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이용환,박명호,최명원,천봉권,허방,탁효정,황인철,Lee, Yong-Hwan,Park, Myung-Ho,Choi, Myung-Won,Chun, Bong-Kwon,Hur, Bang,Tak, Hyo-Jung,Hwang, In-Chul 한국생명과학회 2001 생명과학회지 Vol.11 No.6
마늘 속에서 중금속 중독 시에 킬에이트 작용을 일으킬수 있다는 다량의 황 화합물이 함유되어 있으므로 납 중독 흰쥐에서 그 효과를 확인하고자 본 연구를 실시한 결과 마늘 500mg/kg 투여 흰쥐군에서 유의한 납 배설량의 증가가 있었으며, 납과 마늘의 동시에 투여했을 경우에는 납 단독 투여군 보다 신장에서의 병리조직학적 변화가 경미한 것을 관찰할수 있었다. 이러한 결과는 마늘이 납 중독에대한 킬레이트제로서의 이용 가능성이 있음을 나타내고 있다. Lead poisoning is currently one of the major public health problems in industrialized countries. Several chelating agents have been developed and used to treat the lead poisoning. It was recently proposed that garlic, having a large quantity of S-S compounds, may react readily with lead, producing various sulfur componds, and thus provide curative and protective effects on the lead toxicity. The present study was undertaken to evaluate this possibility in experimental animals. The garlic treatment on rats pre-exposed to lead significantly enhanced urinary excretion of lead at a garlic dose of 500 mg/kg and decreased the bloon level of lead at both 250 and 500 mg/kg doses. The administration of grilic 500mg/kg along with lead significantly alleviated the renal histological alterations induced by lead. These results suggest that garilic has a curative as well as a protective effect against lead poisoning , thus it may act as a chelator of lead.
윤후식,장기경,강정수,김훈,김호균,김병창,천봉권,Yoon, Hoo-Sik,Chang, Ki-Kyung,Kang, Jeong-Soo,Kim, Hun,Kim, Ho-Kyun,Kim, Byung-Chang,Chun, Bong-Kwon 대한흉부심장혈관외과학회 1998 Journal of Chest Surgery (J Chest Surg) Vol.31 No.5
氷복茸兌\ulcorner환자에서 발생하는 연하곤란은 보통 역류성 식도염, 감염성 식도염, 화학요법 및 백혈병의 직접적인 식도 침범에 의해 발생하지만 그중에서도 백혈병 환자의 화학요법의 결과로 발생하는 식도협착중 급성으로 발병하는 경우는 아주 드물다. 본원에서는 40세의 남자환자가 급성 골수성 백혈병으로 화학요법 받은지 1개월 이내에 발생한 급성 식도협착으로 수술위해 입원, 식도 절제술 및 위식도 문합술 과 유문부 성형술을 시행하였다. 병리 조직검사상 단핵구들의 점막 침착 및 점막하조직과 근육층을 침범하는 섬유화소견을 보이고 있다. Although dysphagia in patients with acute leukemia is usually related to reflux esophagitis, infectious esophagitis, chemotherapy1) and leukemic infiltration2), acute esophageal stricture resulting from chemotherapy in the patient with leukemia is very rare. A 40-year-old man with acute myelogenous leukemia was admitted for operation of esophageal stricture which was developed within 1 month of chemotherapy. An esophagectomy and esophagogastrostomy with pyloroplasty was carried out. Histology showed mucosal infiltration of mononuclear cells and transmural fibrosis involving submucosa and the muscle layer.
저용량 Mitomycin-C에 의한 혈전성 미소혈관중 3예
정연순 ( Yeon Soon Jung ),김현영 ( Hyun Young Kim ),육동승 ( Dong Seung Yook ),천봉권 ( Bong Kwon Chun ),황일용 ( Il Yong Hwang ),임학 ( Hark Rim ) 대한신장학회 2003 Kidney Research and Clinical Practice Vol.22 No.1
Mitomycin (MMC) is a naturally ocurring alkylating agent, introduced for clinical use as early as 1958. This drug is useful in the therapy of gastrointestinal carcinoms when used in combination with 5-fluorouracil. Nephrotoxicity among toxicities from MMC is unusual with cumulative doses less than 30 mg/m^2. In large studies in which the incidence of MMC nephrotoxicity were assessed, 3-15% of patients developed total dose related renal dysfunction. Three patients in our clinical practice have developed thrombotic microangiopathy clearly related to MMC. We report the clinical and pathologic features of ourcases. In view of the probable dose-related and delayed toxicity of MMC, it seems necessary to monitor regularly after initiation of chemotherapy. Early detection of the renal impairment and withdrawal of MMC might halt further progression of renal failure.
증례 : 신장 ; 급성 카드뮴 중독에 의한 급속 진행성 신부전 1예
이은영 ( Eun Young Lee ),신호식 ( Ho Sik Shin ),정연순 ( Yeon Soon Jung ),천봉권 ( Bong Kwon Chun ),임학 ( Hark Rim ) 대한내과학회 2010 대한내과학회지 Vol.78 No.6
저자들은 한약 복약 이후 일시적으로 혈중 카드뮴 농도는 정상이면서 요중 카드뮴 배설이 증가한 환자에서 판코니증후군이 발생하여 비교적 빠른 시간 내 만성신부전으로 진행한 환자의 증례를 보고한다. 상기 환자의 증례를 통하여 카드뮴에 노출될 수 있는 가능성이 있는 환자에서 신손상이 유발될 수 있음을 알고 주의할 것을 제시한다. Cadmium (Cd)-induced renal damage primarily affects the cellular and functional integrity of the proximal tubules. Cd intoxication is a rare cause of Fanconi syndrome. We report a 31-year-old woman with Fanconi syndrome confirmed by laboratory findings and a renal biopsy that also showed an elevated urinary Cd. Seven months before admission, the patient had a normal urinalysis and renal function. Six and 3 months before admission, the patient ingested Chinese herbal mixtures. On admission, the blood Cd concentration was normal, and the urine Cd concentration was 58 μg/g of creatinine, 29-times higher than the normal range. A renal biopsy showed degeneration of the proximal tubules with normal glomeruli. The serum creatinine had increased from 1.2 to 3.2 mg/dL over 8 months. This case of Fanconi syndrome and rapidly progressive renal damage over a short period was associated with elevated urinary Cd levels. (Korean J Med 78:761-765, 2010)
김지혜 ( Ji Hye Kim ),최바울 ( Paul Choi ),정연순 ( Yeon Soon Jung ),장성훈 ( Seong Hoon Chang ),어완규 ( Wan Kyu Eo ),천봉권 ( Bong Kwon Chun ),임학 ( Hark Rim ) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.6
Secondary polycythemia occasionally associated with renal diseases such as renal tumors, cysts, hydronephrosis, renal transplantation, renal artery stenosis and Banter`s syndrome and is rarely associated wish nephrotic syndrome, nephrosclerosis, pyelonephritis, chronic gromerulonephritis and membranous nephropathy. The association of polycythemia vera and immunoglobulin A nephropathy (IgAN) is well not known, and there are only a few isolated reports presnting the concomitance of polycythemia vera and IgAN. We report one patient with concomitant polycythemia vera and Ig A nephropathy. A 53 year-old male visited our hospital because of elevated hemoglobin level. Blood value of hemoglobin was 22.1 g/dL. Isotopic blood studies with radioactive chromium (^51CO-labelled red blood cells revealed a total blood volume of 90 mL/㎏ and total red cell volume of 61.8 mL/㎏. The concentration of serum erythropoietin measured by radioimmunoassay was 14.29 mIU/mL (normal 10.2-25.2 mIU/mL). Bone marrow aspirate revealed hypercellularity and panmyelosis, characteristically, Renal biopsy specimens showed moderate mesangioproliferative lesions with mesangial IgA and C_3 deposition. Treatment with phlebotomy, hydroxyurea and oral prednisolone (1 ㎎/㎏/day) was done. There was no decrease of urinary protein following treatment of phlebotomy and hydroxyurea. But urinary protein decreased and hemoglobin level normalized following combination treatment of phlebotomy, hydroxyurea and oral prednisolone.
증례 : Von Hippel-Lindau 유전자 배선 돌연변이와 동반된 가족성 양측성 갈색 세포종 1예
양재홍 ( Jae Hong Yang ),최영식 ( Yonung Sik Choi ),박요한 ( Yo Han Park ),오경승 ( Kyung Seung Oh ),천봉권 ( Bong Kwon Chun ),이상준 ( Sang Jun Lee ),김일진 ( Il Jin Kim ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
Von Hippel-Lindau (VHL)병은 VHL 유전자의 배선 돌연변이(germline mutation)의 결과로 발생하며, 상염색체 우성으로 유전하는 질환으로 소뇌, 척수, 뇌간 및 망막의 혈관모세포종과 신세포암, 갈색세포종 및 췌도종양 등의 여러 장기에 양성 및 악성 종양을 초래 하는 질환이다. 저자들은 양측성 갈색세포종을 가진 딸과 양측성 갈색세포종과 시력장애 및 췌장종양을 가진 환자에서 시행한 유전자 검사상 VHL exon2, codon 121에서 GAT (Asp)가 AAT (Asn)으로 배선돌연변이를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Von Hippel-Lindau (VHL) disease is an autosomal dominant inherited tumor syndrome characterized by multiple benign and malignant tumors of the central nervous system (CNS), retina, kidney, pancreas and adrenal glands. VHL disease is associated with a germline mutation of the VHL tumor suppressor gene on the short arm of chromosome 3. VHL disease has been divided in four subtypes, based on development of different tumors. VHL diseases without pheochromocytoma are classified as type 1, and those with pheochromocytoma type 2. VHL disease type 2 is divided into 2A based on the presence of renal cancer or 2B by the absence of renal cancer, and 2C has pheochromocytoma only. Recently we experienced a family with VHL type 2A and VHL type 2C who carry a novel type GAT (Asp) to AAT (Asn) missense germline mutation in codon 121 of exon 2 of VHL gene. The authors report this case with literature review. (Korean J Med 69:S873-S878, 2005)