만성 정신분열증 환자에서 Paroxetine과 Haloperidol 병합투여시 정신병리증상과 Haloperidol, Reduced Haloperidol 혈중농도의 변화

한창수,이민수,김표한,Han, Chang Su,Lee, Min Soo,Kim, Pyo Han 대한생물정신의학회 1996 생물정신의학 Vol.3 No.2

Selective serotonin reuptake inhibitors(SSRIs), as haloperidol, ore metabolized in the cytochrome P450IID6. They can cause inhibition of metabolism of antipsychotics to elevate the serum level of antipsychotics and exacerbate the extrapyramidal symptoms when co-administered with antipsychotics. Among these SSRIs, there ore a few studies about paroxetine compared to fluoxetine or sertraline. In this study, we have intended to know the drug interaction of paroxetine and haloperidol when co-administered two drugs for the chronic schizophrenics by assessing the changes of positive, negative symptoms and extrapyramidal symptoms. for this purpose, we selected 29 subjects, the chronic schizophrenics with no physical problems. They were under maintenance therapy of haloperidol. They ore randomly assigned to placebo group(n=12) and drug group(n=17) by using double blind method. And then, placebo or paroxetine 20mg were administered to the subjects of each groups during 8 week period. We have assessed their psychopathology and extrapyramidal symptoms using Positive and Negative Syndrome Scale(PANSS), Hamilton Rating Scale lor Depression(HRSD), Simpson-Angus Scale at 0, 2, 4, 6, 8 weeks and serum haloperidol, reduced haloperidol levels at 0, 4, 8 weeks during the period. The results ore analysed by using repeated measure MANOVA. 27 subjects have completed the study during 8 weeks. among the subjects, 1) PANSS, HRSD ; no significant difference between groups. 2) Simpson-Angus Scale ; no significant change according to the time and no significant difference between the groups(no group and time effect). 3) Haloperidol and reduced haloperidol level ; no significant change. When co-administered paroxetine and haloperidol, there ore no significant changes of the psychopothology and no significant changes of the extrapyramidal symptoms. In this result, paroxetine seems to be not to affect the metabolism of haloperidol.

Fluoxetine과 Haloperidol의 병합투여시 정신병리 및 추체외로 증상의 변화

이민수,한창수,김제원,원경식,곽동일,Lee, Min-Soo,Han, Chang-Su,Kim, Jae-Won,Won, Kyung-Sik,Kwak, Dong-Il 대한생물정신의학회 1997 생물정신의학 Vol.4 No.1

본 연구는 정신분열증 환자 38명을 대상으로 하여 haloperidol과 fluoxetine을 8주간 병합투여 하였고, PANSS, CGI, Simpson-Angus 척도를 투여전과 투여후 2, 4, 6, 8주에 시행하여 임상증상 및 추체외로 부작용을 평가하였다. 결과는 다음과 같다. 1) 8주간의 연구기간동안 양성, 음성증상의 유의한 변화가 없었다. 2) 8주의 연구기간동안 추체외로 부작용의 증가가 나타나지 않았다. 이는 기존 연구에서 fluoxetine에 의해 haloperidol의 혈중농도가 증가하여 효과 및 부작용이 증가한다는 연구보고와는 다르며, 이 결과는 haloperidol과 fluoxetine의 병합사용을 안전하게 할 수 있다는 것을 의미한다고 하겠다. Objectives : The authors have intended to know the drug interaction of fluoxetine and haloperidol when coadministering two drugs to the chronic schizophrenics by assessing the changes of positive, negative symptoms and extrapyramidal symptoms. Method : We selected 38 patients, the chronic schizophrenics with no physical problems. they are randomly assigned to placebo group and drug group. And then, placebo or fluoxetine 20mg were administered to the subjects of each group during 8 week period. We have assessed their psychopatholgy and extrapyramidal symptoms using Positive and Negative Syndrome Scale(PANSS), Clinical Global Impression(CGI), Simpson-Angus Scale at 0, 2, 4, 6, 8 week during the period. Results : 38 patients have completed the study during 8 weeks. 1) PANSS, CGI : no significant difference between groups and no significant change according to the times. 2) Simpson-Angus Scale : no significant changes. Conclusion : When co-administering fluoxetine and haloperidol, there were no significant changes of psychopathology and extrapyramidal symptoms. These results suggest that it is safe to coadminister fluoxetine to schizophrenic patients with haloperidol treatmemt.

나노 위치결정기술

한창수,Han, Chang-Su 재료연구소 2002 機械와 材料 Vol.14 No.1

FOCUS - 금속기판에 형성된 그래핀의 직접 전사기술

한창수,Han, Chang-Su 한국과학기술단체총연합회 2014 과학과 기술 Vol.545 No.-

Manic Patient with Meningioma Treated with Low dose Risperidone and Valproic Acid

한창수,이분희,김용구,Han, Chang-Su,Lee, Bun-Hee,Kim, Yong-Ku The Korean Society of Biological Psychiatry 2004 생물정신의학 Vol.11 No.1

We describe the case of a 73 year-old female patient, YSG, who initially presented with a manic episode without any previous psychiatric history and was later diagnosed as having a meningioma in the left frontal lobe. YSG's symptoms were characterized by hyperactivity, insomnia, aggressive behavior with an auditory hallucination. She showed no abnormal signs on a complete neurologic examination. A gadolinium-enhanced MRI study showed a huge, extra-axial mass with homogenous enhancement in the left high convexity of the frontal lobe. Her manic symptoms subsided after administration of risperidone 1mg and valproic acid 500mg daily, for three weeks without surgical resection of the tumor. These findings suggest that YSG's mania might have resulted from the left-sided frontal tumor, and that her symptoms were treated rapidly by small doses of risperidone combined with valproic acid. Medical staff who care for manic patients should be aware of this possibility of a organic lesion without evidence of neurologic disease.

스트레스

한창수,전현두,Han, Chang-Su,Jeon, Hyeon-Du 한국건강관리협회 2006 건강소식 Vol.30 No.10

현대 사회를 살아가는 사람들은 각종 스트레스에 노출되어 있다. 불안한 미래와 과다한 업무, 가족 간의 불화, 각종 사회적 위험요소가 팽배한 현실에서 현대인들이 받은 스트레스는 회피할 수도, 저항할 수도 없는 삶의 과정에서 자연스럽게 나타나는 것이다. 심한 스트레스는 우리의 정신적인 안정을 깨뜨리고 불안감과 긴장감을 유발한다. 스트레스는 정신건강을 해치는 주범이 되기도 하지만 그렇다고 스트레스가 모두 다 해로운 것만은 아니다. 스트레스는 어려움을 극복하게 하고, 목표를 성취하도록 힘을 주며, 동기를 유발시키고 삶의 활력을 불어넣기도 한다. 따라서 건설적일 수도 있고, 파괴적일 수도 있는 스트레스를 어떻게 다루는가에 따라 우리의 건강과 행복을 크게 영향을 받게 된다. 이번 10월호에서는 고디 안산병원 한창수 교수와 한국 심리적성센터 전현두 원장의 도움말로 스트레스에 관해 자세히 알아본다.

잉크젯 프린팅 기법으로 단일벽 탄소나노튜브 패터닝

한창수,송진원,Han, Chang-Su,Song, Jin-Won 한국과학기술단체총연합회 2007 과학과 기술 Vol.40 No.7

저에너지 레이저 조사가 창상치유에 미치는 영향

한창수,김명철,Han, Chang-su,Kim, Myung-cheol 대한수의학회 1997 大韓獸醫學會誌 Vol.37 No.3

This study was performed to determine the optimal dose of laser energy for wound healing. The skin wound with 8mm diameter was induced over the lumbar vertebrae of the rats, and wound squares, scab hardness, hematologic findings and histopathlogic findings according to irradiation of laser energy were studied. 1. Wound square was significantly reduced at Day 1 (p<0.01), 2 (p<0.01), 3 (p<0.05), 7 (p<0.01) and 8 (p<0.05), respectively in experimental groups, especially group II, compared with control group. 2. Scab hardness was significantly increased at Day 1 (p<0.01), 2 (p<0.01), 3 (p<0.05), 5 (p<0.01) and 7 (p<0.01), respectively in experimental groups, especially group II, compared with control group. 3. In hematological findings, red blood cells and white blood cells in experimental group were increased according to the lapse of days, but they were not significant. 4. In histopathologic findings, experimental groups, especially group II, revealed early scab formation, early appearance of phagocytes and fibroblast, rapid growth of granulation tissue and collagen, and promotion of wound healing in the result.

WSN환경에서 센서노드의 생명주기 연장을 위한 고정 분할 기법

한창수,조영복,우성희,이상호,Han, Chang-Su,Cho, Young-Bok,Woo, Sung-Hee,Lee, Sang-Ho 한국정보통신학회 2016 한국정보통신학회논문지 Vol.20 No.5

WSN은 센서 노드에 의해 구성된 네트워크로, 센서 노드는 한번 배치되면 재충전하거나 위치적으로 재배치가 불가능하다. 또한 센서노드들은 제한된 에너지를 가지고 통신에 참여하게 된다. 그러나 기존 제안되었던 클러스터링 기법들은 불균일한 분포로 배치된 WSN환경에 적용 시 지역적 특징으로 통신 단절이 발생되는 문제점으로 네트워크의 신뢰성에 문제점을 갖는다. 따라서 제안 알고리즘에서는 WSN환경에서 센서노드의 불균형 배치를 고려해 센서필드를 분할하고 분할영역의 센서노드 밀집도에 따라 고정, 정적, 동적 클러스터링 알고리즘을 선별적으로 적용함으로 센서노드의 통신 참여율을 25% 향상시켰다. 그리고 전체 네트워크 생명주기는 14%연장하여 네트워크의 신뢰성을 보장하였다. WSN based on wireless sensor nodes, Sensor nodes can not be reassigned and recharged if they once placed. Each sensor node comes into being involved to a communication network with its limited energy. But the existing proposed clustering techniques, being applied to WSN environment with irregular dispersion of sensor nodes, have the network reliability issues which bring about a communication interruption with the local node feature of unbalanced distribution in WSN. Therefore, the communications participation of the sensor nodes in the suggested algorithm is extended by 25% as the sensor field divided in the light of the non-uniformed distribution of sensor nodes and a static or a dynamic clustering algorithm adopted according to its partition of sensor node density in WSN. And the entire network life cycle was extended by 14% to ensure the reliability of the network.

장애인스포츠 실업팀 고용연계를 위한 기관별 협력 방안

한창수 ( Chang Su Han ),최승권 ( Seoung Gweon Choi ) 한국특수체육학회 2014 한국특수체육학회지 Vol.22 No.4

본 연구는 장애인스포츠 실업팀의 안정적 운영을 위해 장애인스포츠 분야와 장애인고용 분야 간 정책연계를 통한 기관별 협력 방안을 제시하는데 목적을 두고 있다. 이를 위해 관련 법·제도 검토와 장애인스포츠실업팀 운영 현황 및 장애인 고용 실태를 파악하였으며, 실증적 자료 보완을 위해 중앙일간지나 인터넷신문을 중심으로 장애선수나 장애인스포츠 실업팀 관계자의 기사인터뷰 자료를 근거로 장애인스포츠실업팀의 효율적 운영 방향을 모색하였다. 장애인스포츠 실업팀의 효율적 운영을 위해 고용을 연계한 기관별 협력방안을 제시하기 위한 본 연구의 결론은 다음과 같다. 첫째, 장애인스포츠 실업팀이 안정적이고 체계적으로 운영되기 위해 법·제도 정비가 선행되어져야 한다. 특히 「국민체육진흥법」이나 「장애인고용촉진 및 직업재활 법」「장애인차별금지 및 권리구제 등에 대한 법률」등의 포괄적인 범위에서 장애인 체육활동을 규정하고 지원하는 것으로 명문화되어져야 하며, 실업팀을 운영하는 지자체마다 제각각인 설치기준을 마련하는 것이 필요하다. 둘째, 관련기관 간 정책연계를 통해 장애인스포츠 실업팀 창단과 운영에 필요한 재정적 어려움을 덜어주어야 한다. 이를 위해 장애인 의무고용률을 장애인스포츠 분야에 적용시켜실업팀을 운영함으로서 선수들에게는 직업안정성을 높여 안정적 훈련환경을 제공하고, 기업은 장애인 의무고용률 달성을 통해 사회적 책임과 고용장려금 지원 및 장애인편의시설 설치지원 효과를 얻을 수 있도록 하여 실질적 팀 운영에 부담을 덜어주어야 한다. 셋째, 장애인스포츠 실업팀의 창단이나 효율적 운영을 위해 실업팀 창단 이후 각 기관별 역할과 업무를 보다 명확히 구분해야 한다. 이를 위해 장애인스포츠부문과 장애인고용부문, 기업부문 간 협력방안을 각각 구분하고 기관별 역할 규정과 업무분장 내용 등 구체적인 협조체제를 구축하여 장애인스포츠 실업팀이 보다 활성화 될 수 있는 기본적 환경을 조성해 주어야 한다. The purpose of this study was to provide cooperative measures by organizations through the policy connection between sports and employment for the disabled for stable operation of Business Sports Team for the disabled (BSTD). To end this, this study analyzes the status of employment of the disabled and the problems presented in the operation of the team. Through this analysis, this study aims to present measures to promote the stable employment of the disabled at public institutions, local autonomous entity and private enterprises. Therefore this study conducted analysis to provided employment-affiliated measures through collaborative governance to present practical means for public institutions, local autonomous entities and private enterprises to overcome the difficulties and provide good environment for disabled athletes. The results are as the followings. First of all, it is necessary to reduce the burden of finance concerning foundation, operation and employment of BSTDs through affiliated poligies of relevant institutions. Operation strategies should be established to achieve effects of social responsibility and budget/convenience facilities installation support through fulfillment of obligated employment rate in public institutions, local autonomous entities and private enterprises. Through this process, the operation of BSTDs can provide athletes with stable employment and environment for training. Secondly, it is necessary to reduce the burden of finance concerning foundation, operation and employment of BSTDs through affiliated policies of relevant institutions. Operation strategies should be established to achieve effects of social responsibility and budget/convenience facilities installation support through fulfillment of obligated employment rate in public institutions, local autonomous entities and private enterprises. Through this process, the operation of BSTDs can operate the BSTDs with less burden substantially. Lastly, each organization has to be categorized specifically in its parts and tasks for effective operation after foundation of BSTDs. To encourage the BSTDs to be fostered by building a concrete cooperative-network for this basic environment such as classifying the methods of cooperation through the sectors of the sports of the disabled, the employment of the disabled and the corporation from the part of the each organization and the duty division should be activated.