jun-Bean,Yoon, Yeonyee E.,Lee, Seung-Pyo,Kim, Hyung-Kwan,Cho, Goo-Yeong,Sohn, Dae-Won UNKNOWN 2016 CIRCULATION JOURNAL Vol.80 No.7
<P>Background: Presence of systemic inflammation in chronic kidney disease (CKD) is associated with advanced coronary artery calcification (CAC). The prognostic significance of this association, however, is unknown. We evaluated the associations between CAC, estimated glomerular filtration rate (eGFR) and all-cause mortality, to determine whether the associations differ according to the presence of systemic inflammation. Methods and Results: We followed 30,703 consecutive individuals who underwent CAC measurement for a median of 79 months (IQR, 65-96 months). Patients were categorized according to baseline CAC score (0, 1-99, 100-399 and >= 400), eGFR (<45, 45-59, 60-74, 75-89, 90-104, and >= 105 ml/min/1.73 m(2)) and high-sensitivity C-reactive protein (hsCRP; <2.0, and >= 2.0 mg/L). Prevalence and extent of CAC were greater in those with lower eGFR and higher hsCRP accordingly, even after adjustment. Lower eGFR was strongly associated with higher CAC score (>= 400), and the association was more significant in patients with higher hsCRP. The greater CAC burden was associated with worse outcome in the CKD patients (eGFR <60 ml/min/1.73 m(2)) only in those with higher hsCRP. Conclusions: Patients with low eGFR and more extensive CAC had greater risk of mortality, and associations differed according to the presence of systemic inflammation. Among the CKD patients, coronary evaluation may be considered for those with elevated hsCRP.</P>
박순민 ( Sun Min Park ),김영인 ( Young In Kim ),박순창 ( Soon Chang Park ),고영빈 ( Young Bean Ko ),이경주 ( Kyong Joo Lee ),안지현 ( Jhii Hyun Ahn ),조미연 ( Mee Yon Cho ),김재우 ( Jae Woo Kim ) 대한췌담도학회 2016 대한췌담도학회지 Vol.21 No.3
간의 염증성 가성종양(inflammatory pseudotumor)은 조직학적으로 형질세포의 침윤 및 반응성 섬유성 염증을 특징으로 하는 양성 질환이다. 이는 악성 종양과의 감별이 쉽지않다. 저자들은 간내 담도암으로 오인된 염증성 가성종양 1예를 보고하는 바이다. 74세 남자가 1-2주 전부터의 근육통과 황달이 있어 입원하였다. 진행한 복부초음파, 복부 전산화단층촬영, 자기공명영상에서 간내 담도암으로 생각되었으나 간 조직검사에서 염증성 가성종양으로 진단되었다. 항생제 사용 및 보존적인 치료 후 증상이 호전되어 퇴원하였고 이후 추적 복부 전산화단층촬영에서 병변은 사라졌다. Inflammatory pseudotumor of the liver is a benign disease which is histologically characterized by plasma cell infiltration and reactive fibrotic inflammation. Differentiating this disease from malignant tumor is not easy. The authors report a case of inflammatory pseudotumor mimicked as intrahepatic cholangiocarcinoma. A 74-year-old man visited the emergency department complaining of jaundice and myalgia which have lasted for 1 to 2 weeks. After computed tomography (CT) scan and magnetic resonance imaging of the liver, he was initially diagnosed with intrahepatic cholangiocarcinoma, but was ultimately found to be inflammatory pseudotumor after pathologic examination of the liver tissue. His symptoms improved after a course of antibiotic therapy and conservative treatment, and the lesion disappeared on follow-up CT scan. Korean J Pancreas Biliary Tract 2016;21(3):180-184
이현빈,박성주,민병우,박창원,Lee, Hyun-Bean,Park, Sung-Ju,Min, Pyoung-Woo,Park, Chang-Won 한국통신학회 2004 韓國通信學會論文誌 Vol.29 No.9A
본 논문은 통신 시스템에서 오류 검출을 위해 널려 사용되고 있는 Cyclic Redundancy Check (CRC) 회로의 병렬 구현을 위한 새로운 회로 축소 알고리즘 및 설계 기술을 소개한다. 논리 수준을 최소화하여 CRC 속도를 증진시키기 위해서 입력데이터와 CRC 내부 신호를 두 개 단위로 그룹화 하는 새로운 알고리즘을 개방하였다 성능 평가를 위해 16 비트와 32 비트 CRC 를 PLD (Programmable Logic Device) 및 표준 셀 라이브러리를 이용하여 합성하였으며, 기존에 제시되었던 방법보다 성능이 향상되었음을 보여준다. This paper presents an optimization algorithm and technique for designing parallel Cyclic Redundancy Check (CRC) circuit, which is most widely adopted for error detection A new heuristic algorithm is developed to find as many shared terms as possible, thus eventually to minimize the number and level of the exclusive-or logic blocks in parallel CRC circuits. 16-bit and 32-bit CRC generators are designed with different types of Programmable Logic Devices, and it has been found that our new algorithm and architecture significantly reduce the delay.