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전병태,김병철,이명선 高麗大學校附設 컴퓨터科學技術硏究所 1999 JOURNAL OF COMPUTER SCIENCE & ENGINEERING TECHNOLO Vol.2 No.-
최근 급격한 인터넷의 발전은 검색 서비스로 인해 주도되었다고 해도 과언이 아닐 것이다. 방대한 정보의 바다 인터넷을 통해 정보를 얻으려 해본 적이 있다면 어떤 검색엔진을 사용하여야 할지 어떤 검색어를 사용하여야 할지 한 번쯤은 고민 해 보았을 것이다. 이러한 이유로 많은 사람들이 메타 검색엔진이라는 것을 이용하게 된다. 그러나 이러한 메타 검색엔진도 자체내의 여러 가지 정보 처리로 인한 느린 결과 처리의 문제점이 있다. 본 논문에서는 인터넷의 정보검색을 하는 사용자의 특성을 고려한 정보 검색 서비스를 제공해 주는 시스템을 설계 구현하여 본다. It is needless to say that information search service leads explosive growth Internet. When you have a experience to get information what you search in Internet, puzzled about what kind of search engine and search keyword should select. Thus many people want to use Meta-search engine. But Meta-search engine has some problem. one of problem is that meta-search engine manages information which is obtained by several search engine. Thus meta-search engine has some severe performance degradation. In this paper we designed and implemented information search service system for the purpose of using internet to get information search result.
랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구
김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1
A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.
Survey on the Current Status of Laboratory Animal Quality Control Program in Korea
Byoung Chun Lee,Mee Kyung Jang,Kab Ryong Chae,Dae Youn Hwang,Byoung Guk Kim,Seung Wan Jee,Sun Bo Shim,Su Hae Lee,Ji Soon Sin,Chang Jun Bae,Jong-Min Woo,Jung Sik Cho,Kwang Soo Joo,Chuel Kyu Kim 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.1
It is critical to harmonize the laboratory animal quality control program of each organization in order to improve the quality of laboratory animals. The aim of this study was to survey the current status of the laboratory animal quality control of 6 major animal suppliers and 14 Good Laboratory Practice (GLP) organizations. First of all, 6 suppliers provided more than 3 million animals, and 99% of them were specific pathogen-free (SPF) mice and rats. 88% of the GLP organizations were also using SPF animals, 81% of which were mice and rats. Two suppliers importing and offering animals were depending on the animal health report certified by providers, 2 suppliers were outsourcing to a domestic monitoring center, and 2 suppliers were monitoring in-house and simultaneously sending live animals to international centers for microbiological monitoring. All suppliers were monitoring the genetic integrity of inbred animals only once in a year. Fifty seven percentage of GLP organizations were doing the in-house microbiological monitoring, and only one of them was evaluating the genetic background of animals. Four suppliers monitoring animal quality were applying more than 5 samples of each animal facility unit quarterly. Fifty five percentage of GLP organizations monitored with each facility unit and 36% of them chose samples in the experimental group. Additionally, the animal number used in monitoring was 3-5, and monitoring frequency was 4 times in a year. Two suppliers sending animals to foreign companies for monitoring adopted almost all agents as testing items. Two suppliers were testing critical items including Ectromelia virus, Sendai virus, Mouse Hepatitis virus, Hantaan virus, Rat Coronavirus, Minute virus of mice, M. pulmonis, C. piliforme, and H. hepaticus. It were only 5 microoragnisms, MHV, Sendai virus, M. pulmonis, C. piliforme, and Ectoparasites which more than half of GLP organizations were monitoring commonly. Almost all organizations had their own SOPs for animal health monitoring and required a nationally harmonized guideline on the laboratory animal quality control. The result of this survey will be basic information on the national policy of the management of laboratory animal quality, and contribute to the improvement of laboratory animal quality in Korea.
Bacterial Composition of Respiratory Organs and Intestine in Mice and Rats
Byoung Chun Lee,Mee Kyung Jang,Jong-Kun Seo,Jin-Ho Kang,Kab Ryong Chae,Dae Youn Hwang,Byoung Guk Kim,Seung Wan Jee,Sun Bo Shim,Su Hae Lee,Ji Soon Sin,Chang Jun Bae,Jong-Min Woo,Chuel Kyu Kim 한국실험동물학회 2008 Laboratory Animal Research Vol.24 No.1
The change of microbial flora in intestine and respiratory organs make some effects on animal health, which can cause some aberrations to experiment data. Therefore, it is an important factor to maintain the homogeneity of the bacterial composition of each organ. In this study, the bacterial distribution of respiratory organs and intestine were analyzed from 247 mice and 200 rats by analyzing biochemical properties and 16S rDNA sequencing. The total of 1,075 isolates were classified to 35 species of 17 genera. In case of rats, intestinal microbial flora were composed of 5 major bacteria including E. coli, P. mirabilis, M. morganii, C. freundii, and P. vulgaris, and 5 bacteria such as E. coli, P. mirabilis, S. aureus, S. cohnii, and M. morganii also mainly consisted of the microbial flora of respiratory organs. In case of mice, intestinal microbial flora were composed of 4 major bacteria including E. coli, P. mirabilis, A. lwoffi, and L. adecarboxylata, and 5 bacteria such as E. coli, B. sphaericus, S. auricularis, A. lwoffi, and L. adecarboxylata also mainly consisted of microbial flora of respiratory organs. This study suggested that B. sphaericus, G. morbillorum, S. paucimobilis, Staphylococcus spp. were specific in respiratory organs, and that M. morganii and Citrobacter spp. were almost specific in intestine. This study also can give some basic information to understand the relationship between animal care environment and microbial composition of animal organs.
( Byoung Ok Cho ),( Hyung Won Ryu ),( Yang Kang So ),( Chang Wook Lee ),( Chang Hyun Jin ),( Hong Sun Yook ),( Yong Wook Jeong ),( Jong Chun Park ),( Il Yun Jeong ) 한국응용약물학회 2014 Biomolecules & Therapeutics(구 응용약물학회지) Vol.22 No.4
Mangostenone F (MF) is a natural xanthone isolated from Garcinia mangostana. However, little is known about the biological activities of MF. This study was designed to investigate the anti-infl ammatory effect and underlying molecular mechanisms of MF in lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages. MF dose-dependently inhibited the production of NO, iNOS, and pro-infl ammatory cytokines (TNF-α, IL-6, and IL-1β) in LPS-stimulated RAW264.7 macrophages. Moreover, MF decreased the NF-κB luciferase activity and NF-κB DNA binding capacity in LPS-stimulated RAW264.7 macrophages. Furthermore, MF suppressed the NF-κB activation by inhibiting the degradation of IκBα and nuclear translocation of p65 subunit of NF-κB. In addition, MF attenuated the AP-1 luciferase activity and phosphorylation of ERK, JNK, and p38 MAP kinases. Taken together, these results suggest that the anti-infl ammatory effect of MF is associated with the suppression of NO production and iNOS expression through the down-regulation of NF-κB activation and MAPK signaling pathway in LPS-stimulated RAW264.7 macrophages.
Sun Bo Shim,Se Hyun Lee,Dae Youn Hwang,Chuel Kyu Kim,Bung Guk Kim,Yong Kyu Kim,Seung Wan Jee,Su Hae Lee,Ji Soon Sin,Chang Jun Bae,Byoung Chun Lee,Mi Kyong Jang,Min Sun Kim,Su Youn Yim,Jung Sik Cho,Kab 한국실험동물학회 2007 Laboratory Animal Research Vol.23 No.1
The transportation stress cause rise in the levels of many hormones and proteins to maintain homeostasis in the laboratory animals. In order to study whether the stress induced by long-term ground transport could contribute to change in the stress-related protein and profile of stress-regulated gene expression, these factors were detected in the animals between before and after the ground transportation. Herein, it is concluded that; ⅰ) the transported mice significantly exhibited the increase of corticosterone concentration in serum. ⅱ) the heat shock protein 70 (HSP70) in the liver were significantly decreased in the transported animals. ⅲ) 372 and 272 genes were up- and down-regulated, respectively, by stress in the long-term ground transported mice compare to the controls. ⅳ) genes encoding for immunity, signal transduction response and response to protein metabolism were significantly over-represented in the up-regulated group. ⅴ) among the down-regulated transcripts, those encoding for protein metabolism were dramatically over-represented, followed by those related to lipid metabolism and development process. These results suggested that the stress induced by ground transportation could significantly changed the level of stress-indicator hormone, proteins and gene profile in the mice. Therefor, the animal transported a long distance should be had the adaptation period to recover the normal physical state.
The Construction of Sports Talent Identification Models
( Byoung Goo Ko ),( Hai Mo Gu ),( Dong Ho Park ),( Jin Ho Back ),( Seong Won Yun ),( Myung Chun Lee ),( Jong Gak Lee ),( Duk Sun Chang ),( Seung Yun Shin ) 한국스포츠정책과학원(구 한국스포츠개발원) 2003 International Journal of Applied Sports Sciences Vol.15 No.2
The purpose of this study was to construct sports talent identification models. To this end, conventional processes for developing talent identification models were reviewed, and, through this effort, basic and specific sports talent identification models that are constructed using theoretical factor models and statistical evaluation models were designed. The basic sports talent identification model is used to diagnose general sports performance ability and identify optimal sports events. This theoretical factor model is constructed using common factors such as height, weight, body composition, arm strength and endurance, arm power, body strength and endurance, leg strength and endurance, leg power, aerobic ability, speed, agility, and flexibility. These common factors are needed to perform most sports and are obtained through inductive classification analysis based on prior research and selection criteria, and through expert seminars. The specific sports talent identification model is used to diagnose event specific abilities of adolescents who are determined to have the best general sports ability (i.e., who rank among the best using the basic sports talent identification model). This theoretical factor model is constructed using specific factors such as physique, fitness, and physiological characteristics needed to perform each sport, and with the use of medical tests, a maturity test, and psychological and sociological tests (the tests are the same for all and not sport-specific). These specific factors are obtained through prior research, investigation of selection criteria, and expert seminars. The evaluation model for sports talent identification was constructed by applying standard distance analysis using T-scores.
H₂O₂에 의해 유도된 HepG2 세포의 산화적 스트레스에 대한 신품종 방사선 돌연변이 블랙베리 γ-B201의 세포 보호 효과
조병옥(Byoung Ok Cho),이창욱(Chang-Wook Lee),소양강(Yangkang So),진창현(Chang-Hyun Jin),육홍선(Hong-Sun Yook),변명우(Myung-Woo Byun),정용욱(Yong-Wook Jeong),박종천(Jong Chun Park),정일윤(Il-Yun Jeong) 한국식품과학회 2014 한국식품과학회지 Vol.46 No.3
본 연구에서는 인간 간암세포주 HepG2세포에서 H₂O₂로 인해 유도된 산화적 스트레스에 대한 방사선 돌연변이 블랙베리 γ-B201 추출물의 세포보호 효능에 대하여 알아보고자 하였다. γ-B201 추출물 처리 시 H₂O₂로 처리된 HepG2 세포에서 ROS 생성이 억제되었으며, 세포 생존율을 증가시키고 LDH의 방출을 억제함을 확인하였다. Comet assay를 통해 DNA 손상 정도를 분석한 결과, H₂O₂로 인해 유도된 산화적 스트레스에 의한 DNA 손상은 γ-B201 추출물의 처리에 의해 감소하였다. 또한, HepG2 세포에 H₂O₂ 처리에 의해 저하된 항산화 효소인 SOD와 CAT의 활성을 γ-B201 추출물에 의해 증가시킴으로써 H₂O₂로 인해 유도된 산화적 스트레스로부터 HepG2 간세포를 보호하는 것으로 판단되며, γ-B201 추출물이 간 손상 보호 및 간 기능 개선 효과를 갖는 기능성 소재로서 활용될 수 있는 것으로 사료된다. The objective of the present study was to investigate the chemical composition of anthocyanin-enriched extract of radiation-induced blackberry (Rubus fruticosus L.) mutant (γ-B201) as well as the protective effect of γ-B201 against oxidative stress in vitro. The cytotoxicity, reactive oxygen species (ROS) scavenging capacity, and DNA damage were assessed by WST-1 assay, flow cytometry, and comet assay, respectively. Lactate dehydrogenase, superoxide dismutase, and catalase activities were determined by using a commercial kit. The in vitro results showed that γ-B201 increased the cell viability, reduction of lactate dehydrogenase release, and intracellular ROS scavenging capacity in hydrogen peroxide (H₂O₂)-treated HepG2 cells. Furthermore, treatment with γ-B201 attenuated DNA damage in H₂O₂-treated HepG2 cells and treatment with γ-B201 restored the activity of superoxide dismutase and catalase in H₂O₂-treated HepG2 cells. In conclusion, the present study suggests that γ-B201 blackberry extract can exert a significant cytoprotective effect against H₂O₂-induced cell damage.