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      • KCI등재

        전도성 소재가 코팅된 신경도관을 이용한 회돌이 후두신경의 재생

        최정석,김현,안혜영,심봉섭,임재열 대한갑상선학회 2015 International Journal of Thyroidology Vol.8 No.1

        Background and Objectives: Recurrent laryngeal nerve (RLN) damage commonly occurs from a thyroid surgery and causes communication impairment, aspiration and dysphagia. The purpose of this study is to develop a polycaprolactone (PCL) nerve guide conduit (NGC) coated with conductive materials for facilitating regeneration from the RLN defects and to evaluate the usefulness of the PCL NGC coated with conductive materials in a rabbit model. Materials and Methods: The PCL NGCs coated with conductive materials were fabricated for this study. The types of conductive materials were single-walled carbon nanotubes (SWNTs) and poly (3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT:PSS) which were coated on the PCL NGCs by layer-by-layer (LBL) assembly techniques. An 8-mm segment of left RLN was resected in 24 New Zealand white rabbits. Three different NGCs (PCL and PCL with two conductive materials) were interposed between both stumps and fixed with suture. For the assessment of functional regeneration, the vocal cord mobility was observed using endoscopic system after RLN stimulation, and the motion change was analyzed. The atrophies of thyroarytenoid muscle and nerve growth were evaluated by Hematoxylin-Eosin (H-E) and toluidine blue (T-B) staining, respectively. Immunohistochemical study using anti-neurofilament, S-100 staining was further performed to evaluate the nerve regeneration. Results: In endoscopic evaluation, the group with conductive PCL NGCs showed an improved tendency of vocal cord mobility compared to that of the other group. Nerve growth was observed with the time for 8 weeks in all groups and immunohistochemical staining revealed the expression of neurofilament and S-100 in regenerated nerve in all groups. The atrophies of thyroarytenoid muscle in the group with conductive PCL NGCs was also shown to be decreased compared to that of the nonconductive PCL NGC group. Conclusion: The study shows that PCL NGC coated with conductive materials appears to be a good alternative option for the repair and regeneration of RNL damages.

      • KCI등재후보

        방사성요오드 치료 후 생긴 타액선염에 대한 타액선내시경술의 유용성

        최정석,임재열,김영모 대한갑상선학회 2012 International Journal of Thyroidology Vol.5 No.1

        Background and Objectives: Ablation of the thyroid remnants using radioiodine (RI) after surgical removal of differentiated thyroid cancer could induce radiation-related salivary gland dysfunction. The purpose of this study is to review our experience with therapeutic sialendoscopy for RI-induced sialadenitis. Materials and Methods: We reviewed medical charts of all patients with RI-induced sialadenitis treated with sialendoscopy retrospectively. The study included 14 patients who underwent sialendoscopy for the treatment of RI-induced sialadenitis after failing conservative management. Results: 14 patients (11 women, 3 men) with a mean age of 43.8 years (range, 26-60) underwent interventional sialendoscopy for the treatment of RI-induced sialadenitis that is unresponsive to conservative management. Symptoms arising from the parotid gland were seen in 12(86%) of patients, whereas symptoms arising from the submandibular gland were seen in 2 (14%). 7 patients (50%) presented symptoms in bilateral parotid or submandibular glands. The mean dose of RI was 203.2 mCi (range, 150-500) received as a single dose. The mean duration from RI ablation therapy to sialendoscopy was 11.1 months (range, 0.5-29). Sialendoscopy was possible in all patients. Ductal stenosis and mucus plugs and debris were the most common types of ductal pathology. Sialendoscopy improved the symptoms in 79% (11/14)of patients, with no serious complications reported in mean follow up of 4 months (range, 1-12). Conclusion:Therapeutic interventional sialendoscopy appears to provide symptom improvement in most patients. Sialendoscopy is effective tool for improving symptoms due to RI-induced sialadenitis in patients who are unresponsive to conservative managements.

      • KCI등재

        중국 유통산업의 경제적 효과 분석 - 2012년 투입산출표를 기준으로-

        최정석 한국중국문화학회 2017 中國學論叢 Vol.0 No.56

        The main purpose of this research is to analyze the Chinese distribution industry and economic effect, to use the Chinese market, to use the Chinese market, to produce the perfect consumption system, , Background. The results of this study are summarized below. First of all, in the influence coefficient, the professional equipment manufacturing industry ranked first, the industry category was 3.780887, accommodation catering industry ranked second 2.600737, other manufacturing ranked third to 1.370608, this sector has a positive impact on the development. As of the end of 2016, the proportion of the second manufacturing sector was 39.8%, the proportion of the tertiary industry was less than 51.6%, but the second manufacturing industry still had a great impact on the Chinese economy, and this was the Chinese government's Chinese manufacturing 2025 policy and other policies related to. Secondly, in terms of inductance coefficient, the chemical industry ranked first 3.451570, metal smelting and rolling process ranked second 2.891365, electricity and heating production supply ranked third to 1.932049, distributed 1.932049-3.451570. Similar to the results of the influence coefficient analysis, the impact of raw materials and energy, which is critical to the development of the manufacturing sector rather than the service sector, is also a policy that affects the long-term projects of China's distribution industry and the Chinese government's policy of 2025. 본 연구는 중국 유통산업의 경제적 효과를 분석한 것으로, 중국 투입산출표의 완전소비계수를 1차 자료로 활용하여 영향력계수와 감응도계수를 도출하였다. 이를 통해 중국경제에 어떠한 영향을 주고받는지 분석함으로서 중국정부의 정책과 배경, 시사점을 알 수 있다는 점에서 큰 의미를 지닌다. 본 연구의 분석 결과를 정리하면 다음과 같다. 첫째, 영향력계수(후방연관효과)를 보면, 상위에 랭크되어 있는 부문이 전문설비 제조업이 3.780887, 숙박 및 요식업이 2.600737, 기타 제조업이 1.370608로 1.370608-3.780887에 분포되어 중국 유통산업의 발전이 중국 제조업의 발전에 긍정적 영향을 주었다는 점을 알 수 있었다. 이는 중국 국가통계국 2016년 기준, 2차 제조업의 비중은 39.8%, 3차 서비스업의 비중은 51.6%보다 낮지만 아직까지 중국경제에서 많은 영향을 미치고 있고, 더불어 중국정부의 제조업 업그레이드를 위한 중국제조 2025 정책 등 여러 정책과도 연관이 있음을 알 수 있었다. 둘째, 감응도계수(전방연관효과)를 보면, 상위에 랭크되어 있는 부문이 화학공업이 3.451570, 금속제련 및 압연가공업이 2.891365, 전력, 난방생산 및 공급이 1.932049로 1.932049-3.451570에 분포되어 영향력계수의 분석결과와 비슷하게 서비스업보다는 제조업 발전에 필수적인 원자재 및 에너지 부분에 영향을 많이 받고 있었고, 또한 중국정부의 중국제조 2025정책뿐만 아니라 중국 유통산업에 영향을 많이 주는 장기적인 프로젝트인 일대일로 정책과도 연관이 있음을 알 수 있었다.

      • KCI등재

        해양레저선박의 지불의사금액 가치평가 연구

        최정석,김화영,최경훈 한국항만경제학회 2023 韓國港灣經濟學會誌 Vol.39 No.1

        This study was conducted to evaluating the willingness to pay for marine leisure ships through acontingent valuation method that can estimate the value of non-market economy. The questionnaireadopted a double-bound dichotomous choice Model and the variables for evaluating the amount ofwillingness to pay consisted of demographic variables and respondent behavior variables, and relatedinformation verified through previous studies. As a result of collecting and analyzing a totalof 309 questionnaires, the amount of willingness to pay for marine leisure ships was estimated tobe 25,510 won. In addition, significant variables affecting the amount of willingness to pay werethe experience of visiting the island, satisfaction with the introduction of new maritime transportation,and intention to revisit the island. Through this study, it can be used as a basis forevaluating the economic value of new maritime transportation by estimating the willingness to payfor marine leisure ships using the contingent valuation method. 본 연구는 비시장재의 경제적 가치를 추정할 수 있는 조건부가치측정법을 통해 해양레저선박의 지불의사금액을 추정하기 위해 수행되었다. 설문지는 이중양분형선택 방식을 채택했으며, 지불의사금액 평가를 위한 변수로는 선행연구를 통해 검증된 인구통계학적 변수, 응답자 행태 변수, 관련 정보에 관한 변수로 구성하였다. 총 309부의 설문지를 회수하여 분석한 결과 해양레저선박에 대한 지불의사금액은25,510원으로 추정되었다. 또한 지불의사금액에 영향을 미치는 유의한 변수는 섬 방문경험, 신규 해상교통수단 도입시 만족도, 섬 재방문 의사인 것으로 나타났다. 본 연구를 통해 조건부가치측정법을 활용하여 해양레저선박의 지불의사금액을 추정함으로써 보다 객관적인 신규 해상교통수단의 경제적 가치평가의 근거로 활용될 수 있을 것이다.

      • KCI등재

        중국 대형철강기업의 부상과 성장전략 연구 -허베이(河北)철강기업을 중심으로-

        최정석,최준환 한중사회과학학회 2015 한중사회과학연구 Vol.13 No.1

        鋼鐵工業作爲基礎原料工業, 在國民經濟中具有居足輕重的地位. 新中國成立60年以來, 中國鋼鐵工業已取得了巨大的成就. 1949年新中國成立初期, 中國鋼産量僅爲15.8億□, 此後, 鋼鐵工業逐步發展和壯大起來;至1996年, 中國鋼鐵産量首次突破億□大關, 位居世界首位, 從此之後, 中國鋼産量壹直穩居世界第壹的寶座. 特別是,由於鋼鐵工業的規模經濟的特征,地區方面的重要性越來越提高了. 最近中國內鋼鐵工業最發達的地區是河北省. 2012年河北省的粗鋼生産量是17000萬□, 這是中國1/4, 河北省經濟的28.9%的比重, 河北省是中國最大的鋼鐵生産基地. 河北省的主要鋼鐵企業是2008年設立的河北鋼鐵公司. 公司的規模是中國最大, 但比寶山鋼鐵公司競爭力方面沒有優勢. 問題的是公司合□效果不大,而且企業管理和R&D水平比較低. 根據河北鋼鐵公司董事長的王義芳提出了, 公司的主要問題是沒有完全構建“市場指向的顧客中心”的經營方式, 因此商品的R&D能力和高級技術人員不足. 以上的背景下, 本論文的構成是如下;第壹章是導論, 第二章考察了中國政府的主要鋼鐵工業政策, 則中國鋼鐵工業的現狀和2005年頒布的鋼鐵工業發展政策, 2009年頒布的中國鋼鐵工業5大振興計劃, 2011年頒布的鋼鐵12·5發展戰略建議, 2013年頒布的鋼鐵工業結構調整7個規制案等, 第三章分析了中國河北鋼鐵公司的增長戰略, 則合□過程和合□模型, SWOT分析, 成長性分析等, 最後導出了結論.

      • KCI등재

        구강건조증의 진단과 치료

        최정석,임재열 대한이비인후과학회 2016 대한이비인후과학회지 두경부외과학 Vol.59 No.6

        Xerostomia is a subjective sensation of a dry mouth which is frequently encountered in otorhinolaryngologic practice. There are a variety of salivary and nonsalivary causes of xerostomia such as side effects of medication, systemic disorders, radiation and Sjögren’s syndrome. The patients with xerostomia have difficulties in chewing, swallowing, speaking, tasting and mataining oral hygiene. Because of the ageing population, and the concomitant increase in medicated individuals, otorhinolaryngologists can expect to be presented with xerostomia in an increasing number of patients in the coming years and therefore should be familiar with its diagnosis and treatment. A systematic approach should be needed to determine the etiology of xerostomia and the management of xerostomia should be multidisciplinary and multimodal. This review summarizes the current literature on the diagnosis, and complications of xerostomia, and on the management of patients with xerostomia. Korean J Otorhinolaryngol-Head Neck Surg 2016;59(6):424-9

      • KCI등재

        갑상선에 생긴 원발성 편평세포암에 관한 고찰

        최정석,임재열,주영채,송순욱,김영모 대한이비인후과학회 2012 대한이비인후과학회지 두경부외과학 Vol.55 No.1

        Background and ObjectivesZZSquamous cell carcinoma of thyroid is uncommon and accounts for less than 1% of all primary thyroid malignancies. Clinical features mimic the natural course of anaplastic carcinoma. This study reviewed the clinical course of six cases of primary squamous cell carcinoma of thyroid. Subjects and MethodZZWe diagnosed six cases of primary squamous cell carcinoma of thyroid diagnosed from 1999 to 2006 at the College of Medicine Department of Pathology. Clinical data, treatment modality, and pathologic test results from medical records were retrospectively analyzed. ResultsZZWe found five women and one man (with the mean age of 52.1 years) with squamous cell carcinoma of thyroid. The main presenting features were abruptly enlarging neck swelling and obstructive symptom. Pre-operative needle aspiration biopsy revealed papillary carcinoma in five cases. Only one patient was diagnosed as squamous cell carcinoma through pre-operative needle aspiration biopsy. Three patients had massive adjacent organ invasion, and four patients had lymph node metastasis according to the pathology review. There were no cases of distant metastasis at the time of treatment. All patients received surgery and adjuvant therapy (radiation therapy, chemotherapy, radioiodine therapy). Three patients are still alive with a mean follow up period of 47.3 months (range, 44-49 months). The other three patients died within one year post-operatively. ConclusionZZPrimary squamous cell carcinoma of thyroid should be considered in patients diagnosed with papillary carcinoma and who exhibit aggressive clinical behavior. Complete tumor resection and radiotherapy should be performed if thyroid squamous cell carcinoma is confirmed.

      • KCI등재

        Rapid-Onset Hyponatremia Induced by Duloxetine in a Middle-Aged Male with Depression and Somatic Symptoms

        최정석,Hae-Woo Lee,이준영,정희연 대한신경정신의학회 2012 PSYCHIATRY INVESTIGATION Vol.9 No.1

        Duloxetine is a relatively balanced selective serotonin and noradrenaline reuptake inhibitor. We report a case of hyponatremia induced by duloxetine developed rapidly after starting the medication in a middle-aged male with multiple somatic symptoms and depression. Two days after discontinuation of duloxetine and management with hypertonic saline as well as fluid restriction, the serum sodium level normalized. The patient had two risk factors for developing hyponatremia, such as severe body weight loss and pneumonia. Therefore, when treating patients with depression and somatic symptoms, especially with risk factors for developing hyponatremia, close monitoring for clinical and laboratory evidence of hyponatremia may be essential.

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