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미만성 거대B세포 항암치료 중 유발된 주기적 저칼륨성 마비
하경선 ( Kyung Sun Ha ),박영재 ( Young Jae Park ),박성수 ( Sung Soo Park ),이준엽 ( Joon Yub Lee ),김지현 ( Ji Hyun Kim ),장인애 ( Inae Jang ),변재호 ( Jae Ho Byun ) 대한내과학회 2014 대한내과학회지 Vol.87 No.5
Hypokalemic periodic paralysis is a rare disorder characterized by sudden onset of weakness and low serum potassium levels. We report a case provoked by combination chemotherapy including prednisolone. A 23-yr-man, diagnosed with diffuse large B-cell lymphoma, received chemotherapy. He developed significant weakness in upper and lower extremities during chemotherapy, and his serum potassium level was 1.7 mmol/L. Potassium replacement restored the weakness. Further workup revealed that prednisolone had provoked hypokalemic paralysis. As prednisolone triggered an attack of hypokalemic periodic paralysis, it should be administered with caution, particularly in patients with periodic paralysis. (Korean J Med 2014;87:625-629)
생쥐의 골격성장과 Ca대사에 미치는 식이Ca과 칼슘조절 호르몬의 영향
정차권(Cha-Kwan Chung),한은경(Eun-Kyung Han),남상명(Sang-Myung Nam),문유선(Yoo-Sun Moon),최수용(Soo-Yong Choi),하경선(Kyung-Sun Ha) 한국식품영양과학회 1999 한국식품영양과학회지 Vol.28 No.3
본 연구는 생체내에서 Ca대사에 미치는 칼슘조절 호르몬과 식이 Ca 수준의 영향을 조사하였다. BALB/c 생쥐를 high Ca, Medium Ca, 그리고 low Ca군으로 나누고 PTH, CT, Vit D 등의 호르몬을 i.p. injection하여 투여하였다. 5주간의 사육후 생쥐는 에테르 마취후 heart puncture에 의해 희생하였다. Femur의 성장율은 low Ca 군보다는 high Ca군에서 약간 높게 나타났으나 통계적 유의성은 없었다. PTH+CT군에서는 평균 femur 성장율이 가장 높았으며, 식이적인 Ca 공급이 충분할수록 성장률이 높은 경향을 보였다. 식이 Ca 수준은 뼈조직내의 무기물 보유에 가장 큰 영향을 끼쳤다. 전반적으로 모든군에서 high Ca은 혈청 Ca 수준을 상승시켰다. 식이 Ca 수준이 낮은 경우 PTH는 뼈로부터 Ca유출을 증가시켜 혈청 Ca 수준을 높여 주는 것으로 나타났고, 이러한 작용은 CT에 의해 억제되는 것으로 보였다. 대조군에 비해 모든 호르몬을 투여한 군에서는 medium 또는 high Ca 공급시 혈청 Ca 증가가 억제되었다. PTH와 Vit D는 식이 Ca 수준에 관계없이 간의 Ca 저장을 억제시켰으나, 식이 Ca 공급이 적을 경우 뼈에서의 Ca 보유를 촉진시키는 것으로 나타났다. 그러나 식이 Ca 공급이 충분시는 반대의 효과를 나타냈다. 식이 Ca 공급이 높을 때보다 식이 Ca 공급이 낮을 때 PTH, Vit D 및 CT이 공동으로 투여되었을 경우는 뼈의 Ca수준이 크게 증가되었다. 이것은 식이적인 Ca 공급이 부적절한 경우에는 적절한 골밀도를 유지하기 위해 생체내에서 이들 호르몬들이 공동으로 협력하는 작용이 존재한다는 것을 시사한다. This study has dealt the effect of Ca-regulating hormones and dietary Ca levels on Ca metabolism. Animals(BALB/c mice) were divided into three dietary groups(high and medium Ca and Ca-free) and hormones including parathyroid hormone(PTH), calcitonin(CT), cholecalciferol(Vit D) were i.p. injected. After feeding experimental diets for five weeks, mice were anaethetized and sacrificed by heart puncture. We found that femur growth of mouse was slightly increased by high dietary Ca without showing statistical significance comparing to low dietary Ca group. The combination of PTH and CT showed the same effect when dietary Ca was high. At the same time, total mineral retention in bone was most affected by dietary Ca. In general, high Ca diet elevated Ca level in the serum. When dietary Ca was low, PTH stimulated Ca release from the bone into the serum, which was shown to be inhibited by CT treatment. Comparing to the control, PTH, Vit D and CT together tended to inhibit serum Ca level at high and medium dietary Ca. PTH and Vit D inhibited Ca reserve in the liver at all dietary levels of Ca. Both PTH and Vit D stimulated bone Ca retention when dietary Ca was low, but this effect was reversed when dietary Ca was high. When PTH, Vit D and CT were administered together, bone Ca level was greatly enhanced at low dietary Ca than at high dietary Ca, which suggests that these hormonal cooperation is needed for proper bone density maintenance especially when dietary minerals are not sufficient.
CA 19-9 상승을 동반한 전이성 골종양으로 오인된 골결핵 1예
장경윤,하경선,박경선,심은희,변재호 영남대학교 의과대학 2011 Yeungnam University Journal of Medicine Vol.28 No.2
A 73-year-old male presented a six-month history of buttock pain radiating into his thigh. The MRI revealed a large enhancing mass lesion involving the sacrum, with extension into the sacral canal. The tumor markers were measured to distinguish skeletal metastasis of carcinoma from primary bone tumor. The CA 19-9 was elevated. Despite the investigation, the primary site of cancer could not be found. Sacral bone biopsy was done. The pathologic examination revealed necrosis, chronic granulomatous inflammation, and multinucleated giant cells, consistent with tuberculosis. Sacral tuberculosis is rare in patients with no history of tuberculosis. Such solitary osteolytic lesions involving the subarticular region of large joints may mimic bone neoplasms and may be called “tuberculous pseudotumors.” This case report intends to emphasize that bone tuberculosis should be a differential diagnosis in the presence of atypical clinical and radiological features. As tuberculous lesions may be mistaken for neoplasms, a small amount of fresh tissue should be sent for culture even if clinical diagnosis of a tumor seems likely. Described herein is a case of sacral tuberculosis mimicking metastatic bone tumor with elevated CA 19-9.