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Critical Role of Plectin in Anti-migration Potential of Curcumin
하영란,최용욱,이상준 한국식품과학회 2011 Food Science and Biotechnology Vol.20 No.6
Plectin, a linker protein that organizes the cytoskeleton, is critical for cell migration and wound healing. It is specifically expressed in epithelial cells,muscles, and other tissues. Numerous studies have shown that curcumin (diferuloylmethane) has anti-cancer potential. Curcumin can inhibit cancer cell migration and invasion through various signaling pathways. In this study, the down-regulation of plectin expression by siRNA was observed to induce the migration and invasion of human breast and lung cancer cell lines. Interestingly, the downregulation of plectin expression by siRNA reversed the curcumin-induced anti-migration and anti-invasion effects in both cancer cell lines while α-tocopherol and genistein inhibited knockdown of plectin induced cancer cell migration. Curcumin did not affect the expression of plectin; however,α-tocopherol and genistein inhibited migration in plectin down-regulated cancer cells. These findings support the novel role of plectin and its effect on the anti-migration and anti-invasion potential of curcumin.
하영란,하호진,이상준 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.5
Inflammation is a biological response to various external stimuli that induces vascular permeability via signaling pathways. Lipopolysaccharide (LPS) activates the acute inflammatory response and induces inflammatory mediators. Genistein has an anti-inflammation activity,however, whether genistein inhibits vascular permeability using the same signaling pathways at different development stages in chick embryos is unclear. Inflammatory processes in the chorioallantoic membrane (CAM) after LPS and genistein treatments at different immune stages were investigated. Genistein suppresses LPS-induced vascular permeability in chick embryos at the immature stage. RTPCR and western blotting were performed for LPSinduced toll-like receptor 4 (TLR4) signaling pathways in the CAM. The LPS-induced TLR4 pathways are attenuated by genistein. Different inflammation mechanisms in TLR4pathways are shown in embryos in the immature stage. Genistein probably inhibits the LPS-induced inflammatory response through different signaling pathways and has a strong therapeutic potential associated with inflammationinduced vascular permeability in chick embryos with immature immune capacities.
하영란,이인애,김효정,강희정,남대환,박지아,김정상 대한암예방학회 2010 Journal of cancer prevention Vol.15 No.1
Our previous study showed that genistein, a tyrosine kinase inhibitor and one of the major isoflavones in soybean, induced the expression of glucose regulated protein 78 (GRP78) which is one of the heat shock proteins in both MCF-7 and MDA-MB-231 cells. Pretreatment with genistein caused the increased resistance to doxorubicin in mammary tumor MCF-7 cells while it sensitized estrogen receptor (ER)-negative mammary tumor MDA-MB-231 cells to the drug. To address the discrepancy in response to the drug between two different cell lines pretreated with genistein, the transfectants expressing high level of GRP78 were generated by transfecting with pcDNA3.1 vector carrying GRP78 gene. Overexpression of GRP78 did not affect the cell morphology but modulated the expression of a set of genes involved in cell expressing different levels of GRP78 survival in cell type-specific manner. The transfectants were used to evaluate whether the level of GRP78 regulates the resistance or sensitivity against anti-cancer drugs including doxorubicin, tamoxifen, paclitaxel, mitomycin C. Overexpression of GRP78 made MCF-7 cells more resistant to doxorubicin and mitomycin C, and it slightly sensitized MDA-MB-231 cells to tamoxifen and paclitaxel. In conclusion, the cellular level of GRP78 or any exogenous factor affecting GRP78 expression may alter the efficacy of anticancer drugs on mammary tumor cells. (Cancer Prev Res 15, 45-51, 2010)
Dexmedetomidine Preconditioning Attenuates Cisplatin-Induced Ototoxicity in Zebrafish
민두재,김운영,하영란,정인영,주인영 대한이비인후과학회 2014 Clinical and Experimental Otorhinolaryngology Vol.7 No.4
Objectives. Utilisation of high-frequency drills is known to increase noise induced hearing loss due to increasing the dam- ages of inner ear cells. This study aimed to investigate whether preconditioning by using dexmedetomidine (DEX) decreased the occurrence of ischemia in inner cells of the ear. Methods. We utilised a transgenic zebrafish line Brn3C, and the embryos were collected from breeding adult zebrafish. Five-day-old larvae were cultured at the density of 50 embryos, and the larvae were classified into 4 groups: control, cisplatin group, DEX group, and DEX+yohimbine; adrenoreceptor blocker group. The DEX group was categorised into 3 subgroups by dosage; 0.1, 1, and 10 μM. Preconditioning was performed for 150 minutes and then exposed to cisplatin for 6 hours. The experiment was performed in 7 replicates for each group and the number of hair cells in 3 parts of the neuromasts of each fish was determined. Results. Hair cell apoptosis by cisplatin was attenuated more significantly in the DEX preconditioning group than in the control group. However, the preconditioning effects were not blocked by yohimbine. Conclusion. The results of this study suggest that hearing loss caused by vibration-induced noise could be reduced by using DEX and may occur through other mechanisms rather than adreno-receptors.