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S-152 Primary hepatic carcinosarcoma in patient with chronic hepatitis C
최세명,신경인,최왕용,권태형,김상진,황재석 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Primary carcinosarcoma of the liver is a malignant tumor that contains a intimate mixture of carcinomatous and sarcomatous elements. It is a very rare disease less than 1% of primary malignant tumors of the liver. Here we report a case of a patient who was finally diagnosed as a primary carcinosarcoma confirmed by pathology following surgical resection. A 54-year-old female patient with epigastric pain for 10 days visited our hospital for evaulation of liver mass that found in CT scan performed at local medical center. She has been diagnosed as chronic hepatitis C at 10 years ago. She consumed heavy alcohol about 3-5 times a week each 1-2 bottles of soju. There were no special findings in physical examination and laboratory findings except HCV RNA 2,540,000IU/mL. Abdominal CT scan revealed a low attenuated mass in liver lateral segment with intrahepatic duct dilatation and left portal vein thrombosis. It was suggested that cholangiocarcinoma. Liver MRI showed also that cholangiocarcionma was suspected. PET CT showed a single mass with no distant metastasis and we clinically diagnosed it as a cholangiocarcinoma. Left hepatectomy with regional lymph node dissection, portal vein resection and reconstruction was performed. Macroscopically, there was the 6cm sized mass that had whitish and yellowish element with irregular margin. Pathologically, its final diagnosis was primary hepatic carcinosarcoma, that was composed by mixed carcinomatous and sarcomatous elements with left portal vein tumor thrombosis, no lymph node metastasis. This patient had a curative operation and recent follow up CT scans shows no recurrence untill now, after 3 years of resection. Hepatic carcinosarcoma is a very rare tumor, with a significantly poorer prognosis respect to hepatocellular carcinoma and cholangiocarcinoma. According to some reported cases, it is known that the prognosis for carcinosarcoma of the liver is poor, and most patients died within a year, except for a few cases in which curative operation for the tumor was performed as an initial treatment. Its pathogenesis, epidemiology and risk factors are also still unknown. Thus the further research of this disease is more needed.
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Synthesis of Idebenonyl Ester Prodrugs and Their Evaluation of Cancer Cells In Vitro
배송미,최세명,원영선,서권일,정대일,송주현,조종현 대한화학회 2021 Bulletin of the Korean Chemical Society Vol.42 No.4
Esterification of idebenone with commercially available straight-chain aliphatic acids, branched-chain aliphatic acids, aromatic acids, or nonsteroidal anti-inflammatory drugs afforded their corresponding idebenonyl esters (5a–k) in good yield. The values of cell viability for RC-58T cell at 50 μM were 86.3% for 5a, 75.9% for 5b, 23.4% for 5d, 61.2% for 5f, 67.9% for 5h, 70.6% for 5i, and 49.0% for 5j.
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박혜민 ( Hye Min Park ),도민영 ( Min Young Do ),최세명 ( Sei Myung Choi ),양경호 ( Kyung Ho Yang ),허창재 ( Chang Jae Hur ),조광범 ( Kwang Bum Cho ) 대한췌담도학회 2015 대한췌담도학회지 Vol.20 No.4
대부분의 십이지장 천공은 증상을 유발하므로 급성기에 발견된다. 그러므로 시기를 알 수 없이 우연히 발견된 만성 십이지장 천공은 드물고 치료의 기준도 명확하지 않다. 본 증례 경우에는 보존적 치료 후에 병변이 호전되었다. 이와 같이 우연히 천공이 발견된 증례는 드물고 향후 관심이 필요할 것으로 사료되어 문헌 고찰과 함께 보고한다. Duodenal perforation can occur due to complications caused by ulcers, other inflammation or by the instrument used during the procedure such as endoscopy, endoscopic retrograde cholangiopancreatography (ERCP); however, its incidence is not high. Most cases of perforation of the lateral wall of the duodenum are acute and require immediate surgical or endoscopic treatment. Cases of chronic duodenal perforation are rarely reported. This report presents the case of a previous perforation that was discovered unexpectedly during ERCP in a patient with cholangitis due to common bile duct stones. The time of occurrence of the perforation was unknown. After medical treatment, the patient was able to return to daily life. We have reported this case along with a literature review.
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