의약품 급여 결정과 다기준의사결정(Multiple Criteria Decision Analysis) 활용에 대한 고찰

황소정,이태진,배은영 한국보건의료기술평가학회 2015 보건의료기술평가 Vol.3 No.2

The aim of this study is to consider the relevance to adopting a multiple criteria decision analysis (MCDA) for drug reimbursement decision making from both theoretical and practical perspectives. The study depends on the reviews on selected papers, legal documents and reimbursement assessment review reports. MCDA approach is one of the complementary value matrices along with ‘broadened cost-utility evaluation’ and ‘weighted incremental cost effectiveness ratios (ICERs)’ to overcome the limitation of economic evaluation method; that lacks consideration of a variety of health-related val- ues. Besides MCDA approach, there are other value matrices beyond a criterion of ‘cost-effectiveness’ already in place. The committees have recommended listing of some drugs on the basis of health-re- lated values such as ‘disease severity’, ‘unmet need’, ‘equity’, ‘budget impact’, and ‘high clinical need’ de- spite uncertainties or unacceptability of ICERs. Also MCDA has many theoretical and methodological limitations. It is more relevant to develop the existing value matrix and to improve deliberation pro- cess than to adopt MCDA approach newly.

신약 진입에 의한 미충족의료 해소가 약제비 변화에 미치는 영향

황소정,이태진 한국보건경제정책학회 2023 보건경제와 정책연구 Vol.29 No.2

The aim of this study is to investigate the impact of the medical unmet needs satisfaction on pharmaceutical expenditures by their type; first satisfaction, satisfaction for treatment failure; satisfaction for selective patients. We analyze the impact of unmet medical needs satisfaction by new drug entry on drug expenditures, treatment substitution and expansion effect considering the differentiation degree of drug classes and patients' group for public concern diseases, rare and intractable diseases, and diseases with new drug entry between 2008 and 2021. And growth of drug expenditures is decomposed into 3 parts; cost, patients' number, drug mix. The result indicates that first satisfaction causes cost to increase by 88.0%, patients' number to increase by 8.0%, drug mix to decrease by 57.0% and overall drug expenditures to increase by 39.0%, (+)31.0% substitution effect, (+)8.0% expansion effect. Satisfaction for treatment failure neither gives rise to significant expansion effects nor causes significant change in drug expenditures, substitution effect due to cost increase being offset by the decrease of drug mix. Satisfaction for selective patients causes drug expenditures to increase by 9.5%, (+)5.4% substitution effect and the significance of increase in cost, patients' number and decrease in drug mix is lost when considering differentiation of drugs' classes. Classes differentiation itself results in 76.9% increase in cost and 81.3% decrease in drug mix. The finding of this study implies the degree of increase in drug expenditures, substitution and expansion effect of the first satisfaction is the largest. And it suggests the impact on the decomposed part of pharmaceutical expenditures and the increase in drug expenditures due to the substitution and expansion effect can be mitigated through active differentiation of drug classes in relation to first satisfaction and satisfaction for selective patients.

토양 미생물 유래 KRA16-334와 AN-2064 혼합 배양여액의 어류 및 물벼룩 급성독성평가

황소정,전경미,윤창영,박경훈,임정현,최정섭,김영숙 한국농약과학회 2023 한국농약과학회 학술발표대회 논문집 Vol.2023 No.11

대만

황소정 한국외국어대학교 학생통역협회 1997 외대통역협회지 Vol.14 No.1

2016년 식품영양성분 DB구축을 위한 조리방법에 따른 함량분석 : 당류

황소정,신정아,이기택 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

과자류 중 지방산 유래 유해물질 분석법 연구

황소정,양세희,정유경,김형수,이동호 한국분석과학회 2018 학술대회논문집 Vol.2018 No.11

진입 신약의 유형이 질환별 의약품 상한금액 및 의료이용에 미치는 영향

황소정 ( So-jung Hwang ),이태진 ( Tae-jin Lee ) 한국보건경제정책학회 2021 보건경제와 정책연구 Vol.27 No.4

As the entry of new medical technology is noted as one of the important phenomena in the healthcare sector, the impact of new drugs on healthcare sector needs to be assessed according to their types. In this study, in order to analyze the impact of entry of new drugs by disease, new drugs that have entered the list of the reimbursed drugs since 2011 are classified by their types of innovation: first-in-class ingredient with improved clinical benefit, first-in-class ingredient without improved clinical benefit, later-in-class ingredient with improved clinical benefit and later-in-class ingredient without improved clinical benefit and by necessity; essential drugs and non-essential drugs. And we performed analysis to evaluate the effect of new drugs entry on the frontier drug's list price, per capita health expenditures and per capita days of outpatient visits or hospitalization. The result indicates that entry of the first-in-class ingredient with improved clinical benefit causes per capita health expenditures to increase by 13.2% while entry of the later-in-class ingredient with improved clinical benefit reduces the frontier drug's list price by 1.29%, per capita health expenditures by 20.3%, and per capita days of outpatient visits or hospitalizations by 6.94%. And the result also indicates that entry of the essential drug reduces the frontier drug's list price by 3.04%, per capita health expenditures by 18.5% and per capita days of outpatient visits or hospitalization by 6.94%. The finding of this study implies that the effect on the drug list price, health expenditures and number of days of outpatient visits or hospitalization could be different depending on the new drug's type of innovation and necessity. This suggests that we could identify the types of new drugs that wouldn't increase pharmaceutical costs and have a positive effect on healthcare sector.

저온처리가 케일(Brassica oleracea)잎 내 Carotenoid에 미치는 영향

황소정 ( So-jung Hwang ),천진혁 ( Jin-hyuk Chun ),김선주 ( Sun-ju Kim ) 한국환경농학회 2017 한국환경농학회지 Vol.36 No.2

BACKGROUND: Kale (Brassica oleracea) biosynthesizes various phytochemicals including glucosinolates, flavonoids, and carotenoids. Phytochemicals of plants are influenced by light, temperature, carbon dioxide, and growing conditions. Specifically, carotenoids are affected by temperature, light, and oxygen. The aim of this study was to investigate the effect of cold stress (day/night: 25℃/20℃, 20℃/15℃, 15℃/10℃) on carotenoids in kale leaves. METHODS AND RESULTS:Kale was grown in pots for up to 50 days after sowing (DAS) in a greenhouse. For cold acclimation experiments, kale grown in growth chambers for 3 days andwas subjected to low temperature for 4 days. The conditionsmaintained in the growth chambers were as follows: photoperiod, 12/12 h (day/night); light, fluorescent; and relative humidity, 60%. Carotenoid (lutein,α-carotene, zeaxanthin, β-carotene) contents were analyzed by high-performance liquid chromatography (HPLC). The total carotenoid content gradually increased during cold acclimation for 3 days. When kale was subjected to cold stress, the total carotenoid content was high at 25℃/20℃ treatment, but low at 15℃/10℃ treatment. The total carotenoid content of kale leaves continuously grown in greenhouse decreased from50 to 57DAS (1,418 and 1,160 mgkg-1 drywt., respectively). The lutein,α-carotene, andβ -carotene contents were very low and the zeaxanthin contentswere very high at 15℃/10℃treatment.When kale was subjected to cold stress, the ratio of individual to the total carotenoid contents of kale leaves was 4553% for -carotene and 210% for zeaxanthin. CONCLUSION: Theβ-carotene and zeaxanthin contents in kale leaves indicate their sensitiveness toward cold stress.

2016년 식품원재료에 함유된 콜레스테롤 함량 분석

신정아,황소정,최용민,이기택 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10

건설사업관리 분야의 증강형 CM 모델

이종국,황소정,김효은 사단법인 인문사회과학기술융합학회 2017 예술인문사회융합멀티미디어논문지 Vol.7 No.2

We suggest the augmented construction management by reviewing the adaptability of advanced and convergent model in construction management (CM) mixed with the skill of strategy planning, feasibility study, marketing technology and project financing of management and the international standard project management technologies, such as integration management, scope management, time management, cost management, quality management, human resource management, communication management, risk management, procurement management, and stakeholder management as the global standard to the domestic construction management industry in this study. The CM (construction management) is the present solution tool for the success of construction project by supervising. But, there are also diverse weaknesses and problems in this area. Therefore, we will review the possibility of the convergence between the CM and those technologies and suggest a model that could apply to the real case study by resulting in augmentation of the service ability in construction management. 본 연구는 건설사업의 원활한 관리와 성공을 위하여 기술적으로 지원하는 제도인 건설사업관리 (CM)업무의 문제점을 고찰하고, 이를 개선할 수 있도록 다양한 관리기술을 접목하여 보다 개선된 방안을 도출하고자 한다. 이를 위하여 현재의 CM업무에 국제표준의 프로젝트 관리기술과 최신 경영기법을 융합하여 증강형 CM이라는 개념을 제시하였다. 건설현장은 수많은 자원과 인력이 투입되는 복잡한 생산과정을 거치게 되는데 이를 원활하게 관리하기 위해서는 과학적이고 발전된 관리기술이 필요하며, 이때 CM 서비스가 그 역할을 하게 된다. 이에 건설사업 초기단계에서 타당성 분석, 프로젝트 파이낸싱, 마케팅 등의 경영 기술을 결합하고, 프로젝트 관리 국제표준기술을 접목함으로써 결과적으로 CM수행능력을 증강시켜 성공적인 건설사업관리를 추진할 수 있다. 이에 따라 본 연구에서는 융합된 CM 모델, 즉, 증강형 CM을 제시하고 이를 사례를 통하여 활용성을 검증하였다.