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State Indicator of Water Quality for Surface Water and Groundwater in Agriculture
Kim, Min-Kyeong,Jung, Goo-Bok,Ro, An-Sung,Choi, Seung-Chul,Choi, Won-Il,Kim, Eun-Jeong,Lee, Jong-Eun,Yun, Yeo-Uk,Kim, Kab-Cheol,Ko, Do-Young,Kim, Byeong-Ho,Kim, Hyeon-Ji,Park, Sang-Jo,Lee, Seong-Tae,H 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5
Indicators of environmental conditions qualitatively and quantitatively describe the state of the environment and natural resources, and the OECD (Organization for Economic Cooperation and Development) has initiated and suggested AEIs (Agri-Environmental Indicators) to assess trends over time of the effects of agriculture on the environment and the effectiveness and efficiency of agricultural and environmental policy measures since 1990's. This study aims to develop the state indicators of water quality for agricultural water, surface and groundwater, to evaluate the environmental impacts of agricultural activities and policies by qualifying the environmental levels of a nation. Status indicators were calculated according to the agricultural water quality standards of OECD and Korea, and their trends were analyzed over time. Particularly, nitrate ($NO_3{^-}$) status indicators of ground water in 2013 were significantly lower than the ones in 2000. Overall, the water quality indicators of surface water in 2013 were higher than the ones in 2012, except for pH and DO. The groundwater quality indicators in 2013 were lower than those of previous years. The optimal management indicators were calculated to assess agricultural surface water and groundwater quality. The findings of this study indicated that the state indicators could play a significant role to establish policies and procedures for managing and conserving water resources. This study also discussed water pollution caused by agricultural and industrial effluents.
State Indicator of Water Quality for Surface Water and Groundwater in Agriculture
Min-Kyeong Kim,Goo-Bok Jung,An-Sung Ro,Seung-Chul Choi,Won-Il Choi,Eun-Jeong Kim,Jong-Eun Lee,Yeo-Uk Yun,Kab-Cheol Kim,Do-Young Ko,Byeong-Ho Kim,Hyeon-Ji Kim,Sang-Jo Park,Seong-Tae Lee,Jae-Young Heo,S 한국토양비료학회 2015 한국토양비료학회지 Vol.48 No.5
Indicators of environmental conditions qualitatively and quantitatively describe the state of the environment and natural resources, and the OECD (Organization for Economic Cooperation and Development) has initiated and suggested AEIs (Agri-Environmental Indicators) to assess trends over time of the effects of agriculture on the environment and the effectiveness and efficiency of agricultural and environmental policy measures since 1990’s. This study aims to develop the state indicators of water quality for agricultural water, surface and groundwater, to evaluate the environmental impacts of agricultural activities and policies by qualifying the environmental levels of a nation. Status indicators were calculated according to the agricultural water quality standards of OECD and Korea, and their trends were analyzed over time. Particularly, nitrate(NO₃<SUP>-</SUP>) status indicators of ground water in 2013 were significantly lower than the ones in 2000. Overall, the water quality indicators of surface water in 2013 were higher than the ones in 2012, except for pH and DO. The groundwater quality indicators in 2013 were lower than those of previous years. The optimal management indicators were calculated to assess agricultural surface water and groundwater quality. The findings of this study indicated that the state indicators could play a significant role to establish policies and procedures for managing and conserving water resources. This study also discussed water pollution caused by agricultural and industrial effluents.
( Sung Woo Park ),( Ae Rin Baek ),( Do Jin Kim ),( An Soo Jang ),( Soo Taek Uh ),( Y Ong Hoon Kim ),( Choon Sik Park ),( Yoon Pyo Kang ),( Sung Won Kwon ) 대한내과학회 2014 대한내과학회 추계학술발표논문집 Vol.2014 No.1
Background: Idiopathic pulmonary fi brosis (IPF) is characterized chronic progressive lung fi brosis with poor prognosis. Many part of pathogenesis of IPF is still not known. Metabolomics is the study of molecules created by cellular metabolic pathways. we hypothesize that exploring the metabolic pathways of lung tissues from IPF could revealing a clear pathogenesis of IPF Methods: Lung tissues obtained from 12 patients with IPF and from 12 normal subjectsand performed global metabolomic profi ling using gas chromatography coupled to mass spectrometry. Results: Through unsupervised principal component analysis (PCA), the variation and outlier of samples were monitored and the clustering patterns between IPF and control groups were confi rmed. Based on this, we performed a supervised method, partial least squares discriminant analysis (PLS-DA), to establish the predictive and discriminative models. To interpret the data more reliably, the metabolites selected by PLS-DA and univariate statistical analyses due to the value of area under the receiver operator characteristic curve (AUROC) more than 0.9, were proved to have high prediction performance between the groups. The expression patterns of the identifi ed metabolites indicated an anaerobic glycolysis, depletion of ATP, impairment of glutathione biosynthesis, and increase of ornithine-proline metabolism as distinctive metabolic phenotypes of IPF. Conclusions: Our enhanced metabolomics approach verifi ed the existing hypotheses of pathogenesis in IPF at the metabolite level and suggested noteworthy signals of pathogenic metabolites related to IPF.
( Sung Woo Park ),( Ki Sung Song ),( Jisu Hong ),( Ae Rin Baek ),( Jong Sook Park ),( June Hyuck Lee ),( An-soo Jang ),( Do Jin Kim ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background OAT is a key enzyme that converts ornithine into proline, an essential precursor of collagen. We previously reported that OAT expression is increased in IPF lung and inhibition of OAT attenuate bleomycin-induced lung fibrosis. EMT is the main process for fibroblast production during lung fibrosis. We investigate the role of OAT in lung fibrosis especially focused on the EMT pathway and its clinical implication in IPF. Methods OAT knockdown A549 alveolar epithelial cell line was treated with TGF-β1. Morphological changes and expression of EMT-related markers, including E-cadherin, N-cadherin, and α-smooth muscle actin were evaluated. Expressions of Smad and non- Smad mediators and EMT- related transcription factors were measured. We measured the OAT level from bronchoalveolar lavage fluid (BALF) in IPF and controls. Results OAT knockdown inhibited the TGF-β1 induced change of the EMT phenotype. OAT knockdown attenuates the TGF-β1 induced increase in the phosphorylation of Smad 2 and 3 as well as that of ERK and p38 mitogen-activated protein kinase mediators. In addition, OAT knockdown reduced TGF-β1 induced expression of EMT transcription factors; Twist, Slug, and Snail 1. OAT levels in IPF BALF are reversely correlated with FVC (% pred.) and DLCO (% pred.). Conclusions Inhibition of OAT attenuates BLM induced lung fibrosis via suppressing of TGF-β1 induced EMT pathways. OAT lung level is associated with lung function decline in IPF. Taken together, regulation of OAT could be a therapeutic target and surrogate marker in fibrotic lung disease. [Grant :NRF-2019R1A2C100635]
Do Joong Park,Sena An,Young Suk Park,Joo-Ho Lee,Hyuk-Joon Lee,Tae Kyung Ha,Yong-Jin Kim,Seung-Wan Ryu,Sang-Moon Han,Moon-Won Yoo,Sungsoo Park,Sang-Uk Han,Jae-Heon Kang,Jin-Won Kwon,Yoonseok Heo 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.101 No.4
Purpose: The aim of this study was to show that bariatric surgery (BS) is more effective than medical therapy (MT) in Asian obese patients. Methods: In this prospective, multicenter, nonrandomized, controlled trial, obese patients with body mass index of ≥35 kg/㎡ or 30.0–34.9 kg/㎡ with obesity-related comorbidities were assigned to undergo BS, such as laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass, or MT. Patients who underwent BS were evaluated 4, 12, 24, and 48 weeks after surgery, whereas patients who received MT were monitored at a hospital every 6 weeks for 1 year. At each visit, weight, waist and hip circumference, and blood pressure were measured, and patients underwent physical examination and laboratory testing. Health-related quality of life (HQOL) was investigated using Euro QOL-5 Dimension, Impact of Weight on Quality of Life questionnaire-Lite and Obesity-related Problems scale. Results: The study included 264 patients from 13 institutions; of these, 64 underwent BS and 200 received MT. Of the patients who underwent BS, 6.3% experienced early complications. Relative weight changes from baseline to 48 weeks were significantly greater in the BS than in the MT group (26.9% vs. 2.1%, P < 0.001), as were the rates of remission of diabetes (47.8% vs. 16.7%, P = 0.014), hypertension (60.0% vs. 26.1%, P < 0.001), and dyslipidemia (63.2% vs. 22.0%, P < 0.001). HQOL was better in the BS than in the MT group at 48 weeks. Conclusion: BS was safe and effective in Korean obese patients, with greater weight reduction, remission of comorbidities, and quality of life improvement than MT.
An, Sung Su,Jin, Hong Lian,Kim, Keung Nyun,Kim, Dong Seok,Cho, Joon,Liu, Meng-Lu,Oh, Jin Soo,Yoon, Do Heum,Lee, Min Hyung,Ha, Yoon Springer Verlag 2010 Child's nervous system Vol.26 No.3
<P>To avoid unwanted adverse effects of higher doses of single treatment of stem cells and gene therapy and increase the therapeutic efficacies, we hypothesized the combined therapy with stem cells and gene therapy. This study assessed the neuroprotective effects of combined gene therapy and stem cell treatment under ischemic hypoxia conditions using hypoxia-inducible vascular endothelial growth factor (VEGF) and bone marrow-derived mesenchymal stem cells (BMSC).</P>
Song, In-Uk,Kim, Young-Do,Cho, Hyun-Ji,Chung, Sung-Woo,Chung, Yong-An Lippincott WilliamsWilkins, Inc. 2013 Alzheimer disease and associated disorders Vol.27 No.1
Previous studies have demonstrated a decreased density of dopamine transporters (DAT) in basal ganglia in patients with idiopathic Parkinson disease (IPD) using I-n-fluoropropyl-2b-carbomethoxy-3b-(4-iodophenyl) nortropane (FP-CIT), and the reductions in striatal DAT levels were inversely correlated with the severity of motor dysfunction in IPD. However, there has been no study on the correlation of DAT levels between IPD patients with and without cognitive dysfunction. Thus, we evaluated the differences in regional DAT density in the brain of patients with IPD without dementia and those with dementia using FP-CIT positron emission tomography. We recruited 24 consecutive patients with IPD, including 7 with IPD without dementia and 17 with IPD with dementia, and 18 healthy controls. FP-CIT positron emission tomography scans were acquired 90 and 210 minutes after the FP-CIT injection. The DAT density did not differ in the caudate nucleus or the putamen between patients with IPD without dementia and those with dementia. However, the DAT density between the 2 groups with IPD demonstrated a significantly decreased density compared with that of healthy controls in the putamen. We cautiously suggest that there is no relationship between DAT density and cognitive severity because there were no significant differences in the DAT density between IPD with dementia and those without dementia.
Overexpression of fatty acid synthase attenuate bleomycin induced lung fibrosis
( Sung Woo Park ),( Mi So Kim ),( Ae Rin Baek ),( Jong Sook Park ),( June Hyuk Lee ),( An Soo Jang ),( Do Jin Kim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Excessive alveolar epithelial cell (AEC) death by repeated injury play a role in the pathogenesis of lung fibrosis. Recently reports show defective lipid metabolism in AEC contributes to development or progression of lung fibrosis. Fatty acid synthase (FASN) is enzyme catalyzes the conversion of acetyl-CoA and malonyl-CoA to saturated fatty acids. Transcriptomic profiling revealed mRNA levels of FASN are significantly reduced in IPF lung. Objectives: We investigated whether regulation of FASN expression in AECs modulate severity of lung fibrosis and to evaluate its precise mechanism. Methods: We generated FASN knock-down, overexpression stable cell lines and human FASN transgenic (TG) mice, with conditionally induced alveolar epithelium to overexpress FASN. Cell proliferation and apoptosis assay were performed treated with bleomycin (BLM). Lung fibrosis was established by BLM inhaled FASN TG mice. Measurement and Results: FASNs mainly expressed at AECs and are significantly reduced in IPF and BLM treated mice lung. Knockdown of FASN significantly increased but overexpression of FASN down-regulate apoptotic cell death. FASN TG mice dramatically attenuated BLM-induced lung inflammation and fibrosis. Conclusions: These findings suggest that defective FASN production may associated with IPF pathogenesis and augmentation of FASN in the lung may have therapeutic potential in preventing lung fibrosis. GRANT: NRF-2019R1A2C1006351