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Synthesis and Antibacterial Activity of 1,3-Diallyltrisulfane Derivatives
Fang-Kui Ren,Xiao-Yan He,Li Deng,Bo-Heng Li,Dong-Soo Shin,Zhu-Bo Li 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.3
A series of novel 1,3-diallyltrisulfane analogues were synthesized and assayed in vitro for antimicrobial activity against Gram positive, Gram negative bacteria and fungi. The antimicrobial activity of the 1,3-diallyltrisulfane derivatives showed, on the whole, very potent towards all the tested Gram positive, Gram negative and fungi (MIC ranging from 4 to 256 μg/mL). 1,3-Di(pent-4-enyl)trisulfane 3b and 1,3-bis(3-methylbut-2-enyl)trisulfane 3e exhibited the strongest antibacterial activity among all the compounds, and both of them were more active than 1,3-diallyltrisulfane (DATS). Results indicated the relationship of either carbon number or lipophilicity with antimicrobial activity presented “V” shape. These observations provided some predictions in order to further design 1,3-diallyltrisulfane derivatives with antimicrobial activity.
Synthesis and Antibacterial Activity of 1,3-Diallyltrisulfane Derivatives
Ren, Fang-Kui,He, Xiao-Yan,Deng, Li,Li, Bo-Heng,Shin, Dong-Soo,Li, Zhu-Bo Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.3
A series of novel 1,3-diallyltrisulfane analogues were synthesized and assayed in vitro for antimicrobial activity against Gram positive, Gram negative bacteria and fungi. The antimicrobial activity of the 1,3-diallyltrisulfane derivatives showed, on the whole, very potent towards all the tested Gram positive, Gram negative and fungi (MIC ranging from 4 to 256 μg/mL). 1,3-Di(pent-4-enyl)trisulfane 3b and 1,3-bis(3-methylbut-2-enyl)trisulfane 3e exhibited the strongest antibacterial activity among all the compounds, and both of them were more active than 1,3-diallyltrisulfane (DATS). Results indicated the relationship of either carbon number or lipophilicity with antimicrobial activity presented “V” shape. These observations provided some predictions in order to further design 1,3-diallyltrisulfane derivatives with antimicrobial activity.
Comparison of Autogenous Tooth Materials and Other Bone Grafts
Zhang Shuxin,Li Xuehan,Qi Yanxin,Ma Xiaoqian,Qiao Shuzhan,Cai HongXin,Zhao Bing Cheng,Jiang Heng Bo,이의석 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.3
Autogenous odontogenic materials are a new, highly biocompatible option for jaw restoration. The inorganic component of autogenous teeth acts as a scaffold to maintain the volume and enable donor cell attachment and proliferation; the organic component contains various growth factors that promote bone reconstruction and repair. The composition of dentin is similar to that of bone, which can be a rationale for promoting bone reconstruction. Recent advances have been made in the field of autogenous odontogenic materials, and studies have confirmed their safety and feasibility after successful clinical application. Autogenous odontogenic materials have unique characteristics compared with other bone-repair materials, such as the conventional autogenous, allogeneic, xenogeneic, and alloplastic bone substitutes. To encourage further research into odontogenic bone grafts, we compared the composition, osteogenesis, and development of autogenous odontogenic materials with those of other bone grafts. In conclusion, odontogenic bone grafts should be classified as a novel bone substitute.
Zhang Shuxin,Zhang Xinyi,Li Yanling,Mao Xuran,Liu Rui,Qi Yanxin,Lee Eui-Seok,Jiang Heng Bo 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.3
Bone graft materials have mixed effects of bone repair in the field of oral maxillofacial surgery. The qualitative analyses performed by previous studies imply that autogenous odontogenic materials and autogenous bone have similar effects on bone repair in clinical jaw bone transplantation. This retrospective systematic assessment and network meta-analysis aimed to analyze the best effect of clinical application of autogenous odontogenic materials and autogenous, allogeneic, and xenogeneic bone grafts in bone defect repair. A systematic review was performed by searching the PubMed, Cochrane Library, and other journal databases using selected keywords and Medical Subject Headings search terms. 10 Papers (n = 466) that met the inclusion criteria were selected. The assessment of heterogeneity did not reveal any overall statistical difference or heterogeneity (P = 0.051 > 0.05), whereas the comparison between autogenous and allogeneic bone grafts revealed local heterogeneity (P = 0.071 < 0.1). Risk of bias revealed nine unclear studies and one high-risk study. The overall consistency was good (P = 0.065 > 0.05), and the local inconsistency test did not reveal any inconsistency. The publication bias was good. The confidence regarding the ranking of bone graft materials after GRADE classification was moderate. The effects on bone repair in the descending order were as follows: autogenous odontogenic materials, xenogeneic bone, autogenous bone, and allogeneic bone. This result indicates that the autogenous odontogenic materials displayed stronger effects on bone repair compared to other bone graft materials. Autogenous odontogenic materials have broad development prospects in oral maxillofacial surgery.
Yang Zhang,Zeyang Wang,Ting Liu,Bo Yang,Shu Hu,Heng Li,ChuanXiang Sheng 대한금속·재료학회 2022 ELECTRONIC MATERIALS LETTERS Vol.18 No.3
On hot substrates with a temperature of 100 °C, the qualities of two-dimensional perovskite PEA2MA2Pb3I10(PEA = phenethylammonium,MA = methylammonium) films have been explored which are constructed with different spin-casting speeds. These films are performed at the speed of 1000, 2000, 4000, and 6000 revolution per minute (RPM). Below 4000 r, a higherRPM results in higher crystalline quality with more uniform morphology. Correspondingly, 4000 r devices show better performanceon average (4.3% power conversion efficiency) and less hysteresis in the J-V curve than 1000 r (3.6%) and 2000 rdevices (3.4%). However, for devices that were fabricated at 6000 r, inferior performance (2.8% on average) may not bepredicted simply by the morphology characterization or optical measurement results at room temperature; instead, carriertrapping states can occur that result in thermally activated PL below 200 K with an activation energy of 18 meV, which donot occur in the 1000 r, 2000 r, and 4000 r films. Our results suggest that for evaluating 2D perovskite films prior to fabricatingoptimal devices, multiple morphology characterizations and optical measurements, including of low-temperature PL,will be helpful.
Cancer Research Advances Regarding the CKLF-like MARVEL Transmembrane Domain Containing Family
Lu, Jia,Wu, Qian-Qian,Zhou, Ya-Bo,Zhang, Kai-Hua,Pang, Bing-Xin,Li, Liang,Sun, Nan,Wang, Heng-Shu,Zhang, Song,Li, Wen-Jian,Zheng, Wei,Liu, Wei Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.6
The CKLF-like MARVEL transmembrane domain-containing family (CMTM) is a novel family of genes first reported at international level by Peking University Human Disease Gene Research Center. The gene products act between chemokines and the transmembrane-4 superfamily. Located in several human chromosomes, the CMTMs CKLF and CMTM1 to CMTM8 may be unregulated in tumors and act as potential tumor suppressor genes with important roles in the immune, male reproductive and hematopoietic systems. In-depth studies in recent years established a close relation between CMTMs and tumorigenesis and metastasis. The CMTM family has a significant clinical value in diagnosis and treatment of diseases linked to tumors and the immune system.