http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Streptozotocin 유발 당뇨쥐의 혈당 및 혈중 지질조성에 미치는 Oligosaccharide의 영향
채영미(Young-Mi Chai),이순재(Soon-Jae Rhee) 한국식품영양과학회 2001 한국식품영양과학회지 Vol.30 No.4
본 연구에서는 oligo당의 당뇨합병증 예방효과를 규명하기 위하여 올리고당 비공급군(DM군) xylooligo당 공급군(DM-XO군), isomaltooligo당 공급군(DM-IMO군) 및 fructooligo당 공급군(DM-FO군)으로 나누어 각각 식이에 10% 씩 올리고당을 첨가하여 4주간 사육 후 STZ로 당뇨 유발한 후 다시 4주간 사육한 후 이당류 분해효소의 활성, 혈당, 장기무게 및 혈중 중성지질과 콜레스테롤 농도를 관찰하였다. 당뇨유발 실험군에서 체중증가량, 식이섭취량 및 식이효율은 올리고당의 영향은 없었다. 간장, 신장 및 소장무게에는 당뇨군에서 올리고당의 영향이 없었으나 맹장의 무게는 올리고당 비공급당뇨군(DM군)에 비해 DM-XO군과 DM-IMO군은 유의적으로 증가되었다. 당뇨쥐의 경구 당부하 검사에서 DM군에 비해 DM-FO군은 차이가 없었으나, DM-XO과 DM-IMO군들은 내당능 개선 효과가 현저하였다. 혈당은 당뇨유발 2주 및 4주에서 DM군에 비해 올리고당 공급군에서 낮았고 그중에서도 DM-XO군이 가장 효과적이었다. 소장내 lactase 및 sucrase의 활성은 DM군에 비해 DM-XO 군과 DM-FO군에서는 현저하게 감소되었으나 maltase 활성은 DM-XO군에서만 유의적으로 감소되었다. 장 통과시간은 DM군에 비해 DM-XO군과 DM-FO군에서 각각 54% 및 46%씩 감소되었다. 혈청 중성지방 농도는 올리고당 공급군 중 DM-XO군에서 DM군에 비해 유의적으로 감소되었다. 혈청 총 콜레스테롤 농도는 DM군과 DM-FO군은 높았지만 DM-XO군과 DM-IMO군에서는 정상군과 유의적인 차이가 없었다. 결론적으로 oligo당은 당뇨쥐의 혈당 및 혈중 지질조성 개선작용의 가능성이 있으므로 당뇨 합병증 예방의 기능성 식품으로서 기대된다. This study was conducted to examine the effects of dietary oligosaccharide on the blood glucose and serum lipid composition in streptozotocin (STZ)-induced diabetic rats. Sprague-Dawley male rats weighing 150±10 g were randomly assigned to one normal and four STZ-induced diabetic groups. Diabetic groups were classified to basal diet (DM group), 10% xylooligosaccharide diet (DM-XO group), 10% isomaltooligosaccharide (DM-IMO group) and 10% fructooligosaccharide (DM-FO). Diabetes was experimentally induced by intravenous injection of 50 mg/kg of body weight of STZ in citrate buffer (pH 4.3) after feeding of experimental diets for 4 weeks. The rats were fed with experimental diet for further 4 weeks in diabetic state. The oligosaccharide diets were not effected on the body weight, food intakes and food efficiency ratio. The oligosaccharide diets were also not effected on the weights of liver, kidney and small intestine, but the weight of cecum was significantly increased on the groups of xylooligosaccharide and isomaltooligosaccharide diet. The levels of oral glucose tolerance test was more effectively improved by DM-XO group. The levels of blood glucose were markedly lower in oligosaccharide supplemented groups than that of DM group. Activities of two intestinal enzymes such as lactase and sucrase in DM-XO and DM-FO groups were lower than that of DM group, while activity of maltase was lower only in DM-XO group than that of DM group. A gastrointestinal transit time were shorter 54% and 46% in DM-XO and DM-FO groups than that of DM-group, respectively. The levels of serum triglyceride in DM-XO groups were lower than that of DM group, however was no significant differences among the oligosaccharide groups. The levels serum cholesterol in DM-XO and DM-IMO groups were as same as that of normal group, while the level of serum cholesterol in DM-FO group was higher than that of normal group. These results suggest that dietary oligosaccharide may act as functional food to be capable of improving carbohydrate and lipid metabolism in diabetic rats.
할로탄 마취견에서 기절심근의 기능회복에 미치는 관동맥내 Nicardipine 의 영향
김경희,유경연,정창영,윤명하,채영미 대한마취과학회 1996 Korean Journal of Anesthesiology Vol.31 No.2
Background: Myocardial calcium overload during reperfusion may contribute to myocardial stunning. The protective effect of nicardipine against post-ischemic myocardial dysfunction was investigated. Methods: Twenty-two halothane-anesthetized dogs were subjected to 15 minutes of left anterior descending coronary artery (LAD) occlusion and subsequent 3 hour reperfusion. One group of dogs (n=ll) received nicardipine (1 ug/kg/min) and another group (n=l1) received saline (0.5 ml/kg/h) through intracoronary catheter for 1 hour beginning 15 minutes before LAD occlusion. Systolic shortening (%SS) and preload recruitable stroke work slope (Mw), as an index of regional myocardial contractility, and IMP-tau (time constant of myocardial relaxation based on intramyocardial pressure (IMP)) and post-systolic shortening (%PSS), as an index of regional diastolic function, were evaluated. LAD blood flow was measured by Doppler flowmeters as well. Results: Regional systolic as well as diastolic functions during acute myocardial ischemia were similar between the two groups. However, Mw recovered to the baseline value with the onset of reperfusion in the nicardipine group but was significantly decreased throughout the reperfusion period in the controls. After 3 hours of reperfusion, the nicardipine group had recovered 67 % of %SS, compared with 20 % of the control group. IMP-tau was restored to the baseline value by 60 min of reperfusion in the control group but was significantly prolonged in the nicardipine group throughout the reperfusion period. Conclusion: Intracoronary nicardipine enhances the recovery of regional contractile function but prolongs myocardial relaxation in the canine model of myocardial stunning.