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Micro-Biopsy Forceps in the Assessment of Peritoneal Carcinomatosis: A Possible New Indication?
Cecilia Binda,Emanuele Dabizzi,Emanuele Sinagra,Adele Fornelli,Luca Saragoni,Vincenzo Cennamo,Andrea Anderloni,Carlo Fabbri 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.4
Peritoneal carcinomatosis (PC) is defined as a metastatic involvement of the peritoneum by several other primary sites and it ischaracterized by a marked worsening of prognosis, with limited treatment opportunities. Subsequently, PC should be ruled outbefore any invasive treatment is administered. A new through-the-needle micro-biopsy forceps (MF) was recently introduced thatpermits micro-histology cores. In this case series, we evaluated the feasibility of MF in the assessment of PC to complete patientdiagnostic work-ups. Five consecutive patients referred for endoscopic ultrasound staging were sampled using MF. Sampling wasfeasible in all patients with a technical success of 100%. No adverse events were reported in any cases. This technique was feasibleand safe with a technical success rate of 100%. It permitted sampling of peritoneal irregularity, obtained high-quality tissue fragmentsin all cases, and enabled an additional assessment, i.e., immunohistochemical staining.
A Review on Intelligent Scheduling and Optimization for Flexible Job Shop
Bin Jiang,Yajie Ma,Lijun Chen,Binda Huang,Yuying Huang,Li Guan 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.10
Flexible job shop scheduling problem is a NP-hard combinatorial optimization problem, which has significant applications in the field of workshop scheduling and intelligent manufacturing. Due to its complexity and significance, lots of attention have been paid to tackle this problem. This paper reviews some of the researches on this problem, by presenting and classifying the different criteria, constraints, and solution approaches. The existing solution methods for the flexible job shop scheduling problem in this literature are classified into exact algorithms, heuristics, and meta-heuristics, which are thoroughly reviewed. Particularly, the paper highlights the flexible job shop scheduling problem in the context of dynamic events and preventive maintenance. These dynamic events, such as machine breakdowns and unexpected changes in job requirements, present additional challenges to the scheduling problem. Furthermore, this paper analyzes the development trends in the manufacturing industry and summarizes detailed future research opportunities for the flexible job shop scheduling problem.
Negative Regulation of Hypoxic Responses via Induced Reptin Methylation
Lee, Jason S.,Kim, Yunho,Kim, Ik Soo,Kim, Bogyou,Choi, Hee June,Lee, Ji Min,Shin, Hi-Jai R.,Kim, Jung Hwa,Kim, Ji-Young,Seo, Sang-Beom,Lee, Ho,Binda, Olivier,Gozani, Or,Semenza, Gregg L.,Kim, Minhyung Elsevier 2010 Molecular cell Vol.39 No.1
<P><B>Summary</B></P><P>Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated. Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia.</P> <P><B>Highlights</B></P><P>► Reptin is a target of G9a methyltransferase ► Reptin K67 methylation is induced by hypoxia ► Genome-wide identification of hypoxia target genes negatively regulated by Reptin ► Hypoxia-driven Reptin methylation negatively regulates tumorigenic behavior in vivo</P>