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Márcia Araújo Motta,Jeonghwa Jang,Mijeong Kim,Eunsil Choi,Jiyoung Kim,Anna Carolina Torracca-Rocha,Won-Sik Kong,Arailde Fontes Urban 한국버섯학회 2017 한국버섯학회지 Vol.15 No.2
The choice of strain, substrate, and environmental conditions are fundamental factors that determine the ability of a fungus to develop and produce mushrooms with high quality. The objective of this study was to compare the strains of Lentinula edodes and Ganoderma lucidum originated from South Korea and Brazil in relation to their vegetative development in different culture media, to obtain isolates with high quality. The strains of the two mushroom species from Brazil and South Korea grew slowly, possibly because of abiotic factors or storage technique used. However, it may be concluded that temperature, humidity, light, pH, and nutrients from the substrate, if not regulated appropriately may affect the vegetative species.
Ki Beom Kim,Renee E. Doyle,Eustáquio A. Araújo,Rolf G. Behrents,Donald R. Oliver,Guilherme Thiesen 대한치과교정학회 2019 대한치과교정학회지 Vol.49 No.2
Objective: The purpose of this study was to assess the long-term stability of rapid palatal expansion (RPE) followed by full fixed edgewise appliances. Methods: This study included 67 patients treated using Haas-type RPE and non-extraction edgewise appliance therapy at a single orthodontic practice. Serial dental casts were obtained at three different time points: pretreatment (T1), after expansion and fixed appliance therapy (T2), and at long-term recall (T3). The mean duration of the T1–T2 and T2–T3 periods was 4.8 ± 3.5 years and 11.0 ± 5.4 years, respectively. The dental casts were digitized, and the computed measurements were compared with untreated reference data. Results: The majority of treatment-related increases in the maxillary and mandibular arch measurements were statistically significant (p < 0.05) and greater than expected for the untreated controls. Although many measurements decreased postretention (T2–T3), the net gains persisted for all of the measurements evaluated. Conclusions: The use of RPE therapy followed by full fixed edgewise appliances is an effective method for increasing maxillary and mandibular arch width dimensions in growing patients.
Kim, Kihwan,Kim, Juran,Gang, Myeng Gil,Kim, Se-Ho,Song, Soomin,Cho, Yunae,Shin, Donghyeop,Eo, Young-Joo,Jeong, Inyoung,Ahn, Seung Kyu,Cho, Ara,Kim, Jayeong,Yoon, Seokhyun,Choi, Pyuck-Pa,Jo, William,Ki Elsevier 2019 Solar energy materials and solar cells Vol.195 No.-
<P><B>Abstract</B></P> <P>In this work, copper indium gallium selenide (Cu(In,Ga)Se<SUB>2</SUB>; CIGS) absorbers were grown on polyimide (PI)/molybdenum substrates by a three-stage co-evaporation process at various temperatures, film formation was systemically studied using various advanced characterization methods such as transmission electron microscopy, micro-Raman spectroscopy, Kelvin probe force microscopy, and atom probe tomography. The CIGS films on PI were found to exhibit considerable physical and electrical variations with respect to the process temperature of three-stage co-evaporation. In particular, when the process temperature reached 400 °C, the CIGS absorber on PI began to exhibit controlled microstructure and intergrain properties. By adjusting the microstructure and intergrain properties of the absorber films by means of the process temperature of three-stage co-evaporation, flexible CIGS solar cells on PI with an efficiency of 16.7% (with anti-refection coating) were achieved.</P> <P><B>Highlights</B></P> <P> <UL> <LI> CIGS absorber films were grown on flexible polyimide/molybdenum substrates. </LI> <LI> Low-temperature three-stage process (≤440 °C) with extrinsic Na addition was used to CIGS growth. </LI> <LI> CIGS film evolution was systemically observed using advanced material characterization techniques. </LI> <LI> Highly efficient CIGS cells on flexible polyimide substrates were realized while maintaining process manufacturability. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kim, Sungroul,Kim, Yongbae,Lee, Mee-Ri,Kim, Junhyoung,Jung, Ara,Park, Jong Sook,Jang, An-Soo,Park, Sung-Woo,Uh, Soo-Taek,Choi, Jae Sung,Kim, Young Hoon,Buckley, Timothy,Park, Choon-Sik Informa Healthcare 2012 The Journal of asthma Vol.49 No.7
<P><I>Objective.</I> According to the American Thoracic Society, approximately 5% of all asthmatics have refractory asthma (RA); these patients fail to recover lost lung function even after long-term treatment with high doses of medications. <I>Methods.</I> Using a time-trend controlled case-crossover study design, we calculated odds ratios to evaluate whether exposure to ambient air pollutants and certain meteorological conditions on the day of admission (Lag 0) and up to 3 days before admission (Lag1 through Lag 3) were associated with acute RA exacerbation. Results were obtained after controlling for the effects of seasonality, smoking, and allergen sensitivity; we stratified our data into four seasons with respect to the median temperature of each month and further stratified them according to self-reported smoking status and skin-prick test results. <I>Results.</I> In our study, RA patients (<I>n</I> = 82), living in metropolitan city of Seoul and Kyunggi Province, accounted for 3.7% of all asthmatics (<I>n</I> = 2298) registered in our asthma cohort between 2005 and 2009. In winter, a 1°C decrease in ambient temperature and a 1 ppb increase in sulfur dioxide concentration on the day of Lag 1 were associated with 14.8% (95% confidence interval [CI]: 0.9-26.7) and 19.7% (95% CI: 3.3-38.7) increases in the risk of RA exacerbation among nonsmokers, respectively. Similar associations were obtained on the day of Lag 2. The association remained unchanged after excluding patients sensitive to <I>Dermatophagoides farinae</I> and <I>Dermatophagoides pteronyssinus</I>. <I>Conclusions.</I> Exposure to temperature drops and increased sulfur dioxide concentrations are positively associated with the occurrence of acute RA exacerbation during winter with 1 or 2 day lags.</P>
Kim, Eunju,Kim, Seong Bum,Baek, Youl Chang,Kim, Min Seok,Choe, Changyong,Yoo, Jae Gyu,Jung, Younghun,Cho, Ara,Kim, Suhee,Do, Yoon Jung The Korean Society of Veterinary Service 2018 韓國家畜衛生學會誌 Vol.41 No.4
Rumen cannulation is used for nutritional and microbiological research, clinical diagnosis, and rumen component transfaunation. However, the cannulation procedure can affect parameters such as complete blood count findings, serum chemistry, and rumen fluid pH. The objective of this study was to evaluate the health risks related to the rumen cannulation procedure over a 1-month period. We did not identify significant differences in red blood cell numbers or morphologies between pre- and postoperative timepoints. Moreover, no inflammation or infection was detected. Despite the absence of apparent clinical signs after surgery, serum chemistry results revealed changes in blood urea nitrogen levels and the activities of liver enzymes, including aspartate transaminase, lactate dehydrogenase, and creatinine kinase, from postoperative days 1 to 14. Rumen fluid pH, as measured from samples collected via an orogastric tube, was slightly increased after a preoperative fasting period and on postoperative day 1 but decreased thereafter from postoperative day 4, indicating a minor influence of cannulation surgery on ruminal fluid pH. This is the first study to evaluate hematological parameters and rumen pH before and after rumen cannulation surgery in Hanwoo cattle. Further research is required to better elucidate the potential effects of rumen cannulation surgery on animal health.
A novel cereblon modulator for targeted protein degradation
Kim, Sung Ah,Go, Ara,Jo, Seung-Hyun,Park, Sun Jun,Jeon, Young Uk,Kim, Ji Eun,Lee, Heung Kyoung,Park, Chi Hoon,Lee, Chong-Ock,Park, Sung Goo,Kim, Pilho,Park, Byoung Chul,Cho, Sung Yun,Kim, Sunhong,Ha, Elsevier 2019 European Journal of Medicinal Chemistry Vol.166 No.-
<P><B>Abstract</B></P> <P>Immunomodulatory drugs (IMiDs) exert anti-myeloma activity by binding to the protein cereblon (CRBN) and subsequently degrading IKZF1/3. Recently, their ability to recruit E3 ubiquitin ligase has been used in the proteolysis targeting chimera (PROTAC) technology. Herein, we design and synthesize a novel IMiD analog TD-106 that induces the degradation of IKZF1/3 and inhibits the proliferation of multiple myeloma cells <I>in vitro</I> as well as <I>in vivo</I>. Moreover, we demonstrate that TD-428, which comprises TD-106 linked to a BET inhibitor, JQ1 efficiently induce BET protein degradation in the prostate cancer cell line 22Rv1. Consequently, cell proliferation is inhibited due to suppressed C-MYC transcription. These results, therefore, firmly suggest that the newly synthesized IMiD analog, TD-106, is a novel CRBN modulator that can be used for targeted protein degradation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We design and synthesize a novel IMiD analog. </LI> <LI> TD-106 induces the degradation of IKZF1/3 and inhibits the proliferation of multiple myeloma cells. </LI> <LI> BET PROTAC with TD-106 efficiently induces the degradation of BET proteins. </LI> <LI> TD-106 as a novel CRBN modulator can be used for targeted protein degradation. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jo, Ara,Jang, Geunseok,Namgung, Ho,Kim, Choongho,Kim, Daigeun,Kim, Yujun,Kim, Jongho,Lee, Taek Seung Elsevier 2015 Journal of hazardous materials Vol.300 No.-
<P><B>Abstract</B></P> <P>We prepared alginate beads that were modified with an azo-based probe molecule to monitor simultaneously the removal (by alginate) and probing (by the azo-probe molecule) of radioisotopes such as cobalt, strontium, and cesium ions. As an azo-probe molecule, Basic Orange 2 (BO2) was immobilized to the alginate bead. The BO2 in aqueous solution exhibited a slight red shift in absorption with a change in color from orange to dark orange upon addition of cobalt and strontium ions. In contrast, the color of BO2 did not change upon exposure to cesium ions. Thus, the covalently embedded BO2 in alginate beads could adsorb cobalt and strontium ions resulting in recognizable color change of the beads, which was induced by the formation of a complex between BO2 and metal ions. The color changes of the beads in the presence of metal ions were determined quantitatively using RGB color coordinate values. In addition to effectively removing metal ions, the colorimetric coordinate method provides a convenient and simple sensing technique for naked-eye metal ion detection.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Modified alginate with azo-based probe (ABO) was synthesized by a reaction between sodium alginate and azo-based probe (BO2). </LI> <LI> BO2 was found to be a good probe molecule for radioisotopes using colorimetric analysis. </LI> <LI> Detection of Co<SUP>2+</SUP> and Sr<SUP>2+</SUP> was mainly carried out via interaction between BO2 and metal ions. </LI> <LI> Simultaneous removal of radioisotopes was assessed by the ion-exchange of carboxylate groups in sodium alginate. </LI> <LI> The alginate beads with dual functions of detection and removal of metal ions are successfully accomplished. </LI> </UL> </P>
Gwanghee Kim,Yoojin Lee,Jin Sun You,Wontae Hwang,Jeewon Hwang,Hwa Young Kim,Jieun Kim,Ara Jo,In ho Park,Mohammed Ali,Jongsun Kim,Jeon-Soo Shin,Ho-Keun Kwon,Hyun Jik Kim,Sang Sun Yoon 대한면역학회 2023 Immune Network Vol.23 No.4
Evidence suggests that the human respiratory tract, as with the gastrointestinal tract, has evolved to its current state in association with commensal microbes. However, little is known about how the airway microbiome affects the development of airway immune system. Here, we uncover a previously unidentified mode of interaction between host airway immunity and a unique strain (AIT01) of Staphylococcus epidermidis, a predominant species of the nasal microbiome. Intranasal administration of AIT01 increased the population of neutrophils and monocytes in mouse lungs. The recruitment of these immune cells resulted in the protection of the murine host against infection by Pseudomonas aeruginosa, a pathogenic bacterium. Interestingly, an AIT01-secreted protein identified as GAPDH, a well-known bacterial moonlighting protein, mediated this protective effect. Intranasal delivery of the purified GAPDH conferred significant resistance against other Gram-negative pathogens (Klebsiella pneumoniae and Acinetobacter baumannii) and influenza A virus. Our findings demonstrate the potential of a native nasal microbe and its secretory protein to enhance innate immune defense against airway infections. These results offer a promising preventive measure, particularly relevant in the context of global pandemics.
Therapeutic Effect of Total Ginseng Saponin on Skin Wound Healing
Young Soo Kim,Ik-Hyun Cho,Moon-Jin Jeong,Soon-Jeong Jeong,Seung Yeol Nah,Young-Sik Cho,Seung Hyun Kim,Ara Go,Se Eun Kim,Seong Soo Kang,Chang Jong Moon,Jong Choon Kim,Sung Ho Kim,Chun Sik Bae 고려인삼학회 2011 Journal of Ginseng Research Vol.35 No.3
In this study, we investigated the effects of total ginseng saponin (TGS) on the cutaneous wound healing process using histological analysis. A total of 24 ICR mice, 5-weeks-old, were used for all in vivo experiments. Mice were divided into control and TGS-treated groups and four equidistant 1-cm full-thickness dorsal incisional wounds were created. The wounds were extracted at days 1, 3, 5, and 7 post-injury for histomorphometrical analysis including wound area and contracture measurements, keratinocyte migration rate, and calculation of infiltrating inflammatory cells. The results showed that the wound area was smaller and keratinocyte migration rate was higher in the TGS-treated group than that of the control group from days 3 to 7. Inflammatory cells in the TGS-treated group at days 1 and 3 were reduced compared to the control group. Wound contraction in the TGS-treated group was greater than in the control group on days 3 to 5, and collagen deposition in the TGS-treated group was higher than in the control group during wound healing. The results indicate a beneficial effect of TGS when used to treat skin wounds.