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전사인자의 핵 전이 억제를 통한 영계출감탕의 면역 억제 효과
홍철희,김남권,이수형,두인선,황충연,Hong, Chul-hee,Kim, Nam-kwen,Lee, Soo-hyeong,Du, In-sun,Hwang, Chung-yeon 대한한방안이비인후피부과학회 2003 한방안이비인후피부과학회지 Vol.16 No.2
Younggaechulgam-tang has been used for treating skin diseases. In this study, I investigated the immunosuppressive effect of Younggaechul-tang in the human T cell line MOLT-4 cells. MOLT-4 cells were stimulated with the phytohemagglutinin (PHA) and phorbol 12-myristate 13-acetate (PMA) + A23187. The secretion appeared to be greater when cells were stimulated with PHA than with PMA + A23187. Younggaechulgam-tang had no affect proliferation stimulated by PHA. I showed that IL-2 secretion and expression by PHA stimulated MOLT-4 cells were inhibited by Younggaechugam-tang treatment. Maximal inhibition rate of IL-2, TNF-${\alpha}$ secretion was 80$\%$ and 30$\%$, respectively. Younggaechulgam-tang also inhibited nuclear translocation of p65 subunit of nuclear factor-kB and nuclear factor of activated T cells (NFAT). In conclusion, these results suggest that Younggaechulgam-tang may contribute to the immunosuppressive oriental drug clinically.
Study on the Moisturizing Effects of Puerariae Radix Ethanol Extract
홍철희,이성진,Hong, Chul-Hee,Lee, Sung-Jin The Society of Korean Medicine Ophthalmology 2017 한방안이비인후피부과학회지 Vol.30 No.1
Objectives : 갈근의 피부 보습 효과에 대해 알아보기 위해 본 연구를 진행하였다. Methods : HaCaT 세포주에 갈근 에탄올 추출물을 처리하였고 Retinoic Acid $1{\mu}M$을 양성 대조군으로 사용하였다. MTT assay, RT-PCR, Hyaluronidase enzyme assay, HA-ELISA kit를 통해 Hyaluronic Acid의 합성량, Hyaluronidase 저해율, 농도별 Hyaluronic Acid 생성량을 측정하였다. 더불어 실제로 피부에 도포 시 보습 능력이 있는지 등에 대하여 확인하였다. Results : 갈근 에탄올 추출물은 뚜렷한 세포독성을 나타내지는 않았고, 모든 농도에서 Hyaluronic Acid 합성과 관련된 hyaluronic acid synthase 2 유전자가 발현되었고, 실제로 Hyaluronic Acid가 생성되는 것을 확인하였다. 임상 효능 평가에서는 유의성 있는 결과를 얻을 수는 없었다. Conclusions : 갈근을 한방 외용제로 사용할 때 유의성 있는 효과를 나타낼 수 있을 것으로 기대할 수 있으며, 실험 결과를 토대로 갈근의 최적 사용 농도를 결정하기 위한 추가적 연구와 복합 처방으로 사용했을 경우에 대한 연구가 추가적으로 진행된다면 한방 외용제로서 잠재적인 가치가 있을 것으로 사료된다.
홍철희,Hong, Chul-Hee 대한한방안이비인후피부과학회 2012 한방안이비인후피부과학회지 Vol.25 No.2
Objectives : The purpose of this study is to report the effect of Hwangryunhaedok-tang Pharmacopuncture Therapy on Seborrheic Dermatitis Methods : An author treated distillation of Hwangryunhaedok-tang Pharmacopuncture(0.8cc) on both LI20(Yenoghyang), SI18(Gwollyo), ST7(Hagwan) of patient's spots on the face suitable for acupuncture and examined variation of two Seborrheic Dermatitis cases Results : The Hwangryunhaedok-tang Pharmacopuncture Therapy was effective on amelioration of symptoms like flare, pricking and itching sense in Seborrheic Dermatitis Conclusions : The above result indicate that Hwangryunhaedok-tang Pharmacopuncture Therapy has an effect on Seborrheic Dermatitis, and an author consider that continuous clinical study will be needed in other Pharmacopuncture and Korean medical treatment.
홍철희,박민철,황충연,김진만,Hong, Chul-Hee,Park, Min-Chul,Hwang, Chung-Yeon,Kim, Jin-Man 대한한방안이비인후피부과학회 2002 한방안이비인후피부과학회지 Vol.15 No.2
Uveitis is a comprehensive term that indicates the inflammation of not only the uvea but also its adjacent tissues, and its etiology, clinical features and prognosis are various. We conducted 2 patients with uveitis seen at Won-Kwang University Kwang- Ju Oriental Medical Hospital in 2002. We treated uveitis in a twenty-nine years old man and a thirty years old woman with the complaint of decreased vision, glaring eye, blood-shot eye, pain of eye, tears in one's eye by herbal medicine (Se-An-Myung-Mok-Tang gami) and Acupunture. Usually, uveitis have chronic phase. We had a significant results. So we report this two cases.
홍철희,심은기,박준영,송성필,홍석훈,황충연,Hong Chul-hee,Shim Eun-ki,Park Joon-young,Song Seong-pil,Hong Seok-hoon,Hwang Chung-yeon 대한한의진단학회 2004 大韓韓醫診斷學會誌 Vol.17 No.2
Background and Objective: Erythema multiforme(EM) is related disorders of skin and mucous membranes which is typically associated with antecedent medications or infections. etc. EM is an erythematous maculopapular cutaneous eruption of variable form. However, the pathophysiology of the EM remains obscure. Treatment at present is symptomatic and supportive. There is no report on EM treated with oriental medical treatment. Methods: We conducted one patient with EM seen at Won-Kwang University Kwang-Ju Oriental Medical Hospital in 2004. We treated EM in a twenty-two years old man by a herbal medicine(Joa-Chang-Bang), a herbal medicine for external use, acupunture, moxa, COTDE-made cosmetics, and P-Tx(carbon). Conclusions. We had a significant results. So we report this case to estimate the efficiency of oriental medical treatment and management on EM.
홍철희(Chul Hee Hong),김선희(Seon Hee Kim) 한국조리학회 2000 한국조리학회지 Vol.6 No.3
This is a study on the ways of improving the current Kwangju Kimch Festival. The Festival has many resources for attracting visitors, nevertheless, it has been criticized for marketing tools, including lack of publicity, institutional inertia, etc. A new approach for improving Kwangju Kimch Festival is needed to satisfy the needs not only for residents but also for visitors, especially japan tourists, the best way of improving the current Kwangju Kimch Festival might be the development of the product(for exemple, effective linkage system with tourist attractions) and promotion(advertising, publicity).
홍철희(Cheul Hee Hong),김희아(Hee Ah Kim) 한국조리학회 1999 한국조리학회지 Vol.5 No.2
The purpose of this study is to explore the considering things for menu development of food industries. there are many important factors to take into consideration. The results are as follows; First, a good understandings of consumers` demand Second, considering of the regional characteristics Third, establishing of the exact target Fourth, careful thinking of a unit cost The national income and the quality of life have continued its growth in these days. so, Food industries have to develop the menu from consumeroriented thinking. that is a key to success in food industries.