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Amatoxin 중독 환자에서 Silymarin, Penicillin, N-acetylcysteine의 효과 비교: 체계적 고찰
최민우,고동률,공태영,좌민홍,유제성,정성필,Choi, Min Woo,Ko, Dong Ryul,Kong, Taeyoung,Choa, Min Hong,You, Je Sung,Chung, Sung Phil 대한임상독성학회 2018 대한임상독성학회지 Vol.16 No.1
Purpose: This study was conducted to evaluate the clinical efficacy of pharmacologic treatment of amatoxin poisoning patients. Methods: Literature was accessed through PubMed, EMBASE, Cochrane library, KoreaMed, KISS and KMBASE. Studies relevant to human use of pharmacologic therapy including silymarin, penicillin and N-acetylcysteine (NAC) for amanita poisoning were included. Case reports, letters, editorials and papers with insufficient information were excluded. Comparison of clinical outcomes (especially mortality and liver transplantation rate) in each study was analyzed. Results: The final analysis included 13 retrospective studies. None of these studies showed direct comparisons of individual agents. Among 12 studies comparing silymarin vs penicillin, eight showed clinical superiority of silymarin. Among eight studies comparing silymarin with NAC, six showed clinical superiority of silymarin. Among seven studies of NAC vs penicillin, five showed clinical superiority of NAC. Conclusion: This systematic review suggested that clinical superiority of various pharmacological agents used to treat amatoxin poisoning is debatable. Nevertheless, the available evidence suggests it is reasonable to consider combinations of multiple agents for patients with amanita poisoning. Further studies are required to establish a treatment regimen for amanita poisoning.
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최민우,조남석,Choi, Min Woo,Cho, Namsuk 한국시뮬레이션학회 2019 한국시뮬레이션학회 논문지 Vol.28 No.1
군 병력 감축, 인명중시 사상의 확산 그리고 4차 산업혁명을 통한 혁신 기술의 국방에서의 활용과 같은 시대적 요구 속에 드론-봇의 적극적인 활용이 요구되고 있다. 특히, 드론을 활용한 감시 및 정찰은 미래 전장에서 큰 역할을 할 것으로 예상된다. 하지만 정찰용 드론의 운용 개념, 특히 적을 찾기 위한 드론의 탐색 경로에 대한 연구는 많이 이루어지지 않았다. 본 연구에서는 정찰 목적용 드론의 효과적인 운용을 위한 탐색 방법을 시뮬레이션 분석을 통해 제안한다. 시뮬레이션에서 드론과 적은 연속공간에서 선형(First-Order)으로 움직이며, 적은 불확실성을 반영하여 랜덤워크 기법을 적용하였다. 연구는 먼저 기존에 군에서 주요하게 활용하던 탐색 방법(Parallel, Spiral)이 실제로 목표를 탐지하는 확률을 제시하며, 이어서 탐지자의 탐색반경과 속도가 탐지 확률에 미치는 영향을 분석한다. 마지막으로, 적이 랜덤하게 이동하지 않고 특정한 목표를 가지고 이동할 때 적용할 수 있는 새로운 탐지방법인 PS(Probability Search), PCS((Probability Circle Search), HS(Hamiltonian Search), HCS(Hamiltonian Circle Search) 방법을 소개하고 이에 대한 실험결과를 제시한다. 본 연구에서 제시한 탐색방법은 드론의 정찰 작전 시 활용도가 클 것으로 기대한다. The use of drone-bots is demanded in times regarding the reduction of military force, the spread of the life-oriented thought, and the use of innovative technology in the defense through the fourth industrial revolution. Especially, the drone's surveillance and reconnaissance are expected to play a big role in the future battlefield. However, there are not many cases in which the concept of operation is studied scientifically. In this study, We propose search algorithms for reconnaissance drone through simulation analysis. In the simulation, the drone and target move linearly in continuous space, and the target is moving adopting the Random-walk concept to reflect the uncertainty of the battlefield. The research investigates the effectiveness of existing search methods such as Parallel and Spiral Search. We analyze the probabilistic analysis for detector radius and the speed on the detection probability. In particular, the new detection algorithms those can be used when an enemy moves toward a specific goal, PS (Probability Search) and HS (Hamiltonian Search), are introduced. The results of this study will have applicability on planning the path for the reconnaissance operations using drone-bots.
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최민우,배민환,안중호,Choi, Min Woo,Bae, Min Hwan,Ahn, Jung-Ho 한국분말야금학회 2016 한국분말재료학회지 (KPMI) Vol.23 No.3
Copper nanoparticles attract much attention as substitutes of noble metals such as silver and can help reduce the manufacturing cost of electronic products due to their lower cost and good conductivity. In the present work, the chemical reduction is examined to optimize the synthesis of nano-sized copper particles from copper sulfate. Sodium borohydride and ascorbic acid are used as reducing and antioxidant agents, respectively. Polyethylene glycol (PEG) is used as a size-control and capping agent. An appropriate dose of PEG inhibits the abnormal growth of copper nanoparticles, maintaining chemical stability. The addition of ascorbic acid prevents the oxidation of nanoparticles during synthesis and storage. Transmission electron microscopy (TEM) and Fourier transform infrared spectroscopy (FTIR) are used to investigate the size of the synthesized nanoparticles and the coordination between copper nanoparticles and PEG. For chemical reduction, copper nanoparticles less than 100 nm in size without oxidized layers are successfully obtained by the present method.
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최민우,노환길,이재용,이현수,Choi Min-Woo,Roh Whan-Gil,Lee Jae-Yong,Lee Hyun-Soo 한국건설관리학회 2000 건설관리 : 한국건설관리학회 학회지 Vol.1 No.3
The average height of buildings in most cities is increasing in an effort to more effectively use land. In addition, as construction technology develops, rapid construction methods have been pursued. However, while there have been great strides in construction technology, the development of a temporary structure that can support the high-rise building under construction and the rapid construction methods has been relatively limited. If the temporary structure is not built on an outer wall of a building being constructed, a worker may be injured or killed in a fall and building materials such as blocks and other objects may fall to the ground, causing the build-up of trash around the building and possible injuries to persons in proximity to the building. This paper proposes a Self Climbing Safety Fence for construction building(SCfence). SCfence was developed to solve the above problems, a tent has been setup to cover the outer wall of the building, or a falling preventing net has been pitched in a direction perpendicular to the outer wall of the building. A case study was performed to verify the validity of SCfence through comparing the safety and cost experience between SCfence and the existing method. 최근 건축공사는 지가의 상승과 토지의 효율적인 이용을 위하여 지하층 깊이의 증가와 초고층화 되는 추세에 있으며, 건축시공 기술의 발달과 관리기법의 선진화에 따라 신속한 공사진행이 요구되고 있다. 그러나 이와 같은 시공기술과 관련시공법의 괄목할만한 발전에도 불구하고 초고층화와 신속한 공사진행을 뒷받침하여 줄만한 적절한 가설기법의 개발은 매우 미미한 실정이다. 공사중에는 건축물 외벽부에 대한 적절한 가설설비의 뒷받침이 없으면 건축물의 상층부에서 건축자재, 블록, 이물질 등이 낙하되어 분진 발생 등기 환경오염과 현장주변을 통행하는 사람이나 차량 등에 피해를 입히는 사고가 발생할 수 있으며 작업자의 추락재해와 같은 사고기 위험성도 높아지게 된다. 이에 본 연구에서는 분진, 낙하, 추락, 보양 등의 문제점을 해결하기 위하여 건축공사용 안전펜스공법(SCfence)을 제시하였으며, 이 공법은 건축물의 외측에 유도용 레일을 부착하여 고정시키고 이 유도용 레일을 따라 안전펜스가 승강하여 이동이 가능하고 건축물의 외부를 완전히 방호할 수 있도록 개발되었다. 또한 개발공법을 현장에 적용한 결과, 안전성 확보와 원가절감의 효과가 기존공법보다 우수한 것으로 나타났다.
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LPS로 유도된 RAW 264.7 대식세포에 대한 미역U(ndaria pinnatifida) Ethyl Acetate 분획물의 항염증 효과
최민우 ( Min Woo Choi ),김재일 ( Jae Il Kim ) 한국수산과학회 2013 한국수산과학회지 Vol.46 No.4
An ethanolic extract of Undaria pinnatifida was fractionated using several solvents. Of the fractions, the ethyl acetate fraction had the greatest inhibitory effect on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophage cells. Using this fraction (U. pinnatifida ethyl acetate extract, UPE), we investigated the molecular mechanism underlying its inhibitory effect on LPS-stimulated RAW 264.7 cells. Pretreatment of the cells with up to 100 μg/mL UPE significantly inhibited NO production and inducible nitric oxide synthase (iNOS) expression, in a dose-dependent manner. Similarly, UPE treatment markedly reduced the production of pro-inflammatory cytokines, such as interleukin (IL)-1, IL-6 and tumor necrosis factor-α (TNF-α), while it strongly suppressed the nuclear translocation of nuclear factor-kappa B (NF-κB) by preventing proteolytic degradation of inhibitor of nuclear factor κB (IκB)-α. Moreover, UPE treatment significantly reduced the phosphorylation of phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK) in LPS-stimulated cells. These results indicate that UPE contains anti-inflammatory compounds and suggest that it might be used as a functional food material that assists in prevention of inflammatory diseases.
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항행 및 항법 : 고고도 장기체공 무인기와 의사위성/트랜시버를 활용한 국지적 대체항법에 관한 연구
최민우 ( Min-woo Choi ),유선경 ( Sun-kyoung Yu ),김오종 ( O-jong Kim ),기창돈 ( Chang-don Kee ),박병운 ( Byung-woon Park ),서승우 ( Seung-woo Seo ),박준표 ( Jun-pyo Park ) 한국항행학회 2015 韓國航行學會論文誌 Vol.19 No.6
GNSS (global navigation satellite systems)은 민·군 차원에서 매우 다양한 분야에 활용되고 있다. 그러나 GNSS 신호는 재밍에 상당히 취약해 쉽게 방해 받을 가능성이 상존하기에 GNSS을 사용 불가능할 시에도 일정 수준의 항법성능을 보장하여 주는 일련의 백업 또는 대체항법 시스템이 필요하다. 본 논문에서는 의사위성 또는 트랜시버를 장착한 고고도 장기체공 무인기(HALE UAV;high altitude long endurance unmanned aerial vehicle)의 개념을 도입하여 국지적인 지역에서 백업 또는 대체항법 시스템을 제안하고자 하였다. 제안된 대체항법 시스템을 기반으로 고고도 장기체공 무인기의 위치 오차를 추정하고, 이를 바탕으로 최종적인 사용자 위치정확도를 산출하여 본 연구에서의 국지적 대체항법의 성능을 나타내었다. Global navigation satellite systems (GNSS) is operating widely in civil and military area. GNSS signals, however, can be easily interfered because its signal is vulnerable to jamming. Thus, a sort of backup or alternative system is needed in order that the navigation performance is assured to a certain degree in case of GNSS jamming. In order to suggest a series of backup or alternative system of regional navigation, in this paper, we introduced a high altitude long endurance unmanned aerial vehicle (HALE UAV) with pseudolites using inverted GPS and transceiver system. We simulated the positioning error of the regional navigation system using HALE UAV with inverted GPS or transceivers concepts. We estimated the position error of HALE UAV calculate user position errors based on the position error of HALE UAV and general pseudorange error.
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