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혈액투석 환자에서 Erythropoietin 저항성에 영향을 미치는 인자 -혈액투석 환자에서 EPO 저항성-
권건호(Kun Ho Kwon),황경화(Kyung Hwa Hwang),김경수(Kyung Soo Kim) 대한내과학회 2000 대한내과학회지 Vol.58 No.5
N/A Background : More than 90% of dialysis patients respond in a dose-dependent manner to erythropoietin(EPO) administration and the others are resistant. The causes of EPO resistance are iron deficiency, vitamin deficiency, severe hyperparathyroidism, aluminum toxicity, and inflammation. Much literature has been published concerning iron deficiency and its role in EPO resistance. However little attention has been given to the contribution of inflammation to the EPO-resistant anemia observed in hemodialysis patients. Methods : In the present study, we examined the contribution of parathyroid hormone levels, iron idices, normalized protein catabolic rate(nPCR), Kt/Vurea, albumin, and C-reactive protein(CRP) to erythropoietin resistance index(weekly rhEPO dose/body weight/hematocrit; ERI) in clinically stable 48 hemodialysis patients. Results : The factors correlated with ERI were CRP(R=0.608, p<0.01), ferritin(R=0.460, p<0.01) and serum albumin(R=-0.359, p<0.05). In stepwise multiple regression analysis, the independent factor affecting on ERI was CRP(β=0.620, p<0.01). Comparing high CRP group(≥0.4 mg/dL) with normal CRP group(<0.4 mg/dL), there were significant differences in serum albumin, creatinine, ferritin, and ERI. Conclusion : Acute-phase response, assessed by the level of CRP, was the most important predictor or EPO resistance in stable hemodialysis patients.(Korean J Med 58:510-515, 2000)
문옥륜,강재헌,이상이,정백근,이신재,윤태호,황경화,김남순,Moon, Ok-Ryun,Kang, Jae-Heon,Lee, Sang-Yi,Jeong, Baek-Geun,Lee, Sin-Jae,Yoon, Tae-Ho,Hwang, Kyung-Hwa,Kim, Nam-Soon 대한예방의학회 2001 예방의학회지 Vol.34 No.4
Objective : To develop a boner understanding of the relationship between weight status and the prevalence of obesity related diseases in the Korean population. Methods : The 1998 Korean National Health and Nutrition Survey was used and 10,880 persons who had previously taken health examinations were selected for study. The Korean Society for the Study of Obesity's classification of weight status was used. Hypertension, diabetes mellitus, dyslipidemia, osteoarthritis, chronic heart disease, stroke were included as obesity related disease. A logistic regression model was developed to estimate the prevalence odds ratio by obesity class adjusted for demographic and socioeconomic factors and we converted the odds ratio to a prevalence ratio using the base line prevalence of disease to aid in the interpretation of the ratios. Results : The prevalence of obesity was 26.3% based on the KSSO classification $(BMI\geq25)$. A graded increase in the prevalence ratio was observed with increasing severity of overweight and obesity for all health outcomes with the exception of chronic heart disease in men and stroke in both men and women. With normal weight individuals as the reference, for men who were younger than 50 years, the prevalence ratios were highest for hypertension BMI<23-25: 1.70(95% CI=1.41-2.05), 25<BMI<30: 2.63(95% CI=2.25-3.05), $BMI\geq30$: 4.83(95% CI=3.70-5.84). The prevalence ratios for dyslipidemia were as high as hypertension, but were lower than hypertension for diabetes mellitus and osteoarthritis. Prevalence ratios generally were greater in younger adults. The prevalence of having 2 or more obesity related diseases increased with weight status category, except in people who were older than 50 years. Conclusions : Based on results, obesity is an increasingly important health problem in Korea and the disease burden increases according to weight status. For Korean adults, the strongest relationship was seen between weight status and hypertension and dyslipidemia. In older people the impact of excess weight and obesity is stronger than that seen in younger people. Increased efforts in the study of obesity and prevention and treatment of obesity and obesity related disease are required.
크론병 환자에서 Coxsackie Virus B 감염에 의한 급성 확장성 심근병증 1예
김경철,황경화,황성규,임규성,권창일,홍성표,박필원,최유정,오재인 대한소화기학회 1999 대한소화기학회지 Vol.34 No.1
A 23-year-old man was admitted for watery diarrhea, abdominal pain and fever. He had received an operation for an anal fistula at a private clinic about 3 years ago. Recently, he was treated under the diagnosis of tuberculosis colitis for about 15 months at another hospital, but showed no improvement. He lost 30 kg of weight for last 18 months. On admission, he was 178 cm high and weighed 50 kg. He had a pararectal abscess and a fistula between terminal ileum and sigmoid colon. He was diagnosed as Crohn's disease. After taking 2 weeks of medications composed with sulfasalazine, corticosteroid, 6-mercaptopurine and antibiotics, his condition improved rapidly and gained 5 kg of weight. On the 6th hospital week, he complained of dyspnea on exertion and orthopnea. His chest X-ray revealed a marked cardiomegaly, while his heart was normal in size and shape. He was diagnosed as dilated cardiomyopathy caused by coxsackie virus B, which was confirmed by serologic test. He died at the 46th hospital day. We report this case with a review of literature.
Isolation and Structures of Guaianolides from Carpesium macrocephalum
Kim, Mi-Ran,Kim, Chang-Soo,Hwang, Kyung-Hwa,Park, Il-Yeong,Hong, Seoung-Soo,Son, Jong-Keun,Moon, Dong-Cheul 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
Two new guaianolides, 4α,10α-dihydrory-1β(H),5β(H)-guai-11(13)-en-8α,12-olide (2) and 4β,10β-dihydroxy-5α(H)-1,11(13)-guaidien-8α,12-olide (3), from Carpesium macrocephalum were isolated, and their structures were elucidated on the basis of spectroscopic studies.