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( Myeong Jun Song ),( Do Seon Song ),( Hee Yeon Kim ),( Sun Hong Yoo ),( Chung Hwa Park ),( Si Hyun Bae ),( Jong Young Choi ),( U Im Chang ),( Jin Mo Yang ),( Seung Kew Yoon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Transarterial chemoembolization (TACE) has been widely used as treatment in hepatocellular carcinoma. In order to maximize the therapeutic efficacy, Doxorubicin loaded drug eluting bead has been developed to deliver higher doses of chemotherapeutic agent and to prolong contact time with tumor. The purpose of this study was to evaluate the efficacy and safety of DC bead® TACE in comparison with conventional TACE. Methods: One hundred twenty nine patients who underwent TACE between Aug. 2008 and Feb. 2011 were retrospectively enrolled. We compared HCC patients (n=60) who had underwent TACE with DC bead® to controls (n=69) who had received conventional TACE. The primary endpoint was treatment response according to modified RECIST criteria, time to recurrence and overall survival. The primary safety endpoint was treatment-related liver toxicity. Results: The objective response rates of the DC bead® group were significantly better than that of conventional TACE group (81.6 vs 49.2 %, p <0.001). Subgroup analysis conducted in patient with intermediate stage confirmed significantly higher objective response and longer time to progression rates in patients receiving DC bead® than those treated with conventional TACE (p<0.001, p=0.038, respectively). DC bead group showed significant overall survival benefit (p=0.005). There was no statistically significant difference in liver toxicity between the DC bead® and conventional TACE group (p >0.05). Conclusions: Transarterial chemoembolization with DC bead® showed better treatment response and time to progression rates compared with conventional TACE. DC bead® TACE may appear to be a feasible and promising approach in the treatment of HCC.
SPA0355 attenuates ischemia/reperfusion-induced liver injury in mice
Bae, Ui-Jin,Yang, Jae Do,Ka, Sun-O,Koo, Jeung-Hyun,Woo, Seong Ji,Lee, Young-Rae,Yu, Hee Chul,Cho, Baik Hwan,Zhao, Hui-Yuan,Ryu, Jae-Ha,Lee, Sang-Myeong,Jeon, Raok,Park, Byung-Hyun Nature Publishing Group 2014 Experimental and molecular medicine Vol.46 No.8
<P>Hepatic ischemia/reperfusion (I/R) injury leads to oxidative stress and acute inflammatory responses that cause liver damage and have a considerable impact on the postoperative outcome. Much research has been performed to develop possible protective techniques. We aimed to investigate the efficacy of SPA0355, a synthetic thiourea analog, in an animal model of hepatic I/R injury. Male C57BL/6 mice underwent normothermic partial liver ischemia for 45 min followed by varying periods of reperfusion. The animals were divided into three groups: sham operated, I/R and SPA0355 pretreated. Pretreatment with SPA0355 protected against hepatic I/R injury, as indicated by the decreased levels of serum aminotransferase and reduced parenchymal necrosis and apoptosis. Liver synthetic function was also restored by SPA0355 as reflected by the prolonged prothrombin time. To gain insight into the mechanism involved in this protection, we measured the activity of nuclear factor-κB (NF-κB), which revealed that SPA0355 suppressed the nuclear translocation and DNA binding of NF-κB subunits. Concomitantly, the expression of NF-κB target genes such as <I>IL-1</I>β<I>, IL-6, TNF-</I>α and <I>iNOS</I> was significantly downregulated. Lastly, the liver antioxidant enzymes superoxide dismutase, catalase and glutathione were upregulated by SPA0355 treatment, which correlated with the reduction in serum malondialdehyde. Our results suggest that SPA0355 pretreatment prior to I/R injury could be an effective method to reduce liver damage.</P>
( Myeong Jun Song ),( Do Seon Song ),( Hee Yeon Kim ),( Sun Hong Yoo ),( Chung Hwa Park ),( Si Hyun Bae ),( Jong Young Choi ),( U Im Chang ),( Jin Mo Yang ),( Seung Kew Yoon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.-
Background: Transarterial chemoembolization (TACE) has been widely used as treatment in hepatocellular carcinoma. In order to maximize the therapeutic efficacy, Doxorubicin loaded drug eluting bead has been developed to deliver higher doses of chemotherapeutic agent and to prolong contact time with tumor. The purpose of this study was to evaluate the efficacy and safety of DC bead® TACE in comparison with conventional TACE. Methods: One hundred twenty nine patients who underwent TACE between Aug. 2008 and Feb. 2011 were retrospectively enrolled. We compared HCC patients (n=60) who had underwent TACE with DC bead® to controls (n=69) who had received conventional TACE. The primary endpoint was treatment response according to modified RECIST criteria, time to recurrence and overall survival. The primary safety endpoint was treatment-related liver toxicity. Results: The objective response rates of the DC bead® group were significantly better than that of conventional TACE group (81.6 vs 49.2 %, p <0.001). Subgroup analysis conducted in patient with intermediate stage confirmed significantly higher objective response and longer time to progression rates in patients receiving DC bead® than those treated with conventional TACE (p<0.001, p=0.038, respectively). DC bead group showed significant overall survival benefit (p=0.005). There was no statistically significant difference in liver toxicity between the DC bead® and conventional TACE group (p>0.05). Conclusions: Transarterial chemoembolization with DC bead® showed better treatment response and time to progression rates compared with conventional TACE. DC bead® TACE may appear to be a feasible and promising approach in the treatment of HCC.
Quality Characteristics of Mackerel Immersed in Sea Wind Mugwort Extract
Sun-Kyung Oh(오선경),Hae-Reon Son(손혜련),Ki-Woong Kim(김기웅),Sang-Ok Bae(배상옥),Sung-Young Kim(김성영),Myeong-Rak Choi(최명락) 한국생명과학회 2017 생명과학회지 Vol.27 No.9
거문도 해풍쑥 추출물을 처리한 고등어의 저장 기간 동안의 품질 특성을 조사하였다. 5% 해풍쑥 추출물에 고등어를 2시간, 3시간, 4시간 처리한 후 개별 포장하여 -20℃에 저장하여 실험하였다. 해풍쑥 추출물을 처리하지 않은 고등어(control)와 해풍쑥에 2, 3, 4시간씩 처리한 고등어의 염도는 2시간 처리한 고등어가 0.07%로 가장 낮은 수치를 나타냈다. pH는 모두 5.90~6.23를 나타냈고 산도는 15일째 감소 후 증가하는 경향을 나타냈다. 또한, 저장기간이 길수록 인장강도는 control은 증가하고, 2, 3, 4시간씩 처리한 고등어는 감소하였다. Volatile basic nitrogen(VBN) 함량은 control은 4.2~50.7 mg%, 2시간 처리한 고등어는 5.6~15.4 mg%로 control보다 가장 낮은 수치를 나타냈다. 2시간 처리한 고등어 제품에서 total polyphenol, total flavonoid 함량은 286.3~497.0 mg GAE/100 g, 177.5~385.6 mg QE/100 g를 나타냈다. DPPH, ABTS radical scavenging activity은 2시간 처리한 고등어 제품에서 50.6%, 61.3%를 각각 나타냈다. 전반적으로, 고등어를 SWM으로 단시간 처리하면 염도, pH, 산도, 경도, 항산화 활성 및 저장기간 연장과 같은 품질특성이 크게 향상되었음을 알 수 있다. This study examined the influence of sea wind mugwort extract treatment on quality characteristics of mackerel during storage. Mackerel were packaged individually and then immersed in 5% sea wind mugwort extract for 2, 3, or 4 hr and stored at -20℃. The salinity of a control (no treatment) and that of mackerel immersed in sea wind mugwort for 2 hr was lowest (0.07%). pH of 5.90-6.23, and the change in acidity was in the opposite range. Immersion for 2, 3, and 4 hr led to a decrease in the tensile strength of the samples following storage, whereas the tensile strength of the control increased. The volatile basic nitrogen (VBN) content of the mackerel immersed for 2 hr was significantly lower than that of the control (5.6-15.4 mg% vs. 4.2-50.7 mg%). In the mackerel immersed for 2 hr, the total polyphenol and total flavonoid content was 286.3-497.0 mg gallic acid equivalents (GAE)/100 g and 177.5-385.6 mg quercetin equivalents (QE)/100 g, respectively. The 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-azino-bis(3-ethyl-benzothizoline-6-sulfonic acid) (ABTS) radical scavenging activities of the mackerel immersed in sea wind mugwort for 2 hr were 50.6% and 61.3%, respectively. Overall, the immersion of mackerel in sea wind mugwort for a short time significantly improved quality characteristics, such as salinity, pH, acidity, hardness, antioxidant activity, and perceptible quality, following storage.
터널 콘크리트 구조물의 보수를 위한 무기게 균열주입기술의 표준화 연구
배기선 ( Bae-kee-sun ),곽수정 ( Kwak Su-jung ),백종명 ( Ba다 Jong-myeong ) 한국구조물진단유지관리공학회 2006 한국구조물진단유지관리공학회 논문집 Vol.10 No.6
본 논문은 터널 콘크리트 구조물의 보수를 위한 무기계 균열주입기술의 표준화에 관한 연구이다. 본 연구를 위하여 균열보수공사가 필요한 터널 라이닝 및 박스 구조물을 선정하여, 균열폭에 따른 주입량, 주입시간 및 주입압력, 주입압력과 주입시간, 구조물 규모에 따른 주입량, 구조물별 균열 위치에 따른 주입량, 균열폭 및 구조물 두께와 주입시간의 관계에 관하여, 현장 조사와 시험평가를 수행하여 구조물의 종류 및 균열의 크기에 따른 균열보수재의 주입압력, 주입량 및 주입시간 등을 명확히 파악하였다. This study is to establish a standardization of injection system by inorganic material for crack repair of tunnel concrete structures. For this various surveys and experiments were carried out as followed. The first we surveyed capability of injection and crack pattern of concrete structures in site. and second we analyzed the relationship between crack width and volume of injection, and decided pressure and volume of injection. Finally we evaluated the relationship between crack width and volume of injection with kind of concrete structures, and between required time for injection and crack width with thickness of structure. From these surveys and experiments, we cleared the relationship between crack patterns and injection technologies such as volume, pressure of injection and required time for injection with kind of structure.
피뢰설비 진단을 위한 설문조사와 낙뢰 사고 현장 실태조사 분석
최명일(Myeong-il Choi),송길목(kill-Mok Song),방선배(Sun-Bae Bang),김영석(Young-Suk Kim),김종민(Jong-Min Kim) 대한전기학회 2010 대한전기학회 학술대회 논문집 Vol.2010 No.11
최근 국내 피뢰설비에 대한 고객의 진단의뢰가 접수되고 있으나 이를 적극적으로 수용하기 위한 진단기법과 진단매뉴얼이 개발되어 있지 않아 이에 대한 시급성이 요구되었다. 이에 피뢰설비 진단에 있어서 국제표준을 준용한 피뢰설비 진단 및 검사기술의 개발이 시급하다. 따라서 피뢰설비 진단 매뉴얼을 개발하기에 앞서 기상청의 낙뢰연보를 참고로 하여 국내 낙뢰발생현황을 분석하고 국내 낙뢰 및 피뢰설비 사고와 관련하여 설문조사를 실시하였으며, 낙뢰 피해 수용가를 방문하여 현장실태를 분석하고 피뢰설비 진단을 위한 다양한 요구사항이 있음을 확인하였다.